What is an appropriate blood pressure goal for the elderly: review of recent studies and practical recommendations

References

• HeWSenguptaMVelkoffVADeBarrosKAUS Census BureauCurrent Population Reports, 65 in the United States: 2005Washington, DCUS Government Printing Office2005P23P209
   Google Scholar
• OstchegaYDillonCFHughesJPCarrollMYoonSTrends in hypertension prevalence, awareness, treatment, and control in older US adults: data from the National Health and Nutrition Examination Survey 1988 to 2004J Am Geriatr Soc20075571056106517608879
   PubMed Web of Science ®Google Scholar
• VasanRSBeiserASeshadriSResidual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart StudyJAMA200228781003101011866648
   PubMed Web of Science ®Google Scholar
• CalhounDAJonesDTextorSResistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure ResearchHypertension20085161403141918391085
   PubMed Web of Science ®Google Scholar
• HayesDKDennyCHKeenanNLCroftJBGreenlundKJHealth-related quality of life and hypertension status, awareness, treatment, and control: National Health and Nutrition Examination Survey, 2001–2004J Hypertens200826464164718327071
   PubMed Web of Science ®Google Scholar
• LawesCMVander HoornSRodgersAInternational Society of HypertensionGlobal burden of blood-pressure-related disease, 2001Lancet200837196231513151818456100
   PubMed Web of Science ®Google Scholar
• LewingtonSClarkeRQizilbashNPetoRCollinsRProspective Studies CollaborationAge-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesLancet200236093491903191312493255
   PubMed Web of Science ®Google Scholar
• GorelickPBSaccoRLSmithDBPrevention of a first stroke: a review of guidelines and a multidisciplinary consensus statement from the National Stroke AssociationJAMA1999281121112112010188663
   PubMed Web of Science ®Google Scholar
• FranklinSSJacobsMJWongNDL’ItalienGJLapuertaPPredominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) IIIHypertension200137386987411244010
   PubMed Web of Science ®Google Scholar
• FranklinSSLarsonMGKhanSADoes the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart StudyCirculation200110391245124911238268
   PubMed Web of Science ®Google Scholar
• BurtVLWheltonPRoccellaEJPrevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988–1991Hypertension19952533053137875754
   PubMed Web of Science ®Google Scholar
• UngvariZKaleyGde CaboRSonntagWECsiszarAMechanisms of vascular aging: new perspectivesJ Gerontol A Biol Sci Med Sci201065101028104120576649
   PubMed Web of Science ®Google Scholar
• WangMTakagiGAsaiKAging increases aortic MMP-2 activity and angiotensin II in nonhuman primatesHypertension20034161308131612743015
   PubMed Web of Science ®Google Scholar
• WangMZhangJSpinettiGAngiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young ratsAm J Pathol200516751429144216251426
   PubMed Web of Science ®Google Scholar
• ChabrashviliTKitiyakaraCBlauJEffects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expressionAm J Physiol Regul Integr Comp Physiol20032851R117R12412609817
   PubMed Web of Science ®Google Scholar
• BassoNCiniRPietrelliAFerderLTerragnoNAInserraFProtective effect of long-term angiotensin II inhibitionAm J Physiol Heart Circ Physiol20072933H1351H135817557916
   PubMed Web of Science ®Google Scholar
• LakattaEGCardiovascular regulatory mechanisms in advanced agePhysiol Rev19937324134678475195
   PubMed Web of Science ®Google Scholar
• GribbinBPickeringTGSleightPPetoREffect of age and high blood pressure on baroreflex sensitivity in manCirc Res19712944244315110922
   PubMed Web of Science ®Google Scholar
• VitaJAKeaneyJFExercise – toning up the endothelium?N Engl J Med2000342750350510675433
   PubMed Web of Science ®Google Scholar
• UlkerSMcKeownPPBayraktutanUVitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activitiesHypertension200341353453912623955
   PubMed Web of Science ®Google Scholar
• d’UscioLVMilstienSRichardsonDSmithLKatusicZSLong-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activityCirc Res2003921889512522125
   PubMed Web of Science ®Google Scholar
• YusufSDagenaisGPogueJBoschJSleightPVitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study InvestigatorsN Engl J Med2000342315416010639540
   PubMed Web of Science ®Google Scholar
• Heart Protection Study Collaborative GroupMRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trialLancet20023609326233312114037
   PubMed Web of Science ®Google Scholar
