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REVIEW

Older Adults and Immune Thrombocytopenia: Considerations for the Clinician

, , &
Pages 115-130 | Received 26 Oct 2022, Accepted 10 Jan 2023, Published online: 26 Jan 2023

References

  • Audia S, Mahévas M, Samson M, Godeau B, Bonnotte B. Pathogenesis of immune thrombocytopenia. Autoimmun Rev. 2017;16(6):620–632. doi:10.1016/j.autrev.2017.04.012
  • Moulis G, Palmaro A, Montastruc JL, Godeau B, Lapeyre-Mestre M, Sailler L. Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood. 2014;124(22):3308–3315. doi:10.1182/blood-2014-05-578336
  • Doobaree IU, Conway K, Miah H, et al. Incidence of adult primary immune thrombocytopenia in England-an update. Eur J Haematol. 2022;109(3):238–249. doi:10.1111/ejh.13803
  • Lucchini E, Fanin R, Cooper N, Zaja F. Management of immune thrombocytopenia in elderly patients. Eur J Intern Med. 2018;58:70–76. doi:10.1016/j.ejim.2018.09.005
  • Mahévas M, Michel M, Godeau B. How we manage immune thrombocytopenia in the elderly. Br J Haematol. 2016;173(6):844–856. doi:10.1111/bjh.14067
  • Terrell DR, Beebe LA, Neas BR, Vesely SK, Segal JB, George JN. Prevalence of primary immune thrombocytopenia in Oklahoma. Am J Hematol. 2012;87(9):848–852. doi:10.1002/ajh.23262
  • Sokal A, de Nadaï T, Maquet J, et al. Primary immune thrombocytopenia in very elderly patients: particularities in presentation and management: results from the prospective CARMEN-France registry. Br J Haematol. 2022;196(5):1262–1270. doi:10.1111/bjh.17935
  • Provan D, Arnold DM, Bussel JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780–3817. doi:10.1182/bloodadvances.2019000812
  • McMillan R. Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production. Hematol Oncol Clin North Am. 2009;23(6):1163–1175. doi:10.1016/j.hoc.2009.08.008
  • Vayne C, Guéry EA, Rollin J, Baglo T, Petermann R, Gruel Y. Pathophysiology and diagnosis of drug-induced immune thrombocytopenia. J Clin Med. 2020;9(7):E2212. doi:10.3390/jcm9072212
  • Crickx E, Moulis G, Ebbo M, et al. Safety of anti-SARS-CoV-2 vaccination for patients with immune thrombocytopenia. Br J Haematol. 2021. doi:10.1111/bjh.17813
  • Fuentes S, Chrétien B, Dolladille C, et al. An updated list of drugs suspected to be associated with immune thrombocytopenia based on the WHO pharmacovigilance database. Blood. 2022;140(8):922–927. doi:10.1182/blood.2022015936
  • Kantarjian H, Giles F, List A, et al. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer. 2007;109(9):1705–1714. doi:10.1002/cncr.22602
  • Waisbren J, Dinner S, Altman J, et al. Disease characteristics and prognosis of myelodysplastic syndrome presenting with isolated thrombocytopenia. Int J Hematol. 2017;105(1):44–51. doi:10.1007/s12185-016-2081-4
  • Brynes RK, Orazi A, Theodore D, et al. Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: data from the EXTEND study. Am J Hematol. 2015;90(7):598–601. doi:10.1002/ajh.24011
  • Rivière É, Viallard JF, Guy A, et al. Intrinsically impaired platelet production in some patients with persistent or chronic immune thrombocytopenia. Br J Haematol. 2015;170(3):408–415. doi:10.1111/bjh.13444
  • Jachiet V, Moulis G, Hadjadj J, et al. Clinical spectrum, outcome and management of immune thrombocytopenia associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Haematologica. 2021;106(5):1414–1422. doi:10.3324/haematol.2020.272559
  • Comont T, Germain J, Beyne-Rauzy O, Adoue D, Moulis G; Group and the C investigators. Positivity rate of systematic bone marrow smear in patients over 60 years old with newly diagnosed immune thrombocytopenia. Blood Adv. 2020;4(10):2136–2138. doi:10.1182/bloodadvances.2020001654
  • Taparia K, Wall E, Arnold DM, Sun HL. Frequency and utility of bone marrow examination in relapsed/refractory immune thrombocytopenia. J Thromb Haemost. 2022;20(9):2119–2126. doi:10.1111/jth.15802
  • Neunert C, Terrell DR, Arnold DM, et al. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019;3(23):3829–3866. doi:10.1182/bloodadvances.2019000966
  • Stasi R, Stipa E, Masi M, et al. Long-term observation of 208 adults with chronic idiopathic thrombocytopenic purpura. Am J Med. 1995;98(5):436–442. doi:10.1016/s0002-9343(99)80342-8
  • Frederiksen H, Schmidt K. The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood. 1999;94(3):909–913. doi:10.1182/blood.V94.3.909.415k02_909_913
  • Vianelli N, Valdrè L, Fiacchini M, et al. Long-term follow-up of idiopathic thrombocytopenic purpura in 310 patients. Haematologica. 2001;86(5):504–509.
