Effect of Dexmedetomidine on Postoperative Plasma Neurofilament Light Chain in Elderly Patients Undergoing Thoracoscopic Surgery: A Prospective, Randomized Controlled Trial

References

• Evered L, Silbert B, Scott DA, Zetterberg H, Blennow K. Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery results from the CAPACITY and ARCADIAN studies. JAMA Neurol. 2018;75(5):542–547. doi:10.1001/jamaneurol.2017.4913
   PubMed Web of Science ®Google Scholar
• van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012;67(3):280–293. doi:10.1111/j.1365-2044.2011.07008.x
   PubMed Web of Science ®Google Scholar
• Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108(1):18–30. doi:10.1097/01.anes.0000296071.19434.1e
   PubMed Web of Science ®Google Scholar
• McDaniel M, Brudney C. Postoperative delirium: etiology and management. Curr Opin Crit Care. 2012;18(4):372–376. doi:10.1097/MCC.0b013e3283557211
   PubMed Web of Science ®Google Scholar
• Crocker E, Beggs T, Hassan A, et al. Long-term effects of postoperative delirium in patients undergoing cardiac operation: a systematic review. Ann Thorac Surg. 2016;102(4):1391–1399. doi:10.1016/j.athoracsur.2016.04.071
   PubMed Web of Science ®Google Scholar
• Cascella M, Muzio MR, Bimonte S, Cuomo A, Jakobsson JG. Postoperative delirium and postoperative cognitive dysfunction: updates in pathophysiology, potential translational approaches to clinical practice and further research perspectives. Minerva Anestesiol. 2018;84(2):246–260. doi:10.23736/S0375-9393.17.12146-2
   PubMed Web of Science ®Google Scholar
• Vutskits L, Xie Z. Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nat Rev Neurosci. 2016;17(11):705–717. doi:10.1038/nrn.2016.128
   PubMed Web of Science ®Google Scholar
• Ramsay MA, Luterman DL. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology. 2004;101(3):787–790. doi:10.1097/00000542-200409000-00028
   PubMed Web of Science ®Google Scholar
• Paris A, Mantz J, Tonner PH, Hein L, Brede M, Gressens P. The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype. Anesth Analg. 2006;102(2):456–461. doi:10.1213/01.ane.0000194301.79118.e9
   PubMed Web of Science ®Google Scholar
• Degos V, Charpentier TL, Chhor V, et al. Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology. 2013;118(5):1123–1132. doi:10.1097/ALN.0b013e318286cf36
   PubMed Web of Science ®Google Scholar
• Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009;21(6):394–400. doi:10.1016/j.jclinane.2008.10.010
   PubMed Web of Science ®Google Scholar
• Li B, Li Y, Tian S, et al. Anti-inflammatory effects of perioperative dexmedetomidine administered as an adjunct to general anesthesia: a meta-analysis. Sci Rep. 2015;5(1):12342. doi:10.1038/srep12342
   PubMedGoogle Scholar
• Li Y, Wang B, Zhang LL, et al. Dexmedetomidine combined with general anesthesia provides similar intraoperative stress response reduction when compared with a combined general and epidural anesthetic technique. Anesth Analg. 2016;122(4):1202–1210. doi:10.1213/ANE.0000000000001165
   PubMed Web of Science ®Google Scholar
• Ma D, Hossain M, Rajakumaraswamy N, et al. Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype. Eur J Pharmacol. 2004;502(1–2):87–97. doi:10.1016/j.ejphar.2004.08.044
   PubMed Web of Science ®Google Scholar
• Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. doi:10.1016/0022-3956(75)90026-6
   PubMed Web of Science ®Google Scholar
• Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med. 1990;113(12):941–948. doi:10.7326/0003-4819-113-12-941
   PubMed Web of Science ®Google Scholar
• Ashton NJ, Janelidze S, Al Khleifat A, et al. A multicentre validation study of the diagnostic value of plasma neurofilament light. Nat Commun. 2021;12(1):3400. doi:10.1038/s41467-021-23620-z
   PubMedGoogle Scholar
