1,001
Views
13
CrossRef citations to date
0
Altmetric
Clinical Trial Report

Changes in Menopausal Risk Factors in Early Postmenopausal Osteopenic Women After 13 Months of High-Intensity Exercise: The Randomized Controlled ACTLIFE-RCT

ORCID Icon, , ORCID Icon, ORCID Icon, , , , , ORCID Icon, , , & ORCID Icon show all
Pages 83-96 | Published online: 11 Jan 2021

References

  • Hoga L, Rodolpho J, Goncalves B, Quirino B. Women’s experience of menopause: a systematic review of qualitative evidence. JBI Database System Rev Implement Rep. 2015;13(8):250–337. doi:10.11124/01938924-201513080-00018
  • Overlie I, Moen MD, Morkrid L. The endocrine transition around menopause - a five year prospective study with profiles of gonadotropins, estrogens, androgens and SHBG among healthy women. Acta Obstet Gynecol Scand. 1999;78:642–647.10422913
  • McKinlay SM. The normal menopause transition: an overview. Maturitas. 1996;23(2):137–145. doi:10.1016/0378-5122(95)00985-X8735352
  • Finkelstein JS, Brockwell SE, Mehta V, et al. Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab. 2008;93(3):861–868. doi:10.1210/jc.2007-187618160467
  • Aloia JF, McGowan DM, Vaswani AN, Ross PL, Cohn SH. Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr. 1991;53:1378–1383.2035465
  • Sowers M, Zheng H, Tomey K, et al. Changes in body composition in women over six years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab. 2007;92(3):895–901. doi:10.1210/jc.2006-139317192296
  • Maltais ML, Desroches J, Dionne IJ. Changes in muscle mass and strength after menopause. J Musculoskelet Neuronal Interact. 2009;9(4):186–197.19949277
  • Sirola J, Rikkonen T. Muscle performance after the menopause. J Br Menopause Soc. 2005;11(2):45–50. doi:10.1258/13621800577554456115970014
  • Nelson HD. Menopause. Lancet. 2008;371(9614):760–770. doi:10.1016/S0140-6736(08)60346-318313505
  • Gao H-L, Gao H-X, Sun FM, Zhang L. Effects of walking on body composition in perimenopausal and postmenopausal women: a systematic review and meta-analysis. Menopause. 2016;23(8):928–934. doi:10.1097/GME.000000000000062727187009
  • Howe TE, Shea B, Dawson LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev. 2011;(7):CD000333.21735380
  • Lobo RA, Davis SR, De Villiers TJ, et al. Prevention of diseases after menopause. Climacteric. 2014;17(5):540–556. doi:10.3109/13697137.2014.93341124969415
  • Slaven L, Lee C. Mood and symptom reporting among middle-aged women: the relationship between menopausal status, hormone replacement therapy, and exercise participation. Health Psychol. 1997;16(3):203–208. doi:10.1037/0278-6133.16.3.2039152697
  • Daley AJ, Stokes-Lampard HJ, Macarthur C. Exercise to reduce vasomotor and other menopausal symptoms: a review. Maturitas. 2009;63(3):176–180. doi:10.1016/j.maturitas.2009.02.00419285813
  • Grindler NM, Santoro NF. Menopause and exercise. Menopause. 2015;22(12):1351–1358. doi:10.1097/GME.000000000000053626382311
  • Shojaa N, von Stengel S, Schoene D, et al. Effect of exercise training on bone mineral density in postmenopausal women: A systematic review and meta-analysis of intervention studies. Front Physiol. 2020;11:1427–1444. doi:10.3389/fphys.2020.00652
  • Kemmler W, Lauber D, Weineck J, Hensen J, Kalender W, Engelke K. Benefits of 2 years of intense exercise on bone density, physical fitness, and blood lipids in early postmenopausal osteopenic women: results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). Arch Intern Med. 2004;164(10):1084–1091. doi:10.1001/archinte.164.10.108415159265
  • Kemmler W, Bebenek M, von Stengel S, Engelke K, Kalender WA. Effect of block-periodized exercise training on bone and coronary heart disease risk factors in early post-menopausal women: a randomized controlled study. Scand J Med Sci Sports. 2013;23(1):121–129. doi:10.1111/j.1600-0838.2011.01335.x21631599
  • World_Medical_Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi:10.1001/jama.2013.28105324141714
  • DVO. Prophylaxe, Diagnostik und Therapie der OSTEOPOROSE bei postmenopausalen Frauen und bei Männern Stuttgart. Schattauer; 2017.
  • Gießing J. HIT-Hochintensitätstraining Arnsberg. Novagenics-Verlag; 2008.
