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ORIGINAL RESEARCH

Coexisting Frailty and Cognitive Impairment as a Predictor of Adverse Outcomes in Older Inpatients After Discharge: Results from a One-Year Follow-Up Study

ORCID Icon, , , &
Pages 1697-1706 | Received 05 Jul 2022, Accepted 17 Nov 2022, Published online: 13 Nov 2023

References

  • Hanlon P, Nicholl BI, Jani BD, et al. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK biobank participants. Lancet Public Health. 2018;3(7):e323–e332. doi:10.1016/S2468-2667(18)30091-4
  • Panza F, Seripa D, Solfrizzi V, et al. Targeting cognitive frailty: clinical and neurobiological roadmap for a single complex phenotype. J Alzheimers Dis. 2015;47(4):793–813. doi:10.3233/JAD-150358
  • Martin Prince MG, Ali G-C, Wimo A. World Alzheimer Report 2015. London: Alzheimer’s Disease International (ADI); 2015.
  • Buurman BM, Hoogerduijn JG, van Gemert EA, et al. Clinical characteristics and outcomes of hospitalized older patients with distinct risk profiles for functional decline: a prospective cohort study. PLoS One. 2012;7(1):e29621. doi:10.1371/journal.pone.0029621
  • Lu C, Zhang H, Fu X, et al. Clinical investigation and analysis of chronic diseases and geriatric syndromes in elderly inpatients. Chin J Geriatr. 2019;38(8):913–916. doi:10.3760/cma.j.issn.0254-9026.2019.08.021
  • Lin CC, Li CI, Chang CK, et al. Reduced health-related quality of life in elders with frailty: a cross-sectional study of community-dwelling elders in Taiwan. PLoS One. 2011;6(7):e21841. doi:10.1371/journal.pone.0021841
  • Wu MS, Lan TH, Chen CM, et al. Socio-demographic and health-related factors associated with cognitive impairment in the elderly in Taiwan. BMC Public Health. 2011;11:22. doi:10.1186/1471-2458-11-22
  • Boyd CM, Landefeld CS, Counsell SR, et al. Recovery of activities of daily living in older adults after hospitalization for acute medical illness. J Am Geriatr Soc. 2008;56(12):2171–2179. doi:10.1111/j.1532-5415.2008.02023.x
  • Buurman BM, Hoogerduijn JG, de Haan RJ, et al. Geriatric conditions in acutely hospitalized older patients: prevalence and one-year survival and functional decline. PLoS One. 2011;6(11):e26951. doi:10.1371/journal.pone.0026951
  • Hoogerduijn JG, Buurman BM, Korevaar JC, et al. The prediction of functional decline in older hospitalised patients. Age Ageing. 2012;41(3):381–387. doi:10.1093/ageing/afs015
  • Gill TM, Allore HG, Gahbauer EA, et al. Change in disability after hospitalization or restricted activity in older persons. JAMA. 2010;304(17):1919–1928. doi:10.1001/jama.2010.1568
  • Brown CJ, Redden DT, Flood KL, et al. The underrecognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc. 2009;57(9):1660–1665. doi:10.1111/j.1532-5415.2009.02393.x
  • Gill TM, Gahbauer EA, Han L, et al. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. BMJ. 2015;350(may14 20):h2361. doi:10.1136/bmj.h2361
  • Ida S, Kaneko R, Imataka K, et al. Relationship between frailty and mortality, hospitalization, and cardiovascular diseases in diabetes: a systematic review and meta-analysis. Cardiovasc Diabetol. 2019;18(1):81. doi:10.1186/s12933-019-0885-2
  • Ehlenbach WJ, Hough CL, Crane PK, et al. Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA. 2010;303(8):763–770. doi:10.1001/jama.2010.167
  • Lee Y, Kim J, Chon D, et al. The effects of frailty and cognitive impairment on 3-year mortality in older adults. Maturitas. 2018;107:50–55. doi:10.1016/j.maturitas.2017.10.006
  • Aliberti MJR, Cenzer IS, Smith AK, et al. Assessing risk for adverse outcomes in older adults: the need to include both physical frailty and cognition. J Am Geriatr Soc. 2019;67(3):477–483. doi:10.1111/jgs.15683
  • St John PD, Tyas SL, Griffith LE, et al. The cumulative effect of frailty and cognition on mortality - results of a prospective cohort study. Int Psychogeriatr. 2017;29(4):535–543. doi:10.1017/S1041610216002088
