220
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Association Between Plasma Ceramides and One-Year Mortality in Patients with Acute Coronary Syndrome: Insight from the PEACP Study

, ORCID Icon, , , , , , , , , ORCID Icon & show all
Pages 571-584 | Received 22 Dec 2022, Accepted 30 Mar 2023, Published online: 06 Apr 2023

References

  • Wong GC, Welsford M, Ainsworth C, et al. Canadian Cardiovascular Society/Canadian Association of interventional cardiology guidelines on the acute management of ST-elevation myocardial infarction: focused update on regionalization and reperfusion. Can J Cardiol. 2019;35(2):107–132.
  • Ibanez B, James S, Agewall S, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119–177.
  • Li F, Li D, Yu J, et al. Barthel Index as a predictor of mortality in patients with acute coronary syndrome: better activities of daily living, better prognosis. Clin Interv Aging. 2021;15:1951–1961.
  • Mundra PA, Barlow CK, Nestel PJ, et al. Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention. JCI Insight. 2018;3:17.
  • Gault CR, Obeid LM, Hannun YA. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010;688:1–23.
  • Pan W, Yu J, Shi R, et al. Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes. Coron Artery Dis. 2014;25(3):230–235.
  • Tarasov K, Ekroos K, Suoniemi M, et al. Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency. J Clin Endocrinol Metab. 2014;99(1):E45–52.
  • Li PL, Zhang Y. Cross talk between ceramide and redox signaling: implications for endothelial dysfunction and renal disease. Handb Exp Pharmacol. 2013;216:171–197.
  • Basnakian AG, Ueda N, Hong X, Galitovsky VE, Yin X, Shah SV. Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Am J Physiol Renal Physiol. 2015;288(2):F308–314.
  • Ueda N. Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. Int J Mol Sci. 2015;16(3):5076–5124.
  • Anroedh S, Hilvo M, Akkerhuis KM, et al. Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients. J Lipid Res. 2018;59(9):1729–1737.
  • Cheng JM, Suoniemi M, Kardys I, et al. Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Atherosclerosis. 2015;243(2):560–566.
  • Laaksonen R, Ekroos K, Sysi-Aho M, et al. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J. 2016;37(25):1967–1976.
  • Tu C, Xie L, Wang Z, et al. Association between ceramides and coronary artery stenosis in patients with coronary artery disease. Lipids Health Dis. 2020;19(1):151.
  • Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2014;64(24):e139–e228.
  • O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Am Coll Cardiol. 2013;61(4):e78–e140.
  • Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2013;163(19):2345–2353.
  • Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol. 1983;51(3):606.
  • Sarafian MH, Gaudin M, Lewis MR, et al. Objective set of criteria for optimization of sample preparation procedures for ultra-high throughput untargeted blood plasma lipid profiling by ultra performance liquid chromatography-mass spectrometry. Anal Chem. 2014;86(12):5766–5774.
  • Huang Q, Hao S, Yao X, et al. High-throughput quantitation of serological ceramides/dihydroceramides by LC/MS/MS: pregnancy baseline biomarkers and potential metabolic messengers. J Pharm Biomed Anal. 2021;192:113639.
  • Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res. 2006;45(1):42–72.
  • Holland WL, Summers SA. Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocr Rev. 2008;29(4):381–402.
  • Summers SA. The ART of lowering ceramides. Cell Metab. 2015;22(2):195–196.
  • Li H, Junk P, Huwiler A, et al. Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase. Circulation. 2002;106(17):2250–2256.
  • Lawrence GD. Perspective: the saturated fat-unsaturated oil dilemma: relations of dietary fatty acids and serum cholesterol, atherosclerosis, inflammation, cancer, and all-cause mortality. Adv Nutr. 2021;12(3):647–656.
  • Mandal N, Grambergs R, Mondal K, Basu SK, Tahia F, Dagogo-Jack S. Role of ceramides in the pathogenesis of diabetes mellitus and its complications. J Diabetes Complications. 2021;35(2):107734.
  • Novgorodov SA, Gudz TI. Ceramide and mitochondria in ischemia/reperfusion. J Cardiovasc Pharmacol. 2009;53(3):198–208.
  • Bielawska AE, Shapiro JP, Jiang L, et al. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997;151(5):1257–1263.
  • Uchida Y, Uchida Y, Kobayashi T, et al. Detection of ceramide, a risk factor for coronary artery disease, in human coronary plaques by fluorescent angioscopy. Circ J. 2017;81(12):1886–1893.
  • Fretts AM, Jensen PN, Hoofnagle A, et al. Plasma ceramide species are associated with diabetes risk in participants of the strong heart study. J Nutr. 2020;150(5):1214–1222.
  • Yang J, Wang M, Yang D, et al. Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients. Front Endocrinol. 2023;13:1065665.
  • Raichur S, Brunner B, Bielohuby M, et al. The role of C16:0 ceramide in the development of obesity and type 2 diabetes: cerS6 inhibition as a novel therapeutic approach. Mol Metab. 2019;21:36–50.
  • Kasumov T, Solomon TP, Hwang C, et al. Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes. Obesity. 2015;23(7):1414–1421.
  • Klein RL, Hammad SM, Baker NL, et al.; DCCT/EDIC Research Group. Decreased plasma levels of select very long chain ceramide species are associated with the development of nephropathy in type 1 diabetes. Metabolism. 2014;63(10):1287–1295.
  • Nicholson RJ, Holland WL, Summers SA. Ceramides and acute kidney injury. Semin Nephrol. 2022;42(3):151281.
  • Ritter O, Jelenik T, Roden M. Lipid-mediated muscle insulin resistance: different fat, different pathways? J Mol Med. 2015;93(8):831–843.
  • Li F, Li D, Yu J, et al. Silent myocardial infarction and long-term risk of frailty: the atherosclerosis risk in communities study. Clin Interv Aging. 2021;16:1139–1149.
  • Bergman BC, Brozinick JT, Strauss A, et al. Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol Endocrinol Metab. 2015;309(4):E398–408.
  • Dong Y, Hao G, Wang Z, Wang X, Chen Z, Zhang L. Ideal cardiovascular health status and risk of cardiovascular disease or all-cause mortality in Chinese middle-aged population. Angiology. 2019;70(6):523–529.
  • Kones R, Rumana U. Prevention of cardiovascular disease: updating the immensity of the challenge and the role of risk factors. Hosp Pract. 2014;42(1):92–100.
  • Kokkinos PF, Faselis C, Myers J, et al. Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study. Lancet. 2013;381(9864):394–399.
  • Okoro EU. TNFα-induced LDL cholesterol accumulation involve elevated LDLR cell surface levels and SR-B1 downregulation in human arterial endothelial cells. Int J Mol Sci. 2021;22:12.