The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus

References

• Andersson J, Rosell M, Kockum K, Soderstrom L, Laurell K. Challenges in diagnosing normal pressure hydrocephalus: evaluation of the diagnostic guidelines. e Neurological Sci. 2017;7:27–31. doi:10.1016/j.ensci.2017.04.002
   Google Scholar
• Zaccaria V, Bacigalupo I, Gervasi G, et al. A systematic review on the epidemiology of normal pressure hydrocephalus. Acta Neurol Scand. 2019;141(2):101–114.31622497
   PubMed Web of Science ®Google Scholar
• Hakim S, Adams RD. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci. 1965;2(4):307–327.5889177
   PubMedGoogle Scholar
• Rekate HL, Blitz AM. Hydrocephalus in children. Handb Clin Neurol. 2016;136:1261–1273.27430467
   PubMedGoogle Scholar
• Martin-Laez R, Caballero-Arzapalo H, Valle-San Roman N, Lopez-Menendez LA, Arango-Lasprilla JC, Vazquez-Barquero A. Incidence of idiopathic normal-pressure hydrocephalus in Northern Spain. World Neurosurg. 2016;87:298–310.26548835
   PubMed Web of Science ®Google Scholar
• Andersson J, Rosell M, Kockum K, Lilja-Lund O, Soderstrom L, Laurell K. Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study. PLoS One. 2019;14(5):e0217705.31141553
   PubMed Web of Science ®Google Scholar
• Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelso C. Prevalence of idiopathic normal-pressure hydrocephalus. Neurology. 2014;82(16):1449–1454.24682964
   PubMed Web of Science ®Google Scholar
• Casmiro M, Benassi G, Cacciatore FM, D’Alessandro R. Frequency of idiopathic normal pressure hydrocephalus. Arch Neurol. 1989;46(6):608.2730373
   PubMedGoogle Scholar
• Brean A, Eide PK. Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population. Acta Neurol Scand. 2008;118(1):48–53.18205881
   PubMed Web of Science ®Google Scholar
• Alvi MA, Brown D, Yolcu Y, et al. Prevalence and trends in management of idiopathic normal pressure hydrocephalus in the united states: insights from the national inpatient sample. World Neurosurg. 2020.
   Web of Science ®Google Scholar
• Mori E, Ishikawa M, Kato T, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir. 2012;52(11):775–809.
   PubMed Web of Science ®Google Scholar
• Hung AL, Vivas-Buitrago T, Adam A, et al. Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2017;157:1–6.28347957
   PubMed Web of Science ®Google Scholar
• Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337–341.26030524
   PubMed Web of Science ®Google Scholar
• Absinta M, Ha SK, Nair G, et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife. 2017;6.
   Web of Science ®Google Scholar
• Potokar M, Jorgacevski J, Zorec R. Astrocyte aquaporin dynamics in health and disease. Int J Mol Sci. 2016;17:7.
   Web of Science ®Google Scholar
• Nakada T. Virchow-Robin space and aquaporin-4: new insights on an old friend. Croat Med J. 2014;55(4):328–336.25165047
   PubMed Web of Science ®Google Scholar
• Nakada T, Kwee IL. Fluid dynamics inside the brain barrier: current concept of interstitial flow, glymphatic flow, and cerebrospinal fluid circulation in the brain. Neuroscientist. 2019;25(2):155–166.29799313
   PubMed Web of Science ®Google Scholar
• Huber VJ, Igarashi H, Ueki S, Kwee IL, Nakada T. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. Neuroreport. 2018;29(9):697–703.29481527
   PubMed Web of Science ®Google Scholar
• Ikeshima-Kataoka H. Neuroimmunological implications of AQP4 in astrocytes. Int J Mol Sci. 2016;17:8.
   Web of Science ®Google Scholar
• Desai B, Hsu Y, Schneller B, Hobbs JG, Mehta AI, Linninger A. Hydrocephalus: the role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluid. Neurosurg Focus. 2016;41(3):E8.
   Web of Science ®Google Scholar
• Nakada T, Kwee IL, Igarashi H, Suzuki Y. Aquaporin-4 functionality and virchow-robin space water dynamics: physiological model for neurovascular coupling and glymphatic flow. Int J Mol Sci. 2017;18:8.
   Web of Science ®Google Scholar
• Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016–1024.30353860
   PubMed Web of Science ®Google Scholar
• Takizawa K, Matsumae M, Hayashi N, et al. The choroid plexus of the lateral ventricle as the origin of CSF pulsation is questionable. Neurol Med Chir. 2018;58(1):23–31.
