Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist

References

• Bonanad C, Garcia-Blas S, Tarazona-Santabalbina F, et al. The effect of age on mortality in patients with COVID-19: a meta-analysis with 611,583 subjects. J Am Med Dir Assoc. 2020;21(7):915–918. doi:10.1016/j.jamda.2020.05.04532674819
   PubMed Web of Science ®Google Scholar
• Kang SJ, Jung SI. Age-related morbidity and mortality among patients with COVID-19. Infect Chemother. 2020;52(2):154–164. doi:10.3947/ic.2020.52.2.15432537961
   PubMed Web of Science ®Google Scholar
• Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–762. doi:10.1016/S0140-6736(12)62167-923395245
   PubMed Web of Science ®Google Scholar
• Rockwood K, Howlett SE. Age-related deficit accumulation and the diseases of ageing. Mech Ageing Dev. 2019;180:107–116. doi:10.1016/j.mad.2019.04.00531002924
   PubMed Web of Science ®Google Scholar
• Joint Committee on Vaccination and Immunisation. Priority groups for coronavirus (COVID-19) vaccination: advice from the JCVI; 2020. Available from: https://www.gov.uk/government/publications/priority-groups-for-coronavirus-covid-19-vaccination-advice-from-the-jcvi-30-december-2020. Accessed 212, 2021.
   Google Scholar
• Dooling K, Marin M, Wallace M, et al. The advisory committee on immunization practices’ updated interim recommendation for allocation of COVID-19 Vaccine – United States, December 2020. MMWR Morb Mortal Wkly Rep. 2021;69(5152):1657–1660. doi:10.15585/mmwr.mm695152e233382671
   PubMed Web of Science ®Google Scholar
• National Advisory Committee on Immunization. Preliminary guidance on key populations for early COVID-10 immunization; 2020. Available from: https://www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/guidance-key-populations-early-covid-19-immunization.html. Accessed 212, 2021.
   Google Scholar
• Andrew MK, McElhaney JE. Age and frailty in COVID-19 vaccine development. Lancet. 2021;396(10267):1942–1944. doi:10.1016/S0140-6736(20)32481-833220853
   PubMed Web of Science ®Google Scholar
• McElhaney JE, Taddio A, Harmon SHE. The elderly, the frail, and COVID-19 vaccines: what we know so far; 2021. Available from: https://rsc-src.ca/en/voices/elderly-frail-and-covid-19-vaccines-what-we-know-so-far. Accessed 49, 2021. Royal Society of Canada.
   Google Scholar
• Fulop T, McElhaney J, Pawelec G, et al. Frailty, inflammation and immunosenescence. Interdiscip Top Gerontol Geriatr. 2015;41:26–40.26301977
   PubMedGoogle Scholar
• McElhaney JE, Verschoor CP, Andrew MK, Haynes L, Kuchel GA, Pawelec G. The immune response to influenza in older humans: beyond immune senescence. Immun Ageing. 2020;17:10. doi:10.1186/s12979-020-00181-132399058
   PubMed Web of Science ®Google Scholar
• Cunningham AL, Lal H, Kovac M, et al. Efficacy of the herpes zoster subunit vaccine in adults 70 years of age or older. N Engl J Med. 2016;375(11):1019–1032. doi:10.1056/NEJMoa160380027626517
   PubMed Web of Science ®Google Scholar
• Curran D, Kim JH, Matthews S, et al. Recombinant zoster vaccine is efficacious and safe in frail individuals. J Am Geriatr Soc. 2020;69:744–752. doi:10.1111/jgs.1691733197294
   PubMed Web of Science ®Google Scholar
• McElhaney JE, Andrew MK, Haynes L, Kuchel GA, McNeil SA, Pawelec G. Influenza vaccination: accelerating the process for new vaccine development in older adults. Interdiscip Top Gerontol Geriatr. 2020;43:98–112.32305974
   PubMedGoogle Scholar
• McElhaney JE, Ewen C, Zhou X, et al. Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine. 2009;27(18):2418–2425. doi:10.1016/j.vaccine.2009.01.13619368783
   PubMed Web of Science ®Google Scholar
• Sahin U, Muik A, Vogler I, et al. BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans; 2021. Available from: https://www.medrxiv.org/content/10.1101/2020.12.09.20245175v1. Accessed 49, 2021. medRxiv preprint server; preprint.
