Knockdown of HDAC9 Inhibits Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Partially by Suppressing the MAPK Signaling Pathway

References

• Weinstein RS, Hogan EA, Borrelli MJ, Liachenko S, O’Brien CA, Manolagas SC. The pathophysiological sequence of glucocorticoid-induced osteonecrosis of the femoral head in male mice. Endocrinology. 2017;158(11):3817–3831. doi:10.1210/en.2017-00662
   PubMed Web of Science ®Google Scholar
• Chughtai M, Piuzzi NS, Khlopas A, Jones LC, Goodman SB, Mont MA. An evidence-based guide to the treatment of osteonecrosis of the femoral head. Bone Joint J. 2017;99-b(10):1267–1279. doi:10.1302/0301-620X.99B10.BJJ-2017-0233.R2
   PubMed Web of Science ®Google Scholar
• Zhao DW, Yu M, Hu K, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey. Chin Med J. 2015;128(21):2843–2850. doi:10.4103/0366-6999.168017
   PubMed Web of Science ®Google Scholar
• Houdek MT, Wyles CC, Sierra RJ. Osteonecrosis of the femoral head: treatment with ancillary growth factors. Curr Rev Musculoskelet Med. 2015;8(3):233–239. doi:10.1007/s12178-015-9281-z
   PubMedGoogle Scholar
• Håkelien AM, Bryne JC, Harstad KG, et al. The regulatory landscape of osteogenic differentiation. Stem Cells. 2014;32(10):2780–2793. doi:10.1002/stem.1759
   PubMed Web of Science ®Google Scholar
• Liu Y, Wu J, Zhu Y, Han J. Therapeutic application of mesenchymal stem cells in bone and joint diseases. Clin Exp Med. 2012;14(1):13–24. doi:10.1007/s10238-012-0218-1
   PubMed Web of Science ®Google Scholar
• Lee JS, Lee JS, Roh HL, Kim CH, Jung JS, Suh KT. Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor. J Orthop Res. 2006;24(4):604–609. doi:10.1002/jor.20078
   PubMed Web of Science ®Google Scholar
• Hao C, Yang S, Xu W, et al. MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3. Sci Rep. 2016;6(1):22599. doi:10.1038/srep22599
   PubMed Web of Science ®Google Scholar
• Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: what are the cancer relevant targets? Cancer Lett. 2009;277(1):8–21. doi:10.1016/j.canlet.2008.08.016
   PubMed Web of Science ®Google Scholar
• Liu F, Zong M, Wen X, et al. Silencing of histone deacetylase 9 expression in podocytes attenuates kidney injury in diabetic nephropathy. Sci Rep. 2016;6(1):33676. doi:10.1038/srep33676
   PubMed Web of Science ®Google Scholar
• Clocchiatti A, Florean C, Brancolini C. Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis. J Cell Mol Med. 2011;15(9):1833–1846. doi:10.1111/j.1582-4934.2011.01321.x
   PubMed Web of Science ®Google Scholar
• Yang G, Hamadeh IS, Katz J, et al. SIRT1/herc4 locus associated with bisphosphonate-induced osteonecrosis of the jaw: an exome-wide association analysis. J Bone Miner Res. 2018;33:91–98. doi:10.1002/jbmr.3285
   PubMed Web of Science ®Google Scholar
• Hawtree S, Muthana M, Wilkinson JM, Akil M, Wilson AG. Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis. Hum Mol Genet. 2015;24(19):5367–5377. doi:10.1093/hmg/ddv258
   PubMed Web of Science ®Google Scholar
• Ho L, Wang L, Roth TM, et al. Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice. Endocrinology. 2017;158(9):2741–2753. doi:10.1210/en.2016-1739
   PubMed Web of Science ®Google Scholar
• Jin Z, Wei W, Dechow PC, Wan Y. HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered beta-catenin switch. J Mol Endocrinol. 2013;27(2):325–335. doi:10.1210/me.2012-1302
   Web of Science ®Google Scholar
• Li H, Xie H, Liu W, et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest. 2009;119(12):3666–3677. doi:10.1172/JCI39832
   PubMed Web of Science ®Google Scholar
• Hu Y, Sun L, Tao S, et al. Clinical significance of HDAC9 in hepatocellular carcinoma. Cell Mol Biol. 2019;65(4):23–28. doi:10.14715/10.14715/cmb/2019.65.4.4
   PubMed Web of Science ®Google Scholar
• Salgado E, Bian X, Feng A, Shim H, Liang Z. HDAC9 overexpression confers invasive and angiogenic potential to triple negative breast cancer cells via modulating microRNA-206. Biochem Biophys Res Commun. 2018;503(2):1087–1091. doi:10.1016/j.bbrc.2018.06.120