   Web of Science ®Google Scholar
• Yamada S, Kelly E. Cerebrospinal fluid dynamics and the pathophysiology of hydrocephalus: new concepts. Seminars Iultrasound, CT MRI. 2016;37(2):84–91.
   Web of Science ®Google Scholar
• Eide PK, Ringstad G. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab. 2019;39(7):1355–1368.29485341
   PubMed Web of Science ®Google Scholar
• Ringstad G, Valnes LM, Dale AM, et al. Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight. 2018;3:13.
   Web of Science ®Google Scholar
• Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017;140(10):2691–2705.28969373
   PubMed Web of Science ®Google Scholar
• Weller RO, Djuanda E, Yow HY, Carare RO. Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol. 2009;117(1):1–14.19002474
   PubMed Web of Science ®Google Scholar
• Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO. Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol. 2006;238(4):962–974.16112683
   PubMed Web of Science ®Google Scholar
• Brautigam K, Vakis A, Tsitsipanis C. Pathogenesis of idiopathic normal pressure hydrocephalus: A review of knowledge. J Clin Neurosci. 2019;61:10–13.30409528
   PubMed Web of Science ®Google Scholar
• Qvarlander S, Lundkvist B, Koskinen LO, Malm J, Eklund A. Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 2013;84(7):735–741.23408066
   PubMed Web of Science ®Google Scholar
• Matsumae M, Kuroda K, Yatsushiro S, et al. Changing the currently held concept of cerebrospinal fluid dynamics based on shared findings of cerebrospinal fluid motion in the cranial cavity using various types of magnetic resonance imaging techniques. Neurol Med Chir. 2019;59(4):133–146.
   Web of Science ®Google Scholar
• Bateman GA. The pathophysiology of idiopathic normal pressure hydrocephalus: cerebral ischemia or altered venous hemodynamics? AJNR Am J Neuroradiol. 2008;29(1):198–203.17925373
   PubMed Web of Science ®Google Scholar
• Eide PK, Sorteberg W. Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients. Neurosurgery. 2010;66(1):80–91.20023540
   PubMed Web of Science ®Google Scholar
• Skalicky P, Mladek A, Vlasak A, De Lacy P, Benes V, Bradac O. Normal pressure hydrocephalus-an overview of pathophysiological mechanisms and diagnostic procedures. Neurosurg Rev. 2019.
   Web of Science ®Google Scholar
• Lindstrom EK, Ringstad G, Mardal KA, Eide PK. Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2018;20:731–741.30238917
   PubMed Web of Science ®Google Scholar
• Eide PK, Hansson HA. Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus. Neuropathol Appl Neurobiol. 2018;44(5):474–490.28627088
   PubMed Web of Science ®Google Scholar
• Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK. Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus. Glia. 2019;67(1):91–100.30306658
   PubMed Web of Science ®Google Scholar
• Ishikawa M, Oowaki H, Takezawa M, et al. Disproportionately enlarged subarachnoid space hydrocephalus in idiopathic normal-pressure hydrocephalus and its implication in pathogenesis. Acta Neurochir Suppl. 2016;122:287–290.27165923
   PubMedGoogle Scholar
• Leinonen V, Vanninen R, Rauramaa T. Cerebrospinal fluid circulation and hydrocephalus. Handb Clin Neurol. 2017;145:39–50.28987185
   PubMedGoogle Scholar
• Jones HC, Keep RF, Drewes LR. CNS fluid and solute movement: physiology, modelling and imaging. Fluids Barriers CNS. 2020;17:1.31931818
   PubMed Web of Science ®Google Scholar
• Leal NS, Dentoni G, Schreiner B, et al. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients. Acta Neuropathol Commun. 2018;6(1):102.30270816
   PubMed Web of Science ®Google Scholar
• Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK. Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients. Fluids Barriers CNS. 2019;16(1):39.31849332
   PubMed Web of Science ®Google Scholar
• Chistyakov AV, Hafner H, Sinai A, Kaplan B, Zaaroor M. Motor cortex disinhibition in normal-pressure hydrocephalus. J Neurosurg. 2012;116(2):453–459.21999318
   PubMed Web of Science ®Google Scholar
