Modulating testosterone pathway: a new strategy to tackle male skin aging?

References

• PhillipsTJDemircayZSahuMHormonal effects on skin agingClin Geriatr Med200117466167211535422
   PubMed Web of Science ®Google Scholar
• WespesESchulmanCCMale andropause: myth, reality, and treatmentInt J Impot Res200214Suppl 1S93S9811850741
   PubMed Web of Science ®Google Scholar
• ZouboulisCCIntrinsic skin aging. A critical appraisal of the role of hormonesHautarzt200354982583212955259
   PubMed Web of Science ®Google Scholar
• TheodorakiABoulouxPMTestosterone therapy in menMenopause Int2009152879219465676
   PubMedGoogle Scholar
• BegSAl-KhouryLCunninghamGRTestosterone replacement in menCurr Opin Endocrinol Diabetes Obes200815436437018594278
   PubMedGoogle Scholar
• DiverMJLaboratory measurement of testosteroneFront Horm Res200937213119011286
   PubMed Web of Science ®Google Scholar
• YeapBBTestosterone and ill-health in aging menNat Clin Pract Endocrinol Metab20095211312119165223
   PubMedGoogle Scholar
• RiggsBLKhoslaSMeltonLJ3rdSex steroids and the construction and conservation of the adult skeletonEndocr Rev200223327930212050121
   PubMed Web of Science ®Google Scholar
• CilottiAFalchettiAMale osteoporosis and androgenic therapy: from testosterone to SARMsClin Cases Miner Bone Metab20096322923322461251
   PubMedGoogle Scholar
• AbdullahFRashidRMAlopecia: botanical approaches in reviewJ Drugs Dermatol20109553754120480798
   PubMed Web of Science ®Google Scholar
• ShapiroJPriceVHHair regrowth. Therapeutic agentsDermatol Clin19981623413569589208
   PubMed Web of Science ®Google Scholar
• LeeWJJungHDChiSGEffect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytesArch Dermatol Res2010302642943320043171
   PubMed Web of Science ®Google Scholar
• ZouboulisCCAcne and sebaceous gland functionClin Dermatol200422536036615556719
   PubMed Web of Science ®Google Scholar
• LarsenPRWilliamsRLWilliams Textbook of EndocrinologyPhiladelphiaWB Saunders2003
   Google Scholar
• SatorPGSchmidtJBSatorMOHuberJCHönigsmannHThe influence of hormone replacement therapy on skin ageing: a pilot studyMaturitas2001391435511451620
   PubMed Web of Science ®Google Scholar
• LawrentschukNFleshnerNSevere irritant contact dermatitis causing skin ulceration secondary to a testosterone patchScientific World Journal20092033333819468653
   PubMed Web of Science ®Google Scholar
• InuiSItamiSMolecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papillaJ Dermatol Sci20116111621167691
   PubMed Web of Science ®Google Scholar
• BaderUTrüebRMAndrogenetic alopecia in the manTher Umsch200259521121612090116
   PubMedGoogle Scholar
• TrüebRMMolecular mechanisms of androgenetic alopeciaExp Gerontol2002378–998199012213548
   PubMed Web of Science ®Google Scholar
• HoffmannRHormonal interaction and hair growthAnn Dermatol Venereol20021295 Pt 278779212223960
   PubMed Web of Science ®Google Scholar
• LoYCTengCMChenCFChenCCHongCYMagnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidationBiochem Pharmacol19944735495538117323
   PubMed Web of Science ®Google Scholar
• MaruyamaYKuribaraHOverview of the pharmacological features of honokiolCNS Drug Rev2000613544
   Google Scholar
• LiouKTShenYCChenCFTsaoCMTsaiSKThe anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species productionEur J Pharmacol20034751–3192712954355
   PubMed Web of Science ®Google Scholar
• BaiXCerimeleFUshio-FukaiMHonokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivoJ Biol Chem200327837355013550712816951
   PubMed Web of Science ®Google Scholar
• AhnKSSethiGShishodiaSSungBArbiserJLAggarwalBBHonokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathwayMol Cancer Res20064962163316966432
   PubMed Web of Science ®Google Scholar
• LeeBKimCHMoonSKHonokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cellsFEBS Lett2006580225177518416962592
   PubMed Web of Science ®Google Scholar
• BattleTEArbiserJFrankDAThe natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cellsBlood2005106269069715802533
   PubMed Web of Science ®Google Scholar
• HahmERSinghSVHonokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activityMol Cancer Ther20076102686269517938262
   PubMed Web of Science ®Google Scholar
• BrunetonJPharmacognosie, Phytochimie, Plantes MédicinalesParis, FranceLavoisier1993viii
   Google Scholar
• DoQTBernardPPharmacognosy and reverse pharmacognosy: a new concept for accelerating natural drug discoveryIDrugs20047111017102715551177
   PubMed Web of Science ®Google Scholar
• HarriganGGBrackettDJBorosLGMedicinal chemistry, metabolic profiling and drug target discovery: a role for metabolic profiling in reverse pharmacology and chemical geneticsMini Rev Med Chem200551132015638788
   PubMed Web of Science ®Google Scholar
• SciorTBernardPMedina-FrancoJLMaggioraGMLarge compound databases for structure-activity relationships studies in drug discoveryMini Rev Med Chem20077885186017692047
   PubMed Web of Science ®Google Scholar
• BernardPSciorTDidierBHibertMBerthonJYEthnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitorsPhytochemistry200158686587411684183
   PubMed Web of Science ®Google Scholar
• BermanHMWestbrookJFengZThe Protein Data BankNucleic Acids Res200028123524210592235
   PubMed Web of Science ®Google Scholar
• SciorTWahabHAStructure prediction of proteins with very low homology: A comprehensive introduction and a case study on aminopeptidaseKaplanSPDrug Design Research PerspectivesNew York, NYNova Science Publishers2007675708
   Google Scholar
• GrishkovskayaIAvvakumovGVSklenarGDalesDHammondGLMullerYACrystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domainEMBO J200019450451210675319
   PubMed Web of Science ®Google Scholar
• GhoshDGriswoldJErmanMPangbornWStructural basis for androgen specificity and oestrogen synthesis in human aromataseJournal Nature20094577226219223
   PubMed Web of Science ®Google Scholar
• FaucherFCantinLLuu-TheVLabrieFBretonRCrystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibitionBiochemistry20084751135371354619075558
   PubMed Web of Science ®Google Scholar
• SYBYLTripos Inc1699 South Hanley Road, St Louis, MO, 63144, USA
   Google Scholar
• SciorTBenderATresadernGRecognizing pitfalls in virtual screening: a critical reviewJ Chem Inf Model462012 [Epub ahead of print.]