  • Liu Z, Han L, Gahbauer EA, et al. Joint trajectories of cognition and frailty and associated burden of patient-reported outcomes. J Am Med Dir Assoc. 2018;19(4):304–309 e302. doi:10.1016/j.jamda.2017.10.010
  • Li CL, Chang HY, Stanaway FF. Combined effects of frailty status and cognitive impairment on health-related quality of life among community dwelling older adults. Arch Gerontol Geriatr. 2020;87:103999. doi:10.1016/j.archger.2019.103999
  • Brigola AG, Ottaviani AC, Alexandre TDS, et al. Cumulative effects of cognitive impairment and frailty on functional decline, falls and hospitalization: a four-year follow-up study with older adults. Arch Gerontol Geriatr. 2020;87:104005. doi:10.1016/j.archger.2019.104005
  • Naharci MI, Tasci I. Frailty status and increased risk for falls: the role of anticholinergic burden. Arch Gerontol Geriatr. 2020;90:104136. doi:10.1016/j.archger.2020.104136
  • Ge ML, Simonsick EM, Dong BR, et al. Frailty, with or without cognitive impairment, is a strong predictor of recurrent falls in a US population-representative sample of older adults. J Gerontol a Biol Sci Med Sci. 2021;76(11):e354–e360. doi:10.1093/gerona/glab083
  • Montero-Odasso MM, Barnes B, Speechley M, et al. Disentangling cognitive-frailty: results from the gait and brain study. J Gerontol a Biol Sci Med Sci. 2016;71(11):1476–1482. doi:10.1093/gerona/glw044
  • Aprahamian I, Suemoto CK, Aliberti MJR, et al. Frailty and cognitive status evaluation can better predict mortality in older adults? Arch Gerontol Geriatr. 2018;77:51–56. doi:10.1016/j.archger.2018.04.005
  • Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol a Biol Sci Med Sci. 2001;56(3):M146–M156. doi:10.1093/gerona/56.3.M146
  • Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci World J. 2001;1:323–336. doi:10.1100/tsw.2001.58
  • Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–495. doi:10.1503/cmaj.050051
  • Church S, Rogers E, Rockwood K, et al. A scoping review of the clinical frailty scale. BMC Geriatr. 2020;20(1):393. doi:10.1186/s12877-020-01801-7
  • Wallis SJ, Wall J, Biram RW, et al. Association of the clinical frailty scale with hospital outcomes. QJM. 2015;108(12):943–949. doi:10.1093/qjmed/hcv066
  • Fu L, Wang Q, Lv W, et al. Comparison of predictability on adverse events among different assessment tools in elderly discharged inpatients. Chin J Geriatr. 2019;38(12):1329–1333. doi:10.3760/cma.j.issn.0254-9026.2019.12.003
  • Mystakidou K, Tsilika E, Parpa E, et al. Brief cognitive assessment of cancer patients: evaluation of the Mini-Mental State Examination (MMSE) psychometric properties. Psychooncology. 2007;16(4):352–357. doi:10.1002/pon.1090
  • Fountoulakis KN, Tsolaki M, Chantzi H, et al. Mini Mental State Examination (MMSE): a validation study in Greece. Am J Alzheimers Dis Other Demen. 2000;15(6):342–345. doi:10.1177/153331750001500604
  • Li H, Jia J, Yang Z, Moreau N. Mini-mental state examination in elderly Chinese: a population-based normative study. J Alzheimers Dis. 2016;53(2):487–496. doi:10.3233/JAD-160119
  • Salive ME. Multimorbidity in older adults. Epidemiol Rev. 2013;35(1):75–83. doi:10.1093/epirev/mxs009
  • Viktil KK, Blix HS, Moger TA, et al. Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol. 2007;63(2):187–195. doi:10.1111/j.1365-2125.2006.02744.x
  • Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypharmacy? A systematic review of definitions. BMC Geriatr. 2017;17(1):230. doi:10.1186/s12877-017-0621-2
  • Kahlon S, Pederson J, Majumdar SR, et al. Association between frailty and 30-day outcomes after discharge from hospital. CMAJ. 2015;187(11):799–804. doi:10.1503/cmaj.150100
  • Folstein MF, Folstein SE, McHugh PR. ”Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. doi:10.1016/0022-3956(75)90026-6
  • Mahoney FI, Barthel DW. Functional evaluation: the Barthel index. Md State Med J. 1965;14:61–65.