  • Cortelazzo S, Finazzi G, Buelli M, Molteni A, Viero P, Barbui T. High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura. Blood. 1991;77(1):31–33. doi:10.1182/blood.V77.1.31.31
  • Bourgeois E, Caulier MT, Delarozee C, Brouillard M, Bauters F, Fenaux P. Long-term follow-up of chronic autoimmune thrombocytopenic purpura refractory to splenectomy: a prospective analysis. Br J Haematol. 2003;120(6):1079–1088. doi:10.1046/j.1365-2141.2003.04211.x
  • Bizzoni L, Mazzucconi MG, Gentile M, et al. Idiopathic thrombocytopenic purpura (ITP) in the elderly: clinical course in 178 patients. Eur J Haematol. 2006;76(3):210–216. doi:10.1111/j.1600-0609.2005.00602.x
  • Daou S, Federici L, Zimmer J, Maloisel F, Serraj K, Andrès E. Idiopathic thrombocytopenic purpura in elderly patients: a study of 47 cases from a single reference center. Eur J Intern Med. 2008;19(6):447–451. doi:10.1016/j.ejim.2007.07.006
  • Cohen YC, Djulbegovic B, Shamai-Lubovitz O, Mozes B. The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts. Arch Intern Med. 2000;160(11):1630–1638. doi:10.1001/archinte.160.11.1630
  • Michel M, Rauzy OB, Thoraval FR, et al. Characteristics and outcome of immune thrombocytopenia in elderly: results from a single center case-controlled study. Am J Hematol. 2011;86(12):980–984. doi:10.1002/ajh.22170
  • Mithoowani S, Cervi A, Shah N, et al. Management of major bleeds in patients with immune thrombocytopenia. J Thromb Haemost. 2020;18(7):1783–1790. doi:10.1111/jth.14809
  • Zhou H, Fu R, Wang H, et al. Immune thrombocytopenia in the elderly: clinical course in 525 patients from a single center in China. Ann Hematol. 2013;92(1):79–87. doi:10.1007/s00277-012-1567-2
  • Palandri F, Catani L, Auteri G, et al. Understanding how older age drives decision-making and outcome in immune thrombocytopenia. A single centre study on 465 adult patients. Br J Haematol. 2019;184(3):424–430. doi:10.1111/bjh.15668
  • Piel-Julian ML, Mahévas M, Germain J, et al. Risk factors for bleeding, including platelet count threshold, in newly diagnosed immune thrombocytopenia adults. J Thromb Haemost. 2018;16(9):1830–1842. doi:10.1111/jth.14227
  • Swan D, Newland A, Rodeghiero F, Thachil J. Thrombosis in immune thrombocytopenia - current status and future perspectives. Br J Haematol. 2021;194(5):822–834. doi:10.1111/bjh.17390
  • Sarpatwari A, Bennett D, Logie JW, et al. Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom general practice research database. Haematologica. 2010;95(7):1167–1175. doi:10.3324/haematol.2009.018390
  • Doobaree IU, Nandigam R, Bennett D, Newland A, Provan D. Thromboembolism in adults with primary immune thrombocytopenia: a systematic literature review and meta-analysis. Eur J Haematol. 2016;97(4):321–330. doi:10.1111/ejh.12777
  • Ekstrand C, Linder M, Baricault B, et al. Impact of risk factors on the occurrence of arterial thrombosis and venous thromboembolism in adults with primary immune thrombocytopenia – results from two nationwide cohorts. Thromb Res. 2019;178:124–131. doi:10.1016/j.thromres.2019.04.016
  • Naess IA, Christiansen SC, Romundstad P, Cannegieter SC, Rosendaal FR, Hammerstrøm J. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5(4):692–699. doi:10.1111/j.1538-7836.2007.02450.x
  • Paran D, Herishanu Y, Elkayam O, Shopin L, Ben-Ami R. Venous and arterial thrombosis following administration of intravenous immunoglobulins. Blood Coagul Fibrinolysis. 2005;16(5):313–318. doi:10.1097/01.mbc.0000172694.85233.a8
  • Thai LH, Mahévas M, Roudot-Thoraval F, et al. Long-term complications of splenectomy in adult immune thrombocytopenia. Medicine. 2016;95(48):e5098. doi:10.1097/MD.0000000000005098