  • Bebenek M, Kemmler W, von Stengel S, Engelke K, Kalender W. Effect of exercise and Cimicifuga racemosa (CR BNO 1055) on postmenopausal risk factors and complaints - the randomized controlled TRACE Study. Menopause. 2010;17(4):791–800.20220537
  • Steele J, Fisher J, Giessing J, Gentil P. Clarity in reporting terminology and definitions of set end points in resistance training. Muscle Nerve. 2017;368–374(3):368–374. doi:10.1002/mus.25557
  • Zourdos MC, Klemp A, Dolan C, et al. Novel resistance training-specific rating of perceived exertion scale measuring repetitions in reserve. J Strength Cond Res. 2016;30(1):267–275. doi:10.1519/JSC.000000000000104926049792
  • Kemmler WK, Lauber D, Wassermann A, Mayhew JL. Predicting maximal strength in trained postmenopausal woman. J Strength Cond Res. 2006;20(4):838–842.17194251
  • Borg G, Borg E. The Borg CR Scales® Folder. Hasselby, Sweden; 2010.
  • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome–a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006;23(5):469–480. doi:10.1111/j.1464-5491.2006.01858.x16681555
  • Johnson JL, Slentz CA, Houmard JA, et al. Exercise training amount and intensity effects on metabolic syndrome (from studies of a targeted risk reduction intervention through defined exercise). Am J Cardiol. 2007;100(12):1759–1766. doi:10.1016/j.amjcard.2007.07.02718082522
  • Hauser GA, Schneider HP, Rosemeier PJ, Potthoff P. Die Selbstbeurteilungs-Skala für klimakterischen Beschwerden (Menopause Rating Scale II). J Menopause. 1999;4:13–17.
  • Kemmler W, Weineck J, Kalender WA, Engelke K. The effect of habitual physical activity, non-athletic exercise, muscle strength, and VO2max on bone mineral density is rather low in early postmenopausal osteopenic women. J Musculoskelet Neuronal Interact. 2004;4(3):325–334.15615501
  • Schneider HP, Heinemann LA, Rosemeier HP, Potthoff P, Behre HM. The Menopause Rating Scale (MRS): reliability of scores of menopausal complaints. Climacteric. 2000;3(1):59–64. doi:10.3109/1369713000916760011910611
  • Kemmler W, Engelke K, Lauber D, Weineck J, Hensen J, Kalender WA. Exercise effects on fitness and bone mineral density in early postmenopausal women: 1-year EFOPS results. Med Sci Sports Exerc. 2002;34(12):2115–2123. doi:10.1097/00005768-200212000-0003812471325
  • R_Development_Core_Team R. A language and environment for statistical computing. Vienna, Austria: R Foundation Statistical Computing. 2019.
  • Honaker J, King G, Blackwell M. Amelia II: A program for missing data. JSS. 2011;45(7):1–47.
  • Cohen J Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale NJ eds Lawrence Earlbaum Associate; 1988.
  • Karlamangla AS, Burnett-Bowie SM, Crandall CJ. Bone health during the menopause transition and beyond. Obstet Gynecol Clin North Am. 2018;45(4):695–708. doi:10.1016/j.ogc.2018.07.01230401551
  • Beck BR, Daly RM, Singh MA, Taaffe DR. Exercise and Sports Science Australia (ESSA) position statement on exercise prescription for the prevention and management of osteoporosis. J Sci Med Sport. 2016;20(5):438–445. doi:10.1016/j.jsams.2016.10.00127840033
  • Daly RM, Dalla Via J, Duckham RL, Fraser SF, Helge EW. Exercise for the prevention of osteoporosis in postmenopausal women: an evidence-based guide to the optimal prescription. Braz J Phys Ther. 2019;23(2):170–180. doi:10.1016/j.bjpt.2018.11.01130503353
  • Kemmler W, von Stengel S. Exercise and osteoporosis-related fractures: perspectives and recommendations of the sports and exercise scientist. Physician Sportmed. 2011;39(1):142–157. doi:10.3810/psm.2011.02.1872
  • Watson SL, Weeks BK, Weis LJ, Harding AT, Horan SA, Beck BR. High-intensity resistance and impact training improves bone mineral density and physical function in postmenopausal women with osteopenia and osteoporosis: the LIFTMOR randomized controlled trial. J Bone Miner Res. 2018;33(2):211–220. doi:10.1002/jbmr.328428975661
  • Eriksen EF. Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord. 2010;11(4):219–227. doi:10.1007/s11154-010-9153-121188536
  • Tong A, Flemming K, McInnes E, Oliver S, Craig J. Enhancing transparency in reporting the synthesis of qualitative research: ENTREQ. BMC Med Res Methodol. 2012;12:181. doi:10.1186/1471-2288-12-18123185978
