References
- United States Cancer Statistics: 1999–2007 incidence and mortality web-based reportAtlanta, GACenters for Disease Control and Prevention Available from: http://apps.nccd.cdc.gov/uscs/Accessed April 16, 2012
- MaXDoesMRazaAMayneSTMyelodysplastic syndromes: incidence and survival in the United StatesCancer200710981536154217345612
- US Census BureauCurrent Population Reports1193
- SteensmaDPHeptinstallKVJohnsonVMCommon troublesome symptoms and their impact on quality of life in patients with myelodysplastic syndromes (MDS): results of a large Internet-based surveyLeuk Res200832569169818054795
- JansenAJEssink-BotMLBeckersEAHopWCSchipperusMRVan RhenenDJQuality of life measurement in patients with transfusion-dependent myelodysplastic syndromesBr J Haematol2003121227027412694248
- PlatzbeckerUHofbauerLCEhningerGHoligKThe clinical, quality of life, and economic consequences of chronic anemia and transfusion support in patients with myelodysplastic syndromesLeuk Res1312012 [Epub ahead of print.]
- Hellstrom-LindbergEGulbrandsenNLindbergGA validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of lifeBr J Haematol200312061037104612648074
- SeymourJFFenauxPSilvermanLREffects of azacitidine compared with conventional care regimens in elderly (≥75 years) patients with higher-risk myelodysplastic syndromesCrit Rev Oncol Hematol201076321822720451404
- SekeresMASchoonenWMKantarjianHCharacteristics of US patients with myelodysplastic syndromes: results of six cross-sectional physician surveysJ Natl Cancer Inst2008100211542155118957672
- BurnettAKMilliganDPrenticeAGA comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatmentCancer200710961114112417315155
- ShihAHLevineRLMolecular biology of myelodysplastic syndromesSemin Oncol201138561362021943667
- GreenbergPCoxCLeBeauMMInternational scoring system for evaluating prognosis in myelodysplastic syndromesBlood1997896207920889058730
- JiangYDunbarAGondekLPAberrant DNA methylation is a dominant mechanism in MDS progression to AMLBlood200911361315132518832655
- WardAJCooperTAThe pathobiology of splicingJ Pathol2010220215216319918805
- YoshidaKSanadaMShiraishiYFrequent pathway mutations of splicing machinery in myelodysplasiaNature20114787367646921909114
- VisconteVMakishimaHJankowskaASF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblastsLeukemia201226354254521886174
- PapaemmanuilECazzolaMBoultwoodJSomatic SF3B1 mutation in myelodysplasia with ring sideroblastsN Engl J Med2011365151384139521995386
- DammFKosmiderOGelsi-BoyerVMutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromesBlood2012119143211321822343920
- JaderstenMSaftLSmithATP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progressionJ Clin Oncol201129151971197921519010
- KoMHuangYJankowskaAMImpaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2Nature2010468732583984321057493
- JankowskaAMMakishimaHTiuRVMutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3ABlood2011118143932394121828135
- HarriesLWHernandezDHenleyWHuman aging is characterized by focused changes in gene expression and deregulation of alternative splicingAging Cell201110586887821668623
- ForsbergLARasiCRazzaghianHRAge-related somatic structural changes in the nuclear genome of human blood cellsAm J Hum Genet201290221722822305530
- FenauxPMuftiGJHellstrom-LindbergEEfficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III studyLancet Oncol200910322323219230772
- KantarjianHIssaJPRosenfeldCSDecitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized studyCancer200610681794180316532500
- LubbertMSuciuSBailaLLow-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study GroupJ Clin Oncol201129151987199621483003
- SteensmaDPBaerMRSlackJLMulticenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trialJ Clin Oncol200927233842384819528372
- KantarjianHOkiYGarcia-ManeroGResults of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemiaBlood20071091525716882708
- SilvermanLRMcKenzieDRPetersonBLFurther analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group BJ Clin Oncol200624243895390316921040
- KornblithABHerndonJE2ndSilvermanLRImpact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B studyJ Clin Oncol200220102441245212011121
- ItzyksonRThepotSQuesnelBPrognostic factors for response and overall survival in 282 patients with higher-risk myelodysplastic syndromes treated with azacitidineBlood2011117240341120940414
- FenauxPGattermannNSeymourJFProlonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-CBr J Haematol2010149224424920136825
- KantarjianHO’BrienSCortesJResults of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcomeCancer200610651090109816435386
- MarcucciGSilvermanLEllerMLintzLBeachCLBioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromesJ Clin Pharmacol200545559760215831784
- LyonsRMCosgriffTMModiSSHematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromesJ Clin Oncol200927111850185619255328
- GarciaRde MiguelDBailenADifferent clinical results with the use of different dosing schedules of azacitidine in patients with myelodysplastic syndrome managed in community-based practice: effectiveness and safety data from the Spanish azacitidine compassionate use registry (Abstract 2773)Blood200914422
- Garcia-ManeroGGoreSDCogleCPhase I study of oral azacitidine in myelodysplastic sydromes, chronic myelomonocytic leukemia and acute myeloid leukemiaJ Clin Oncol201129182521252721576646
- SilvermanLRDemakosEPPetersonBLRandomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the Cancer and Leukemia Group BJ Clin Oncol200220102429244012011120
- SantiniVFenauxPMuftiGJManagement and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine*Eur J Haematol201085213013820394651
- ItzyksonRThepotSBeyne-RauzyODoes addition of erythropoiesis stimulating agents improve the outcome of higher-risk myelodysplastic syndromes treated with azacitidine?Leuk Res201136439740022177456
- KantarjianHMGilesFJGreenbergPLPhase 2 study of romiplostim in patients with low-or intermediate-risk myelodysplastic syndrome receiving azacitidine therapyBlood2010116173163317020631375
- ListAKurtinSRoeDJEfficacy of lenalidomide in myelodysplastic syndromesN Engl J Med2005352654955715703420
- ListADewaldGBennettJLenalidomide in the myelodysplastic syndrome with chromosome 5q deletionN Engl J Med2006355141456146517021321
- MustoPMaurilloLSpagnoliAAzacitidine for the treatment of lower risk myelodysplastic syndromes: a retrospective study of 74 patients enrolled in an Italian named patient programCancer201011661485149420151429
- GrovdalMKarimiMKhanRMaintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapyBr J Haematol2010150329330220497178
- BraitehFSorianoAOGarcia-ManeroGPhase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancersClin Cancer Res200814196296630118829512
- SekeresMAListAFCuthbertsonDPhase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromesJ Clin Oncol201028132253225820354132
- SekeresMAO’KeefeCListAFDemonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromesAm J Hematol201186110210321080340
- PollyeaDAKohrtHEGallegosLSafety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemiaLeukemia10282011 [Epub ahead of print.]