  • Wong RSM, Saleh MN, Khelif A, et al. Safety and efficacy of long-term treatment of chronic/persistent ITP with eltrombopag: final results of the EXTEND study. Blood. 2017;130(23):2527–2536. doi:10.1182/blood-2017-04-748707
  • Kuter DJ, Bussel JB, Newland A, et al. Long-term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy. Br J Haematol. 2013;161(3):411–423. doi:10.1111/bjh.12260
  • Catalá-López F, Corrales I, de la Fuente-Honrubia C, et al. Risk of thromboembolism with thrombopoietin receptor agonists in adult patients with thrombocytopenia: systematic review and meta-analysis of randomized controlled trials. Med Clin. 2015;145(12):511–519. doi:10.1016/j.medcli.2015.03.014
  • Ghanima W, Cooper N, Rodeghiero F, Godeau B, Bussel JB. Thrombopoietin receptor agonists: ten years later. Haematologica. 2019;104(6):1112–1123. doi:10.3324/haematol.2018.212845
  • Bussel JB, Kuter DJ, Pullarkat V, Lyons RM, Guo M, Nichol JL. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood. 2009;113(10):2161–2171. doi:10.1182/blood-2008-04-150078
  • Lozano ML, Mingot-Castellano ME, Perera MM, et al. A decade of changes in management of immune thrombocytopenia, with special focus on elderly patients. Blood Cells Mol Dis. 2021;86:102505. doi:10.1016/j.bcmd.2020.102505
  • Michel M, Wasser J, Godeau B, et al. Efficacy and safety of the thrombopoietin receptor agonist romiplostim in patients aged ≥ 65 years with immune thrombocytopenia. Ann Hematol. 2015;94(12):1973–1980. doi:10.1007/s00277-015-2485-x
  • Palandri F, Rossi E, Bartoletti D, et al. Real-world use of thrombopoietin receptor agonists in older patients with primary immune thrombocytopenia. Blood. 2021;138(7):571–583. doi:10.1182/blood.2021010735
  • Ruggeri M, Tosetto A, Palandri F, et al. Thrombotic risk in patients with primary immune thrombocytopenia is only mildly increased and explained by personal and treatment-related risk factors. J Thromb Haemost. 2014;12(8):1266–1273. doi:10.1111/jth.12636
  • Nørgaard M, Jensen AØ, Engebjerg MC, et al. Long-term clinical outcomes of patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. Blood. 2011;117(13):3514–3520. doi:10.1182/blood-2010-10-312819
  • Portielje JE, Westendorp RG, Kluin-Nelemans HC, Brand A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood. 2001;97(9):2549–2554. doi:10.1182/blood.v97.9.2549
  • Schoonen WM, Kucera G, Coalson J, et al. Epidemiology of immune thrombocytopenic purpura in the general practice research database. Br J Haematol. 2009;145(2):235–244. doi:10.1111/j.1365-2141.2009.07615.x
  • Cooper N, Kruse A, Kruse C, et al. Immune thrombocytopenia (ITP) World Impact Survey (iWISh): patient and physician perceptions of diagnosis, signs and symptoms, and treatment. Am J Hematol. 2021;96(2):188–198. doi:10.1002/ajh.26045
  • Cooper N, Kruse A, Kruse C, et al. Immune thrombocytopenia (ITP) World Impact Survey (I-WISh): impact of ITP on health-related quality of life. Am J Hematol. 2021;96(2):199–207. doi:10.1002/ajh.26036
  • Giordano P, Lassandro G, Valente M, Molinari AC, Ieranò P, Coppola A. Current management of the hemophilic child: a demanding interlocutor. Quality of life and adequate cost-efficacy analysis. Pediatr Hematol Oncol. 2014;31(8):687–702. doi:10.3109/08880018.2014.930768
  • Provan D, Stasi R, Newland AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115(2):168–186. doi:10.1182/blood-2009-06-225565
  • Matzdorff A, Beer JH. Immune thrombocytopenia patients requiring anticoagulation--maneuvering between scylla and charybdis. Semin Hematol. 2013;50(Suppl 1):S83–S88. doi:10.1053/j.seminhematol.2013.03.020