   Web of Science ®Google Scholar
• PurbaHSBhatnagarASA comparison of methods measuring aromatase activity in human placenta and rat ovaryJ Enzyme Inhib1990421691782151521
   PubMedGoogle Scholar
• ReichertWHartmannRWJoseJStable expression of the human 5alpha-reductase isoenzymes type I and type II in HEK293 cells to identify dual and selective inhibitorsJ Enzyme Inhib2001161475311496834
   PubMed Web of Science ®Google Scholar
• DélosSIehléCMartinPMRaynaudJPInhibition of the activity of ‘basic’ 5 alpha-reductase (type 1) detected in DU 145 cells and expressed in insect cellsJ Steroid Biochem Mol Biol19944843473528142312
   PubMed Web of Science ®Google Scholar
• BoudonCLobaccaroJMLumbrosoS5 alpha-reductase activity in cultured epithelial and stromal cells from normal and hyperplastic human prostates – effect of finasteride (Proscar), a 5 alpha-reductase inhibitorCell Mol Biol (Noisy-le-grand)1995418100710158747081
   PubMed Web of Science ®Google Scholar
• LowryOHRosebroughNJFarrALRandallRJProtein measurement with the Folin phenol reagentJ Biol Chem1951193126527514907713
   PubMed Web of Science ®Google Scholar
• KanehisaMGotoSFurumichiMTanabeMHirakawaMKEGG for representation and analysis of molecular networks involving diseases and drugsNucleic Acids Res201038Database issueD355D36019880382
   PubMed Web of Science ®Google Scholar
• SeraliniGMoslemiSAromatase inhibitors: past, present and futureMol Cell Endocrinol20011781–211713111403901
   PubMed Web of Science ®Google Scholar
• OcchiatoEGGuarnaADanzaGSerioMSelective non-steroidal inhibitors of 5 alpha-reductase type 1J Steroid Biochem Mol Biol200488111615026079
   PubMed Web of Science ®Google Scholar
• KahnSMHrybDJNakhlaAMRomasNARosnerWSex hormone-binding globulin is synthesized in target cellsJ Endocrinol2002175111312012379495
   PubMed Web of Science ®Google Scholar
• MakrantonakiESchoenknechtPHossiniAMSkin and brain age together: The role of hormones in the ageing processExp Gerontol2010451080181320719245
   PubMed Web of Science ®Google Scholar
• BologniaJLAging skinAm J Med1995981A99S103S7825648
   PubMed Web of Science ®Google Scholar
• RoskosKVMaibachHIGuyRHThe effect of aging on percutaneous absorption in manJ Pharmacokinet Biopharm19891766176302635737
   PubMedGoogle Scholar
• SchreiberGZiemerMThe aging male – diagnosis and therapy of late-onset hypogonadismJ Dtsch Dermatol Ges20086427327918218041
   PubMed Web of Science ®Google Scholar
• MatsumotoAMPhysical, metabolic and endocrine correlates of male agingFilicoriMEndocrine Basis of Reproductive Function, Proceedings of the ConferenceJanuary 20–22, 2000Tampa, FL, US525535
   Google Scholar
• BaulieuEEThomasGLegrainSDehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a socio-biomedical issueProc Natl Acad Sci U S A20009784279428410760294
   PubMed Web of Science ®Google Scholar
• CalofOMSinghABLeeMLAdverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trialsJ Gerontol A Biol Med Sci2005601114511457
   PubMed Web of Science ®Google Scholar
• WrightETMcGillisTJSobelHAction of testosterone on the skin of aging male subjectsDermatologica19701402124128
   Google Scholar
• ZouboulisCCChenWCThorntonMJQinKRosenfieldRSexual hormones in human skinHorm Metab Res2007392859517326004
   PubMed Web of Science ®Google Scholar
• El-AlfyMLabrieFAzziLEndorech IncUse of androgens to reduce the likelihood of acquiring or to treat skin aging United States patent US 2006/0178352 A1 11 12005
   Google Scholar
• SergeevPVUkhinaTVShimanovskiiNLEffects of hormones on phospholipase A2 activity in rat skinPharmacology and Toxicology200012916062
   Google Scholar
• EblingFJHairJ Invest Dermatol197667198105778301
   PubMed Web of Science ®Google Scholar