  • Lamb SE, Jorstad-Stein EC, Hauer K, et al. Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc. 2005;53(9):1618–1622. doi:10.1111/j.1532-5415.2005.53455.x
  • Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord. 2008;23(3):329–342; quiz 472. doi:10.1002/mds.21720
  • Panza F, Solfrizzi V, Frisardi V, et al. Different models of frailty in predementia and dementia syndromes. J Nutr Health Aging. 2011;15(8):711–719. doi:10.1007/s12603-011-0126-1
  • Buchman AS, Bennett DA. Cognitive frailty. J Nutr Health Aging. 2013;17(9):738–739. doi:10.1007/s12603-013-0397-9
  • Halil M, Cemal Kizilarslanoglu M, Emin Kuyumcu M, et al. Cognitive aspects of frailty: mechanisms behind the link between frailty and cognitive impairment. J Nutr Health Aging. 2015;19(3):276–283. doi:10.1007/s12603-014-0535-z
  • Mulero J, Zafrilla P, Martinez-Cacha A. Oxidative stress, frailty and cognitive decline. J Nutr Health Aging. 2011;15(9):756–760. doi:10.1007/s12603-011-0130-5
  • Afilalo J, Karunananthan S, Eisenberg MJ, et al. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103(11):1616–1621. doi:10.1016/j.amjcard.2009.01.375
  • Xie B, Ma C, Chen Y, et al. Prevalence and risk factors of the co-occurrence of physical frailty and cognitive impairment in Chinese community-dwelling older adults. Health Soc Care Community. 2021;29(1):294–303. doi:10.1111/hsc.13092
  • Peel NM, Alapatt LJ, Jones LV, et al. The association between gait speed and cognitive status in community-dwelling older people: a systematic review and meta-analysis. J Gerontol a Biol Sci Med Sci. 2019;74(6):943–948. doi:10.1093/gerona/gly140
  • Derry HM, Johnston CD, Burchett CO, et al. Gait speed is associated with cognitive function among older adults with HIV. J Aging Health. 2020;32(10):1510–1515. doi:10.1177/0898264320943330
  • Millan-Calenti JC, Tubio J, Pita-Fernandez S, et al. Prevalence of functional disability in activities of daily living (ADL), instrumental activities of daily living (IADL) and associated factors, as predictors of morbidity and mortality. Arch Gerontol Geriatr. 2010;50(3):306–310. doi:10.1016/j.archger.2009.04.017
  • DALYs GBD, Collaborators H, Murray CJ, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet. 2015;386(10009):2145–2191. doi:10.1016/S0140-6736(15)61340-X
  • Bossola M, Marino C, Di Napoli A, et al. Functional impairment and risk of mortality in patients on chronic hemodialysis: results of the Lazio dialysis registry. J Nephrol. 2018;31(4):593–602. doi:10.1007/s40620-018-0484-4
  • Solfrizzi V, Scafato E, Lozupone M, et al. Additive role of a potentially reversible cognitive frailty model and inflammatory state on the risk of disability: the Italian longitudinal study on aging. Am J Geriatr Psychiatry. 2017;25(11):1236–1248. doi:10.1016/j.jagp.2017.05.018
  • McDonagh TA, Metra M, Adamo M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42(36):3599–3726. doi:10.1093/eurheartj/ehab368
  • Williams B, Mancia G, Spiering W, et al. 2018 practice guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH/ESC task force for the management of arterial hypertension. J Hypertens. 2018;36(12):2284–2309. doi:10.1097/HJH.0000000000001961
  • Martinez-Velilla N, Casas-Herrero A, Zambom-Ferraresi F, et al. Effect of exercise intervention on functional decline in very elderly patients during acute hospitalization: a randomized clinical trial. JAMA Intern Med. 2019;179(1):28–36. doi:10.1001/jamainternmed.2018.4869
  • Naczk M, Marszalek S, Naczk A. Inertial training improves strength, balance, and gait speed in elderly nursing home residents. Clin Interv Aging. 2020;15:177–184. doi:10.2147/CIA.S234299
  • Negm AM, Kennedy CC, Thabane L, et al. Management of frailty: a systematic review and network meta-analysis of randomized controlled trials. J Am Med Dir Assoc. 2019;20(10):1190–1198. doi:10.1016/j.jamda.2019.08.009
  • Veronese N, Stubbs B, Noale M, et al. Adherence to a Mediterranean diet is associated with lower incidence of frailty: a longitudinal cohort study. Clin Nutr. 2018;37(5):1492–1497. doi:10.1016/j.clnu.2017.08.028
  • Ng TP, Ling LHA, Feng L, et al. Cognitive effects of multi-domain interventions among pre-frail and frail community-living older persons: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2018;73(6):806–812. doi:10.1093/gerona/glx207
  • Romera-Liebana L, Orfila F, Segura JM, et al. Effects of a primary care-based multifactorial intervention on physical and cognitive function in frail, elderly individuals: a randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2018;73(12):1688. doi:10.1093/gerona/glx259