  • Godeau B, Bierling P. High-dose dexamethasone as initial treatment for immune thrombocytopenic purpura. N Engl J Med. 2003;349(23):2267–2268;author reply 2267–2268. doi:10.1056/NEJM200312043492318
  • Pirunsarn A, Kijrattanakul P, Chamnanchanunt S, Polprasert C, Rojnuckarin P. A randomized multicenter trial comparing low-dose prednisolone versus observation for prevention of recurrences in adult immune thrombocytopenia. Clin Appl Thromb Hemost. 2018;24(6):867–873. doi:10.1177/1076029618764843
  • Wei Y, Ji XB, Wang YW, et al. High-dose dexamethasone vs prednisone for treatment of adult immune thrombocytopenia: a prospective multicenter randomized trial. Blood. 2016;127(3):296–302;quiz 370. doi:10.1182/blood-2015-07-659656
  • Mithoowani S, Gregory-Miller K, Goy J, et al. High-dose dexamethasone compared with prednisone for previously untreated primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol. 2016;3(10):e489–e496. doi:10.1016/S2352-3026(16)30109-0
  • Palandri F, Santoro C, Carpenedo M, et al. Management of elderly patients with immune thrombocytopenia: real-world evidence from 451 patients older than 60 years. Thromb Res. 2020;185:88–95. doi:10.1016/j.thromres.2019.11.026
  • Moulis G, Palmaro A, Sailler L, Lapeyre-Mestre M, Latus J. Corticosteroid risk function of severe infection in primary immune thrombocytopenia adults. A nationwide nested case-control study. PLoS One. 2015;10(11):e0142217. doi:10.1371/journal.pone.0142217
  • Bellucci S, Charpak Y, Chastang C, Tobelem G. Low doses v conventional doses of corticoids in immune thrombocytopenic purpura (ITP): results of a randomized clinical trial in 160 children, 223 adults. Blood. 1988;71(4):1165–1169. doi:10.1182/blood.V71.4.1165.1165
  • Godeau B, Chevret S, Varet B, et al. Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial. Lancet. 2002;359(9300):23–29. doi:10.1016/S0140-6736(02)07275-6
  • Khellaf M, Michel M, Schaeffer A, Bierling P, Godeau B. Assessment of a therapeutic strategy for adults with severe autoimmune thrombocytopenic purpura based on a bleeding score rather than platelet count. Haematologica. 2005;90(6):829–832.
  • Godeau B, Caulier MT, Decuypere L, et al. Intravenous immunoglobulin for adults with autoimmune thrombocytopenic purpura: results of a randomized trial comparing 0.5 and 1 g/kg b.w. Br J Haematol. 1999;107(4). doi:10.1046/j.1365-2141.1999.01766.x
  • Caress JB, Kennedy BL, Eickman KD. Safety of intravenous immunoglobulin treatment. Expert Opin Drug Saf. 2010;9(6):971–979. doi:10.1517/14740338.2010.484419
  • Marie I, Maurey G, Hervé F, Hellot MF, Levesque H. Intravenous immunoglobulin-associated arterial and venous thrombosis; report of a series and review of the literature. Br J Dermatol. 2006;155(4):714–721. doi:10.1111/j.1365-2133.2006.07390.x
  • Stiehm ER. Adverse effects of human immunoglobulin therapy. Transfus Med Rev. 2013;27(3):171–178. doi:10.1016/j.tmrv.2013.05.004
  • Gaines AR. Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. Blood. 2000;95(8):2523–2529. doi:10.1182/blood.V95.8.2523
  • Ar G. Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. Blood. 2005;106:5. doi:10.1182/blood-2004-11-4303
  • Salama A, Kiesewetter H, Kalus U, Movassaghi K, Meyer O. Massive platelet transfusion is a rapidly effective emergency treatment in patients with refractory autoimmune thrombocytopenia. Thromb Haemost. 2008;100(5):762–765. doi:10.1160/TH08-06-0418
  • Spahr JE, Rodgers GM. Treatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: a retrospective review of 40 patients. Am J Hematol. 2008;83(2):122–125. doi:10.1002/ajh.21060
  • Roumier M, Le Burel S, Audia S, et al. High dose romiplostim as a rescue therapy for adults with severe bleeding and refractory immune thrombocytopenia. Am J Hematol. 2021;96(2):E43–E46. doi:10.1002/ajh.26040
