Intrinsic Capacity Declines with Elevated Homocysteine in Community-Dwelling Chinese Older Adults

References

• Beard JR, Officer A, de Carvalho IA, et al. The World report on ageing and health: a policy framework for healthy ageing. Lancet. 2016;387(10033):2145–2154. doi:10.1016/S0140-6736(15)00516-4
   PubMed Web of Science ®Google Scholar
• Zhou Y, Ma L. Intrinsic capacity in older adults: recent advances. Aging Dis. 2022;13(2):353–359. doi:10.14336/AD.2021.0818
   PubMed Web of Science ®Google Scholar
• World Health Organization. Integrated Care for Older People: Guidelines on Community-Level Interventions to Manage Declines in Intrinsic Capacity. Geneva: World Health Organization; 2017.
   Google Scholar
• George PP, Lun P, Ong SP, Lim WS. A rapid review of the measurement of intrinsic capacity in older adults. J Nutr Health Aging. 2021;25(6):774–782. doi:10.1007/s12603-021-1622-6
   PubMed Web of Science ®Google Scholar
• Chhetri JK, Xue QL, Ma L, Chan P, Varadhan R. Intrinsic capacity as a determinant of physical resilience in older adults. J Nutr Health Aging. 2021;25(8):1006–1011. doi:10.1007/s12603-021-1629-z
   PubMed Web of Science ®Google Scholar
• González-Bautista E, de Souto Barreto P, Andrieu S, Rolland Y, Vellas B. Screening for intrinsic capacity impairments as markers of increased risk of frailty and disability in the context of integrated care for older people: secondary analysis of MAPT. Maturitas. 2021;150:1–6. doi:10.1016/j.maturitas.2021.05.011
   PubMed Web of Science ®Google Scholar
• Leung A, Su JJ, Lee E, Fung J, Molassiotis A. Intrinsic capacity of older people in the community using WHO Integrated Care for Older People (ICOPE) framework: a cross-sectional study. BMC Geriatr. 2022;22(1):304. doi:10.1186/s12877-022-02980-1
   PubMed Web of Science ®Google Scholar
• Liu S, Kang L, Liu X, et al. Trajectory and correlation of intrinsic capacity and frailty in a Beijing elderly community. Front Med. 2021;8:751586. doi:10.3389/fmed.2021.751586
   Web of Science ®Google Scholar
• Ma L, Zhang Y, Liu P, et al. Plasma N-terminal pro-B-type natriuretic peptide is associated with intrinsic capacity decline in an older population. J Nutr Health Aging. 2021;25(2):271–277. doi:10.1007/s12603-020-1468-3
   PubMed Web of Science ®Google Scholar
• Zhao J, Chhetri JK, Chang Y, Zheng Z, Ma L, Chan P. Intrinsic capacity vs. multimorbidity: a function-centered construct predicts disability better than a disease-based approach in a community-dwelling older population cohort. Front Med. 2021;8:753295. doi:10.3389/fmed.2021.753295
   Web of Science ®Google Scholar
• Ma L, Chhetri JK, Zhang Y, et al. Integrated care for older people screening tool for measuring intrinsic capacity: preliminary findings from ICOPE pilot in China. Front Med. 2020;7:576079. doi:10.3389/fmed.2020.576079
   Web of Science ®Google Scholar
• Beard JR, Si Y, Liu Z, Chenoweth L, Hanewald K. Intrinsic capacity: validation of a new WHO concept for healthy aging in a longitudinal Chinese study. J Gerontol a Biol Sci Med Sci. 2022;77(1):94–100. doi:10.1093/gerona/glab226
   PubMed Web of Science ®Google Scholar
• Kumar A, Palfrey HA, Pathak R, Kadowitz PJ, Gettys TW, Murthy SN. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab. 2017;14:78. doi:10.1186/s12986-017-0233-z
   Google Scholar
• Koklesova L, Mazurakova A, Samec M, et al. Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person. EPMA J. 2021;12(4):1–29. doi:10.1007/s13167-021-00263-0
   PubMed Web of Science ®Google Scholar
