184
Views
6
CrossRef citations to date
0
Altmetric
Original Research

Changes in Body Composition and Cardiometabolic Health After Detraining in Older Men with Osteosarcopenia: 6-Month Follow-Up of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST) Study

ORCID Icon, ORCID Icon, ORCID Icon &
Pages 571-582 | Published online: 06 Apr 2021

References

  • Eichberg S, Rott C. Sportverhalten im mittleren und höheren Erwachsenenalter. Bedingungsfaktoren für Kontinuität und Diskontinuität. J Public Health. 2004;12:93–104. doi:10.1007/s10389-004-0020-y
  • Pahmeier I. Sportliche Aktivität aus der Lebensperspektive. Z Gerontol Geriat. 2008;41:168–176. doi:10.1007/s00391-008-0543-x
  • Bickel CS, Cross JM, Bamman MM. Exercise dosing to retain resistance training adaptations in young and older adults. Med Sci Sports Exerc. 2011;43(7):1177–1187. doi:10.1249/MSS.0b013e318207c15d21131862
  • Douda HT, Kosmidou KV, Smilios I, Volaklis KA, Tokmakidis SP. Community-based training-detraining intervention in older women: a five-year follow-up study. J Aging Phys Act. 2015;23(4):496–512. doi:10.1123/japa.2013-024125415933
  • Elliott KJ, Sale C, Cable NT. Effects of resistance training and detraining on muscle strength and blood lipid profiles in postmenopausal women. Br J Sports Med. 2002;36(5):340–344. doi:10.1136/bjsm.36.5.34012351331
  • Esain I, Gil SM, Bidaurrazaga-Letona I, Rodriguez-Larrad A. Effects of 3 months of detraining on functional fitness and quality of life in older adults who regularly exercise. Aging Clin Exp Res. 2019;31(4):503–510. doi:10.1007/s40520-018-0990-129959666
  • Fatouros IG, Kambas A, Katrabasas I, et al. Strength training and detraining effects on muscular strength, anaerobic power, and mobility of inactive older men are intensity dependent. Br J Sports Med. 2005;39(10):776–780. doi:10.1136/bjsm.2005.01911716183776
  • Hakkinen K, Alen M, Kallinen M, Newton RU, Kraemer WJ. Neuromuscular adaptation during prolonged strength training, detraining and re-strength-training in middle-aged and elderly people. Eur J Appl Physiol. 2000;83(1):51–62. doi:10.1007/s00421000024811072774
  • Henwood TR, Taaffe DR. Detraining and retraining in older adults following long-term muscle power or muscle strength specific training. J Gerontol a Biol Sci Med Sci. 2008;63(7):751–758. doi:10.1093/gerona/63.7.75118693231
  • Lovell DI, Cuneo R, Gass GC. The effect of strength training and short-term detraining on maximum force and the rate of force development of older men. Eur J Appl Physiol. 2010;109(3):429–435. doi:10.1007/s00421-010-1375-020140683
  • Porter MM, Nelson ME, Singh MAF, et al. Effects of long-term resistance training and detraining on strength and physical activity in older women. JAPA. 2002;10(3):260–270. doi:10.1123/japa.10.3.260
  • Sakugawa RL, Moura BM, Orssatto L, Bezerra ES, Cadore EL, Diefenthaeler F. Effects of resistance training, detraining, and retraining on strength and functional capacity in elderly. Aging Clin Exp Res. 2019;31(1):31–39. doi:10.1007/s40520-018-0970-529777475
  • Snijders T, Leenders M, de Groot L, van Loon LJC, Verdijk LB. Muscle mass and strength gains following 6months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults. Exp Gerontol. 2019;121:71–78. doi:10.1016/j.exger.2019.04.00230978433
  • Taaffe DR, Henwood TR, Nalls MA, Walker DG, Lang TF, Harris TB. Alterations in muscle attenuation following detraining and retraining in resistance-trained older adults. Gerontology. 2009;55(2):217–223. doi:10.1159/00018208419060453
  • Tokmakidis SP, Kalapotharakos VI, Smilios I, Parlavantzas A. Effects of detraining on muscle strength and mass after high or moderate intensity of resistance training in older adults. Clin Physiol Funct Imaging. 2009;29(4):316–319. doi:10.1111/j.1475-097X.2009.00866.x19302225
  • Zech A, Drey M, Freiberger E, et al. Residual effects of muscle strength and muscle power training and detraining on physical function in community-dwelling prefrail older adults: a randomized controlled trial. BMC Geriatr. 2012;12:68. doi:10.1186/1471-2318-12-6823134737
  • Kemmler W, Kohl M, Froehlich M, Engelke K, von Stengel S, Schoene D. Effects of high intensity resistance training on fitness and fatness in older men with osteosarcopenia. Front Physiol. 2020;11:1014. doi:10.3389/fphys.2020.0101432973550