  • Zhang J, Liang Y, Ai Y, et al. Eltrombopag versus romiplostim in treatment of children with persistent or chronic immune thrombocytopenia: a systematic review incorporating an indirect-comparison meta-analysis. Sci Rep. 2018;8(1):576. doi:10.1038/s41598-017-19099-8
  • Kuter DJ, Macahilig C, Grotzinger KM, et al. Treatment patterns and clinical outcomes in patients with chronic immune thrombocytopenia (ITP) switched to eltrombopag or romiplostim. Int J Hematol. 2015;101(3):255–263. doi:10.1007/s12185-014-1731-7
  • Al-Samkari H, Jiang D, Gernsheimer T, et al. Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: a multicentre US study. Br J Haematol. 2022;197(3):359–366. doi:10.1111/bjh.18081
  • Bussel JB, Wang X, Lopez A, Eisen M. Case study of remission in adults with immune thrombocytopenia following cessation of treatment with the thrombopoietin mimetic romiplostim. Hematology. 2016;21(4):257–262. doi:10.1179/1607845415Y.0000000041
  • Mahévas M, Fain O, Ebbo M, et al. The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study. Br J Haematol. 2014;165(6):865–869. doi:10.1111/bjh.12888
  • González-López TJ, Sánchez-González B, Jarque I, et al. Use of eltrombopag for patients 65 years old or older with immune thrombocytopenia. Eur J Haematol. 2020;104(3):259–270. doi:10.1111/ejh.13370
  • Ghanima W, Geyer JT, Lee CS, et al. Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: a single-center, long-term follow-up. Haematologica. 2014;99(5):937–944. doi:10.3324/haematol.2013.098921
  • Rizvi H, Butler T, Calaminici M, et al. United Kingdom immune thrombocytopenia registry: retrospective evaluation of bone marrow fibrosis in adult patients with primary immune thrombocytopenia and correlation with clinical findings. Br J Haematol. 2015;169(4):590–594. doi:10.1111/bjh.13330
  • Godeau B, Porcher R, Fain O, et al. Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter Phase 2 study. Blood. 2008;112(4):999–1004. doi:10.1182/blood-2008-01-131029
  • Auger S, Duny Y, Rossi JF, Quittet P. Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis. Br J Haematol. 2012;158(3):386–398. doi:10.1111/j.1365-2141.2012.09169.x
  • Marangon M, Vianelli N, Palandri F, et al. Rituximab in immune thrombocytopenia: gender, age, and response as predictors of long-term response. Eur J Haematol. 2017;98(4):371–377. doi:10.1111/ejh.12839
  • Arnold DM, Dentali F, Crowther MA, et al. Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Ann Intern Med. 2007;146(1):25–33. doi:10.7326/0003-4819-146-1-200701020-00006
  • Khellaf M, Charles-Nelson A, Fain O, et al. Safety and efficacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients. Blood. 2014;124(22):3228–3236. doi:10.1182/blood-2014-06-582346
  • Deshayes S, Khellaf M, Zarour A, et al. Long-term safety and efficacy of rituximab in 248 adults with immune thrombocytopenia: results at 5 years from the French prospective registry ITP-ritux. Am J Hematol. 2019;94(12):1314–1324. doi:10.1002/ajh.25632
  • Patel VL, Mahévas M, Lee SY, et al. Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia. Blood. 2012;119(25):5989–5995. doi:10.1182/blood-2011-11-393975
  • Hasan A, Michel M, Patel V, et al. Repeated courses of rituximab in chronic ITP: three different regimens. Am J Hematol. 2009;84(10):661–665. doi:10.1002/ajh.21512
  • Zaja F, Vianelli N, Volpetti S, et al. Low-dose rituximab in adult patients with primary immune thrombocytopenia. Eur J Haematol. 2010;85(4):329–334. doi:10.1111/j.1600-0609.2010.01486.x
  • Chugh S, Darvish-Kazem S, Lim W, et al. Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis. Lancet Haematol. 2015;2(2):e75–e81. doi:10.1016/S2352-3026(15)00003-4
