Vascular Aging: Assessment and Intervention

References

• North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–1108. doi:10.1161/CIRCRESAHA.111.246876
   PubMed Web of Science ®Google Scholar
• Cortes-Canteli M, Iadecola C. Alzheimer’s disease and vascular aging: JACC focus seminar. J Am Coll Cardiol. 2020;75(8):942–951. doi:10.1016/j.jacc.2019.10.062
   PubMed Web of Science ®Google Scholar
• Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol a Biol Sci Med Sci. 2010;65(10):1028–1041. doi:10.1093/gerona/glq113
   PubMed Web of Science ®Google Scholar
• Zhang C, Tao J; Cardiovascular Group SoGCMA. Expert consensus on clinical assessment and intervention of vascular aging in China (2018). Aging Med. 2018;1(3):228–237. doi:10.1002/agm2.12049
   PubMedGoogle Scholar
• Tian XL, Li Y. Endothelial cell senescence and age-related vascular diseases. J Genet Genomics. 2014;41(9):485–495. doi:10.1016/j.jgg.2014.08.001
   PubMed Web of Science ®Google Scholar
• Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities. Am J Pathol. 1991;139(5):1119–1129.
   PubMed Web of Science ®Google Scholar
• Cai Y, Song W, Li J, et al. The landscape of aging. Sci China Life Sci. 2022;65(12):2354–2454. doi:10.1007/s11427-022-2161-3
   PubMed Web of Science ®Google Scholar
• Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation. 1986;74(6):1399–1406. doi:10.1161/01.CIR.74.6.1399
   PubMed Web of Science ®Google Scholar
• O’Leary DH, Polak JF, Kronmal RA, et al. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke. 1992;23(12):1752–1760. doi:10.1161/01.STR.23.12.1752
   PubMed Web of Science ®Google Scholar
• Salonen R, Salonen JT. Progression of carotid atherosclerosis and its determinants: a population-based ultrasonography study. Atherosclerosis. 1990;81(1):33–40. doi:10.1016/0021-9150(90)90056-O
   PubMed Web of Science ®Google Scholar
• Homma S, Hirose N, Ishida H, Ishii T, Araki G. Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians. Stroke. 2001;32(4):830–835. doi:10.1161/01.STR.32.4.830
   PubMed Web of Science ®Google Scholar
• Nagai Y, Metter EJ, Earley CJ, et al. Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation. 1998;98(15):1504–1509. doi:10.1161/01.CIR.98.15.1504
   PubMed Web of Science ®Google Scholar
• Ando F, Takekuma K, Niino N, Shimokata H. Ultrasonic evaluation of common carotid intima-media thickness (IMT)--influence of local plaque on the relationship between IMT and age. J Epidemiol. 2000;10(1 Suppl):S10–S17. doi:10.2188/jea.10.1sup_10
   PubMedGoogle Scholar
• Koç AS, Sümbül HE. Age should be considered in cut-off values for increased carotid intima-media thickness. Turk Kardiyol Dern Ars. 2019;47(4):301–311. doi:10.5543/tkda.2018.94770
   PubMed Web of Science ®Google Scholar
• Juonala M, Kähönen M, Laitinen T, et al. Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: the cardiovascular risk in Young Finns Study. Eur Heart J. 2008;29(9):1198–1206. doi:10.1093/eurheartj/ehm556
   PubMed Web of Science ®Google Scholar
• Stein JH, Douglas PS, Srinivasan SR, et al. Distribution and cross-sectional age-related increases of carotid artery intima-media thickness in young adults: the Bogalusa Heart Study. Stroke. 2004;35(12):2782–2787. doi:10.1161/01.STR.0000147719.27237.14
   PubMed Web of Science ®Google Scholar
• Dinenno FA, Jones PP, Seals DR, Tanaka H. Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. Am J Physiol Heart Circ Physiol. 2000;278(4):H1205–H1210. doi:10.1152/ajpheart.2000.278.4.H1205
   PubMed Web of Science ®Google Scholar
• van den Munckhof I, Scholten R, Cable NT, Hopman MT, Green DJ, Thijssen DH. Impact of age and sex on carotid and peripheral arterial wall thickness in humans. Acta Physiol. 2012;206(4):220–228. doi:10.1111/j.1748-1716.2012.02457.x
   PubMed Web of Science ®Google Scholar
• Watanabe D, Gando Y, Murakami H, et al. Longitudinal trajectory of vascular age indices and cardiovascular risk factors: a repeated-measures analysis. Sci Rep. 2023;13(1):5401. doi:10.1038/s41598-023-32443-5
   PubMed Web of Science ®Google Scholar
• O’Rourke MF, Nichols WW. Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension. 2005;45(4):652–658. doi:10.1161/01.HYP.0000153793.84859.b8
   PubMed Web of Science ®Google Scholar