  • Yuan Y, Chen X, Zhang L, et al. The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis. Prog Biophys Mol Biol. 2016;122(2):122–130. doi:10.1016/j.pbiomolbio.2015.11.00526657214
  • Kemmler W, von Stengel S. Exercise frequency, health risk factors, and diseases of the elderly. Arch Phys Med Rehabil. 2013;94(11):2046–2053. doi:10.1016/j.apmr.2013.05.01323748185
  • Kemmler W, von Stengel S, Kohl M. Exercise frequency and bone mineral density development in exercising postmenopausal osteopenic women. Is there a critical dose of exercise for affecting bone? Results of the erlangen fitness and osteoporosis prevention study. Bone. 2016;89:1–6. doi:10.1016/j.bone.2016.04.01927108341
  • Ho SC, Wu S, Chan SG, Sham A. Menopausal transition and changes of body composition: a prospective study in Chinese perimenopausal women. Int J Obes. 2010;34(8):1265–1274. doi:10.1038/ijo.2010.33
  • Poehlman ET, Toth MJ, Gardner AW. Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Int Med. 1995;123(5):673–675. doi:10.7326/0003-4819-123-9-199511010-000057574222
  • Hagstrom AD, Marshall PW, Halaki M, Hackett DA. The effect of resistance training in women on dynamic strength and muscular hypertrophy: a systematic review with meta-analysis. Sports Med. 2020;50(6):1075–1093. doi:10.1007/s40279-019-01247-x31820374
  • Schwingshackl L, Dias S, Strasser B, Hoffmann G. Impact of different training modalities on anthropometric and metabolic characteristics in overweight/obese subjects: a systematic review and network meta-analysis. PLoS One. 2013;8(12):e82853. doi:10.1371/journal.pone.008285324358230
  • Stiegler P, Cunliffe A. The role of diet and exercise for the maintenance of fat-free mass and resting metabolic rate during weight loss. Sports Med. 2006;36(3):239–262. doi:10.2165/00007256-200636030-0000516526835
  • Weck M, Bornstein SR, Barthel A, Bluher M. [Strategies for successful weight reduction - focus on energy balance]. Dtsch Med Wochenschr. 2012;137(43):2223–2228. German.23076670
  • Lesser IA, Guenette JA, Hoogbruin A, et al. Association between exercise-induced change in body composition and change in cardiometabolic risk factors in postmenopausal South Asian women. Appl Physiol Nutr Metab. 2016;41(9):931–937. doi:10.1139/apnm-2016-008227507007
  • Nicklas BJ, Wang X, You T, et al. Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr. 2009;89(4):1043–1052. doi:10.3945/ajcn.2008.2693819211823
  • Mandrup CM, Egelund J, Nyberg M, et al. Effects of high-intensity training on cardiovascular risk factors in premenopausal and postmenopausal women. Am J Obstet Gynecol. 2017;216(4):384e381–384 e311. doi:10.1016/j.ajog.2016.12.01728024987
  • Bateman LA, Slentz CA, Willis LH, et al. Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the studies of a targeted risk reduction intervention through defined exercise - STRRIDE-AT/RT). Am J Cardiol. 2011;108(6):838–844. doi:10.1016/j.amjcard.2011.04.03721741606
  • Conceicao MS, Bonganha B, Vechin V, et al. Sixteen weeks of resistance training can decrease the risk of metabolic syndrome in healthy postmenopausal women. Clin Interv Aging. 2013;8:1221–1228. doi:10.2147/CIA.S4424524072967
  • Dieli-Conwright CM, Courneya KS, Demark-Wahnefried W, et al. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: a randomized controlled trial. J Clin Oncol. 2018;36(9):875–883. doi:10.1200/JCO.2017.75.752629356607
  • Earnest CP, Johannsen NM, Swift DL, et al. Aerobic and strength training in concomitant metabolic syndrome and type 2 diabetes. Med Sci Sports Exerc. 2014;46(7):1293–1301. doi:10.1249/MSS.000000000000024224389523
  • Kemmler W, von Stengel S, Bebenek M, Kalender WA. Long-term exercise and risk of metabolic and cardiac diseases: the erlangen fitness and prevention study. Evidence-Based Complementary Alternative Med. 2013;2013:768431. doi:10.1155/2013/768431
  • Kemmler W, Kohl M. Effects of high intensity resistance training versus whole-body electromyostimulation on cardiometabolic risk factors in untrained middle aged males. A randomized controlled trial. J Sports Res. 2016;3(2):44–55. doi:10.18488/journal.90/2016.3.2/90.2.44.55
