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Review

The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus

, , , , , , & ORCID Icon show all
Pages 139-153 | Published online: 15 Jan 2021

References

  • Andersson J, Rosell M, Kockum K, Soderstrom L, Laurell K. Challenges in diagnosing normal pressure hydrocephalus: evaluation of the diagnostic guidelines. e Neurological Sci. 2017;7:27–31. doi:10.1016/j.ensci.2017.04.002
  • Zaccaria V, Bacigalupo I, Gervasi G, et al. A systematic review on the epidemiology of normal pressure hydrocephalus. Acta Neurol Scand. 2019;141(2):101–114.31622497
  • Hakim S, Adams RD. The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J Neurol Sci. 1965;2(4):307–327.5889177
  • Rekate HL, Blitz AM. Hydrocephalus in children. Handb Clin Neurol. 2016;136:1261–1273.27430467
  • Martin-Laez R, Caballero-Arzapalo H, Valle-San Roman N, Lopez-Menendez LA, Arango-Lasprilla JC, Vazquez-Barquero A. Incidence of idiopathic normal-pressure hydrocephalus in Northern Spain. World Neurosurg. 2016;87:298–310.26548835
  • Andersson J, Rosell M, Kockum K, Lilja-Lund O, Soderstrom L, Laurell K. Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study. PLoS One. 2019;14(5):e0217705.31141553
  • Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelso C. Prevalence of idiopathic normal-pressure hydrocephalus. Neurology. 2014;82(16):1449–1454.24682964
  • Casmiro M, Benassi G, Cacciatore FM, D’Alessandro R. Frequency of idiopathic normal pressure hydrocephalus. Arch Neurol. 1989;46(6):608.2730373
  • Brean A, Eide PK. Prevalence of probable idiopathic normal pressure hydrocephalus in a Norwegian population. Acta Neurol Scand. 2008;118(1):48–53.18205881
  • Alvi MA, Brown D, Yolcu Y, et al. Prevalence and trends in management of idiopathic normal pressure hydrocephalus in the united states: insights from the national inpatient sample. World Neurosurg. 2020.
  • Mori E, Ishikawa M, Kato T, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir. 2012;52(11):775–809.
  • Hung AL, Vivas-Buitrago T, Adam A, et al. Ventriculoatrial versus ventriculoperitoneal shunt complications in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2017;157:1–6.28347957
  • Louveau A, Smirnov I, Keyes TJ, et al. Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337–341.26030524
  • Absinta M, Ha SK, Nair G, et al. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife. 2017;6.
  • Potokar M, Jorgacevski J, Zorec R. Astrocyte aquaporin dynamics in health and disease. Int J Mol Sci. 2016;17:7.
  • Nakada T. Virchow-Robin space and aquaporin-4: new insights on an old friend. Croat Med J. 2014;55(4):328–336.25165047
  • Nakada T, Kwee IL. Fluid dynamics inside the brain barrier: current concept of interstitial flow, glymphatic flow, and cerebrospinal fluid circulation in the brain. Neuroscientist. 2019;25(2):155–166.29799313
  • Huber VJ, Igarashi H, Ueki S, Kwee IL, Nakada T. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. Neuroreport. 2018;29(9):697–703.29481527
  • Ikeshima-Kataoka H. Neuroimmunological implications of AQP4 in astrocytes. Int J Mol Sci. 2016;17:8.
  • Desai B, Hsu Y, Schneller B, Hobbs JG, Mehta AI, Linninger A. Hydrocephalus: the role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluid. Neurosurg Focus. 2016;41(3):E8.
  • Nakada T, Kwee IL, Igarashi H, Suzuki Y. Aquaporin-4 functionality and virchow-robin space water dynamics: physiological model for neurovascular coupling and glymphatic flow. Int J Mol Sci. 2017;18:8.
  • Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016–1024.30353860
  • Takizawa K, Matsumae M, Hayashi N, et al. The choroid plexus of the lateral ventricle as the origin of CSF pulsation is questionable. Neurol Med Chir. 2018;58(1):23–31.
  • Yamada S, Kelly E. Cerebrospinal fluid dynamics and the pathophysiology of hydrocephalus: new concepts. Seminars Iultrasound, CT MRI. 2016;37(2):84–91.
  • Eide PK, Ringstad G. Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study. J Cereb Blood Flow Metab. 2019;39(7):1355–1368.29485341
  • Ringstad G, Valnes LM, Dale AM, et al. Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. JCI Insight. 2018;3:13.
  • Ringstad G, Vatnehol SAS, Eide PK. Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain. 2017;140(10):2691–2705.28969373
  • Weller RO, Djuanda E, Yow HY, Carare RO. Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol. 2009;117(1):1–14.19002474
  • Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO. Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol. 2006;238(4):962–974.16112683
  • Brautigam K, Vakis A, Tsitsipanis C. Pathogenesis of idiopathic normal pressure hydrocephalus: A review of knowledge. J Clin Neurosci. 2019;61:10–13.30409528
  • Qvarlander S, Lundkvist B, Koskinen LO, Malm J, Eklund A. Pulsatility in CSF dynamics: pathophysiology of idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry. 2013;84(7):735–741.23408066
  • Matsumae M, Kuroda K, Yatsushiro S, et al. Changing the currently held concept of cerebrospinal fluid dynamics based on shared findings of cerebrospinal fluid motion in the cranial cavity using various types of magnetic resonance imaging techniques. Neurol Med Chir. 2019;59(4):133–146.
  • Bateman GA. The pathophysiology of idiopathic normal pressure hydrocephalus: cerebral ischemia or altered venous hemodynamics? AJNR Am J Neuroradiol. 2008;29(1):198–203.17925373
  • Eide PK, Sorteberg W. Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients. Neurosurgery. 2010;66(1):80–91.20023540
  • Skalicky P, Mladek A, Vlasak A, De Lacy P, Benes V, Bradac O. Normal pressure hydrocephalus-an overview of pathophysiological mechanisms and diagnostic procedures. Neurosurg Rev. 2019.
  • Lindstrom EK, Ringstad G, Mardal KA, Eide PK. Cerebrospinal fluid volumetric net flow rate and direction in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2018;20:731–741.30238917
  • Eide PK, Hansson HA. Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus. Neuropathol Appl Neurobiol. 2018;44(5):474–490.28627088
  • Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK. Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus. Glia. 2019;67(1):91–100.30306658
  • Ishikawa M, Oowaki H, Takezawa M, et al. Disproportionately enlarged subarachnoid space hydrocephalus in idiopathic normal-pressure hydrocephalus and its implication in pathogenesis. Acta Neurochir Suppl. 2016;122:287–290.27165923
  • Leinonen V, Vanninen R, Rauramaa T. Cerebrospinal fluid circulation and hydrocephalus. Handb Clin Neurol. 2017;145:39–50.28987185
  • Jones HC, Keep RF, Drewes LR. CNS fluid and solute movement: physiology, modelling and imaging. Fluids Barriers CNS. 2020;17:1.31931818
  • Leal NS, Dentoni G, Schreiner B, et al. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients. Acta Neuropathol Commun. 2018;6(1):102.30270816
  • Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK. Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients. Fluids Barriers CNS. 2019;16(1):39.31849332