• O’Rourke MF. Arterial aging: pathophysiological principles. Vasc Med. 2007;12(4):329–341. doi:10.1177/1358863X07083392
   PubMed Web of Science ®Google Scholar
• Vriz O, Driussi C, Bettio M, Ferrara F, D’Andrea A, Bossone E. Aortic root dimensions and stiffness in healthy subjects. Am J Cardiol. 2013;112(8):1224–1229. doi:10.1016/j.amjcard.2013.05.068
   PubMed Web of Science ®Google Scholar
• Vasan RS, Larson MG, Benjamin EJ, Levy D. Echocardiographic reference values for aortic root size: the Framingham Heart Study. J Am Soc Echocardiogr. 1995;8(6):793–800. doi:10.1016/S0894-7317(05)80003-3
   PubMedGoogle Scholar
• Roman MJ, Devereux RB, Kramer-Fox R, O’Loughlin J. Two-dimensional echocardiographic aortic root dimensions in normal children and adults. Am J Cardiol. 1989;64(8):507–512. doi:10.1016/0002-9149(89)90430-X
   PubMed Web of Science ®Google Scholar
• Daimon M, Watanabe H, Abe Y, et al. Normal values of echocardiographic parameters in relation to age in a healthy Japanese population: the JAMP study. Circ J. 2008;72(11):1859–1866. doi:10.1253/circj.CJ-08-0171
   PubMed Web of Science ®Google Scholar
• Wang X, Ren XS, An YQ, et al. A specific assessment of the normal anatomy of the aortic root in relation to age and gender. Int J Gen Med. 2021;14:2827–2837. doi:10.2147/IJGM.S312439
   PubMed Web of Science ®Google Scholar
• Devereux RB, de Simone G, Arnett DK, et al. Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age. Am J Cardiol. 2012;110(8):1189–1194. doi:10.1016/j.amjcard.2012.05.063
   PubMed Web of Science ®Google Scholar
• Campens L, Demulier L, De Groote K, et al. Reference values for echocardiographic assessment of the diameter of the aortic root and ascending aorta spanning all age categories. Am J Cardiol. 2014;114(6):914–920. doi:10.1016/j.amjcard.2014.06.024
   PubMed Web of Science ®Google Scholar
• Bjarnegård N, Länne T. Arterial properties along the upper arm in humans: age-related effects and the consequence of anatomical location. J Appl Physiol. 2010;108(1):34–38. doi:10.1152/japplphysiol.00479.2009
   PubMed Web of Science ®Google Scholar
• Sandgren T, Sonesson B, Ahlgren AR, Länne T. Factors predicting the diameter of the popliteal artery in healthy humans. J Vasc Surg. 1998;28(2):284–289. doi:10.1016/S0741-5214(98)70164-8
   PubMed Web of Science ®Google Scholar
• Sandgren T, Sonesson B, Ahlgren R, Länne T. The diameter of the common femoral artery in healthy human: influence of sex, age, and body size. J Vasc Surg. 1999;29(3):503–510. doi:10.1016/S0741-5214(99)70279-X
   PubMed Web of Science ®Google Scholar
• Bia D, Zócalo Y, Farro I, et al. Integrated evaluation of age-related changes in structural and functional vascular parameters used to assess arterial aging, subclinical atherosclerosis, and cardiovascular risk in Uruguayan adults: cUiiDARTE project. Int J Hypertens. 2011;2011:587303. doi:10.4061/2011/587303
   PubMedGoogle Scholar
• Astrand H, Rydén-Ahlgren A, Sandgren T, Länne T. Age-related increase in wall stress of the human abdominal aorta: an in vivo study. J Vasc Surg. 2005;42(5):926–931. doi:10.1016/j.jvs.2005.07.010
   PubMed Web of Science ®Google Scholar
• Egashira K, Inou T, Hirooka Y, et al. Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans. Circulation. 1993;88(1):77–81. doi:10.1161/01.CIR.88.1.77
   PubMed Web of Science ®Google Scholar
• Taddei S, Virdis A, Ghiadoni L, et al. Age-related reduction of NO availability and oxidative stress in humans. Hypertension. 2001;38(2):274–279. doi:10.1161/01.HYP.38.2.274
   PubMed Web of Science ®Google Scholar
• James MA, Tullett J, Hemsley AG, Shore AC. Effects of aging and hypertension on the microcirculation. Hypertension. 2006;47(5):968–974. doi:10.1161/01.HYP.0000209939.05482.61
   PubMed Web of Science ®Google Scholar
• Soltis EE. Effect of age on blood pressure and membrane-dependent vascular responses in the rat. Circ Res. 1987;61(6):889–897. doi:10.1161/01.RES.61.6.889
   PubMed Web of Science ®Google Scholar
• Vanhoutte PM. Aging and vascular responsiveness. J Cardiovasc Pharmacol. 1988;12(8):S11–S19. doi:10.1097/00005344-198812081-00004
   PubMedGoogle Scholar
• Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315(17):1046–1051. doi:10.1056/NEJM198610233151702
   PubMed Web of Science ®Google Scholar