  • van Vollenhoven RF, Emery P, Bingham CO, et al. Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients. Ann Rheum Dis. 2013;72(9):1496–1502. doi:10.1136/annrheumdis-2012-201956
  • Cho CH, Hwang WL, Cheng SB, Lee TY, Teng CL. Hepatitis B reactivation induced by Rituximab maintenance therapy for lymphoma. Ann Hematol. 2011;90(1):111–112. doi:10.1007/s00277-010-0962-9
  • Carson KR, Evens AM, Richey EA, et al. Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the research on adverse drug events and reports project. Blood. 2009;113(20):4834–4840. doi:10.1182/blood-2008-10-186999
  • Nazi I, Kelton JG, Larché M, et al. The effect of rituximab on vaccine responses in patients with immune thrombocytopenia. Blood. 2013;122(11):1946–1953. doi:10.1182/blood-2013-04-494096
  • Bussel JB, Lee CS, Seery C, et al. Rituximab and three dexamethasone cycles provide responses similar to splenectomy in women and those with immune thrombocytopenia of less than two years duration. Haematologica. 2014;99(7):1264–1271. doi:10.3324/haematol.2013.103291
  • Choi PYI, Roncolato F, Badoux X, Ramanathan S, Ho SJ, Chong BH. A novel triple therapy for ITP using high-dose dexamethasone, low-dose rituximab, and cyclosporine (TT4). Blood. 2015;126(4):500–503. doi:10.1182/blood-2015-03-631937
  • Zaja F, Baccarani M, Mazza P, et al. Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia. Blood. 2010;115(14):2755–2762. doi:10.1182/blood-2009-07-229815
  • Gudbrandsdottir S, Birgens HS, Frederiksen H, et al. Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia. Blood. 2013;121(11):1976–1981. doi:10.1182/blood-2012-09-455691
  • Mahévas M, Azzaoui I, Crickx E, et al. Efficacy, safety and immunological profile of combining rituximab with belimumab for adults with persistent or chronic immune thrombocytopenia: results from a prospective phase 2b trial. Haematologica. 2021;106(9):2449–2457. doi:10.3324/haematol.2020.259481
  • Kojouri K, Vesely SK, Terrell DR, George JN. Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications. Blood. 2004;104(9):2623–2634. doi:10.1182/blood-2004-03-1168
  • Mageau A, Terriou L, Ebbo M, et al. Splenectomy for primary immune thrombocytopenia revisited in the era of thrombopoietin receptor agonists: new insights for an old treatment. Am J Hematol. 2022;97(1):10–17. doi:10.1002/ajh.26378
  • Gonzalez-Porras JR, Escalante F, Pardal E, et al. Safety and efficacy of splenectomy in over 65-yrs-old patients with immune thrombocytopenia. Eur J Haematol. 2013;91(3):236–241. doi:10.1111/ejh.12146
  • Andrès E, Zimmer J, Noel E, Kaltenbach G, Koumarianou A, Maloisel F. Idiopathic thrombocytopenic purpura: a retrospective analysis in 139 patients of the influence of age on the response to corticosteroids, splenectomy and danazol. Drugs Aging. 2003;20(11):841–846. doi:10.2165/00002512-200320110-00005
  • Kavic SM, Segan RD, Park AE. Laparoscopic splenectomy in the elderly: a morbid procedure? Surg Endosc. 2005;19(12):1561–1564. doi:10.1007/s00464-005-0125-6
  • Park YH, Yi HG, Kim CS, et al. Clinical outcome and predictive factors in the response to splenectomy in elderly patients with primary immune thrombocytopenia: a multicenter retrospective study. Acta Haematol. 2016;135(3):162–171. doi:10.1159/000442703
  • Vianelli N, Palandri F, Polverelli N, et al. Splenectomy as a curative treatment for immune thrombocytopenia: a retrospective analysis of 233 patients with a minimum follow up of 10 years. Haematologica. 2013;98(6):875–880. doi:10.3324/haematol.2012.075648