  • Chistyakov AV, Hafner H, Sinai A, Kaplan B, Zaaroor M. Motor cortex disinhibition in normal-pressure hydrocephalus. J Neurosurg. 2012;116(2):453–459.21999318
  • Miyoshi N, Kazui H, Ogino A, et al. Association between cognitive impairment and gait disturbance in patients with idiopathic normal pressure hydrocephalus. Dement Geriatr Cogn Disord. 2005;20(2–3):71–76.15908748
  • Nardone R, Golaszewski S, Schwenker K, et al. Cholinergic transmission is impaired in patients with idiopathic normal-pressure hydrocephalus: a TMS study. J Neural Transm. 2019;126(8):1073–1080.31227893
  • Nikolakopoulou AM, Montagne A, Kisler K, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019;22(7):1089–1098.31235908
  • Ueno M, Tomita S, Nakagawa T, et al. Effects of aging and HIF-1alpha deficiency on permeability of hippocampal vessels. Microsc Res Tech. 2006;69(1):29–35.16416408
  • Andreone BJ, Chow BW, Tata A, et al. Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron. 2017;94(3):581–594 e585.28416077
  • Tripathi BJ, Tripathi RC. Vacuolar transcellular channels as a drainage pathway for cerebrospinal fluid. J Physiol. 1974;239(1):195–206.4369428
  • Eide PK, Hansson HA. Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus. Brain Res. 2020;1727:146547.31712085
  • Satow T, Aso T, Nishida S, et al. Alteration of venous drainage route in idiopathic normal pressure hydrocephalus and normal aging. Front Aging Neurosci. 2017;9:387.29218007
  • Eidsvaag VA, Hansson HA, Heuser K, Nagelhus EA, Eide PK. Brain capillary ultrastructure in idiopathic normal pressure hydrocephalus: relationship with static and pulsatile intracranial pressure. J Neuropathol Exp Neurol. 2017;76(12):1034–1045.29040647
  • Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450.27808256
  • Isaacs AM, Williams MA, Hamilton MG. Current update on treatment strategies for idiopathic normal pressure hydrocephalus. Curr Treat Options Neurol. 2019;21:12.30809735
  • Williams MA, Malm J. Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. Continuum. 2016;22(2Dementia):579–599.27042909
  • Hasslacher-Arellano JF, Arellano-Aguilar G, Funes-Rodriguez JF, Lopez-Forcen S, Torres-Zapiain F, Dominguez-Carrillo LG. Ventriculo-gallbladder shunt: an alternative for the treatment of hydrocephalus. Cir Cir. 2016;84(3):225–229.26259740
  • Arighi A, Di Cristofori A, Fenoglio C, et al. Cerebrospinal fluid level of aquaporin4: a new window on glymphatic system involvement in neurodegenerative disease? J Alzheimers Dis. 2019;69(3):663–669.31156164
  • Williams MA, Relkin NR. Diagnosis and management of idiopathic normal-pressure hydrocephalus. Neurol Clin Pract. 2013;3(5):375–385.24175154
  • Stolze H, Kuhtz-Buschbeck JP, Drucke H, et al. Gait analysis in idiopathic normal pressure hydrocephalus–which parameters respond to the CSF tap test? Clin Neurophysiol. 2000;111(9):1678–1686.10964082
  • Nikaido Y, Akisue T, Kajimoto Y, et al. Postural instability differences between idiopathic normal pressure hydrocephalus and Parkinson’s disease. Clin Neurol Neurosurg. 2018;165:103–107.29331870
  • Selge C, Schoeberl F, Zwergal A, et al. Gait analysis in PSP and NPH: dual-task conditions make the difference. Neurology. 2018;90(12):e1021–e1028.29467306
  • Nikaido Y, Akisue T, Kajimoto Y, et al. The effect of CSF drainage on ambulatory center of mass movement in idiopathic normal pressure hydrocephalus. Gait Posture. 2018;63:5–9.29698845
  • Nikaido Y, Urakami H, Akisue T, et al. Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019;183:105385.31207457