   Google Scholar
• Crome P. Clinical trials in older people: are we being ageist? Clin Invest. 2012;2(3):231–234. doi:10.4155/cli.12.2
   Google Scholar
• McConeghy KW, Davidson HE, Canaday DH, et al. Cluster-randomized trial of adjuvanted vs. non-adjuvanted trivalent influenza vaccine in 823 U.S. nursing homes. Clin Infect Dis. 2020. doi:10.1093/cid/ciaa1233
   Web of Science ®Google Scholar
• Gravenstein S, Davidson HE, Taljaard M, et al. Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial. Lancet Respir Med. 2017;5(9):738–746. doi:10.1016/S2213-2600(17)30235-728736045
   PubMed Web of Science ®Google Scholar
• DiazGranados CA, Dunning AJ, Kimmel M, et al. Efficacy of high-dose versus standard-dose influenza vaccine in older adults. N Engl J Med. 2014;371(7):635–645. doi:10.1056/NEJMoa131572725119609
   PubMed Web of Science ®Google Scholar
• DiazGranados CA, Dunning AJ, Robertson CA, Talbot HK, Landolfi V, Greenberg DP. Efficacy and immunogenicity of high-dose influenza vaccine in older adults by age, comorbidities, and frailty. Vaccine. 2015;33(36):4565–4571. doi:10.1016/j.vaccine.2015.07.00326187260
   PubMed Web of Science ®Google Scholar
• Banzhoff A, Nacci P, Podda A. A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis. Gerontology. 2003;49(3):177–184. doi:10.1159/00006917212679609
   PubMed Web of Science ®Google Scholar
• Andrew MK, Bowles SK, Pawelec G, et al. Influenza vaccination in older adults: recent innovations and practical applications. Drugs Aging. 2019;36(1):29–37. doi:10.1007/s40266-018-0597-430411283
   PubMed Web of Science ®Google Scholar
• Gotz FM, Gvirtz A, Galinsky AD, Jachimowicz JM. How personality and policy predict pandemic behavior: understanding sheltering-in-place in 55 countries at the onset of COVID-19. Am Psychol. 2021;76(1):39–49. doi:10.1037/amp000074033475389
   PubMed Web of Science ®Google Scholar
• Bailey L, Ward M, DiCosimo A, et al. Physical and mental health of older people while cocooning during the COVID-19 Pandemic. QJM. 2021. doi:10.1093/qjmed/hcab015
   Web of Science ®Google Scholar
• Monaco A, Palmer K, Holm Ravn Faber N, et al. Digital health tools for managing noncommunicable diseases during and after the COVID-19 pandemic: perspectives of patients and caregivers. J Med Internet Res. 2021;23(1):e25652. doi:10.2196/2565233464206
   PubMed Web of Science ®Google Scholar
• Jarrett PG, Rockwood K, Carver D, Stolee P, Cosway S. Illness presentation in elderly patients. Arch Intern Med. 1995;155(10):1060–1064. doi:10.1001/archinte.1995.004301000860107748049
   PubMedGoogle Scholar
• Rockwood K, Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can Geriatr J. 2020;23(3):210–215. doi:10.5770/cgj.23.46332904824
   PubMed Web of Science ®Google Scholar
• Hadley EC, Kuchel GA, Newman AB, Workshop S. Participants. Report: NIA workshop on measures of physiologic resiliencies in human aging. J Gerontol a Biol Sci Med Sci. 2017;72(7):980–990. doi:10.1093/gerona/glx01528475732
   PubMed Web of Science ®Google Scholar
• Voysey M, Clemens SAC, Madhi SA, et al. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2021;397(10269):99–111.33306989
   PubMed Web of Science ®Google Scholar
• Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2020.