  • Cuker A, Cines DB. Evidence-based mini-review: is indium-labeled autologous platelet scanning predictive of response to splenectomy in patients with chronic immune thrombocytopenia? Hematol Am Soc Hematol Educ Program. 2010;2010(1):385–386. doi:10.1182/asheducation-2010.1.385
  • Sarpatwari A, Provan D, Erqou S, Sobnack R, David Tai FW, Newland AC. Autologous 111 in-labelled platelet sequestration studies in patients with primary immune thrombocytopenia (ITP) prior to splenectomy: a report from the United Kingdom ITP registry. Br J Haematol. 2010;151(5):477–487. doi:10.1111/j.1365-2141.2010.08377.x
  • Togasaki E, Shimizu N, Nagao Y, et al. Long-term efficacy of partial splenic embolization for the treatment of steroid-resistant chronic immune thrombocytopenia. Ann Hematol. 2018;97(4):655–662. doi:10.1007/s00277-018-3232-x
  • Hou M, Peng J, Shi Y, et al. Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol. 2003;70(6):353–357. doi:10.1034/j.1600-0609.2003.00076.x
  • Taylor A, Neave L, Solanki S, et al. Mycophenolate mofetil therapy for severe immune thrombocytopenia. Br J Haematol. 2015;171(4):625–630. doi:10.1111/bjh.13622
  • Provan D, Moss AJ, Newland AC, Bussel JB. Efficacy of mycophenolate mofetil as single-agent therapy for refractory immune thrombocytopenic purpura. Am J Hematol. 2006;81(1):19–25. doi:10.1002/ajh.20515
  • Bradbury CA, Pell J, Hill Q, et al. Mycophenolate mofetil for first-line treatment of immune thrombocytopenia. N Engl J Med. 2021;385(10):885–895. doi:10.1056/NEJMoa2100596
  • Vesely SK, Perdue JJ, Rizvi MA, Terrell DR, George JN. Management of adult patients with persistent idiopathic thrombocytopenic purpura following splenectomy: a systematic review. Ann Intern Med. 2004;140(2):112–120. doi:10.7326/0003-4819-140-3-200402030-00012
  • Mishra K, Pramanik S, Sandal R, et al. Safety and efficacy of azathioprine in immune thrombocytopenia. Am J Blood Res. 2021;11(3):217–226.
  • Choudhary DR, Naithani R, Mahapatra M, Kumar R, Mishra P, Saxena R. Efficacy of cyclosporine as a single agent therapy in chronic idiopathic thrombocytopenic purpura. Haematologica. 2008;93(10):e61–e62;discussion e63. doi:10.3324/haematol.13481
  • Kappers-Klunne MC, Van’t Veer MB. Cyclosporin A for the treatment of patients with chronic idiopathic thrombocytopenic purpura refractory to corticosteroids or splenectomy. Br J Haematol. 2001;114(1):121–125. doi:10.1046/j.1365-2141.2001.02893.x
  • Emilia G, Morselli M, Luppi M, et al. Long-term salvage therapy with cyclosporin A in refractory idiopathic thrombocytopenic purpura. Blood. 2002;99(4):1482–1485. doi:10.1182/blood.V99.4.1482
  • Li H, Ji J, Du Y, et al. Sirolimus is effective for primary relapsed/refractory autoimmune cytopenia: a multicenter study. Exp Hematol. 2020;89:87–95. doi:10.1016/j.exphem.2020.08.001
  • Feng Y, Xiao Y, Yan H, et al. Sirolimus as rescue therapy for refractory/relapsed immune thrombocytopenia: results of a single-center, prospective, single-arm study. Front Med. 2020;7:110. doi:10.3389/fmed.2020.00110
  • Li J, Wang Z, Dai L, et al. Effects of rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia. Clin Dev Immunol. 2013;2013:548085. doi:10.1155/2013/548085
  • Verlin M, Laros RK, Penner JA. Treatment of refractory thrombocytopenic purpura with cyclophosphamine. Am J Hematol. 1976;1(1):97–104. doi:10.1002/ajh.2830010111
  • Pizzuto J, Ambriz R. Therapeutic experience on 934 adults with idiopathic thrombocytopenic purpura: multicentric trial of the cooperative Latin American group on hemostasis and thrombosis. Blood. 1984;64(6):1179–1183. doi:10.1182/blood.V64.6.1179.1179
  • Godeau B, Oksenhendler E, Bierling P. Dapsone for autoimmune thrombocytopenic purpura. Am J Hematol. 1993;44(1):70–72. doi:10.1002/ajh.2830440117