• Smith AD, Refsum H. Homocysteine - from disease biomarker to disease prevention. J Intern Med. 2021;290(4):826–854. doi:10.1111/joim.13279
   PubMed Web of Science ®Google Scholar
• Cohen E, Margalit I, Shochat T, Goldberg E, Krause I. Gender differences in homocysteine concentrations, a population-based cross-sectional study. Nutr Metab Cardiovasc Dis. 2019;29(1):9–14. doi:10.1016/j.numecd.2018.09.003
   PubMed Web of Science ®Google Scholar
• Xu R, Huang F, Wang Y, Liu Q, Lv Y, Zhang Q. Gender- and age-related differences in homocysteine concentration: a cross-sectional study of the general population of China. Sci Rep. 2020;10(1):17401. doi:10.1038/s41598-020-74596-7
   PubMed Web of Science ®Google Scholar
• Tu W, Yan F, Chao B, Ji X, Wang L. Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening Program, 2018. Front Med. 2021;15(6):903–912. doi:10.1007/s11684-021-0871-4
   PubMed Web of Science ®Google Scholar
• Lim HS, Heo YR. Plasma total homocysteine, folate, and vitamin B12 status in Korean adults. J Nutr Sci Vitaminol. 2002;48(4):290–297. doi:10.3177/jnsv.48.290
   PubMed Web of Science ®Google Scholar
• Adachi H, Hirai Y, Fujiura Y, Matsuoka H, Satoh A, Imaizumi T. Plasma homocysteine levels and atherosclerosis in Japan: epidemiological study by use of carotid ultrasonography. Stroke. 2002;33(9):2177–2181. doi:10.1161/01.STR.0000026861.18199.89
   PubMed Web of Science ®Google Scholar
• Ganji V, Kafai MR. Population reference values for plasma total homocysteine concentrations in US adults after the fortification of cereals with folic acid. Am J Clin Nutr. 2006;84(5):989–994. doi:10.1093/ajcn/84.5.989
   PubMed Web of Science ®Google Scholar
• Nurk E, Tell GS, Vollset SE, et al. Changes in lifestyle and plasma total homocysteine: the Hordaland Homocysteine Study. Am J Clin Nutr. 2004;79(5):812–819. doi:10.1093/ajcn/79.5.812
   PubMed Web of Science ®Google Scholar
• Vidoni ML, Pettee Gabriel K, Luo ST, Simonsick EM, Day RS. Vitamin B12 and homocysteine associations with gait speed in older adults: the Baltimore longitudinal study of aging. J Nutr Health Aging. 2017;21(10):1321–1328. doi:10.1007/s12603-017-0893-4
   PubMed Web of Science ®Google Scholar
• Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, et al. Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: the Toledo Study for Healthy Aging. Exp Gerontol. 2018;108:201–208. doi:10.1016/j.exger.2018.04.019
   PubMed Web of Science ®Google Scholar
• Lee WJ, Peng LN, Loh CH, Chen LK. Sex-different associations between serum homocysteine, high-sensitivity C-reactive protein and sarcopenia: results from I-lan longitudinal aging study. Exp Gerontol. 2020;132:110832. doi:10.1016/j.exger.2020.110832
   PubMed Web of Science ®Google Scholar
• Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, et al. Homocysteine and C-reactive protein levels are associated with frailty in older Spaniards: the Toledo study for healthy aging. J Gerontol a Biol Sci Med Sci. 2020;75(8):1488–1494. doi:10.1093/gerona/glz168
   PubMed Web of Science ®Google Scholar
• Chen LT, Xu TT, Qiu YQ, et al. Homocysteine induced a calcium-mediated disruption of mitochondrial function and dynamics in endothelial cells. J Biochem Mol Toxicol. 2021;35(5):e22737. doi:10.1002/jbt.22737
   PubMed Web of Science ®Google Scholar
• Majumder A, Singh M, Behera J, et al. Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury. Am J Physiol Cell Physiol. 2018;315(5):C609–C622. doi:10.1152/ajpcell.00147.2018
   PubMed Web of Science ®Google Scholar
• Belloni G, Cesari M. Frailty and intrinsic capacity: two distinct but related constructs. Front Med. 2019;6:133. doi:10.3389/fmed.2019.00133