• Fong TG, Vasunilashorn SM, Ngo L, et al. Association of plasma neurofilament light with postoperative delirium. Ann Neurol. 2020;88(5):984–994. doi:10.1002/ana.25889
   PubMed Web of Science ®Google Scholar
• Casey CP, Lindroth H, Mohanty R, et al. Postoperative delirium is associated with increased plasma neurofilament light. Brain. 2020;143(1):47–54. doi:10.1093/brain/awz354
   PubMed Web of Science ®Google Scholar
• Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, Zetterberg H. Neurofilament light chain as a biomarker in neurological disorders. J Neurol Neurosurg Psychiatry. 2019;90(8):870–881. doi:10.1136/jnnp-2018-320106
   PubMed Web of Science ®Google Scholar
• Khalil M, Teunissen CE, Otto M, et al. Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol. 2018;14(10):577–589. doi:10.1038/s41582-018-0058-z
   PubMed Web of Science ®Google Scholar
• Yuan A, Rao MV, Nixon RA. Neurofilaments and neurofilament proteins in health and disease. Cold Spring Harb Perspect Biol. 2017;9(4):a018309. doi:10.1101/cshperspect.a018309
   PubMed Web of Science ®Google Scholar
• Todd J, Freese B, Lu A, et al. Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem. 2007;53(11):1990–1995. doi:10.1373/clinchem.2007.091181
   PubMed Web of Science ®Google Scholar
• Tessler LA, Reifenberger JG, Mitra RD. Protein quantification in complex mixtures by solid phase single-molecule counting. Anal Chem. 2009;81(17):7141–7148. doi:10.1021/ac901068x
   PubMed Web of Science ®Google Scholar
• Rissin DM, Kan CW, Campbell TG, et al. Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol. 2010;28(6):595–599. doi:10.1038/nbt.1641
   PubMed Web of Science ®Google Scholar
• Palmqvist S, Janelidze S, Stomrud E, et al. Performance of fully automated plasma assays as screening tests for Alzheimer disease-related β-amyloid status. JAMA Neurol. 2019;76(9):1060–1069. doi:10.1001/jamaneurol.2019.1632
   PubMed Web of Science ®Google Scholar
• Myles PS, Weitkamp B, Jones K, Melick J, Hensen S. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000;84(1):11–15. doi:10.1093/oxfordjournals.bja.a013366
   PubMed Web of Science ®Google Scholar
• Chen Y, Wang J, Liu S, et al. Development and validation of the Chinese version of the quality of recovery-40 questionnaire. Ther Clin Risk Manag. 2020;16:1165–1173. doi:10.2147/TCRM.S281572
   PubMed Web of Science ®Google Scholar
• Casey JD, Janz DR, Russell DW, et al. Bag-mask ventilation during tracheal intubation of critically ill adults. N Engl J Med. 2019;380(9):811–821. doi:10.1056/NEJMoa1812405
   PubMed Web of Science ®Google Scholar
• Gisslén M, Price RW, Andreasson U, et al. Plasma concentration of the Neurofilament Light Protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-sectional study. EBioMedicine. 2016;3:135–140. doi:10.1016/j.ebiom.2015.11.036
   PubMed Web of Science ®Google Scholar
• Disanto G, Barro C, Benkert P, et al. Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis. Ann Neurol. 2017;81(6):857–870. doi:10.1002/ana.24954
   PubMed Web of Science ®Google Scholar
• Nguyen V, Tiemann D, Park E, et al. Alpha-2 Agonists. Anesthesiol Clin. 2017;35(2):233–245. doi:10.1016/j.anclin.2017.01.009
   PubMedGoogle Scholar
• Stahel PF, Smith WR, Moore EE. Hypoxia and hypotension, the “lethal duo” in traumatic brain injury: implications for prehospital care. Intensive Care Med. 2008;34(3):402–404. doi:10.1007/s00134-007-0889-3
   PubMed Web of Science ®Google Scholar
• Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367(9522):1618–1625. doi:10.1016/S0140-6736(06)68700-X
   PubMed Web of Science ®Google Scholar
• Pak DJ, Yong RJ, Kaye AD, et al. Chronification of pain: mechanisms, current understanding, and clinical implications. Curr Pain Headache Rep. 2018;22(2):9. doi:10.1007/s11916-018-0666-8
   PubMed Web of Science ®Google Scholar