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ORIGINAL RESEARCH

Predictors of Adverse Outcomes in Healthy Aging Adults: Coronary Artery Disease, Lower Educational Status and Higher P-Selectin Levels

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Pages 1173-1185 | Published online: 13 Nov 2023

References

  • Madrazo Cabo JM, Monter Valera NA, Hernández Sánchez EJ, Ruiz Sánchez M, Sánchez Machorro G, Kurezyn Díaz C. Demographic variables associated with Covid-19 mortality. J Public Health Res. 2020;9(4):1827. doi:10.4081/jphr.2020.1827
  • Ogura S, Jakovljevic MM. Editorial: global population aging - health care, social and economic consequences. Front Public Health. 2018;6:335. doi:10.3389/fpubh.2018.00335
  • Puig J, Biarnes C, Pedraza S, et al. The Aging Imageomics Study: rationale, design and baseline characteristics of the study population. Mech Ageing Dev. 2020;189:111257. doi:10.1016/j.mad.2020.111257
  • Lee SJ, Kim CM. Individualizing prevention for older adults. J Am Geriatr Soc. 2018;66(2):229–234. doi:10.1111/jgs.15216
  • Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andrés V. Biological versus chronological aging: JACC focus seminar. J Am Coll Cardiol. 2020;75(8):919–930. doi:10.1016/j.jacc.2019.11.062
  • Colloca G, Di Capua B, Bellieni A, et al. Biological and functional biomarkers of aging: definition, characteristics, and how they can impact everyday cancer treatment. Curr Oncol Rep. 2020;22(11):115. doi:10.1007/s11912-020-00977-w
  • Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR. Biological age, not chronological age, is associated with late-life depression. J Gerontol a Biol Sci Med Sci. 2018;73(10):1370–1376. doi:10.1093/gerona/glx162
  • Lusardi MM, Fritz S, Middleton A, et al. Determining risk of falls in community dwelling older adults: a systematic review and meta-analysis using posttest probability. J Geriatr Phys Ther. 2017;40:1–36. doi:10.1519/JPT.0000000000000099
  • Liotta G, Ussai S, Illario M, et al. Frailty as the future core business of public health: report of the activities of the A3 action group of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Int J Environ Res Public Health. 2018;15(12):2843. doi:10.3390/ijerph15122843
  • Apóstolo J, Cooke R, Bobrowicz-Campos E, et al. Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools. JBI Database System Rev Implement Rep. 2017;15:1154–1208. doi:10.11124/JBISRIR-2016-003018
  • Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet. 2019;394:1365–1375. doi:10.1016/S0140-6736(19)31786-6
  • Ekram ARM, Woods RL, Britt C, Espinoza S, Ernst ME, Ryan J. The association between frailty and all-cause mortality in community-dwelling older individuals: an Umbrella review. J Frailty Aging. 2021;10(4):320–326. doi:10.14283/jfa.2021.20
  • Chu W, Chang SF, Ho HY. Adverse health effects of frailty: systematic review and meta-analysis of middle-aged and older adults with implications for evidence-based practice. Worldviews Evid Based Nurs. 2021;18(4):282–289. doi:10.1111/wvn.12508
  • Chen LK. Challenges of promoting healthy aging and healthy longevity in the communities. Arch Gerontol Geriatr. 2022;99:104624. doi:10.1016/j.archger.2022.104624
  • Khow KSF, Visvanathan R. Falls in the Aging Population. Clin Geriatr Med. 2017;33(3):357–368. doi:10.1016/j.cger.2017.03.002
  • Lee J, Negm A, Peters R, Wong EKC, Holbrook A. Deprescribing fall-risk increasing drugs (FRIDs) for the prevention of falls and fall-related complications: a systematic review and meta-analysis. BMJ Open. 2021;11(2):e035978. doi:10.1136/bmjopen-2019-035978
  • Batko-Szwaczka A, Dudzińska-Griszek J, Hornik B, et al. Frailty phenotype: evidence of both physical and mental health components in community-dwelling early-old adults. Clin Interv Aging. 2020;15:141–150. doi:10.2147/CIA.S238521
  • Batko-Szwaczka A, Wilczyński K, Hornik B, et al. Predicting adverse outcomes in healthy aging community-dwelling early-old adults with the timed up and go test. Clin Interv Aging. 2020;15:1263–1270. doi:10.2147/CIA.S256312
  • Fried LP, Tangen CM, Walston J, et al. Cardiovascular health study collaborative research group. Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci. 2001;56A:M146–M156. doi:10.1093/gerona/56.3.M146
  • Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383. doi:10.1016/0021-9681(87)90171-8
  • Mahoney FI, Barthel DW. Functional evaluation: the Barthel Index. Md State Med J. 1965;14:56–61.
  • Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–186. doi:10.1093/geront/9.3_Part_1.179
  • Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198. doi:10.1016/0022-3956(75)90026-6
  • Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS). Recent evidence and development of a shorter version. Clin Gerontol. 1986;5:165–173. doi:10.1300/J018v05n01_09
  • Norton D. Calculating the risk: reflections on the Norton Scale. Decubitus. 1989;2(3):24–31. PMID: 2775471.
  • Harada ND, Chiu V, Stewart AL. Mobility-related function in older adults: assessment with a 6-minute walk test. Arch Phys Med Rehabil. 1999;80:837–841. doi:10.1016/S0003-9993(99)90236-8
  • Steffen TM, Hacker TA, Mollinger L. Age- and gender-related test performance in community-dwelling elderly people: six-minute walk test, berg balance scale, timed up & go test, and gait speeds. Phys Ther. 2002;82:128–137. doi:10.1093/ptj/82.2.128
  • Tinetti ME. Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc. 1986;34:119–126. doi:10.1111/jgs.1986.34.issue-2
  • Podsiadlo D, Richardson S. The timed ”Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39(2):142–148. doi:10.1111/j.1532-5415.1991.tb01616.x
  • World Health Organization. Ageing: healthy ageing and functional ability. Available from: https://www.who.int/news-room/q-a-detail/ageing-healthy-ageing-and-functional-ability. Accessed December 15, 2020.
  • Agarwala P, Salzman SH. Six-minute walk test: clinical role, technique, coding, and reimbursement. Chest. 2020;157(3):603–611. doi:10.1016/j.chest.2019.10.014
  • Zhang H, Hu D, Xu Y, Wu L, Lou L. Effect of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials. Ann Med. 2022;54(1):262–273. doi:10.1080/07853890.2021.1999494
  • Singh SJ, Puhan MA, Andrianopoulos V, et al. An official systematic review of the European respiratory society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir J. 2014;44(6):1447–1478. doi:10.1183/09031936.00150414
  • Smith NL, Barzilay JI, Shaffer D, et al. Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the cardiovascular health study. Arch Intern Med. 2002;162(2):209–216. PMID: 11802755. doi:10.1001/archinte.162.2.209
  • Ju SY, Lee JY, Kim DH. Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly: a meta-analysis of prospective cohort studies. Medicine. 2017;96(45):e8491. PMID: 29137039; PMCID: PMC5690732. doi:10.1097/MD.0000000000008491
  • Marcos-Pérez D, Sánchez-Flores M, Maseda A, et al. Serum cortisol but not oxidative stress biomarkers are related to frailty: results of a cross-sectional study in Spanish older adults. J Toxicol Environ Health A. 2019;82(14):815–825. PMID: 31405343. doi:10.1080/15287394.2019.1654639
  • Ho JE, Lyass A, Courchesne P, et al. Protein biomarkers of cardiovascular disease and mortality in the community. J Am Heart Assoc. 2018;7(14):e008108. PMID: 30006491; PMCID: PMC6064847. doi:10.1161/JAHA.117.008108
  • Lana A, Struijk E, Guallar-Castillón P, Martín-Moreno JM, Rodríguez Artalejo F, Lopez-Garcia E. Leptin concentration and risk of impaired physical function in older adults: the Seniors-ENRICA cohort. Age Ageing. 2016;45(6):819–826. PMID: 27515676. doi:10.1093/ageing/afw142
  • Nakou ES, Parthenakis FI, Kallergis EM, Marketou ME, Nakos KS, Vardas PE. Healthy aging and myocardium: a complicated process with various effects in cardiac structure and physiology. Int J Cardiol. 2016;209:167–175. doi:10.1016/j.ijcard.2016.02.039
  • Triposkiadis F, Xanthopoulos A, Parissis J, Butler J, Farmakis D. Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers. Heart Fail Rev. 2022;27(1):337–344. doi:10.1007/s10741-020-09987-z