• Egashira K, Inou T, Hirooka Y, et al. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions. J Clin Invest. 1993;91(1):29–37. doi:10.1172/JCI116183
   PubMed Web of Science ®Google Scholar
• Ishida S, Hamasaki S, Kamekou M, et al. Advancing age is associated with diminished vascular remodeling and impaired vasodilation in resistance coronary arteries. Coron Artery Dis. 2003;14(6):443–449. doi:10.1097/00019501-200309000-00005
   PubMed Web of Science ®Google Scholar
• Yasue H, Matsuyama K, Matsuyama K, Okumura K, Morikami Y, Ogawa H. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis. Circulation. 1990;81(2):482–490. doi:10.1161/01.CIR.81.2.482
   PubMed Web of Science ®Google Scholar
• Tew GA, Klonizakis M, Saxton JM. Effects of ageing and fitness on skin-microvessel vasodilator function in humans. Eur J Appl Physiol. 2010;109(2):173–181. doi:10.1007/s00421-009-1342-9
   PubMed Web of Science ®Google Scholar
• Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26(5):1235–1241. doi:10.1016/0735-1097(95)00327-4
   PubMed Web of Science ®Google Scholar
• Anderson EA, Mark AL. Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation. 1989;79(1):93–100. doi:10.1161/01.CIR.79.1.93
   PubMed Web of Science ®Google Scholar
• Cho JM, Park SK, Kwon OS, et al. Activating P2Y1 receptors improves function in arteries with repressed autophagy. Cardiovasc Res. 2023;119(1):252–267. doi:10.1093/cvr/cvac061
   PubMedGoogle Scholar
• Tajima E, Sakuma M, Tokoi S, et al. The comparison of endothelial function between conduit artery and microvasculature in patients with coronary artery disease. Cardiol J. 2020;27(1):38–46. doi:10.5603/CJ.a2018.0077
   PubMed Web of Science ®Google Scholar
• Babcock MC, DuBose LE, Witten TL, et al. Assessment of macrovascular and microvascular function in aging males. J Appl Physiol. 2021;130(1):96–103. doi:10.1152/japplphysiol.00616.2020
   PubMed Web of Science ®Google Scholar
• Donato AJ, Eskurza I, Silver AE, et al. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007;100(11):1659–1666. doi:10.1161/01.RES.0000269183.13937.e8
   PubMed Web of Science ®Google Scholar
• Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. J Physiol. 2006;571(Pt 3):661–668. doi:10.1113/jphysiol.2005.102566
   PubMed Web of Science ®Google Scholar
• Aizawa K, Ramalli A, Sbragi S, et al. Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans. J Physiol. 2019;597(16):4151–4163. doi:10.1113/JP278310
   PubMed Web of Science ®Google Scholar
• Skaug EA, Aspenes ST, Oldervoll L, et al. Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study. Eur J Prev Cardiol. 2013;20(4):531–540. doi:10.1177/2047487312444234
   PubMed Web of Science ®Google Scholar
• Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24(2):471–476. doi:10.1016/0735-1097(94)90305-0
   PubMed Web of Science ®Google Scholar
• McEniery CM, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR, Cockcroft JR. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005;46(9):1753–1760. doi:10.1016/j.jacc.2005.07.037
   PubMed Web of Science ®Google Scholar
• Aguilar VM, Paul A, Lazarko D, Levitan I. Paradigms of endothelial stiffening in cardiovascular disease and vascular aging. Front Physiol. 2022;13:1081119. doi:10.3389/fphys.2022.1081119
   PubMed Web of Science ®Google Scholar
• Bulpitt CJ, Rajkumar C, Cameron JD. Vascular compliance as a measure of biological age. J Am Geriatr Soc. 1999;47(6):657–663. doi:10.1111/j.1532-5415.1999.tb01586.x
   PubMed Web of Science ®Google Scholar
• González-Clemente JM, Cano A, Albert L, et al. Arterial stiffness in type 1 diabetes: the case for the arterial wall itself as a target organ. J Clin Med. 2021;10(16):3616. doi:10.3390/jcm10163616
   PubMed Web of Science ®Google Scholar
• Heffernan KS, Stoner L, London AS, Augustine JA, Lefferts WK. Estimated pulse wave velocity as a measure of vascular aging. PLoS One. 2023;18(1):e0280896. doi:10.1371/journal.pone.0280896
   PubMed Web of Science ®Google Scholar
• Laurent S, Cockcroft J, Van Bortel L, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27(21):2588–2605. doi:10.1093/eurheartj/ehl254
   PubMed Web of Science ®Google Scholar
• Lehmann ED, Hopkins KD, Gosling RG. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Hypertension. 1996;27(5):1188–1191.
