N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: Glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population

References

• GulewitschWAmiradzibiS[Uber das carnosin, eine neue organische Base des Fleischextraktes.]Ber Deutch Chem Ges19003319023
   Google Scholar
• BabizhayevMASeguinM-CGueyneJL-Carnosine (β-alanyl-L-histidine) and carcinine (β-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid peroxidase activitiesBiochem J1994304509167998987
   PubMed Web of Science ®Google Scholar
• BabizhayevMAYermakovaVNSakinaNLN-acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidantClin Chim Acta19962541218894306
   PubMed Web of Science ®Google Scholar
• BoldyrevAADupinAMBuninAYThe antioxidative properties of carnosine, a natural histidine containing dipeptideBiochem Int1987151105133326603
   PubMedGoogle Scholar
• BabizhayevMADeyevAIYermakovaVNRevival of the lens transparency with N-acetylcarnosineCurr Drug Ther2006191116
   Google Scholar
• KupferCUnderwoodBGillenTLeading causes of visual impairment worldwideAlbertDMJakobiecFAPhiladelphiaWB Saunders and Co1994124955
   Google Scholar
• Vision Research A National Plan 1999–2002Report of the National Advisory CouncilNational Eye Institute199859
   Google Scholar
• KupferCThe conquest of cataract: a global challengeTrans Ophthalmol Soc1984104110
   Google Scholar
• BabizhayevMADeyevAIYermakovaVNImage analysis and glare sensitivity in human age-related cataractsClin Exp Optom2003861577212767250
   PubMedGoogle Scholar
• BabizhayevMADeyevAIYermakovaVNEfficacy of N-acetylcarnosine in the treatment of cataractsDrugs R D200238710312001824
   PubMedGoogle Scholar
• BabizhayevMAGlare disability and driving safetyOphthalmic Res200335192512566859
   PubMed Web of Science ®Google Scholar
• BabizhayevMASeguinM-CProcess of assessment of ocular dysfunctions and implementation devices of this process US Patent No. 6,007,203. Date of patent: December 28, 1999
   Google Scholar
• BaileyILBullimoreMAA new test for the evaluation of disability glareOptom Vis Sci199168911171787947
   PubMed Web of Science ®Google Scholar
• American Academy of OphthalmologyContrast sensitivity and glare testing in the evaluation of anterior segment diseaseOphthalmology (Rochester)19909712337
   Web of Science ®Google Scholar
• BabizhayevMAOphthalmic pharmacology of N-acetylcarnosine lubricant eye dropsJ Pharmacol Toxicol2006120133
   Google Scholar
• BabizhayevMADeyevAIYermakovaVNN-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataractsPeptides2001229799411390029
   PubMed Web of Science ®Google Scholar
• BabizhayevMAYermakovaVNDeyevAIImidazole-containing peptidomimetic NACA as a potent drug for the medicinal treatment of age-related cataract in humansJ Anti-Aging Med200034362
   Google Scholar
• BabizhayevMARejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye dropsRejuvenation Res200471869815588519
   PubMed Web of Science ®Google Scholar
• FerrisFLKassoffABresnickGHNew visual acuity charts for clinical researchAm J Ophthalmol1982949167091289
   PubMed Web of Science ®Google Scholar
• FerrisFLSperdutoRDStandardized illumination for visual acuity testing in clinical researchAm J Ophthalmol1982949787091290
   PubMed Web of Science ®Google Scholar
• BabizhayevMABozzo CostaEComposizioni farmaceutiche contenenti N-acetilcarnosina per il trattamento della cataratta Italian Patent A61K gruppo 37/00 20122 MI, Priority. October 15, 1993
   Google Scholar
• BabizhayevMABozzo CostaEPharmaceutical compositions containing N-acetylcarnosine for the treatment of cataract Patent PCT/EP 94/03340 SCB 238 PCT. October 10, 1994
   Google Scholar
• BabizhayevMAMethod for topical treatment of eye disease and composition and device for said treatment PCT Patent Application. International Publication Number WO 2004/028536 A1. April 8, 2004
   Google Scholar
• OwsleyCStalveyBTWellsJVisual risk factors for crash involvement in older drivers with cataractArch Ophthalmol2001119881711405840
   PubMed Web of Science ®Google Scholar
• WrightISKeeping an eye on the rest of the bodyOphthalmology198794119683684238
   PubMed Web of Science ®Google Scholar
• FishmanGABacaWAlexanderKRVisual acuity in patients with best vitelliform macular dystrophyOphthalmology19931001665708233392
   PubMed Web of Science ®Google Scholar
• WuDZWuLChangFXVisual rehabilitation in low vision patients with aging macular degenerationJ Am Optom Assoc19956639417884140
   PubMedGoogle Scholar
• CarterTLAge-related vision changes: a primary care guideGeriatrics19944937478088558
   PubMed Web of Science ®Google Scholar
• KleinRAge-related eye disease, visual impairment, and driving in the elderlyHum Factors19913352151769672
   PubMed Web of Science ®Google Scholar
• ElliottDBBullimoreMAAssessing the reliability, discriminative ability, and validity of disability glare testsInvest Ophthalmol Vis Sci199334108198425818
   PubMed Web of Science ®Google Scholar
• Van den BergTJTPImportance of pathological intraocular light scatter for visual disabilityDoc Ophthalmol198661327333948666
   PubMed Web of Science ®Google Scholar
• KangJHKimKSChoiSYProtective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modificationBiochim Biophys Acta20021570899611985892
   PubMed Web of Science ®Google Scholar
• AldiniGCariniMBerettaGCarnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reactionBiochem Biophys Res Commun200229869970612419310
   PubMed Web of Science ®Google Scholar
• BabizhayevMADeyevAILens opacity induced by lipid peroxidation products as a model of cataract associated with retinal diseaseBiochim Biophys Acta19891004124332742866
   PubMed Web of Science ®Google Scholar
• BabizhayevMAAntioxidant activity of L-carnosine, a natural histidine-containing dipeptide in crystalline lensBiochim Biophys Acta19891004363712758030
   PubMed Web of Science ®Google Scholar
• HobartLJSeibelIYeargansGSAnti-crosslinking properties of carnosine: Significance of histidineLife Sci20047513798915234195
   PubMed Web of Science ®Google Scholar
• TaylorADaviesKJProtein oxidation and loss of protease activity may lead to cataract formation in the aged lensFree Radic Biol Med1987337173322949
   PubMed Web of Science ®Google Scholar
• MurakamiKJahngenJHLinSWLens proteasome shows enhanced rates of degradation of hydroxyl radical modified alpha-crystallinFree Radic Biol Med19908217222341052
   PubMed Web of Science ®Google Scholar
• SeidlerNWYeargansGSMorganTGCarnosine disaggregates glycated alpha-crystallin: an in vitro studyArch Biochem Biophys20044271101515178493
   PubMed Web of Science ®Google Scholar
• GuiottoARuzzaPBabizhayevMAMalondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogsBioorg Med Chem20071561586317604632
   PubMed Web of Science ®Google Scholar
• HipkissARBrownsonCBertaniMFReaction of carnosine with aged proteins: another protective processAnn N Y Acad Sci20029592859411976203
   PubMed Web of Science ®Google Scholar
• BabizhayevMAFailure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageingBiochim Biophys Acta1996131587998608175
   PubMed Web of Science ®Google Scholar