  • Kemmler W, Kohl M, Jakob F, Engelke K, von Stengel S. Effects of high intensity dynamic resistance exercise and whey protein supplements on osteosarcopenia in older men with low bone and muscle mass. Final results of the randomized controlled FrOST study. Nutrients. 2020;12(8):2341. doi:10.3390/nu12082341
  • Kemmler W, Kohl M, Frohlich M, Schoene D, von Stengel S. Detraining effects after 18 months of high intensity resistance training on osteosarcopenia in older men-Six-month follow-up of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). Bone. 2021;142:115772. doi:10.1016/j.bone.2020.11577233249320
  • World Medical Association. World Medical Association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013;310(20):2191–2194. doi:10.1001/jama.2013.28105324141714
  • Lichtenberg T, von Stengel S, Sieber C, Kemmler W. The favorable effects of a high-intensity resistance training on sarcopenia in older community-dwelling men with osteosarcopenia: the randomized controlled FrOST study. Clin Interv Aging. 2019;14:2173–2186. doi:10.2147/CIA.S22561831908428
  • Kemmler W, Kohl M, Frohlich M, et al. Effects of high intensity resistance training on osteopenia and sarcopenia parameters in older men with osteosarcopenia - one-year results of the randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). J Bone Miner Res. 2020;35(9):1634–1644. doi:10.1002/jbmr.402732270891
  • Baumgartner RN, Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147(8):755–763. doi:10.1093/oxfordjournals.aje.a0095209554417
  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on sarcopenia in older people. Consensus development conference practice guideline research support, non-U.S. Gov’t. Age Ageing. 2010;39(4):412–423. doi:10.1093/ageing/afq03420392703
  • World Health Organization. Assessment of osteoporotic fracture risk and its application to screening for postmenopausal osteoporosis. 1994: WHO technical report series No. 843. 1994.
  • Bauer J, Biolo G, Cederholm T, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc. 2013;14(8):542–559. doi:10.1016/j.jamda.2013.05.02123867520
  • DVO. Prophylaxe, Diagnostik Und Therapie Der OSTEOPOROSE Bei Postmenopausalen Frauen Und Bei Männern Schattauer. Schattauer Verlag; 2017.
  • Zourdos MC, Klemp A, Dolan C, et al. Novel resistance training-specific rating of perceived exertion scale measuring repetitions in reserve. J Strength Cond Res. 2016;30(1):267–275. doi:10.1519/JSC.000000000000104926049792
  • Steele J, Fisher J, Giessing J, Gentil P. Clarity in reporting terminology and definitions of set end points in resistance training. Muscle Nerve. 2017;56(3):368–374. doi:10.1002/mus.2555728044366
  • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome–a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469–480. doi:10.1111/j.1464-5491.2006.01858.x16681555
  • Kemmler W, Kohl M, von Stengel S, Schoene D. Effect of high-intensity resistance exercise on cardiometabolic health in older men with osteosarcopenia. The randomized controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). BMJ OPEN. 2020;accepted for publication.
  • Kemmler W, Weineck J, Kalender WA, Engelke K. The effect of habitual physical activity, non-athletic exercise, muscle strength, and VO2max on bone mineral density is rather low in early postmenopausal osteopenic women. J Musculoskelet Neuronal Interact. 2004;4(3):325–334.15615501
  • Schoeffl I, Kemmler W, von Stengel S, Engelke K, Kalender W, Engelke K. In healthy elderly postmenopausal women variations in BMD and BMC at various skeletal sites are associated with differences in weight and lean body mass rather than by variations in habitual physical activity, strength or VO2max. J Musculoskelet Neuronal Interact. 2008;8(4):363–374.19147974
  • Honaker J, King G, Blackwell M. Amelia II: a program for missing data. JSS. 2011;45(7):1–47.
  • Rubin DB. Multiple Imputation for Nonresponse in Surveys. John Wiley and Sons; 1987.
  • Barnard J, Rubin DB. Small-sample degrees of freedom with multiple imputation. Biometrika. 1999;86(4):948–955. doi:10.1093/biomet/86.4.948
  • Baumgartner RN. Body composition in healthy aging. Ann NY Acad Sci. 2000;904:437–448. doi:10.1111/j.1749-6632.2000.tb06498.x10865787
  • Schafer I, von Leitner EC, Schon G, et al. Multimorbidity patterns in the elderly: a new approach of disease clustering identifies complex interrelations between chronic conditions. PLoS One. 2010;5(12):e15941. doi:10.1371/journal.pone.001594121209965
  • Weineck J. Optimales Training. Spitta-Verlag; 2019.