   PubMed Web of Science ®Google Scholar
• Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension. 2009;54(6):1328–1336. doi:10.1161/HYPERTENSIONAHA.109.137653
   PubMed Web of Science ®Google Scholar
• Vaitkevicius PV, Fleg JL, Engel JH, et al. Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation. 1993;88(4 Pt 1):1456–1462. doi:10.1161/01.CIR.88.4.1456
   PubMed Web of Science ®Google Scholar
• Avolio AP, Deng FQ, Li WQ, et al. Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation. 1985;71(2):202–210. doi:10.1161/01.CIR.71.2.202
   PubMed Web of Science ®Google Scholar
• Mitchell GF, Parise H, Benjamin EJ, et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43(6):1239–1245. doi:10.1161/01.HYP.0000128420.01881.aa
   PubMed Web of Science ®Google Scholar
• AlGhatrif M, Strait JB, Morrell CH, et al. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension. 2013;62(5):934–941. doi:10.1161/HYPERTENSIONAHA.113.01445
   PubMed Web of Science ®Google Scholar
• Avolio AP, Kuznetsova T, Heyndrickx GR, Kerkhof PLM, Li JK. Arterial flow, pulse pressure and pulse wave velocity in men and women at various ages. Adv Exp Med Biol. 2018;1065:153–168.
   PubMed Web of Science ®Google Scholar
• Reference Values for Arterial Stiffness’ Collaboration. Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’. Eur Heart J. 2010;31(19):2338–2350. doi:10.1093/eurheartj/ehq165
   PubMed Web of Science ®Google Scholar
• Kim OY, Paik JK, Lee JY, Lee SH, Lee JH. Follow-ups of metabolic, inflammatory and oxidative stress markers, and brachial-ankle pulse wave velocity in middle-aged subjects without metabolic syndrome. Clin Exp Hypertens. 2013;35(5):382–388. doi:10.3109/10641963.2012.739232
   PubMed Web of Science ®Google Scholar
• Ishida A, Fujisawa M, Del Saz EG, et al. Arterial stiffness, not systolic blood pressure, increases with age in native Papuan populations. Hypertens Res. 2018;41(7):539–546. doi:10.1038/s41440-018-0047-z
   PubMed Web of Science ®Google Scholar
• Sang Y, Wu X, Miao J, Cao M, Ruan L, Zhang C. Determinants of Brachial-Ankle pulse wave velocity and vascular aging in healthy older subjects. Med Sci Monit. 2020;26:e923112. doi:10.12659/MSM.923112
   PubMed Web of Science ®Google Scholar
• Nichols WW, Singh BM. Augmentation index as a measure of peripheral vascular disease state. Curr Opin Cardiol. 2002;17(5):543–551. doi:10.1097/00001573-200209000-00016
   PubMed Web of Science ®Google Scholar
• Yao Y, Hao L, Xu L, et al. Diastolic augmentation index improves radial augmentation index in assessing arterial stiffness. Sci Rep. 2017;7(1):5864. doi:10.1038/s41598-017-06094-2
   PubMedGoogle Scholar
• Sakurai M, Yamakado T, Kurachi H, et al. The relationship between aortic augmentation index and pulse wave velocity: an invasive study. J Hypertens. 2007;25(2):391–397. doi:10.1097/HJH.0b013e3280115b7c
   PubMed Web of Science ®Google Scholar
• Filipovský J, Tichá M, Cífková R, Lánská V, Stastná V, Roucka P. Large artery stiffness and pulse wave reflection: results of a population-based study. Blood Press. 2005;14(1):45–52. doi:10.1080/08037050510008814
   PubMed Web of Science ®Google Scholar
• Hidvégi EV, Illyés M, Molnár FT, Cziráki A. Influence of body height on aortic systolic pressure augmentation and wave reflection in childhood. J Hum Hypertens. 2015;29(8):495–501. doi:10.1038/jhh.2014.118
   PubMed Web of Science ®Google Scholar
• Diaz A, Zócalo Y, Bia D, Cabrera Fischer E. Reference Intervals of central aortic blood pressure and augmentation index assessed with an oscillometric device in healthy children, adolescents, and young adults from Argentina. Int J Hypertens. 2018;2018:1469651. doi:10.1155/2018/1469651
   PubMed Web of Science ®Google Scholar
• Kelly R, Hayward C, Avolio A, O’Rourke M. Noninvasive determination of age-related changes in the human arterial pulse. Circulation. 1989;80(6):1652–1659. doi:10.1161/01.CIR.80.6.1652
   PubMed Web of Science ®Google Scholar
• Kiran VR, Nabeel PM, Shah MI, Sivaprakasam M, Joseph J. Gaussian-Mixture modelling of a-mode radiofrequency scans for the measurement of arterial wall thickness. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. IEEE; 2021.