   PubMed Web of Science ®Google Scholar
• Kaluza D, Kroll J, Gesierich S, et al. Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33(3):533–543. doi:10.1161/ATVBAHA.112.300415
   PubMed Web of Science ®Google Scholar
• Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell. 2009;136(6):1056–1072. doi:10.1016/j.cell.2008.12.040
   PubMed Web of Science ®Google Scholar
• Han X, Han X, Wang Z, Shen J, Dong Q. HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Front Biosci. 2016;21:907–917. doi:10.2741/4428
   PubMed Web of Science ®Google Scholar
• Wang L, Wu F, Song Y, Duan Y, Jin Z. Erythropoietin induces the osteogenesis of periodontal mesenchymal stem cells from healthy and periodontitis sources via activation of the p38 MAPK pathway. Int J Mol Med. 2018;41(2):829–835. doi:10.3892/ijmm.2017.3294
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen X, Yin Y, Li S. Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway. BMB Rep. 2018;51(4):194–199. doi:10.5483/BMBRep.2018.51.4.005
   PubMed Web of Science ®Google Scholar
• Park M, Park TS, Wu D, Xu A, Sweeney GJCR Abstract P247: APPL1 transgenic mice are protected from high-fat diet–induced lipotoxic cardiomyopathy. 2011:AP247.
   Google Scholar
• Fakhry M, Hamade E, Badran B, Buchet R, Magne D. Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells. 2013;5:136–148. doi:10.4252/wjsc.v5.i4.136
   PubMedGoogle Scholar
• Martin M, Kettmann R, Dequiedt F. Class IIa histone deacetylases: conducting development and differentiation. Int J Dev Biol. 2009;53(2–3):291–301. doi:10.1387/ijdb.082698mm
   PubMed Web of Science ®Google Scholar
• Yang XJ, Grégoire S. Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol. 2005;25(8):2873–2884. doi:10.1128/MCB.25.8.2873-2884.2005
   PubMed Web of Science ®Google Scholar
• Lee HW, Suh JH, Kim AY, Lee YS, Park SY, Kim JB. Histone deacetylase 1-mediated histone modification regulates osteoblast differentiation. J Mol Endocrinol. 2006;20(10):2432–2443. doi:10.1210/me.2006-0061
   Web of Science ®Google Scholar
• Schroeder TM, Kahler RA, Li X, Westendorf JJ. Histone deacetylase 3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation. J Biol Chem. 2004;279(40):41998–42007. doi:10.1074/jbc.M403702200
   PubMed Web of Science ®Google Scholar
• Kang JS, Alliston T, Delston R, Derynck R. Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005;24(14):2543–2555. doi:10.1038/sj.emboj.7600729
   PubMed Web of Science ®Google Scholar
• Jensen ED, Schroeder TM, Bailey J, Gopalakrishnan R, Westendorf JJ. Histone deacetylase 7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner. J Bone Miner Res. 2008;23(3):361–372. doi:10.1359/jbmr.071104
   PubMed Web of Science ®Google Scholar
• Liu GX, Ma S, Li Y, et al. Hsa-let-7c controls the committed differentiation of IGF-1-treated mesenchymal stem cells derived from dental pulps by targeting IGF-1R via the MAPK pathways. Exp Mol Med. 2018;50(4):25. doi:10.1038/s12276-018-0048-7
   PubMed Web of Science ®Google Scholar
• Zhang W, Dong R, Diao S, Du J, Fan Z, Wang F. Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells. Stem Cell Res Ther. 2017;8(1):30. doi:10.1186/s13287-017-0485-6
   PubMed Web of Science ®Google Scholar
• Zhu JH, Liao YP, Li FS, et al. Wnt11 promotes BMP9-induced osteogenic differentiation through BMPs/Smads and p38 MAPK in mesenchymal stem cells. J Cell Biochem. 2018;119(11):9462–9473. doi:10.1002/jcb.27262
   PubMed Web of Science ®Google Scholar
• Lu M, Guo S, Hong F, et al. Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2. Exp Cell Res. 2018;371(2):342–352. doi:10.1016/j.yexcr.2018.08.026
   PubMed Web of Science ®Google Scholar
• Artigas N, Ureña C, Rodríguez-Carballo E, Rosa JL, Ventura F. Mitogen-activated protein kinase (MAPK)-regulated interactions between Osterix and Runx2 are critical for the transcriptional osteogenic program. J Biol Chem. 2014;289(39):27105–27117. doi:10.1074/jbc.M114.576793
   PubMed Web of Science ®Google Scholar