  • Cassar A, Holmes DR Jr, Rihal CS, Gersh BJ. Chronic coronary artery disease: diagnosis and management. Mayo Clin Proc. 2009;84(12):1130–1146. doi:10.4065/mcp.2009.0391
  • García-Blas S, Cordero A, Diez-Villanueva P, et al. Acute Coronary Syndrome in the Older Patient. J Clin Med. 2021;10(18):4132. PMID: 34575243. doi:10.3390/jcm10184132
  • World Health Organization. The top 10 causes of death. Available from: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed February 5, 2022.
  • Lange SA, Reinecke H. Coronary artery disease and cancer: treatment and prognosis regarding gender differences. Cancers. 2022;14(2):434. doi:10.3390/cancers14020434
  • Vellakkal S, Khan Z, Alavani H, Fledderjohann J, Stuckler D. Effects of public policies in the prevention of cardiovascular diseases: a systematic review of global literature. Public Health. 2022;207(73–81):73–81. PMID: 35567826. doi:10.1016/j.puhe.2022.03.021
  • Li YH, Song GX, Yu Y, Zhou de D, Zhang HW. Study on age and education level and their relationship with fall-related injuries in Shanghai, China. Biomed Environ Sci. 2013;26(2):79–86. doi:10.3967/0895-3988.2013.02.001
  • Yoo JS, Kim CG, Yim J, Jeon MY. Factors influencing falls in the frail elderly individuals in urban and rural areas. Aging Clin Exp Res. 2016;28(4):687–697. doi:10.1007/s40520-015-0469-2
  • Petersen N, König HH, Hajek A. The onset of falls and its effects on perceived social exclusion and loneliness. Evidence from a nationally representative longitudinal study. Arch Gerontol Geriatr. 2022;100:104622. doi:10.1016/j.archger.2022.104622
  • Hassen HY, Bowyer M, Gibson L, Abrams S, Bastiaens H. Level of cardiovascular disease knowledge, risk perception and intention towards healthy lifestyle and socioeconomic disparities among adults in vulnerable communities of Belgium and England. BMC Public Health. 2022;22(1):197. doi:10.1186/s12889-022-12608-z
  • Lassale C, Cené CW, Asselin A, Sims M, Jouven X, Gaye B. Sociodemographic determinants of change in cardiovascular health in middle adulthood in a bi-racial cohort. Atherosclerosis. 2022;346:98–108. doi:10.1016/j.atherosclerosis.2022.01.006
  • Petrelli A, Sebastiani G, Di Napoli A, et al. Education inequalities in cardiovascular and coronary heart disease in Italy and the role of behavioral and biological risk factors. Nutr Metab Cardiovasc Dis. 2021;32:918–928. doi:10.1016/j.numecd.2021.10.022
  • Belo P, Navarro-Pardo E, Pocinho R, Carrana P, Margarido C. Relationship between mental health and the education level in elderly people: mediation of leisure attitude. Front Psychol. 2020;11:573. doi:10.3389/fpsyg.2020.00573
  • Iraniparast M, Shi Y, Wu Y, et al. Cognitive reserve and mild cognitive impairment: predictors and rates of reversion to intact cognition vs progression to dementia. Neurology. 2022;98:e1114–e1123. doi:10.1212/WNL.0000000000200051
  • Billot M, Calvani R, Urtamo A, et al. Preserving mobility in older adults with physical frailty and sarcopenia: opportunities, challenges, and recommendations for physical activity interventions. Clin Interv Aging. 2020;15:1675–1690. PMID: 32982201; PMCID: PMC7508031. doi:10.2147/CIA.S253535
  • Lyngbakken MN, Myhre PL, Røsjø H, Omland T. Novel biomarkers of cardiovascular disease: applications in clinical practice. Crit Rev Clin Lab Sci. 2019;56(1):33–60. doi:10.1080/10408363.2018.1525335
  • Borsig L. Selectins in cancer immunity. Glycobiology. 2018;28(9):648–655. doi:10.1093/glycob/cwx105
  • Campo G, Contoli M, Fogagnolo A, et al. Over time relationship between platelet reactivity, myocardial injury and mortality in patients with SARS-CoV-2-associated respiratory failure. Platelets. 2020;32:1–8.