• Miyoshi N, Kazui H, Ogino A, et al. Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord. 2005;20(2–3):71–76.15908748
   PubMed Web of Science ®Google Scholar
• Nardone R, Golaszewski S, Schwenker K, et al. Cholinergic transmission is impaired in patients with idiopathic normal-pressure hydrocephalus: a TMS study. J Neural Transm. 2019;126(8):1073–1080.31227893
   PubMed Web of Science ®Google Scholar
• Nikolakopoulou AM, Montagne A, Kisler K, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019;22(7):1089–1098.31235908
   PubMed Web of Science ®Google Scholar
• Ueno M, Tomita S, Nakagawa T, et al. Effects of aging and HIF-1alpha deficiency on permeability of hippocampal vessels. Microsc Res Tech. 2006;69(1):29–35.16416408
   PubMed Web of Science ®Google Scholar
• Andreone BJ, Chow BW, Tata A, et al. Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron. 2017;94(3):581–594 e585.28416077
   PubMed Web of Science ®Google Scholar
• Tripathi BJ, Tripathi RC. Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid. J Physiol. 1974;239(1):195–206.4369428
   PubMed Web of Science ®Google Scholar
• Eide PK, Hansson HA. Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus. Brain Res. 2020;1727:146547.31712085
   PubMed Web of Science ®Google Scholar
• Satow T, Aso T, Nishida S, et al. Alteration of venous drainage route in idiopathic normal pressure hydrocephalus and normal aging. Front Aging Neurosci. 2017;9:387.29218007
   PubMed Web of Science ®Google Scholar
• Eidsvaag VA, Hansson HA, Heuser K, Nagelhus EA, Eide PK. Brain capillary ultrastructure in idiopathic normal pressure hydrocephalus: relationship with static and pulsatile intracranial pressure. J Neuropathol Exp Neurol. 2017;76(12):1034–1045.29040647
   PubMed Web of Science ®Google Scholar
• Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450.27808256
   PubMed Web of Science ®Google Scholar
• Isaacs AM, Williams MA, Hamilton MG. Current update on treatment strategies for idiopathic normal pressure hydrocephalus. Curr Treat Options Neurol. 2019;21:12.30809735
   PubMed Web of Science ®Google Scholar
• Williams MA, Malm J. Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. Continuum. 2016;22(2Dementia):579–599.27042909
   PubMedGoogle Scholar
• Hasslacher-Arellano JF, Arellano-Aguilar G, Funes-Rodriguez JF, Lopez-Forcen S, Torres-Zapiain F, Dominguez-Carrillo LG. Ventriculo-gallbladder shunt: an alternative for the treatment of hydrocephalus. Cir Cir. 2016;84(3):225–229.26259740
   PubMed Web of Science ®Google Scholar
• Arighi A, Di Cristofori A, Fenoglio C, et al. Cerebrospinal fluid level of aquaporin4: a new window on glymphatic system involvement in neurodegenerative disease? J Alzheimers Dis. 2019;69(3):663–669.31156164
   PubMed Web of Science ®Google Scholar
• Williams MA, Relkin NR. Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 2013;3(5):375–385.24175154
   PubMedGoogle Scholar
• Stolze H, Kuhtz-Buschbeck JP, Drucke H, et al. Gait analysis in idiopathic normal pressure hydrocephalus–which parameters respond to the CSF tap test? Clin Neurophysiol. 2000;111(9):1678–1686.10964082
   PubMed Web of Science ®Google Scholar
• Nikaido Y, Akisue T, Kajimoto Y, et al. Postural instability differences between idiopathic normal pressure hydrocephalus and Parkinson’s disease. Clin Neurol Neurosurg. 2018;165:103–107.29331870
   PubMed Web of Science ®Google Scholar
• Selge C, Schoeberl F, Zwergal A, et al. Gait analysis in PSP and NPH: dual-task conditions make the difference. Neurology. 2018;90(12):e1021–e1028.29467306
   PubMed Web of Science ®Google Scholar
• Nikaido Y, Akisue T, Kajimoto Y, et al. The effect of CSF drainage on ambulatory center of mass movement in idiopathic normal pressure hydrocephalus. Gait Posture. 2018;63:5–9.29698845
   PubMed Web of Science ®Google Scholar
• Nikaido Y, Urakami H, Akisue T, et al. Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019;183:105385.31207457
   PubMed Web of Science ®Google Scholar