  • Gallagher R, Marquez J, Osmotherly P. Gait and balance measures can identify change from a cerebrospinal fluid tap test in idiopathic normal pressure hydrocephalus. Arch Phys Med Rehabil. 2018;99(11):2244–2250.29702069
  • Gallagher R, Marquez J, Osmotherly P. Clinimetric properties and minimal clinically important differences for a battery of gait, balance, and cognitive examinations for the tap test in idiopathic normal pressure hydrocephalus. Neurosurgery. 2019;84(6):E378–E384.30010977
  • Nikaido Y, Kajimoto Y, Akisue T, et al. Dynamic balance measurements can differentiate patients who fall from patients who do not fall in patients with idiopathic normal pressure hydrocephalus. Arch Phys Med Rehabil. 2019;100(8):1458–1466.30731067
  • Isik AT, Kaya D, Ates Bulut E, Dokuzlar O, Soysal P. The outcomes of serial cerebrospinal fluid removal in elderly patients with idiopathic normal pressure hydrocephalus. Clin Interv Aging. 2019;14:2063–2069.31819388
  • Liouta E, Gatzonis S, Kalamatianos T, et al. Finger tapping and verbal fluency post-tap test improvement in INPH: its value in differential diagnosis and shunt-treatment outcomes prognosis. Acta Neurochir. 2017;159(12):2301–2307.28828534
  • Picascia M, Zangaglia R, Bernini S, Minafra B, Sinforiani E, Pacchetti C. A review of cognitive impairment and differential diagnosis in idiopathic normal pressure hydrocephalus. Funct Neurol. 2015;30(4):217–228.26727700
  • Ko PW, Lee HW, Kang K. Frontal assessment battery and cerebrospinal fluid tap test in idiopathic normal-pressure hydrocephalus. Eur Neurol. 2017;77(5–6):327–332.28472801
  • Larsson J, Israelsson H, Eklund A, Malm J. Epilepsy, headache, and abdominal pain after shunt surgery for idiopathic normal pressure hydrocephalus: the INPH-CRasH study. J Neurosurg. 2018;128(6):1674–1683.28885121
  • Matsuoka T, Kawano S, Fujimoto K, Kawahara M, Hashimoto H. Characteristics of cognitive function evaluation using the Montreal cognitive assessment in a cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2019;186:105524.31541862
  • Sakakibara R, Kanda T, Sekido T, et al. Mechanism of bladder dysfunction in idiopathic normal pressure hydrocephalus. Neurourol Urodyn. 2008;27(6):507–510.18092331
  • Halperin JJ, Kurlan R, Schwalb JM, Cusimano MD, Gronseth G, Gloss D. Practice guideline: idiopathic normal pressure hydrocephalus: response to shunting and predictors of response: report of the guideline development, dissemination, and implementation subcommittee of the american academy of neurology. Neurology. 2015;85(23):2063–2071.26644048
  • Ferrari A, Milletti D, Giannini G, et al. The effects of cerebrospinal fluid tap-test on idiopathic normal pressure hydrocephalus: an inertial sensors based assessment. J Neuroeng Rehabil. 2020;17(1):7.31948485
  • Yamada S, Aoyagi Y, Yamamoto K, Ishikawa M. Quantitative evaluation of gait disturbance on an instrumented timed up-and-go test. Aging Dis. 2019;10(1):23–36.30705765
  • Gallagher RM, Marquez J, Osmotherly P. Cognitive and upper limb symptom changes from a tap test in idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2018;174:92–96.30219624
  • Yamada S, Ishikawa M, Miyajima M, et al. Disease duration: the key to accurate CSF tap test in iNPH. Acta Neurol Scand. 2017;135(2):189–196.26923727
  • Kaya D, Erken N, Ontan MS, Altun ZS, Isik AT. The applause sign in elderly patients with idiopathic normal pressure hydrocephalus. Appl Neuropsychol Adult. 2020;1–6.