   Web of Science ®Google Scholar
• Tsoi KK, Chan JY, Hirai HW, Wong SY, Kwok TC. Cognitive tests to detect dementia: a systematic review and meta-analysis. JAMA Intern Med. 2015;175(9):1450–1458. doi:10.1001/jamainternmed.2015.2152
   PubMed Web of Science ®Google Scholar
• Zeng X, Shen S, Xu L, et al. The impact of intrinsic capacity on adverse outcomes in older hospitalized patients: a one-year follow-up study. Gerontology. 2021;67(3):267–275. doi:10.1159/000512794
   PubMed Web of Science ®Google Scholar
• Arokiasamy P, Selvamani Y, Jotheeswaran AT, Sadana R. Socioeconomic differences in handgrip strength and its association with measures of intrinsic capacity among older adults in six middle-income countries. Sci Rep. 2021;11(1):19494. doi:10.1038/s41598-021-99047-9
   PubMed Web of Science ®Google Scholar
• Gutiérrez-Robledo LM, García-Chanes RE, González-Bautista E, Rosas-Carrasco O. Validation of two intrinsic capacity scales and its relationship with frailty and other outcomes in Mexican community-dwelling older adults. J Nutr Health Aging. 2021;25(1):33–40. doi:10.1007/s12603-020-1555-5
   PubMed Web of Science ®Google Scholar
• Charles A, Buckinx F, Locquet M, et al. Prediction of adverse outcomes in nursing home residents according to intrinsic capacity proposed by the World Health Organization. J Gerontol a Biol Sci Med Sci. 2020;75(8):1594–1599. doi:10.1093/gerona/glz218
   PubMed Web of Science ®Google Scholar
• Chen LK, Woo J, Assantachai P, et al. Asian Working Group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300–307.e2. doi:10.1016/j.jamda.2019.12.012
   PubMed Web of Science ®Google Scholar
• Huang CH, Okada K, Matsushita E, et al. Dietary patterns and intrinsic capacity among community-dwelling older adults: a 3-year prospective cohort study. Eur J Nutr. 2021;60(6):3303–3313. doi:10.1007/s00394-021-02505-3
   PubMed Web of Science ®Google Scholar
• Ma L, Liu P, Zhang Y, Sha G, Zhang L, Li Y. High serum tumor necrosis factor receptor 1 levels are related to risk of low intrinsic capacity in elderly adults. J Nutr Health Aging. 2021;25(4):416–418. doi:10.1007/s12603-020-1533-y
   PubMed Web of Science ®Google Scholar
• Ramírez-Vélez R, Correa-Bautista JE, García-Hermoso A, Cano CA, Izquierdo M. Reference values for handgrip strength and their association with intrinsic capacity domains among older adults. J Cachexia Sarcopenia Muscle. 2019;10(2):278–286. doi:10.1002/jcsm.12373
   PubMed Web of Science ®Google Scholar
• Huang CH, Okada K, Matsushita E, et al. The association of social frailty with intrinsic capacity in community-dwelling older adults: a prospective cohort study. BMC Geriatr. 2021;21(1):515. doi:10.1186/s12877-021-02466-6
   PubMed Web of Science ®Google Scholar
• Prince MJ, Acosta D, Guerra M, et al. Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: a population-based cohort study. PLoS Med. 2021;18(9):e1003097. doi:10.1371/journal.pmed.1003097
   PubMed Web of Science ®Google Scholar
• Lera L, Sánchez H, Ángel B, Albala C. Mini nutritional assessment short-form: validation in five Latin American cities. SABE study. J Nutr Health Aging. 2016;20(8):797–805. doi:10.1007/s12603-016-0696-z
   PubMed Web of Science ®Google Scholar
• Kaiser MJ, Bauer JM, Ramsch C, et al. Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging. 2009;13(9):782–788. doi:10.1007/s12603-009-0214-7
   PubMed Web of Science ®Google Scholar