• Gallagher R, Marquez J, Osmotherly P. Gait and balance measures can identify change from a cerebrospinal fluid tap test in idiopathic normal pressure hydrocephalus. Arch Phys Med Rehabil. 2018;99(11):2244–2250.29702069
   PubMed Web of Science ®Google Scholar
• Gallagher R, Marquez J, Osmotherly P. Clinimetric properties and minimal clinically important differences for a battery of gait, balance, and cognitive examinations for the tap test in idiopathic normal pressure hydrocephalus. Neurosurgery. 2019;84(6):E378–E384.30010977
   PubMed Web of Science ®Google Scholar
• Nikaido Y, Kajimoto Y, Akisue T, et al. Dynamic balance measurements can differentiate patients who fall from patients who do not fall in patients with idiopathic normal pressure hydrocephalus. Arch Phys Med Rehabil. 2019;100(8):1458–1466.30731067
   PubMed Web of Science ®Google Scholar
• Isik AT, Kaya D, Ates Bulut E, Dokuzlar O, Soysal P. The outcomes of serial cerebrospinal fluid removal in elderly patients with idiopathic normal pressure hydrocephalus. Clin Interv Aging. 2019;14:2063–2069.31819388
   PubMed Web of Science ®Google Scholar
• Liouta E, Gatzonis S, Kalamatianos T, et al. Finger tapping and verbal fluency post-tap test improvement in INPH: its value in differential diagnosis and shunt-treatment outcomes prognosis. Acta Neurochir. 2017;159(12):2301–2307.28828534
   PubMed Web of Science ®Google Scholar
• Picascia M, Zangaglia R, Bernini S, Minafra B, Sinforiani E, Pacchetti C. A review of cognitive impairment and differential diagnosis in idiopathic normal pressure hydrocephalus. Funct Neurol. 2015;30(4):217–228.26727700
   PubMedGoogle Scholar
• Ko PW, Lee HW, Kang K. Frontal assessment battery and cerebrospinal fluid tap test in idiopathic normal-pressure hydrocephalus. Eur Neurol. 2017;77(5–6):327–332.28472801
   PubMed Web of Science ®Google Scholar
• Larsson J, Israelsson H, Eklund A, Malm J. Epilepsy, headache, and abdominal pain after shunt surgery for idiopathic normal pressure hydrocephalus: the INPH-CRasH study. J Neurosurg. 2018;128(6):1674–1683.28885121
   PubMed Web of Science ®Google Scholar
• Matsuoka T, Kawano S, Fujimoto K, Kawahara M, Hashimoto H. Characteristics of cognitive function evaluation using the Montreal cognitive assessment in a cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019;186:105524.31541862
   PubMed Web of Science ®Google Scholar
• Sakakibara R, Kanda T, Sekido T, et al. Mechanism of bladder dysfunction in idiopathic normal pressure hydrocephalus. Neurourol Urodyn. 2008;27(6):507–510.18092331
   PubMed Web of Science ®Google Scholar
• Halperin JJ, Kurlan R, Schwalb JM, Cusimano MD, Gronseth G, Gloss D. Practice guideline: idiopathic normal pressure hydrocephalus: response to shunting and predictors of response: report of the guideline development, dissemination, and implementation subcommittee of the american academy of neurology. Neurology. 2015;85(23):2063–2071.26644048
   PubMed Web of Science ®Google Scholar
• Ferrari A, Milletti D, Giannini G, et al. The effects of cerebrospinal fluid tap-test on idiopathic normal pressure hydrocephalus: an inertial sensors based assessment. J Neuroeng Rehabil. 2020;17(1):7.31948485
   PubMed Web of Science ®Google Scholar
• Yamada S, Aoyagi Y, Yamamoto K, Ishikawa M. Quantitative evaluation of gait disturbance on an instrumented timed up-and-go test. Aging Dis. 2019;10(1):23–36.30705765
   PubMed Web of Science ®Google Scholar
• Gallagher RM, Marquez J, Osmotherly P. Cognitive and upper limb symptom changes from a tap test in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2018;174:92–96.30219624
   PubMed Web of Science ®Google Scholar
• Yamada S, Ishikawa M, Miyajima M, et al. Disease duration: the key to accurate CSF tap test in iNPH. Acta Neurol Scand. 2017;135(2):189–196.26923727
   PubMed Web of Science ®Google Scholar
• Kaya D, Erken N, Ontan MS, Altun ZS, Isik AT. The applause sign in elderly patients with idiopathic normal pressure hydrocephalus. Appl Neuropsychol Adult. 2020;1–6.
