Advanced search
Publication Cover
Clinical Interventions in Aging Volume 17, 2022 - Issue
Submit an article Journal homepage
344
Views
14
CrossRef citations to date
0
Altmetric
Clinical Trial Report

The Median Effective Dose and Bispectral Index of Remimazolam Tosilate for Anesthesia Induction in Elderly Patients: An Up-and-Down Sequential Allocation Trial

Miao Liu1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
,
Yuan Sun1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
,
Lingxue Zhou1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
,
Kunpeng Feng1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
,
Tianlong Wang1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China
&
Xuexin Feng1 Department of Anesthesiology, Capital Medical University Xuanwu Hospital, Beijing, People’s Republic of China;2 Center for Sleep and Consciousness Disorders, Capital Medical University, Beijing, People’s Republic of China;3 Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence[email protected]
Pages 837-843 | Published online: 20 May 2022

References

  • Noor N, Legendre R, Cloutet A, et al. A comprehensive review of remimazolam for sedation. Health Psychol Res. 2021;9(1):24514. doi:10.52965/001c.24514
  • Kilpatrick GJ. Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent. Front Pharmacol. 2021;12:690875. doi:10.3389/fphar.2021.690875
  • Kanto J, Klotz U. Intravenous benzodiazepines as anaesthetic agents: pharmacokinetics and clinical consequences. Acta Anaesthesiol Scand. 1982;26:554–569. doi:10.1111/j.1399-6576.1982.tb01817.x
  • Wesolowski AM, Zaccagnino MP, Malapero RJ, et al. Remimazolam: pharmacologic considerations and clinical role in anesthesiology. Pharmacotherapy. 2016;36(9):1021–1027. doi:10.1002/phar.1806
  • Kilpatrick GJ, McIntyre MS, Cox RF, et al. CNS 7056: a novel ultra-short-acting benzodiazepine. Anesthesiology. 2007;107(1):60–66. doi:10.1097/01.anes.0000267503.85085.c0
  • Worthington MT, Antonik LJ, Goldwater DR, et al. A phase ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy. Anesth Analg. 2013;117:1093–1100. doi:10.1213/ANE.0b013e3182a705ae
  • Wang F, Zhou Q, Shen M, et al. Efficacy and safety of remimazolam in procedural sedation and analgesia: a protocol for systematic review and meta-analysis. Medicine. 2020;99:e20765. doi:10.1097/MD.0000000000020765
  • Su WY. The characteristics of medication in elderly patients and the principles of rational drug application (In Chinese). J Pract Med. 2008;15:3957–3958.
  • Dixon WJ. Staircase bioassay: the up-and-down method. Neurosci Biobehav Rev. 1991;15:47–50. doi:10.1016/S0149-7634(05)80090-9
  • Dixon WJ. The up-and-down method for small samples. J Am Stat Assoc. 1965;60:967–978. doi:10.1080/01621459.1965.10480843
  • Pace NL, Stylianou MP, Warltier DC. Advances in and limitations of up-and-down methodology: a précis of clinical use, study design, and dose estimation in anesthesia research. Anesthesiology. 2007;107:144–152. doi:10.1097/01.anes.0000267514.42592.2a
  • Xing XU, Xiulan WEI. Determination of BIS50 and ED50 for propofol during induction by sequential experimental method. Chin J Anesthesil. 2001;21:7–9.
  • Wang W, Sun Q. Novel targeted drugs approved by the NMPA and FDA in 2019. Signal Transduct Target Ther. 2020;5:65. doi:10.1038/s41392-020-0164-4
  • Sheng X-Y, Liang Y, Yang X, et al. Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers. Eur J Clin Pharmacol. 2020;76:383–391. doi:10.1007/s00228-019-02800-3
  • Doi M, Morita K, Takeda J, et al. Efficacy and safety of remimazolam versus propofol for general anesthesia: a multicenter, single-blind, randomized, parallel-group, phase IIb/III trial. J Anesth. 2020;34(4):543. doi:10.1007/s00540-020-02788-6
  • Evered L, Scott DA, Silbert B. Cognitive decline associated with anesthesia and surgery in the elderly: does this contribute to dementia prevalence? Curr Opin Psychiatry. 2017;30:220–226. doi:10.1097/YCO.0000000000000321
  • Liu X, Ding B, Shi F, et al. The efficacy and safety of remimazolam tosilate versus etomidate-propofol in elderly outpatients undergoing colonoscopy: a prospective, randomized, single-blind, non-inferiority trial. Drug Des Devel Ther. 2021;15:4675–4685. doi:10.2147/DDDT.S339535
  • Kerssens C, Klein J, van der Woerd A, et al. Auditory information processing during adequate propofol anesthesia monitored by electroencephalogram bispectral index. Anesth Analg. 2001;92(5):1210–1214. doi:10.1097/00000539-200105000-00024
  • Wang D, Song Z, Zhang C, et al. Bispectral index monitoring of the clinical effects of propofol closed-loop target-controlled infusion: systematic review and meta-analysis of randomized controlled trials. Medicine. 2021;100(4):e23930. doi:10.1097/MD.0000000000023930
  • Rüsch D, Arndt C, Eberhart L, et al. Bispectral index to guide induction of anesthesia: a randomized controlled study. BMC Anesthesiol. 2018;18(1):66. doi:10.1186/s12871-018-0522-8
  • Glass PS, Bloom M, Kearse L, et al. Bispectral analysis measures sedation and memory effects of propofol, midazolam, isoflurane, and alfentanil in healthy volunteers. Anesthesiology. 1997;86(4):836–847. doi:10.1097/00000542-199704000-00014
  • Zhipeng X, Liu F, Yue Y, et al. C50 for propofol-remifentanil target-controlled infusion and bispectral index at loss of consciousness and response to painful stimulus in Chinese patients: a multicenter clinical trial. Anesth Analg. 2009;108:478–483. doi:10.1213/ane.0b013e31818f8a30

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.