   Web of Science ®Google Scholar
• Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603–2615. doi:10.1056/NEJMoa203457733301246
   PubMed Web of Science ®Google Scholar
• Rawle MJ, Bertfield DL, Brill SE. Atypical presentations of COVID-19 in care home residents presenting to secondary care: a UK single centre study. Aging Med (Milton). 2020;3(4):237–244. doi:10.1002/agm2.1212633392429
   PubMedGoogle Scholar
• Gan JM, Kho J, Akhunbay-Fudge M, et al. Atypical presentation of COVID-19 in hospitalised older adults. Ir J Med Sci. 2020. doi:10.1007/s11845-020-02372-7
   Web of Science ®Google Scholar
• Palermo S. Covid-19 pandemic: maximizing future vaccination treatments considering aging and frailty. Front Med (Lausanne). 2020;7:558835. doi:10.3389/fmed.2020.55883533072783
   PubMed Web of Science ®Google Scholar
• Schmader KE, Johnson GR, Saddier P, et al. Effect of a zoster vaccine on herpes zoster-related interference with functional status and health-related quality-of-life measures in older adults. J Am Geriatr Soc. 2010;58(9):1634–1641. doi:10.1111/j.1532-5415.2010.03021.x20863322
   PubMed Web of Science ®Google Scholar
• Schmader KE, Levin MJ, Grupping K, et al. The impact of reactogenicity after the first dose of recombinant zoster vaccine on the physical functioning and quality of life of older adults: an open-label, Phase III trial. J Gerontol a Biol Sci Med Sci. 2019;74(8):1217–1224. doi:10.1093/gerona/gly21830256905
   PubMed Web of Science ®Google Scholar
• Andrew MK, Shinde V, Ye L, et al. The importance of frailty in the assessment of influenza vaccine effectiveness against influenza-related hospitalization in elderly people. J Infect Dis. 2017;216(4):405–414. doi:10.1093/infdis/jix28228931244
   PubMed Web of Science ®Google Scholar
• Disabled Living Foundation. Losing independence is a bigger ageing worry than dying; 2009. Available from: http://www.dlf.org.uk/blog/losing-independence-bigger-ageing-worry-dying. Accessed 49, 2021.
   Google Scholar
• Phelan EA, Anderson LA, LaCroix AZ, Larson EB. Older adults’ views of “successful aging” – how do they compare with researchers’ definitions? J Am Geriatr Soc. 2004;52(2):211–216. doi:10.1111/j.1532-5415.2004.52056.x14728629
   PubMed Web of Science ®Google Scholar
• Canadian Frailty Network. AVOID Frailty; 2019. Available from: https://www.cfn-nce.ca/frailty-matters/avoid-frailty/. Accessed 212, 2021.
   Google Scholar
• International Federation on Ageing. Vaccines4Life; 2021. Available from: https://www.vaccines4life.com. Accessed 212, 2021.
   Google Scholar
• McGarrigle L, Squires E, Wallace LMK, et al. Investigating the feasibility and reliability of the Pictorial Fit-Frail Scale. Age Ageing. 2019;48(6):832–837. doi:10.1093/ageing/afz11131579907
   PubMed Web of Science ®Google Scholar
• Theou O, Andrew M, Ahip SS, et al. The pictorial fit-frail scale: developing a visual scale to assess frailty. Can Geriatr J. 2019;22(2):64–74. doi:10.5770/cgj.22.35731258829
   PubMed Web of Science ®Google Scholar
• Curran D, Andrew MK, Levin MJ, et al. Evaluation of two frailty indices, with practical application in a vaccine clinical trial. Hum Vaccin Immunother. 2019;15(12):2960–2968. doi:10.1080/21645515.2019.162297431157595
   PubMed Web of Science ®Google Scholar
• Wilkinson C, Wu J, Searle SD, et al. Clinical outcomes in patients with atrial fibrillation and frailty: insights from the ENGAGE AF-TIMI 48 trial. BMC Med. 2020;18(1):401. doi:10.1186/s12916-020-01870-w33357217
   PubMed Web of Science ®Google Scholar