   Web of Science ®Google Scholar
• Mahr CV, Dengl M, Nestler U, et al. Idiopathic normal pressure hydrocephalus: diagnostic and predictive value of clinical testing, lumbar drainage, and CSF dynamics. J Neurosurg. 2016;125(3):591–597.26824377
   PubMed Web of Science ®Google Scholar
• Kahlon B, Sundbarg G, Rehncrona S. Lumbar infusion test in normal pressure hydrocephalus. Acta Neurol Scand. 2005;111(6):379–384.15876339
   PubMed Web of Science ®Google Scholar
• Raneri F, Zella MAS, Di Cristofori A, Zarino B, Pluderi M, Spagnoli D. Supplementary tests in idiopathic normal pressure hydrocephalus: a single-center experience with a combined lumbar infusion test and tap test. World Neurosurg. 2017;100:567–574.28089835
   PubMed Web of Science ®Google Scholar
• Ryding E, Kahlon B, Reinstrup P. Improved lumbar infusion test analysis for normal pressure hydrocephalus diagnosis. Brain Behav. 2018;8(11):e01125.30259701
   PubMed Web of Science ®Google Scholar
• Schirinzi T, Sancesario GM, Di Lazzaro G, et al. Cerebrospinal fluid biomarkers profile of idiopathic normal pressure hydrocephalus. J Neural Transm. 2018;125(4):673–679.29353355
   PubMed Web of Science ®Google Scholar
• Chen Z, Liu C, Zhang J, Relkin N, Xing Y, Li Y. Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis. Fluids Barriers CNS. 2017;14:1.28132644
   PubMed Web of Science ®Google Scholar
• Kim HJ, Lim TS, Lee SM, et al. Cerebrospinal fluid levels of beta-amyloid 40 and beta-amyloid 42 are proportionately decreased in amyloid positron-emission tomography negative idiopathic normal-pressure hydrocephalus patients. J Clin Neurol. 2019;15(3):353–359.31286708
   PubMed Web of Science ®Google Scholar
• Jeppsson A, Wikkelsö C, Blennow K, et al. CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics. J Neurol Neurosurg Psychiatry. 2019;90(10):1117–1123.31167811
   PubMed Web of Science ®Google Scholar
• Abu-Rumeileh S, Giannini G, Polischi B, et al. Revisiting the cerebrospinal fluid biomarker profile in idiopathic normal pressure hydrocephalus: the bologna pro-hydro study. J Alzheimer’s Disease. 2019;68(2):723–733.30883350
   PubMed Web of Science ®Google Scholar
• Jingami N, Uemura K, Asada-Utsugi M, et al. Two-point dynamic observation of alzheimer’s disease cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. J Alzheimer’s Disease. 2019;72(1):271–277.31561378
   PubMed Web of Science ®Google Scholar
• Naganawa S, Taoka T. The glymphatic system: a review of the challenges in visualizing its structure and function with MR imaging. Magn Reson Med Sci. 2020.
   Web of Science ®Google Scholar
• Bae YJ, Choi BS, Kim JM, Choi JH, Cho SJ, Kim JH. Altered glymphatic system in idiopathic normal pressure hydrocephalus. Parkinsonism Relat Disord. 2020;82:56–60.33248394
   PubMed Web of Science ®Google Scholar
• Yokota H, Vijayasarathi A, Cekic M, et al. Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers. Curr Gerontol Geriatr Res. 2019;2019:5675014.31320896
   PubMedGoogle Scholar
• Kamiya K, Hori M, Irie R, et al. Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2017;14:663–671.28348958
   PubMed Web of Science ®Google Scholar
• Ghosh S, Lippa C. Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 2014;29(7):583–589.24550545
   PubMed Web of Science ®Google Scholar
• Siasios I, Kapsalaki EZ, Fountas KN, et al. The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review. Neurosurg Focus. 2016;41(3):E12.
