Prevalence and Predictors of Potentially Inappropriate Medications Among Patients Aged ≥65 Years on Hospital Admissions in Kuwait

References

• Marengoni A, Angleman S, Melis R, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev. 2011;10(4):430–439. doi:10.1016/j.arr.2011.03.003
   PubMed Web of Science ®Google Scholar
• Almirall J, Fortin M. The coexistence of terms to describe the presence of multiple concurrent diseases. J Comorb. 2013;3:4–9. doi:10.15256/joc.2013.3.22
   PubMedGoogle Scholar
• Sinnott C, Bradley CP. Multimorbidity or polypharmacy: two sides of the same coin? J Comorb. 2015;5(1):29–31. doi:10.15256/joc.2015.5.51
   PubMedGoogle Scholar
• Maher RL, Hanlon JT, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):57–65. doi:10.1517/14740338.2013.827660
   PubMed Web of Science ®Google Scholar
• Wastesson JW, Morin L, Tan ECK, Johnell K. An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opin Drug Saf. 2018;17(12):1185–1196. doi:10.1080/14740338.2018.1546841
   PubMed Web of Science ®Google Scholar
• Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med. 2003;163(22):2716–2724. doi:10.1001/archinte.163.22.2716
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhou S, Pan K, et al. Potentially inappropriate medications in hospitalized older patients: a cross-sectional study using the Beers 2015 criteria versus the 2012 criteria. Clin Interv Aging. 2017;53:1697–1703. doi:10.2147/CIA.S146009
   Web of Science ®Google Scholar
• Bradley MC, Fahey T, Cahir C, et al. Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland enhanced prescribing database. Eur J Clin Pharmacol. 2012;68(10):1425–1433. doi:10.1007/s00228-012-1249-y
   PubMed Web of Science ®Google Scholar
• Passarelli MCG, Jacob-Filho W, Figueras A. Adverse drug reactions in an elderly hospitalised population. Drugs Aging. 2005;22(9):767–777. doi:10.2165/00002512-200522090-00005
   PubMed Web of Science ®Google Scholar
• Xing XX, Zhu C, Liang HY, et al. Associations between potentially inappropriate medications and adverse health outcomes in the elderly: a systematic review and meta-analysis. Ann Pharmacother. 2019;53(10):1005–1019. doi:10.1177/1060028019853069
   PubMed Web of Science ®Google Scholar
• Bhagavathula AS, Gebreyohannes EA, Fialova D. Prevalence of polypharmacy and risks of potentially inappropriate medication use in the older population in a developing country: a systematic review and meta-analysis. Gerontology. 2021;68(2):136–145. doi:10.1159/000516075
   PubMed Web of Science ®Google Scholar
• Alosaimy S, Vaidya A, Day K, Stern G. Effect of a pharmacist-driven medication management intervention among older adults in an inpatient setting. Drugs Aging. 2019;36(4):371–378. doi:10.1007/s40266-018-00634-9
   PubMed Web of Science ®Google Scholar
• Sheikh-Taha M, Dimassi H. Potentially inappropriate home medications among older patients with cardiovascular disease admitted to a cardiology service in USA. BMC Cardiovasc Disord. 2017;17(1):189. doi:10.1186/s12872-017-0623-1
   PubMed Web of Science ®Google Scholar
• Fick DM, Mion LC, Beers MH, Waller JL. Health outcomes associated with potentially inappropriate medication use in older adults. Res Nurs Health. 2008;31(1):42–51. doi:10.1002/nur.20232
   PubMed Web of Science ®Google Scholar
• Gallagher P, Lang PO, Cherubini A, et al. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol. 2011;67(11):1175. doi:10.1007/s00228-011-1061-0
   PubMed Web of Science ®Google Scholar
• Hamilton H, Gallagher P, Ryan C, Byrne S, O’Mahony D. Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Int Med. 2011;171(11):1013–1019.
   PubMed Web of Science ®Google Scholar
• Alhmoud E, Khalifa S, Bahi AA. Prevalence and predictors of potentially inappropriate medications among home care elderly patients in Qatar. Int J Clin Pharm. 2015;37(5):815–821. doi:10.1007/s11096-015-0125-0
   PubMed Web of Science ®Google Scholar
• Al-Dahshan A, Kehyayan V. Prevalence and predictors of potentially inappropriate medication prescription among older adults: a cross-sectional study in the state of Qatar. Drugs Real World Outcomes. 2020;8(1):95–103. doi:10.1007/s40801-020-00220-9
   PubMedGoogle Scholar
• Al-Busaidi S, Al-Kharusi A, Al-Hinai M, et al. potentially inappropriate prescribing among elderly patients at a primary care clinic in Oman. J Cross Cult Gerontol. 2019;35(2):209–216. doi:10.1007/s10823-019-09393-5
   Web of Science ®Google Scholar
• Bulatova N, Elayeh E, Abdullah S, et al. Assessment of inappropriate medication use in Jordanian elderly hospitalized patients using 2015 beers criteria. Turk J Geriatr. 2019;22(3):258–268.