   Google Scholar
• Raj KV, Joseph J, Nabeel PM, Sivaprakasam M. Automated measurement of compression-decompression in arterial diameter and wall thickness by image-free ultrasound. Comput Methods Programs Biomed. 2020;194:105557. doi:10.1016/j.cmpb.2020.105557
   PubMed Web of Science ®Google Scholar
• Nabeel PM, Manoj R, Abhidev VV, Joseph J, Kiran VR, Sivaprakasam M. High-throughput vascular screening by ARTSENS pen during a medical camp for early-stage detection of chronic kidney disease. 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society. IEEE; 2020.
   Google Scholar
• Nabeel PM, Raj KV, Joseph J. Image-free ultrasound for local and regional vascular stiffness assessment: the ARTSENS Plus. J Hypertens. 2022;40(8):1537–1544. doi:10.1097/HJH.0000000000003181
   PubMed Web of Science ®Google Scholar
• Joseph J, Nabeel PM, Rao SR, Venkatachalam R, Shah MI, Kaur P. Assessment of carotid arterial stiffness in community settings with ARTSENS(R). IEEE J Transl Eng Health Med. 2021;9:1900111. doi:10.1109/JTEHM.2020.3042386
   PubMedGoogle Scholar
• Joseph J, Kiran R, Nabeel PM, et al. ARTSENS((R)) Pen-portable easy-to-use device for carotid stiffness measurement: technology validation and clinical-utility assessment. Biomed Phys Eng Express. 2020;6(2):025013. doi:10.1088/2057-1976/ab74ff
   PubMed Web of Science ®Google Scholar
• Parker BA, Ridout SJ, Proctor DN. Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries. Am J Physiol Heart Circ Physiol. 2006;291(6):H3043–H3049. doi:10.1152/ajpheart.00190.2006
   PubMed Web of Science ®Google Scholar
• Thijssen DH, de Groot P, Kooijman M, Smits P, Hopman MT. Sympathetic nervous system contributes to the age-related impairment of flow-mediated dilation of the superficial femoral artery. Am J Physiol Heart Circ Physiol. 2006;291(6):H3122–H3129. doi:10.1152/ajpheart.00240.2006
   PubMed Web of Science ®Google Scholar
• Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85(3):221–228. doi:10.1161/01.RES.85.3.221
   PubMed Web of Science ®Google Scholar
• Walter DH, Rittig K, Bahlmann FH, et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation. 2002;105(25):3017–3024. doi:10.1161/01.CIR.0000018166.84319.55
   PubMed Web of Science ®Google Scholar
• Kawamoto A, Gwon HC, Iwaguro H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 2001;103(5):634–637. doi:10.1161/01.CIR.103.5.634
   PubMed Web of Science ®Google Scholar
• Griese DP, Ehsan A, Melo LG, et al. Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. Circulation. 2003;108(21):2710–2715. doi:10.1161/01.CIR.0000096490.16596.A6
   PubMed Web of Science ®Google Scholar
• Fujiyama S, Amano K, Uehira K, et al. Bone marrow monocyte lineage cells adhere on injured endothelium in a monocyte chemoattractant protein-1-dependent manner and accelerate reendothelialization as endothelial progenitor cells. Circ Res. 2003;93(10):980–989. doi:10.1161/01.RES.0000099245.08637.CE
   PubMed Web of Science ®Google Scholar
• Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348(7):593–600. doi:10.1056/NEJMoa022287
   PubMed Web of Science ®Google Scholar
• Tao J, Wang Y, Yang Z, Tu C, Xu MG, Wang JM. Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age. J Hum Hypertens. 2006;20(7):490–495. doi:10.1038/sj.jhh.1001996
   PubMed Web of Science ®Google Scholar
• Yang Z, Chen L, Su C, et al. Impaired endothelial progenitor cell activity is associated with reduced arterial elasticity in patients with essential hypertension. Clin Exp Hypertens. 2010;32(7):444–452. doi:10.3109/10641961003686435
   PubMed Web of Science ®Google Scholar
• Keymel S, Kalka C, Rassaf T, Yeghiazarians Y, Kelm M, Heiss C. Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening. Basic Res Cardiol. 2008;103(6):582–586. doi:10.1007/s00395-008-0742-z
   PubMed Web of Science ®Google Scholar
• Buffa S, Borzì D, Chiarelli R, et al. Biomarkers for vascular ageing in aorta tissues and blood samples. Exp Gerontol. 2019;128:110741. doi:10.1016/j.exger.2019.110741
   PubMed Web of Science ®Google Scholar
• Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621. doi:10.1016/0014-4827(61)90192-6
   PubMed Web of Science ®Google Scholar
• Strazhesko I, Tkacheva O, Boytsov S, et al. Association of insulin resistance, arterial stiffness and telomere length in adults free of cardiovascular diseases. PLoS One. 2015;10(8):e0136676. doi:10.1371/journal.pone.0136676
   PubMed Web of Science ®Google Scholar
• Mehdizadeh M, Aguilar M, Thorin E, Ferbeyre G, Nattel S. The role of cellular senescence in cardiac disease: basic biology and clinical relevance. Nat Rev Cardiol. 2022;19(4):250–264. doi:10.1038/s41569-021-00624-2
   PubMed Web of Science ®Google Scholar
• Strazhesko ID, Tkacheva ON, Akasheva DU, et al. Growth hormone, insulin-like growth factor-1, insulin resistance, and leukocyte telomere length as determinants of arterial aging in subjects free of cardiovascular diseases. Front Genet. 2017;8:198. doi:10.3389/fgene.2017.00198
   PubMed Web of Science ®Google Scholar
• Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the cardiovascular health study. Am J Epidemiol. 2007;165(1):14–21. doi:10.1093/aje/kwj346
   PubMed Web of Science ®Google Scholar
• Spigoni V, Aldigeri R, Picconi A, et al. Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study. Acta Diabetol. 2016;53(4):661–667. doi:10.1007/s00592-016-0857-x
   PubMed Web of Science ®Google Scholar
• Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43(2):182–185. doi:10.1161/01.HYP.0000113081.42868.f4
   PubMed Web of Science ®Google Scholar
• Raymond AR, Norton GR, Woodiwiss AJ, Brooksbank RL. Impact of gender and menopausal status on relationships between biological aging, as indexed by telomere length, and aortic stiffness. Am J Hypertens. 2015;28(5):623–630. doi:10.1093/ajh/hpu212
   PubMed Web of Science ®Google Scholar
• Peng H, Zhu Y, Yeh F, et al. Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study. Aging. 2016;8(8):1583–1592. doi:10.18632/aging.101013
   PubMedGoogle Scholar
• Nakashima H, Ozono R, Suyama C, Sueda T, Kambe M, Oshima T. Telomere attrition in white blood cell correlating with cardiovascular damage. Hypertens Res. 2004;27(5):319–325. doi:10.1291/hypres.27.319
   PubMed Web of Science ®Google Scholar
• Bucala R, Cerami A. Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol. 1992;23:1–34.
   PubMedGoogle Scholar
• Sims TJ, Rasmussen LM, Oxlund H, Bailey AJ. The role of glycation cross-links in diabetic vascular stiffening. Diabetologia. 1996;39(8):946–951. doi:10.1007/BF00403914
   PubMed Web of Science ®Google Scholar
• Basta G. Receptor for advanced glycation endproducts and atherosclerosis: from basic mechanisms to clinical implications. Atherosclerosis. 2008;196(1):9–21. doi:10.1016/j.atherosclerosis.2007.07.025
   PubMed Web of Science ®Google Scholar
• Yonekura H, Yamamoto Y, Sakurai S, et al. Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J. 2003;370(Pt 3):1097–1109. doi:10.1042/bj20021371
   PubMed Web of Science ®Google Scholar
• Prasad K. Is there any evidence that AGE/sRAGE is a universal biomarker/risk marker for diseases? Mol Cell Biochem. 2019;451(1–2):139–144. doi:10.1007/s11010-018-3400-2
   PubMed Web of Science ®Google Scholar
• Geroldi D, Falcone C, Emanuele E, et al. Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension. J Hypertens. 2005;23(9):1725–1729. doi:10.1097/01.hjh.0000177535.45785.64
   PubMed Web of Science ®Google Scholar
• Schram MT, Schalkwijk CG, Bootsma AH, Fuller JH, Chaturvedi N, Stehouwer CD. Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. Hypertension. 2005;46(1):232–237. doi:10.1161/01.HYP.0000164574.60279.ba
   PubMed Web of Science ®Google Scholar
• McNulty M, Mahmud A, Feely J. Advanced glycation end-products and arterial stiffness in hypertension. Am J Hypertens. 2007;20(3):242–247. doi:10.1016/j.amjhyper.2006.08.009
   PubMed Web of Science ®Google Scholar
• Semba RD, Najjar SS, Sun K, Lakatta EG, Ferrucci L. Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults. Am J Hypertens. 2009;22(1):74–79. doi:10.1038/ajh.2008.320