   Web of Science ®Google Scholar
• Kockum K, Lilja-Lund O, Larsson EM, et al. The idiopathic normal-pressure hydrocephalus Radscale: a radiological scale for structured evaluation. Eur J Neurol. 2018;25(3):569–576.29281156
   PubMed Web of Science ®Google Scholar
• Mantovani P, Albini-Riccioli L, Giannini G, et al. Anterior callosal angle: a new marker of idiopathic normal pressure hydrocephalus? World Neurosurg. 2020;139:e548–e552.32348895
   PubMed Web of Science ®Google Scholar
• Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelso C. Estimated ventricle size using Evans index: reference values from a population-based sample. Eur J Neurol. 2017;24(3):468–474.28052454
   PubMed Web of Science ®Google Scholar
• Reeves BC, Karimy JK, Kundishora AJ, et al. Glymphatic system impairment in alzheimer’s disease and idiopathic normal pressure hydrocephalus. Trends Mol Med. 2020;26(3):285–295.31959516
   PubMed Web of Science ®Google Scholar
• Shprecher D, Schwalb J, Kurlan R. Normal pressure hydrocephalus: diagnosis and treatment. Curr Neurol Neurosci Rep. 2008;8(5):371–376.18713572
   PubMed Web of Science ®Google Scholar
• He W, Fang X, Wang X, et al. A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans’ index. Neuroradiology. 2020;62(6):661–667.32008047
   PubMed Web of Science ®Google Scholar
• Miyazaki K, Ishii K, Hanaoka K, Kaida H, Nakajima K. The tight medial and high convexity subarachnoid spaces is the first finding of idiopathic normal pressure hydrocephalus at the preclinical stage. Neurol Med Chir (Tokyo). 2019;59(11):436–443.31582642
   PubMed Web of Science ®Google Scholar
• Akiba C, Gyanwali B, Villaraza S, et al. The prevalence and clinical associations of disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts. J Neurol Sci. 2020;408:116510.31810041
   PubMed Web of Science ®Google Scholar
• Neikter J, Agerskov S, Hellstrom P, et al. Ventricular volume is more strongly associated with clinical improvement than the evans index after shunting in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2020;41(7):1187–1192.32527841
   PubMed Web of Science ®Google Scholar
• Suehiro T, Kazui H, Kanemoto H, et al. Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus. Psychogeriatrics. 2019;19(6):557–565.30950145
   PubMed Web of Science ®Google Scholar
• Takagi K, Watahiki R, Machida T, Onouchi K, Kato K, Oshima M. Reliability and interobserver variability of evans’ index and disproportionately enlarged subarachnoid space hydrocephalus as diagnostic criteria for idiopathic normal pressure hydrocephalus. Asian J Neurosurg. 2020;15:1.32181163
   PubMedGoogle Scholar
• Tinelli M, Guldemond N, Kehler U. Idiopathic Normal Pressure Hydrocephalus (iNPH): the cost-effectiveness of delivering timely and adequate treatment in Germany. Eur J Neurol. 2020.
   Web of Science ®Google Scholar
• Aimard G, Vighetto A, Gabet JY, Bret P, Henry E. Acetazolamide: an alternative to shunting in normal pressure hydrocephalus? Preliminary results. Rev Neurol. 1990;146(6–7):437–439.2399408
   PubMed Web of Science ®Google Scholar
• Swenson ER. Pharmacology of acute mountain sickness: old drugs and newer thinking. J Appl Physiol. 2016;120(2):204–215.26294748
   PubMed Web of Science ®Google Scholar
• Alperin N, Oliu CJ, Bagci AM, et al. Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH. Neurology. 2014;82(15):1347–1351.24634454
   PubMed Web of Science ®Google Scholar
• Del Bigio MR, Di Curzio DL. Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids Barriers CNS. 2016;13:3.26846184
   PubMed Web of Science ®Google Scholar
• Gavrilov GV, Gaydar BV, Svistov DV, et al. Idiopathic normal pressure hydrocephalus (hakim-adams syndrome): clinical symptoms, diagnosis and treatment. Psychiatr Danub. 2019;31(Suppl 5):737–744.32160166
   PubMedGoogle Scholar
• Nakajima M, Miyajima M, Ogino I, et al. Preoperative phosphorylated tau concentration in the cerebrospinal fluid can predict cognitive function three years after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Alzheimer’s Disease. 2018;66(1):319–331.30248058
   PubMed Web of Science ®Google Scholar
• Miyajima M, Kazui H, Mori E, Ishikawa M. Sinphoni-Investigators obot. One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt. J Neurosurg. 2016;125(6):1483–1492.26871203
   PubMed Web of Science ®Google Scholar
• Razay G, Wimmer M, Robertson I. Incidence, diagnostic criteria and outcome following ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus in a memory clinic population: a prospective observational cross-sectional and cohort study. BMJ Open. 2019;9(12):e028103.