  • Marzetti E, Picca A, Marini F, et al. Inflammatory signatures in older persons with physical frailty and sarcopenia: the frailty ”cytokinome” at its core. Exp Gerontol. 2019;122:129–138. doi:10.1016/j.exger.2019.04.019
  • Arauna D, García F, Rodríguez-Mañas L, et al. Older adults with frailty syndrome present an altered platelet function and an increased level of circulating oxidative stress and mitochondrial dysfunction biomarker GDF-15. Free Radic Biol Med. 2020;149:64–71. doi:10.1016/j.freeradbiomed.2020.01.007
  • Zinellu A, Mangoni AA. Systematic review and meta-analysis of the effect of statins on circulating E-Selectin, L-Selectin, and P-Selectin. Biomedicines. 2021;9(11):1707. doi:10.3390/biomedicines9111707
  • Chen Q, Jin M, Yang F, Zhu J, Xiao Q, Zhang L. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 2013;2013:928315. PMID: 23840100. doi:10.1155/2013/928315
  • Hardy E, Hardy-Sosa A, Fernandez-Patron C. Fernandez-Patron C. MMP-2: is too low as bad as too high in the cardiovascular system? Am J Physiol Heart Circ Physiol. 2018;315(5):H1332–H1340. PMID: 30118342. doi:10.1152/ajpheart.00198.2018
  • Oates J, Russell DL, Van Beusecum JP. Endothelial cells: potential novel regulators of renal inflammation. Am J Physiol Renal Physiol. 2022;322:F309–F321. PMID: 35129369. doi:10.1152/ajprenal.00371.2021
  • Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J. BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol Neurobiol. 2018;38(3):579–593. PMID: 28623429; PMCID: PMC5835061. doi:10.1007/s10571-017-0510-4
  • Chacón-Fernández P, Säuberli K, Colzani M, Moreau T, Ghevaert C, Barde YA. Brain-derived neurotrophic factor in megakaryocytes. J Biol Chem. 2016;291(19):9872–9881. PMID: 27006395; PMCID: PMC4858990. doi:10.1074/jbc.M116.720029
  • Bélanger JC, Bouchard V, Le Blanc J, et al. Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment. Front Cardiovasc Med. 2021;8:739045. PMID: 34557534; PMCID: PMC8452906. doi:10.3389/fcvm.2021.739045
  • Saarma M, Sariola H. Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF). Microsc Res Tech. 1999;45(4–5):292–302. PMID: 10383122. doi:10.1002/(SICI)1097-0029(19990515/01)45:4/5<292::AID-JEMT13>3.0.CO;2-8
  • Morel L, Domingues O, Zimmer J, Michel T. Revisiting the role of neurotrophic factors in inflammation. Cells. 2020;9(4):865. PMID: 32252363; PMCID: PMC7226825. doi:10.3390/cells9040865
  • Shen Z, Zhu J, Yuan Y, et al. The roles of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in predicting treatment remission in a Chinese Han population with generalized anxiety disorder. Psychiatry Res. 2019;271:319–324. PMID: 30529313. doi:10.1016/j.psychres.2018.08.111