• Krishnamoorthy Y, Rajaa S, Rehman T. Diagnostic accuracy of various forms of geriatric depression scale for screening of depression among older adults: systematic review and meta-analysis. Arch Gerontol Geriatr. 2020;87:104002. doi:10.1016/j.archger.2019.104002
   PubMed Web of Science ®Google Scholar
• Johansson S, Lövheim H, Olofsson B, Gustafson Y, Niklasson J. A clinically feasible short version of the 15-item geriatric depression scale extracted using item response theory in a sample of adults aged 85 years and older. Aging Ment Health. 2022;26(2):431–437. doi:10.1080/13607863.2021.1881759
   PubMed Web of Science ®Google Scholar
• Sánchez-Sánchez JL, Rolland Y, Cesari M, de Souto Barreto P. Associations between intrinsic capacity and adverse events among nursing home residents: the INCUR study. J Am Med Dir Assoc. 2022;23(5):872–876.e4. doi:10.1016/j.jamda.2021.08.035
   PubMed Web of Science ®Google Scholar
• Locquet M, Sanchez-Rodriguez D, Bruyère O, et al. Intrinsic capacity defined using four domains and mortality risk: a 5-year follow-up of the SarcoPhAge cohort. J Nutr Health Aging. 2022;26(1):23–29. doi:10.1007/s12603-021-1702-7
   PubMed Web of Science ®Google Scholar
• Chew J, Lim JP, Yew S, et al. Disentangling the relationship between frailty and intrinsic capacity in healthy community-dwelling older adults: a cluster analysis. J Nutr Health Aging. 2021;25(9):1112–1118. doi:10.1007/s12603-021-1679-2
   PubMed Web of Science ®Google Scholar
• Huang CH, Umegaki H, Makino T, et al. Effect of various exercises on intrinsic capacity in older adults with subjective cognitive concerns. J Am Med Dir Assoc. 2021;22(4):780–786.e2. doi:10.1016/j.jamda.2020.06.048
   PubMed Web of Science ®Google Scholar
• Yeung S, Sin D, Yu R, Leung J, Woo J. Dietary patterns and intrinsic capacity in community-dwelling older adults: a cross-sectional study. J Nutr Health Aging. 2022;26(2):174–182. doi:10.1007/s12603-022-1742-7
   PubMed Web of Science ®Google Scholar
• Gutiérrez-Robledo LM, García-Chanes RE, Pérez-Zepeda MU. Allostatic load as a biological substrate to intrinsic capacity: a secondary analysis of CRELES. J Nutr Health Aging. 2019;23(9):788–795. doi:10.1007/s12603-019-1251-5
   PubMed Web of Science ®Google Scholar
• Giudici KV, de Souto Barreto P, Guerville F, et al. Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). Exp Gerontol. 2019;127:110716. doi:10.1016/j.exger.2019.110716
   PubMed Web of Science ®Google Scholar
• Alghadir AH, Gabr SA, Anwer S, Li H. Associations between vitamin E, oxidative stress markers, total homocysteine levels, and physical activity or cognitive capacity in older adults. Sci Rep. 2021;11(1):12867. doi:10.1038/s41598-021-92076-4
   PubMed Web of Science ®Google Scholar
• Nelson ME, Andel R, Nedelska Z, et al. The association between homocysteine and memory in older adults. J Alzheimers Dis. 2021;81(1):413–426. doi:10.3233/JAD-201558
   PubMed Web of Science ®Google Scholar
• Gopinath B, Flood VM, Rochtchina E, McMahon CM, Mitchell P. Serum homocysteine and folate concentrations are associated with prevalent age-related hearing loss. J Nutr. 2010;140(8):1469–1474. doi:10.3945/jn.110.122010
   PubMed Web of Science ®Google Scholar
• Martínez-Vega R, Garrido F, Partearroyo T, et al. Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB J. 2015;29(2):418–432. doi:10.1096/fj.14-259283
   PubMed Web of Science ®Google Scholar
• Moradi F, Lotfi K, Armin M, Clark C, Askari G, Rouhani MH. The association between serum homocysteine and depression: a systematic review and meta-analysis of observational studies. Eur J Clin Invest. 2021;51(5):e13486. doi:10.1111/eci.13486
   PubMed Web of Science ®Google Scholar