• de GaetanoGCollaborative Group of the Primary Prevention ProjectLow-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention ProjectLancet20013579250899511197445
   PubMed Web of Science ®Google Scholar
• GhiadoniLMagagnaAVersariDDifferent effect of antihypertensive drugs on conduit artery endothelial functionHypertension20034161281128612719441
   PubMed Web of Science ®Google Scholar
• BerryCAndersonNKirkAJDominiczakAFMcMurrayJJRenin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart diseaseHeart200186221722011454847
   PubMed Web of Science ®Google Scholar
• OnYKKimCHOhBHLeeMMParkYBEffects of angiotensin converting enzyme inhibitor and calcium antagonist on endothelial function in patients with essential hypertensionHypertens Res200225336537112135314
   PubMed Web of Science ®Google Scholar
• MasonRPMarchePHintzeTHNovel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipineArterioscler Thromb Vasc Biol200323122155216314512371
   PubMed Web of Science ®Google Scholar
• CollinsRMacMahonSBlood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart diseaseBr Med Bull19945022722988205459
   PubMed Web of Science ®Google Scholar
• StaessenJAGasowskiJWangJGRisks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trialsLancet2000355920786587210752701
   PubMed Web of Science ®Google Scholar
• JuliusSKjeldsenSEWeberMVALUE trial groupOutcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trialLancet200436394262022203115207952
   PubMed Web of Science ®Google Scholar
• MesserliFHManciaGContiCRDogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous?Ann Intern Med20061441288489316785477
   PubMed Web of Science ®Google Scholar
• SleightPRedonJVerdecchiaPONTARGET investigatorsPrognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial studyJ Hypertens20092771360136919506526
   PubMed Web of Science ®Google Scholar
• BangaloreSMesserliFHWunCCTreating to New Targets Steering Committee and InvestigatorsJ-curve revisited: An analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) TrialEur Heart J201031232897290820846991
   PubMed Web of Science ®Google Scholar
• BoshuizenHCIzaksGJvan BuurenSLigthartGJBlood pressure and mortality in elderly people aged 85 and older: community based studyBMJ19983167147178017849624064
   PubMed Web of Science ®Google Scholar
• LangerRDGaniatsTGBarrett-ConnorEFactors associated with paradoxical survival at higher blood pressures in the very oldAm J Epidemiol1991134129381853858
   PubMed Web of Science ®Google Scholar
• HakalaSMTilvisRSStrandbergTEBlood pressure and mortality in an older population. A 5-year follow-up of the Helsinki Ageing StudyEur Heart J1997186101910239183596
   PubMed Web of Science ®Google Scholar
• van BemmelTGusseklooJWestendorpRGBlauwGJIn a population-based prospective study, no association between high blood pressure and mortality after age 85 yearsJ Hypertens200624228729216508574
   PubMed Web of Science ®Google Scholar
• MolanderLLövheimHNormanTNordströmPGustafsonYLower systolic blood pressure is associated with greater mortality in people aged 85 and olderJ Am Geriatr Soc200856101853185918811610
   PubMed Web of Science ®Google Scholar
• SatishSFreemanDHRayLGoodwinJSThe relationship between blood pressure and mortality in the oldest oldJ Am Geriatr Soc200149436737411347778
   PubMed Web of Science ®Google Scholar
• BoutitieFGueyffierFPocockSFagardRBoisselJPINDANA Project Steering CommitteeINdividual Data ANalysis of Antihypertensive intervention. J-shaped relationship between blood pressure and mortality in hypertensive patients: new insights from a meta-analysis of individual-patient dataAnn Intern Med2002136643844811900496
   PubMed Web of Science ®Google Scholar
• ChobanianAVBakrisGLBlackHRNational Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureNational High Blood Pressure Education Program Coordinating CommitteeThe Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportJAMA2003289192560257212748199
   PubMed Web of Science ®Google Scholar
• ManciaGFagardRNarkiewiczK2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)Eur Heart J201334282159221923771844
   PubMed Web of Science ®Google Scholar
• Brandão RondonMUAlvesMJBragaAMPostexercise blood pressure reduction in elderly hypertensive patientsJ Am Coll Cardiol200239467668211849868
   PubMed Web of Science ®Google Scholar
• AppelLJEspelandMAEasterLWilsonACFolmarSLacyCREffects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE)Arch Intern Med2001161568569311231700