  • Godeau B, Durand JM, Roudot-Thoraval F, et al. Dapsone for chronic autoimmune thrombocytopenic purpura: a report of 66 cases. Br J Haematol. 1997;97(2):336–339. doi:10.1046/j.1365-2141.1997.412687.x
  • Zaja F, Marin L, Chiozzotto M, Puglisi S, Volpetti S, Fanin R. Dapsone salvage therapy for adult patients with immune thrombocytopenia relapsed or refractory to steroid and rituximab. Am J Hematol. 2012;87(3):321–323. doi:10.1002/ajh.22266
  • Durand JM, Lefèvre P, Hovette P, Mongin M, Soubeyrand J. Dapsone for idiopathic autoimmune thrombocytopenic purpura in elderly patients. Br J Haematol. 1991;78(3):459–460. doi:10.1111/j.1365-2141.1991.tb04467.x
  • Sauvetre G, MahÉvas M, Limal N, et al. Cutaneous rash and dapsone-induced hypersensitivity syndrome a common manifestation in adult immune thrombocytopenia. Presentation and outcome in 16 cases. Am J Hematol. 2015;90(10):E201–E202. doi:10.1002/ajh.24068
  • Maloisel F, Andrès E, Zimmer J, et al. Danazol therapy in patients with chronic idiopathic thrombocytopenic purpura: long-term results. Am J Med. 2004;116(9):590–594. doi:10.1016/j.amjmed.2003.12.024
  • Liu W, Gu X, Fu R, et al. The effect of danazol in primary immune thrombocytopenia: an analysis of a large cohort from a single center in China. Clin Appl Thromb Hemost. 2016;22(8):727–733. doi:10.1177/1076029615622002
  • Bussel J, Arnold DM, Grossbard E, et al. Fostamatinib for the treatment of adult persistent and chronic immune thrombocytopenia: results of two Phase 3, randomized, placebo-controlled trials. Am J Hematol. 2018;93(7):921–930. doi:10.1002/ajh.25125
  • Audia S, Mahévas M, Nivet M, Ouandji S, Ciudad M, Bonnotte B. Immune thrombocytopenia: recent advances in pathogenesis and treatments. Hemasphere. 2021;5(6):e574. doi:10.1097/HS9.0000000000000574
  • Zent CS, Ding W, Reinalda MS, et al. Autoimmune cytopenia in chronic lymphocytic leukemia/small lymphocytic lymphoma: changes in clinical presentation and prognosis. Leuk Lymphoma. 2009;50(8):1261–1268. doi:10.1080/10428190903026492
  • Rogers KA, Woyach JA. Secondary autoimmune cytopenias in chronic lymphocytic leukemia. Seminars in Oncology. 2016;43(2):300–310. doi:10.1053/j.seminoncol.2016.02.011
  • Hauswirth AW, Skrabs C, Schützinger C, et al. Autoimmune thrombocytopenia in non-Hodgkin’s lymphomas. Haematologica. 2008;93(3):447–450. doi:10.3324/haematol.11934
  • Ferretti A, Baldacci E, Miulli E, et al. Thrombopoietin receptor agonists to control immune thrombocytopenia in patients with active lymphoma. Br J Haematol. 2019;186(6):e217–e219. doi:10.1111/bjh.16114
  • Kantarjian HM, Giles FJ, Greenberg PL, et al. Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy. Blood. 2010;116(17):3163–3170. doi:10.1182/blood-2010-03-274753
  • Giagounidis A, Mufti GJ, Fenaux P, et al. Results of a randomized, double-blind study of romiplostim versus placebo in patients with low/intermediate-1-risk myelodysplastic syndrome and thrombocytopenia. Cancer. 2014;120(12):1838–1846. doi:10.1002/cncr.28663
  • Fenaux P, Muus P, Kantarjian H, et al. Romiplostim monotherapy in thrombocytopenic patients with myelodysplastic syndromes: long-term safety and efficacy. Br J Haematol. 2017;178(6):906–913. doi:10.1111/bjh.14792
  • Kantarjian HM, Fenaux P, Sekeres MA, et al. Long-term follow-up for up to 5 years on the risk of leukaemic progression in thrombocytopenic patients with lower-risk myelodysplastic syndromes treated with romiplostim or placebo in a randomised double-blind trial. Lancet Haematol. 2018;5(3):e117–e126. doi:10.1016/S2352-3026(18)30016-4
  • Mahévas M, Gerfaud-Valentin M, Moulis G, et al. Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia. Blood. 2016;128(12):1625–1630. doi:10.1182/blood-2016-03-704734