   Google Scholar
• Saab YB, Hachem A, Sinno S, El-Moalem H. Inappropriate medication use in elderly Lebanese outpatients. Drugs Aging. 2006;23(9):743–752. doi:10.2165/00002512-200623090-00004
   PubMed Web of Science ®Google Scholar
• Awad A, Hanna O. Potentially inappropriate medication use among geriatric patients in primary care setting: a cross-sectional study using the Beers, STOPP, FORTA and MAI criteria. PLoS One. 2019;14(6):e0218174. doi:10.1371/journal.pone.0218174
   PubMed Web of Science ®Google Scholar
• Al‐Omar HA, Al‐Sultan MS, Abu‐Auda HS. Prescribing of potentially inappropriate medications among the elderly population in an ambulatory care setting in a Saudi military hospital: trend and cost. Geriatr Gerontol Int. 2013;13(3):616–621. doi:10.1111/j.1447-0594.2012.00951.x
   PubMed Web of Science ®Google Scholar
• Jastaniah NA, Almaqati AS, Alsuraihi AK, Abughanim SA, Aseeri M. Inappropriate prescribing in elderly inpatients at a university hospital in Saudi Arabia. Drugs Real World Outcomes. 2018;5(4):211–216. doi:10.1007/s40801-018-0142-0
   PubMedGoogle Scholar
• Alhawassi TM, Alatawi W, Alwhaibi M. Prevalence of potentially inappropriate medications use among older adults and risk factors using the 2015 American Geriatrics Society Beers criteria. BMC Geriatr. 2019;19(1):154. doi:10.1186/s12877-019-1168-1
   PubMed Web of Science ®Google Scholar
• Alyazeedi A, Fouad Algendy A, Sharabash M, Karawia A. Prevalence, determinants and associated risk of potentially inappropriate prescribing for older adults in Qatar: a national retrospective study. Clin Interv Aging. 2019;14:1889–1899. doi:10.2147/CIA.S222532
   PubMed Web of Science ®Google Scholar
• 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–694. doi:10.1111/jgs.15767
   PubMed Web of Science ®Google Scholar
• Cochran W. Sampling Techniques. 3rd ed. New York: John Wiley & Sons; 1977.
   Google Scholar
• Niang L, Winn T, Rusli BN. Practical issues in calculating the sample size for prevalence studies. Med Stat. 2006;1:9–14.
   Google Scholar
• Arellano C, Saldivia G, Córdova P, et al. Using two tools to identify potentially inappropriate medications (PIM) in elderly patients in Southern Chile. Arch Gerontol Geriatr. 2016;67:139–144. doi:10.1016/j.archger.2016.08.001
   PubMed Web of Science ®Google Scholar
• Kersten H, Hvidsten LT, Gløersen G, Wyller TB, Wang-Hansen MS. Clinical impact of potentially inappropriate medications during hospitalization of acutely ill older patients with multimorbidity. Scand J Prim Health Care. 2015;33(4):243–251. doi:10.3109/02813432.2015.1084766
   PubMed Web of Science ®Google Scholar
• Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–349. doi:10.1016/j.jclinepi.2007.11.008
   PubMed Web of Science ®Google Scholar
• Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230. doi:10.1186/s12877-017-0621-2
   PubMed Web of Science ®Google Scholar
• Damoiseaux-Volman BA, Raven K, Sent D, et al. Potentially inappropriate medications and their effect on falls during hospital admission. Age Ageing. 2021;51:afab205.