  • Mahr CV, Dengl M, Nestler U, et al. Idiopathic normal pressure hydrocephalus: diagnostic and predictive value of clinical testing, lumbar drainage, and CSF dynamics. J Neurosurg. 2016;125(3):591–597.26824377
  • Kahlon B, Sundbarg G, Rehncrona S. Lumbar infusion test in normal pressure hydrocephalus. Acta Neurol Scand. 2005;111(6):379–384.15876339
  • Raneri F, Zella MAS, Di Cristofori A, Zarino B, Pluderi M, Spagnoli D. Supplementary tests in idiopathic normal pressure hydrocephalus: a single-center experience with a combined lumbar infusion test and tap test. World Neurosurg. 2017;100:567–574.28089835
  • Ryding E, Kahlon B, Reinstrup P. Improved lumbar infusion test analysis for normal pressure hydrocephalus diagnosis. Brain Behav. 2018;8(11):e01125.30259701
  • Schirinzi T, Sancesario GM, Di Lazzaro G, et al. Cerebrospinal fluid biomarkers profile of idiopathic normal pressure hydrocephalus. J Neural Transm. 2018;125(4):673–679.29353355
  • Chen Z, Liu C, Zhang J, Relkin N, Xing Y, Li Y. Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis. Fluids Barriers CNS. 2017;14:1.28132644
  • Kim HJ, Lim TS, Lee SM, et al. Cerebrospinal fluid levels of beta-amyloid 40 and beta-amyloid 42 are proportionately decreased in amyloid positron-emission tomography negative idiopathic normal-pressure hydrocephalus patients. J Clin Neurol. 2019;15(3):353–359.31286708
  • Jeppsson A, Wikkelsö C, Blennow K, et al. CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics. J Neurol Neurosurg Psychiatry. 2019;90(10):1117–1123.31167811
  • Abu-Rumeileh S, Giannini G, Polischi B, et al. Revisiting the cerebrospinal fluid biomarker profile in idiopathic normal pressure hydrocephalus: the bologna pro-hydro study. J Alzheimer’s Disease. 2019;68(2):723–733.30883350
  • Jingami N, Uemura K, Asada-Utsugi M, et al. Two-point dynamic observation of alzheimer’s disease cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. J Alzheimer’s Disease. 2019;72(1):271–277.31561378
  • Naganawa S, Taoka T. The glymphatic system: a review of the challenges in visualizing its structure and function with MR imaging. Magn Reson Med Sci. 2020.
  • Bae YJ, Choi BS, Kim JM, Choi JH, Cho SJ, Kim JH. Altered glymphatic system in idiopathic normal pressure hydrocephalus. Parkinsonism Relat Disord. 2020;82:56–60.33248394
  • Yokota H, Vijayasarathi A, Cekic M, et al. Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers. Curr Gerontol Geriatr Res. 2019;2019:5675014.31320896
  • Kamiya K, Hori M, Irie R, et al. Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus. Neuroimage Clin. 2017;14:663–671.28348958
  • Ghosh S, Lippa C. Diagnosis and prognosis in idiopathic normal pressure hydrocephalus. Am J Alzheimers Dis Other Demen. 2014;29(7):583–589.24550545
  • Siasios I, Kapsalaki EZ, Fountas KN, et al. The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review. Neurosurg Focus. 2016;41(3):E12.