• Dewan P, Jackson A, Jhund PS, et al. The prevalence and importance of frailty in heart failure with reduced ejection fraction – an analysis of PARADIGM-HF and ATMOSPHERE. Eur J Heart Fail. 2020;22(11):2123–2133. doi:10.1002/ejhf.183232353205
   PubMed Web of Science ®Google Scholar
• Farooqi MAM, Gerstein H, Yusuf S, Leong DP. Accumulation of deficits as a key risk factor for cardiovascular morbidity and mortality: a pooled analysis of 154 000 individuals. J Am Heart Assoc. 2020;9(3):e014686. doi:10.1161/JAHA.119.01468631986990
   PubMed Web of Science ®Google Scholar
• Arriola C, Garg S, Anderson EJ, et al. Influenza vaccination modifies disease severity among community-dwelling adults hospitalized with influenza. Clin Infect Dis. 2017;65(8):1289–1297. doi:10.1093/cid/cix46828525597
   PubMed Web of Science ®Google Scholar
• Talbot HK, Griffin MR, Chen Q, Zhu Y, Williams JV, Edwards KM. Effectiveness of seasonal vaccine in preventing confirmed influenza-associated hospitalizations in community dwelling older adults. J Infect Dis. 2011;203(4):500–508. doi:10.1093/infdis/jiq07621220776
   PubMed Web of Science ®Google Scholar
• Thompson MG, Pierse N, Sue Huang Q, et al. Influenza vaccine effectiveness in preventing influenza-associated intensive care admissions and attenuating severe disease among adults in New Zealand 2012–2015. Vaccine. 2018;36(39):5916–5925. doi:10.1016/j.vaccine.2018.07.02830077480
   PubMed Web of Science ®Google Scholar
• Hsu PS, Lian IB, Chao DY. A population-based propensity score-matched study to assess the impact of repeated vaccination on vaccine effectiveness for influenza-associated hospitalization among the elderly. Clin Interv Aging. 2020;15:301–312. doi:10.2147/CIA.S23878632184579
   PubMed Web of Science ®Google Scholar
• Andrew MK, MacDonald S, Godin J, et al. Persistent functional decline following hospitalization with influenza or acute respiratory illness. J Am Geriatr Soc. 2020. Online ahead of print.
   Web of Science ®Google Scholar
• Lees C, Godin J, McElhaney JE, et al. Frailty hinders recovery from influenza and acute respiratory illness in older adults. J Infect Dis. 2020;222(3):428–437. doi:10.1093/infdis/jiaa09232147711
   PubMed Web of Science ®Google Scholar
• Franceschi C, Capri M, Monti D, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev. 2007;128(1):92–105. doi:10.1016/j.mad.2006.11.01617116321
   PubMed Web of Science ®Google Scholar
• Torjesen I. Covid-19: Norway investigates 23 deaths in frail elderly patients after vaccination. BMJ. 2021;372:n149. doi:10.1136/bmj.n14933451975
   PubMed Web of Science ®Google Scholar
• Ruiz JB, Bell RA. Predictors of intention to vaccinate against COVID-19: results of a nationwide survey. Vaccine. 2021;39:1080–1086. doi:10.1016/j.vaccine.2021.01.01033461833
   PubMed Web of Science ®Google Scholar
• Sherman SM, Smith LE, Sim J. et al. COVID-19 vaccination intention in the UK: results from the COVID-19 vaccination acceptability study (CoVAccS), a nationally representative cross-sectional survey. Hum Vaccin Immunother;2020. 1–10. doi:10.1080/21645515.2020.1846397
   PubMed Web of Science ®Google Scholar
• Alzheimer Society of Canada. COVID-19 vaccination rollout; 2021. Available from: https://alzheimer.ca/en/whats-happening/news/covid-19-vaccination-rollout. Accessed 212, 2021.
   Google Scholar
• CanAge. Adult vaccination in Canada: cross-country report card 2021; 2021. Available from: https://www.canage.ca/vaccinereport. Accessed 212, 2021.
   Google Scholar
• Help Age International. Coronavirus (COVID-19). Available from: https://www.helpage.org/what-we-do/coronavirus-covid19/. Accessed 212, 2021.
   Google Scholar