   Web of Science ®Google Scholar
• Tosato M, Landi F, Martone AM, et al. Potentially inappropriate drug use among hospitalised older adults: results from the CRIME study. Age Ageing. 2014;43(6):767–773. doi:10.1093/ageing/afu029
   PubMed Web of Science ®Google Scholar
• Dalleur O, Spinewine A, Henrard S, Losseau C, Speybroeck N, Boland B. Inappropriate prescribing and related hospital admissions in frail older persons according to the STOPP and START criteria. Drugs Aging. 2012;29(10):829–837. doi:10.1007/s40266-012-0016-1
   PubMed Web of Science ®Google Scholar
• Nothelle SK, Sharma R, Oakes AH, Jackson M, Segal JB. Determinants of potentially inappropriate medication use in long term and acute care settings: a systematic review. J Am Med Dir Assoc. 2017;18(9):806.e1–e17. doi:10.1016/j.jamda.2017.06.005
   PubMed Web of Science ®Google Scholar
• Abdulah R, Insani WN, Destiani D, Rohmaniasari N, Mohenathas N, Barliana MI. Polypharmacy leads to increased prevalence of potentially inappropriate medication in the Indonesian geriatric population visiting primary care facilities. Ther Clin Risk Manag. 2018;14:1591–1597. doi:10.2147/TCRM.S170475
   PubMed Web of Science ®Google Scholar
• Harugeri A, Joseph J, Parthasarathi G, Ramesh M, Guido S. Potentially inappropriate medication use in elderly patients: a study of prevalence and predictors in two teaching hospitals. J Postgrad Med. 2010;56(3):186–191. doi:10.4103/0022-3859.68642
   PubMed Web of Science ®Google Scholar
• Kondo N, Nakamura F, Yamazaki S, et al. Prescription of potentially inappropriate medications to elderly hemodialysis patients: prevalence and predictors. Nephrol Dial Transplant. 2015;30(3):498–505. doi:10.1093/ndt/gfu070
   PubMed Web of Science ®Google Scholar
• Moquaddam F, Al-Jeheidli A, Salmin N. General practitioner’s view of geriatric care in Kuwait. Kuwait Med J. 2005;37(4):251–256.
   Google Scholar
• Piau A, Huet Y, Gallini A, Andre L, Vellas B, Nourhashemi F. Optimization of drug therapy in elderly individuals admitted to a geriatric unit. Clin Interv Aging. 2017;12:1691–1696. doi:10.2147/CIA.S132309
   PubMed Web of Science ®Google Scholar
• Onatade R, Auyeung V, Scutt G, Fernando J. Potentially Inappropriate prescribing in patients on admission and discharge from an older peoples’ unit of an acute UK hospital. Drugs Aging. 2013;30(9):729–737. doi:10.1007/s40266-013-0097-5
   PubMed Web of Science ®Google Scholar
• Johansen JS, Halvorsen KH, Svendsen K, Havnes K, Garcia BH. The impact of hospitalisation to geriatric wards on the use of medications and potentially inappropriate medications - a health register study. BMC Geriatr. 2020;20(1):190. doi:10.1186/s12877-020-01585-w
   PubMed Web of Science ®Google Scholar
• Santos NS, Marengo LL, Moraes FDS, Barberato-Filho S. Interventions to reduce the prescription of inappropriate medicines in older patients. Rev Saúde Pública. 2019;53:7. doi:10.11606/S1518-8787.2019053000781
   PubMed Web of Science ®Google Scholar
• Scott IA, Hilmer SN, Reeve E, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Int Med. 2015;175(5):827–834. doi:10.1001/jamainternmed.2015.0324
   PubMed Web of Science ®Google Scholar
• Thillainadesan J, Gnjidic D, Green S, Hilmer SN. Impact of deprescribing interventions in older hospitalised patients on prescribing and clinical outcomes: a systematic review of randomised trials. Drugs Aging. 2018;35(4):303–319. doi:10.1007/s40266-018-0536-4
   PubMed Web of Science ®Google Scholar
• Pruskowski JA, Springer S, Thorpe CT, Klein-Fedyshin M, Handler SM. Does deprescribing improve quality of life? A systematic review of the literature. Drugs Aging. 2019;36(12):1097–1110. doi:10.1007/s40266-019-00717-1
   PubMed Web of Science ®Google Scholar
• Page AT, Clifford RM, Potter K, Schwartz D, Etherton-Beer CD. The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis. Brit J Clin Pharmacol. 2016;82(3):583–623. doi:10.1111/bcp.12975
   PubMed Web of Science ®Google Scholar
• Wang P, Wang Q, Li F, Bian M, Yang K. Relationship Between potentially inappropriate medications and the risk of hospital readmission and death in hospitalized older patients. Clin Interv Aging. 2019;14:1871–1878. doi:10.2147/CIA.S218849
   PubMed Web of Science ®Google Scholar
• Varga S, Alcusky M, Keith SW, et al. Hospitalization rates during potentially inappropriate medication use in a large population‐based cohort of older adults. Br J Clin Pharmacol. 2017;83(11):2572–2580. doi:10.1111/bcp.13365
   PubMed Web of Science ®Google Scholar
• Scott S, Clark A, Farrow C, et al. Attitudinal predictors of older peoples’ and caregivers’ desire to deprescribe in hospital. BMC Geriatr. 2019;19(1):108. doi:10.1186/s12877-019-1127-x
   PubMed Web of Science ®Google Scholar
• Pohontsch NJ, Löffler A, Luck T, et al. Informal caregivers’ perspectives on health of and (potentially inappropriate) medication for (relatively) independent oldest-old people – a qualitative interview study. BMC Geriatr. 2018;18(1):169. doi:10.1186/s12877-018-0849-5
   PubMed Web of Science ®Google Scholar