   PubMed Web of Science ®Google Scholar
• AmeryABirkenhagerWBrixkoPMortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trialLancet198518442134913542861311
   PubMed Web of Science ®Google Scholar
• Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research GroupJAMA199126524325532642046107
   PubMed Web of Science ®Google Scholar
• PerryHMDavisBRPriceTREffect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: the Systolic Hypertension in the Elderly Program (SHEP)JAMA2000284446547110904510
   PubMed Web of Science ®Google Scholar
• DahlöfBLindholmLHHanssonLSchersténBEkbomTWesterPOMorbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)Lancet19913388778128112851682683
   PubMed Web of Science ®Google Scholar
• HanssonLLindholmLHEkbomTRandomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 studyLancet199935491921751175610577635
   PubMed Web of Science ®Google Scholar
• StaessenJAFagardRThijsLRandomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial InvestigatorsLancet199735090807577649297994
   PubMed Web of Science ®Google Scholar
• LiuLWangJGGongLLiuGStaessenJAComparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative GroupJ Hypertens19981612 Pt 1182318299869017
   PubMed Web of Science ®Google Scholar
• Medical Research Council trial of treatment of hypertension in older adults: principal resultsMRC Working PartyBMJ199230468244054121445513
   PubMed Web of Science ®Google Scholar
• KhanNMcAlisterFARe-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysisCMAJ2006174121737174216754904
   PubMed Web of Science ®Google Scholar
• DahlöfBDevereuxRBKjeldsenSELIFE Study GroupCardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenololLancet20023599311995100311937178
   PubMed Web of Science ®Google Scholar
• ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research GroupThe Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)JAMA2002288232981299712479763
   PubMed Web of Science ®Google Scholar
• WingLMReidCMRyanPSecond Australian National Blood Pressure Study GroupA comparison of outcomes with angiotensin-converting – enzyme inhibitors and diuretics for hypertension in the elderlyN Engl J Med2003348758359212584366
   PubMed Web of Science ®Google Scholar
• JamersonKWeberMABakrisGLACCOMPLISH Trial InvestigatorsBenazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patientsN Engl J Med2008359232417242819052124
   PubMed Web of Science ®Google Scholar
• GueyffierFBulpittCBoisselJPAntihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA GroupLancet1999353915579379610459960
   PubMed Web of Science ®Google Scholar
• BeckettNSPetersRFletcherAEHYVET Study GroupTreatment of hypertension in patients 80 years of age or olderN Engl J Med2008358181887189818378519
   PubMed Web of Science ®Google Scholar
• OgiharaTSarutaTRakugiHValsartan in Elderly Isolated Systolic Hypertension Study GroupTarget blood pressure for treatment of isolated systolic hypertension in the elderly: valsartan in elderly isolated systolic hypertension studyHypertension201056219620220530299
   PubMed Web of Science ®Google Scholar
• JATOS Study GroupPrincipal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS)Hypertens Res200831122115212719139601
   PubMed Web of Science ®Google Scholar
• StrandgaardSCerebral blood flow in the elderly: impact of hypertension and antihypertensive treatmentCardiovasc Drugs Ther19914Suppl 6121712212009245
   PubMedGoogle Scholar
• MansoorGAMcCabeEJWhiteWBDeterminants of the white-coat effect in hypertensive subjectsJ Hum Hypertens199610287928867561
   PubMed Web of Science ®Google Scholar
• WardAMTakahashiOStevensRHeneghanCHome measurement of blood pressure and cardiovascular disease: systematic review and meta-analysis of prospective studiesJ Hypertens201230344945622241136
   PubMed Web of Science ®Google Scholar
• WangJGStaessenJBenefits of antihypertensive pharmacologic therapy and blood pressure reduction in outcome trialsJ Clin Hypertens (Greenwich)200351667512556657
   PubMedGoogle Scholar
• AronowWSFlegJLPepineCJACCF Task ForceACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus DocumentsCirculation2011123212434250621518977
   PubMed Web of Science ®Google Scholar
• SacktorNGraySKawasCHerbstJCostaPFlegJSystolic blood pressure within an intermediate range may reduce memory loss in an elderly hypertensive cohortJ Geriatr Psychiatry Neurol19991211610447147
   PubMed Web of Science ®Google Scholar