   PubMed Web of Science ®Google Scholar
• Gelžinský J, Mayer O Jr, Seidlerová J, et al. Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness. Hypertens Res. 2020;43(2):111–120. doi:10.1038/s41440-019-0347-y
   PubMed Web of Science ®Google Scholar
• Mayer O, Gelžinský J, Seidlerová J, et al. The role of advanced glycation end products in vascular aging: which parameter is the most suitable as a biomarker? J Hum Hypertens. 2021;35(3):240–249. doi:10.1038/s41371-020-0327-3
   PubMed Web of Science ®Google Scholar
• Gelžinský J, Mayer O Jr, Seidlerová J, et al. Serum biomarkers, skin autofluorescence and other methods. Which parameter better illustrates the relationship between advanced glycation end products and arterial stiffness in the general population? Hypertens Res. 2021;44(5):518–527. doi:10.1038/s41440-020-00601-1
   PubMed Web of Science ®Google Scholar
• Birukov A, Cuadrat R, Polemiti E, Eichelmann F, Schulze MB. Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study. Cardiovasc Diabetol. 2021;20(1):110. doi:10.1186/s12933-021-01296-5
   PubMed Web of Science ®Google Scholar
• Du Clos TW. Function of C-reactive protein. Ann Med. 2000;32(4):274–278. doi:10.3109/07853890009011772
   PubMed Web of Science ®Google Scholar
• Vlachopoulos C, Dima I, Aznaouridis K, et al. Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation. 2005;112(14):2193–2200. doi:10.1161/CIRCULATIONAHA.105.535435
   PubMed Web of Science ®Google Scholar
• Fichtlscherer S, Rosenberger G, Walter DH, Breuer S, Dimmeler S, Zeiher AM. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation. 2000;102(9):1000–1006. doi:10.1161/01.CIR.102.9.1000
   PubMed Web of Science ®Google Scholar
• Mattace-Raso FU, van der Cammen TJ, van der Meer IM, et al. C-reactive protein and arterial stiffness in older adults: the Rotterdam Study. Atherosclerosis. 2004;176(1):111–116. doi:10.1016/j.atherosclerosis.2004.04.014
   PubMed Web of Science ®Google Scholar
• Yasmin MCM, Wallace S, Mackenzie IS, Cockcroft JR, Wilkinson IB, Wilkinson IB. C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler Thromb Vasc Biol. 2004;24(5):969–974. doi:10.1161/01.ATV.zhq0504.0173
   PubMed Web of Science ®Google Scholar
• Kampus P, Kals J, Ristimäe T, Fischer K, Zilmer M, Teesalu R. High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons. J Hypertens. 2004;22(6):1133–1139. doi:10.1097/00004872-200406000-00014
   PubMed Web of Science ®Google Scholar
• Kullo IJ, Seward JB, Bailey KR, et al. C-reactive protein is related to arterial wave reflection and stiffness in asymptomatic subjects from the community. Am J Hypertens. 2005;18(8):1123–1129. doi:10.1016/j.amjhyper.2005.03.730
   PubMed Web of Science ®Google Scholar
• Nakhai-Pour HR, Grobbee DE, Bots ML, Muller M, van der Schouw YT. C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community. J Hum Hypertens. 2007;21(12):949–955. doi:10.1038/sj.jhh.1002255
   PubMed Web of Science ®Google Scholar
• Sun L, Ning C, Liu J, et al. The association between cumulative C-reactive protein and brachial-ankle pulse wave velocity. Aging Clin Exp Res. 2020;32(5):789–796. doi:10.1007/s40520-019-01274-8
   PubMed Web of Science ®Google Scholar
• McEniery CM, Spratt M, Munnery M, et al. An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension. 2010;56(1):36–43. doi:10.1161/HYPERTENSIONAHA.110.150896
   PubMed Web of Science ®Google Scholar
• Khutan H, Aggarwal S, Kajal KS, Garg R, Kaur R, Kaur A. Study of carotid intimal medial thickness in essential hypertension with or without left ventricular hypertrophy. Ann Afr Med. 2017;16(4):192–195. doi:10.4103/aam.aam_9_17
   PubMedGoogle Scholar
• Diaz A, Tringler M, Wray S, Ramirez AJ, Cabrera Fischer EI. The effects of age on pulse wave velocity in untreated hypertension. J Clin Hypertens. 2018;20(2):258–265. doi:10.1111/jch.13167
   Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Kajiyama G, Oshima T. Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. J Am Coll Cardiol. 2001;37(3):863–870. doi:10.1016/S0735-1097(00)01177-3