   Web of Science ®Google Scholar
• Toma AK, Papadopoulos MC, Stapleton S, Kitchen ND, Watkins LD. Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. Acta Neurochir. 2013;155(10):1977–1980.23975646
   PubMed Web of Science ®Google Scholar
• Bådagård H, Braun M, Nilsson D, Stridh L, Virhammar J. Negative predictors of shunt surgery outcome in normal pressure hydrocephalus. Acta Neurol Scand. 2019;141(3):219–225.31778218
   PubMed Web of Science ®Google Scholar
• Feletti A, d’Avella D, Wikkelso C, et al. Ventriculoperitoneal shunt complications in the european idiopathic normal pressure hydrocephalus multicenter study. Oper Neurosurg. 2019;17(1):97–102.
   Web of Science ®Google Scholar
• Farahmand D, Saehle T, Eide PK, Tisell M, Hellstrom P, Wikkelso C. A double-blind randomized trial on the clinical effect of different shunt valve settings in idiopathic normal pressure hydrocephalus. J Neurosurg. 2016;124(2):359–367.26315004
   PubMed Web of Science ®Google Scholar
• Giordan E, Palandri G, Lanzino G, Murad MH, Elder BD. Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. J Neurosurg. 2018;1–13.
   Web of Science ®Google Scholar
• Liu A, Sankey EW, Jusue-Torres I, et al. Clinical outcomes after ventriculoatrial shunting for idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2016;143:34–38.26895207
   PubMed Web of Science ®Google Scholar
• Krahulik D, Vaverka M, Hrabalek L, et al. Ventriculoperitoneal shunt in treating of idiopathic normal pressure hydrocephalus-single-center study. Acta Neurochir. 2020;162(1):1–7.31728709
   PubMed Web of Science ®Google Scholar
• Clark DJ, Chakraborty A, Roebuck DJ, Thompson DN. Ultrasound guided placement of the distal catheter in paediatric ventriculoatrial shunts-an appraisal of efficacy and complications. Childs Nerv Syst. 2016;32(7):1219–1225.27207611
   PubMed Web of Science ®Google Scholar
• Nunoo-Mensah JW, Rosen M, Chan LS, Wasserberg N, Beart RW. Prevalence of intra-abdominal surgery: what is an individual’s lifetime risk? South Med J. 2009;102(1):25–29.19077782
   PubMed Web of Science ®Google Scholar
• McGovern RA, Kelly KM, Chan AK, Morrissey NJ, McKhann GM 2nd. Should ventriculoatrial shunting be the procedure of choice for normal-pressure hydrocephalus? J Neurosurg. 2014;120(6):1458–1464.24605842
   PubMed Web of Science ®Google Scholar
• Nakajima M, Miyajima M, Ogino I, et al. Shunt intervention for possible idiopathic normal pressure hydrocephalus improves patient outcomes: a nationwide hospital-based survey in Japan. Front Neurol. 2018;9.29434565
   PubMed Web of Science ®Google Scholar
• Kazui H, Miyajima M, Mori E, Ishikawa M, Investigators S. Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol. 2015;14(6):585–594.25934242
   PubMed Web of Science ®Google Scholar
• Oliveira MF, Teixeira MJ, Reis RC, Petitto CE, Gomes Pinto FC. Failed ventriculoperitoneal shunt: is retrograde ventriculosinus shunt a reliable option? World Neurosurg. 2016;92:445–453.27237416
   PubMed Web of Science ®Google Scholar
• Paidakakos N, Borgarello S, Naddeo M. Indications for endoscopic third ventriculostomy in normal pressure hydrocephalus. Acta Neurochir Suppl. 2012;113:123–127.22116437
   PubMedGoogle Scholar
• Pinto FC, Saad F, Oliveira MF, et al. Role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. Neurosurgery. 2013;72(5):845–853; discussion 853–844.
   Web of Science ®Google Scholar
• Hailong F, Guangfu H, Haibin T, et al. Endoscopic third ventriculostomy in the management of communicating hydrocephalus: a preliminary study. J Neurosurg. 2008;109(5):923–930.18976086
   PubMed Web of Science ®Google Scholar
• Tudor KI, Tudor M, McCleery J, Car J. Endoscopic third ventriculostomy (ETV) for idiopathic normal pressure hydrocephalus (iNPH). Cochrane Database Syst Rev. 2015;(7):CD010033.26222251
   PubMed Web of Science ®Google Scholar