  • Kockum K, Lilja-Lund O, Larsson EM, et al. The idiopathic normal-pressure hydrocephalus Radscale: a radiological scale for structured evaluation. Eur J Neurol. 2018;25(3):569–576.29281156
  • Mantovani P, Albini-Riccioli L, Giannini G, et al. Anterior callosal angle: a new marker of idiopathic normal pressure hydrocephalus? World Neurosurg. 2020;139:e548–e552.32348895
  • Jaraj D, Rabiei K, Marlow T, Jensen C, Skoog I, Wikkelso C. Estimated ventricle size using Evans index: reference values from a population-based sample. Eur J Neurol. 2017;24(3):468–474.28052454
  • Reeves BC, Karimy JK, Kundishora AJ, et al. Glymphatic system impairment in alzheimer’s disease and idiopathic normal pressure hydrocephalus. Trends Mol Med. 2020;26(3):285–295.31959516
  • Shprecher D, Schwalb J, Kurlan R. Normal pressure hydrocephalus: diagnosis and treatment. Curr Neurol Neurosci Rep. 2008;8(5):371–376.18713572
  • He W, Fang X, Wang X, et al. A new index for assessing cerebral ventricular volume in idiopathic normal-pressure hydrocephalus: a comparison with Evans’ index. Neuroradiology. 2020;62(6):661–667.32008047
  • Miyazaki K, Ishii K, Hanaoka K, Kaida H, Nakajima K. The tight medial and high convexity subarachnoid spaces is the first finding of idiopathic normal pressure hydrocephalus at the preclinical stage. Neurol Med Chir (Tokyo). 2019;59(11):436–443.31582642
  • Akiba C, Gyanwali B, Villaraza S, et al. The prevalence and clinical associations of disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of idiopathic normal pressure hydrocephalus in community and memory clinic based Singaporean cohorts. J Neurol Sci. 2020;408:116510.31810041
  • Neikter J, Agerskov S, Hellstrom P, et al. Ventricular volume is more strongly associated with clinical improvement than the evans index after shunting in idiopathic normal pressure hydrocephalus. AJNR Am J Neuroradiol. 2020;41(7):1187–1192.32527841
  • Suehiro T, Kazui H, Kanemoto H, et al. Changes in brain morphology in patients in the preclinical stage of idiopathic normal pressure hydrocephalus. Psychogeriatrics. 2019;19(6):557–565.30950145
  • Takagi K, Watahiki R, Machida T, Onouchi K, Kato K, Oshima M. Reliability and interobserver variability of evans’ index and disproportionately enlarged subarachnoid space hydrocephalus as diagnostic criteria for idiopathic normal pressure hydrocephalus. Asian J Neurosurg. 2020;15:1.32181163
  • Tinelli M, Guldemond N, Kehler U. Idiopathic Normal Pressure Hydrocephalus (iNPH): the cost-effectiveness of delivering timely and adequate treatment in Germany. Eur J Neurol. 2020.
  • Aimard G, Vighetto A, Gabet JY, Bret P, Henry E. Acetazolamide: an alternative to shunting in normal pressure hydrocephalus? Preliminary results. Rev Neurol. 1990;146(6–7):437–439.2399408
  • Swenson ER. Pharmacology of acute mountain sickness: old drugs and newer thinking. J Appl Physiol. 2016;120(2):204–215.26294748
  • Alperin N, Oliu CJ, Bagci AM, et al. Low-dose acetazolamide reverses periventricular white matter hyperintensities in iNPH. Neurology. 2014;82(15):1347–1351.24634454
  • Del Bigio MR, Di Curzio DL. Nonsurgical therapy for hydrocephalus: a comprehensive and critical review. Fluids Barriers CNS. 2016;13:3.26846184
  • Gavrilov GV, Gaydar BV, Svistov DV, et al. Idiopathic normal pressure hydrocephalus (hakim-adams syndrome): clinical symptoms, diagnosis and treatment. Psychiatr Danub. 2019;31(Suppl 5):737–744.32160166
  • Nakajima M, Miyajima M, Ogino I, et al. Preoperative phosphorylated tau concentration in the cerebrospinal fluid can predict cognitive function three years after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Alzheimer’s Disease. 2018;66(1):319–331.30248058
  • Miyajima M, Kazui H, Mori E, Ishikawa M. Sinphoni-Investigators obot. One-year outcome in patients with idiopathic normal-pressure hydrocephalus: comparison of lumboperitoneal shunt to ventriculoperitoneal shunt. J Neurosurg. 2016;125(6):1483–1492.26871203
  • Razay G, Wimmer M, Robertson I. Incidence, diagnostic criteria and outcome following ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus in a memory clinic population: a prospective observational cross-sectional and cohort study. BMJ Open. 2019;9(12):e028103.