  • Bauer JM, Verlaan S, Bautmans I, et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2015;16(9):740–747. doi:10.1016/j.jamda.2015.05.02126170041
  • Komar B, Schwingshackl L, Hoffmann G. Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging. 2015;19(4):437–446. doi:10.1007/s12603-014-0559-425809808
  • Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review. J Am Med Dir Assoc. 2013;14(1):10–17. doi:10.1016/j.jamda.2012.08.00122980996
  • Xu ZR, Tan ZJ, Zhang Q, Gui QF, Yang YM. Clinical effectiveness of protein and amino acid supplementation on building muscle mass in elderly people: a meta-analysis. PLoS One. 2014;9(9):e109141. doi:10.1371/journal.pone.010914125268791
  • Xu ZR, Tan ZJ, Zhang Q, Gui QF, Yang YM. The effectiveness of leucine on muscle protein synthesis, lean body mass and leg lean mass accretion in older people: a systematic review and meta-analysis. Br J Nutr. 2015;113(1):25–34. doi:10.1017/S000711451400247525234223
  • Zhu K, Kerr DA, Meng X, et al. Two-year whey protein supplementation did not enhance muscle mass and physical function in well-nourished healthy older postmenopausal women. J Nutr. 2015;145(11):2520–2526. doi:10.3945/jn.115.21829726400966
  • Baer DJ, Stote KS, Paul DR, Harris GK, Rumpler WV, Clevidence BA. Whey protein but not soy protein supplementation alters body weight and composition in free-living overweight and obese adults. J Nutr. 2011;141(8):1489–1494. doi:10.3945/jn.111.13984021677076
  • Tahavorgar A, Vafa M, Shidfar F, Gohari M, Heydari I. Whey protein preloads are more beneficial than soy protein preloads in regulating appetite, calorie intake, anthropometry, and body composition of overweight and obese men. Nutr Res. 2014;34(10):856–861. doi:10.1016/j.nutres.2014.08.01525277886
  • Fekete AA, Givens DI, Lovegrove JA. Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials. Proc Nutr Soc. 2016;75(3):328–341. doi:10.1017/S002966511600026427150497
  • Toraman NF. Short term and long term detraining: is there any difference between young-old and old people? Br J Sports Med. 2005;39(8):561–564. doi:10.1136/bjsm.2004.01542016046344
  • Ivey FM, Tracy BL, Lemmer JT, et al. Effects of strength training and detraining on muscle quality: age and gender comparisons. J Gerontol a Biol Sci Med Sci. 2000;55(3):B152–B159. doi:10.1093/gerona/55.3.B15210795719
  • Slentz CA, Houmard JA, Johnson JL, et al. Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount. J Appl Physiol. 2007;103(2):432–442. doi:10.1152/japplphysiol.01314.200617395756
  • Theodorou AA, Panayiotou G, Volaklis KA, et al. Aerobic, resistance and combined training and detraining on body composition, muscle strength, lipid profile and inflammation in coronary artery disease patients. Res Sports Med. 2016;24(3):171–184. doi:10.1080/15438627.2016.119148827258806
  • da Cunha Nascimento D, Tibana RA, Benik FM, et al. Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study. Clin Interv Aging. 2014;9:219. doi:10.2147/CIA.S5605824477221
  • Leitao L, Pereira A, Mazini M, et al. Effects of three months of detraining on the health profile of older women after a multicomponent exercise program. Int J Environ Res Public Health. 2019;16(20):3881. doi:10.3390/ijerph16203881
  • Lovell DI, Cuneo R, Gass GC. Strength training improves submaximum cardiovascular performance in older men. J Geriatr Phys Ther. 2009;32(3):117–124. doi:10.1519/00139143-200932030-0000720128336
  • Moraes MR, Bacurau RF, Casarini DE, et al. Chronic conventional resistance exercise reduces blood pressure in stage 1 hypertensive men. J Strength Cond Res. 2012;26(4):1122–1129. doi:10.1519/JSC.0b013e31822dfc5e22126975
  • Nikseresht M, Hafezi Ahmadi MR, Hedayati M. Detraining-induced alterations in adipokines and cardiometabolic risk factors after nonlinear periodized resistance and aerobic interval training in obese men. Appl Physiol Nutr Metab. 2016;41(10):1018–1025. doi:10.1139/apnm-2015-069327636349
  • Nolan PB, Keeling SM, Robitaille CA, Buchanan CA, Dalleck LC. The effect of detraining after a period of training on cardiometabolic health in previously sedentary individuals. Int J Environ Res Public Health. 2018;15(10):2303. doi:10.3390/ijerph15102303
  • Rossi FE, Diniz TA, Neves LM, et al. The beneficial effects of aerobic and concurrent training on metabolic profile and body composition after detraining: a 1-year follow-up in postmenopausal women. Eur J Clin Nutr. 2017;71(5):638–645. doi:10.1038/ejcn.2016.26328120855
  • Tokmakidis SP, Volaklis KA. Training and detraining effects of a combined-strength and aerobic exercise program on blood lipids in patients with coronary artery disease. J Cardiopulm Rehabil. 2003;23(3):193–200. doi:10.1097/00008483-200305000-0000612782903
  • Li G, Taljaard M, Van den Heuvel ER, et al. An introduction to multiplicity issues in clinical trials: the what, why, when and how. Int J Epidemiol. 2017;46(2):746–755. doi:10.1093/ije/dyw32028025257