  • Kemmler W, Wittke A, Bebenek M, Fröhlich M, von Stengel S. High intensity resistance training methods with and without protein supplementation to fight cardiometabolic risk in middle-aged males A randomized controlled trial. Biomed Res Int. 2016;2016:1–9. doi:10.1155/2016/9705287
  • Tomeleri CM, Souza MF, Burini RC, et al. Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial. J Diabetes. 2016;3(2):328–337. doi:10.1111/1753-0407.12614
  • Wittmann K, Sieber C, von Stengel S, et al. Impact of whole body electromyostimulation on cardiometabolic risk factors in older women with sarcopenic obesity: the randomized controlled FORMOsA-sarcopenic obesity study. Clin Interv Aging. 2016;11:1697–1706. doi:10.2147/CIA.S11643027920508
  • Mirzaiinjmabadi K, Anderson D, Barnes M. The relationship between exercise, Body Mass Index and menopausal symptoms in midlife Australian women. International J Nursing Practice. 2006;12(1):28–34. doi:10.1111/j.1440-172X.2006.00547.x
  • Perez-Lopez FR, Martinez-Dominguez SJ, Lajusticia H, Chedraui P. Health Outcomes Systematic Analyses P. Effects of programmed exercise on depressive symptoms in midlife and older women: A meta-analysis of randomized controlled trials. Maturitas. 2017;106:38–47. doi:10.1016/j.maturitas.2017.09.00129150165
  • Daley A, Stokes-Lampard H, Thomas A, MacArthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2014;(11):CD006108.25431132
  • Rubio-Arias JA, Marin-Cascales E, Ramos-Campo DJ, Hernandez AV, Perez-Lopez FR. Effect of exercise on sleep quality and insomnia in middle-aged women: A systematic review and meta-analysis of randomized controlled trials. Maturitas. 2017;100:49–56. doi:10.1016/j.maturitas.2017.04.00328539176
  • Bassey EJ, Ramsdale SJ. Weight-bearing exercise and ground reaction forces: a 12-month randomized controlled trial of effects on bone mineral density in healthy postmenopausal women. Bone. 1995;16(4):469–476.7605708
  • Bemben DA, Fetters NL, Bemben MG, Nabavi N, Koh ET. Musculoskeletal responses to high- and low-intensity resistance training in early postmenopausal women. Med Sci Sports Exerc. 2000;32(11):1949–1957. doi:10.1097/00005768-200011000-0002011079527
  • Chilibeck PD, Davison KS, Whiting SJ, Suzuki Y, Janzen CL, Peloso P. The effect of strength training combined with bisphosphonate (etidronate) therapy on bone mineral, lean tissue, and fat mass in postmenopausal women. Can J Physiol Pharmacol. 2002;80(10):941–950. doi:10.1139/y02-12612450060
  • Figueroa A, Going SB, Milliken LA, et al. Effects of exercise training and hormone replacement therapy on lean and fat mass in postmenopausal women. J Gerontol Biol Sci Med Sci. 2003;58(3):266–270. doi:10.1093/gerona/58.3.M266
  • Humphries B, Newton RU, Bronks R, et al. Effect of exercise intensity on bone density, strength, and calcium turnover in older women. Med Sci Sports Exerc. 2000;32(6):1043–1050. doi:10.1097/00005768-200006000-0000210862528
  • Pruitt LA, Jackson RD, Bartels RL, Lehnhard HJ. Weight-training effects on bone mineral density in early postmenopausal women. J Bone Miner Res. 2009;7(2):179–185. doi:10.1002/jbmr.5650070209
  • Kemmler W, Kohl M, Froehlich M, Engelke K, von Stengel S, Schoene D. Effects of high intensity resistance training on fitness and fatness in older men with osteosarcopenia. final results of the randomized controlled franconian osteopenia and sarcopenia trial (FrOST). Front Physiol. 2020;11. doi:10.3389/fphys.2020.01014
  • Zha R, Harel O. Power calculation in multiply imputed data. J Statistical Papers. 2019;1–27.
  • Rütten A, Abu-Omar K, Lampert T, Ziese T Körperliche Aktivität [Physical Activity]. Report. Berlin: Statistisches Bundesamt;2005.
  • Carlson SA, Fulton JE, Schoenborn CA, Loustalot F. Trend and prevalence estimates based on the 2008 physical activity guidelines for Americans. Am J Prev Med. 2010;39(4):305–313. doi:10.1016/j.amepre.2010.06.00620837280
  • Reid IRB, Grey MJ. A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet. 2014;383.24485569
  • Abadie BR, Altorfer GL, Schuler PB. Does a regression equation to predict maximal strength in untrained lifters remain valid when the subjects are technique trained? J Strength Cond Res. 1999;13(3):259–263.