  • Toma AK, Papadopoulos MC, Stapleton S, Kitchen ND, Watkins LD. Systematic review of the outcome of shunt surgery in idiopathic normal-pressure hydrocephalus. Acta Neurochir. 2013;155(10):1977–1980.23975646
  • Bådagård H, Braun M, Nilsson D, Stridh L, Virhammar J. Negative predictors of shunt surgery outcome in normal pressure hydrocephalus. Acta Neurol Scand. 2019;141(3):219–225.31778218
  • Feletti A, d’Avella D, Wikkelso C, et al. Ventriculoperitoneal shunt complications in the european idiopathic normal pressure hydrocephalus multicenter study. Oper Neurosurg. 2019;17(1):97–102.
  • Farahmand D, Saehle T, Eide PK, Tisell M, Hellstrom P, Wikkelso C. A double-blind randomized trial on the clinical effect of different shunt valve settings in idiopathic normal pressure hydrocephalus. J Neurosurg. 2016;124(2):359–367.26315004
  • Giordan E, Palandri G, Lanzino G, Murad MH, Elder BD. Outcomes and complications of different surgical treatments for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis. J Neurosurg. 2018;1–13.
  • Liu A, Sankey EW, Jusue-Torres I, et al. Clinical outcomes after ventriculoatrial shunting for idiopathic normal pressure hydrocephalus. Clin Neurol Neurosurg. 2016;143:34–38.26895207
  • Krahulik D, Vaverka M, Hrabalek L, et al. Ventriculoperitoneal shunt in treating of idiopathic normal pressure hydrocephalus-single-center study. Acta Neurochir. 2020;162(1):1–7.31728709
  • Clark DJ, Chakraborty A, Roebuck DJ, Thompson DN. Ultrasound guided placement of the distal catheter in paediatric ventriculoatrial shunts-an appraisal of efficacy and complications. Childs Nerv Syst. 2016;32(7):1219–1225.27207611
  • Nunoo-Mensah JW, Rosen M, Chan LS, Wasserberg N, Beart RW. Prevalence of intra-abdominal surgery: what is an individual’s lifetime risk? South Med J. 2009;102(1):25–29.19077782
  • McGovern RA, Kelly KM, Chan AK, Morrissey NJ, McKhann GM 2nd. Should ventriculoatrial shunting be the procedure of choice for normal-pressure hydrocephalus? J Neurosurg. 2014;120(6):1458–1464.24605842
  • Nakajima M, Miyajima M, Ogino I, et al. Shunt intervention for possible idiopathic normal pressure hydrocephalus improves patient outcomes: a nationwide hospital-based survey in Japan. Front Neurol. 2018;9.29434565
  • Kazui H, Miyajima M, Mori E, Ishikawa M, Investigators S. Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol. 2015;14(6):585–594.25934242
  • Oliveira MF, Teixeira MJ, Reis RC, Petitto CE, Gomes Pinto FC. Failed ventriculoperitoneal shunt: is retrograde ventriculosinus shunt a reliable option? World Neurosurg. 2016;92:445–453.27237416
  • Paidakakos N, Borgarello S, Naddeo M. Indications for endoscopic third ventriculostomy in normal pressure hydrocephalus. Acta Neurochir Suppl. 2012;113:123–127.22116437
  • Pinto FC, Saad F, Oliveira MF, et al. Role of endoscopic third ventriculostomy and ventriculoperitoneal shunt in idiopathic normal pressure hydrocephalus: preliminary results of a randomized clinical trial. Neurosurgery. 2013;72(5):845–853; discussion 853–844.
  • Hailong F, Guangfu H, Haibin T, et al. Endoscopic third ventriculostomy in the management of communicating hydrocephalus: a preliminary study. J Neurosurg. 2008;109(5):923–930.18976086
  • Tudor KI, Tudor M, McCleery J, Car J. Endoscopic third ventriculostomy (ETV) for idiopathic normal pressure hydrocephalus (iNPH). Cochrane Database Syst Rev. 2015;(7):CD010033.26222251