   PubMed Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Nakagawa K, et al. A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: a multicenter study. J Am Coll Cardiol. 2000;35(2):284–291. doi:10.1016/S0735-1097(99)00561-6
   PubMed Web of Science ®Google Scholar
• Ding H, Liu S, Zhao KX, Pu J, Xie YF, Zhang XW. Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: network Meta-Analysis of Randomized Controlled Trial. Int J Hypertens. 2022;2022:2432567. doi:10.1155/2022/2432567
   PubMed Web of Science ®Google Scholar
• Shahin Y, Khan JA, Samuel N, Chetter I. Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: a meta-analysis of randomised controlled trials. Atherosclerosis. 2011;216(1):7–16. doi:10.1016/j.atherosclerosis.2011.02.044
   PubMed Web of Science ®Google Scholar
• Ong KT, Delerme S, Pannier B, et al. Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients. J Hypertens. 2011;29(6):1034–1042. doi:10.1097/HJH.0b013e328346a583
   PubMed Web of Science ®Google Scholar
• Boutouyrie P, Lacolley P, Briet M, et al. Pharmacological modulation of arterial stiffness. Drugs. 2011;71(13):1689–1701. doi:10.2165/11593790-000000000-00000
   PubMed Web of Science ®Google Scholar
• Williams B, Lacy PS, Thom SM, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006;113(9):1213–1225. doi:10.1161/CIRCULATIONAHA.105.595496
   PubMed Web of Science ®Google Scholar
• Wu CF, Liu PY, Wu TJ, Hung Y, Yang SP, Lin GM. Therapeutic modification of arterial stiffness: an update and comprehensive review. World J Cardiol. 2015;7(11):742–753. doi:10.4330/wjc.v7.i11.742
   PubMedGoogle Scholar
• White WB, Duprez D, St Hillaire R, et al. Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension. Hypertension. 2003;41(5):1021–1026. doi:10.1161/01.HYP.0000067463.13172.EA
   PubMed Web of Science ®Google Scholar
• Chen X, Huang B, Liu M, Li X. Effects of different types of antihypertensive agents on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials. J Thorac Dis. 2015;7(12):2339–2347. doi:10.3978/j.issn.2072-1439.2015.12.58
   PubMed Web of Science ®Google Scholar
• Li X, Chang P, Wang Q, et al. Effects of angiotensin-converting enzyme inhibitors on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials. Cardiovasc Ther. 2020;2020:7056184. doi:10.1155/2020/7056184
   PubMed Web of Science ®Google Scholar
• Alem M, Milia P, Muir S, Lees K, Walters M. Comparison of the effects of diuretics on blood pressure and arterial stiffness in patients with stroke. J Stroke Cerebrovasc Dis. 2008;17(6):373–377. doi:10.1016/j.jstrokecerebrovasdis.2008.04.011
   PubMedGoogle Scholar
• Kithas PA, Supiano MA. Spironolactone and hydrochlorothiazide decrease vascular stiffness and blood pressure in geriatric hypertension. J Am Geriatr Soc. 2010;58(7):1327–1332. doi:10.1111/j.1532-5415.2010.02905.x
   PubMed Web of Science ®Google Scholar
• Mahmud A, Feely J. Effect of angiotensin ii receptor blockade on arterial stiffness: beyond blood pressure reduction. Am J Hypertens. 2002;15(12):1092–1095. doi:10.1016/S0895-7061(02)02982-5
   PubMed Web of Science ®Google Scholar
• Boutouyrie P, Beaussier H, Achouba A, Laurent S. Destiffening effect of valsartan and atenolol: influence of heart rate and blood pressure. J Hypertens. 2014;32(1):108–114. doi:10.1097/HJH.0000000000000014
   PubMed Web of Science ®Google Scholar
• Wilkinson IB, MacCallum H, Flint L, Cockcroft JR, Newby DE, Webb DJ. The influence of heart rate on augmentation index and central arterial pressure in humans. J Physiol. 2000;525(Pt 1):263–270. doi:10.1111/j.1469-7793.2000.t01-1-00263.x
   PubMed Web of Science ®Google Scholar
• Mahmud A, Feely J. Beta-blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection. Am J Hypertens. 2008;21(6):663–667. doi:10.1038/ajh.2008.156
   PubMed Web of Science ®Google Scholar
• McEniery CM, Schmitt M, Qasem A, et al. Nebivolol increases arterial distensibility in vivo. Hypertension. 2004;44(3):305–310. doi:10.1161/01.HYP.0000137983.45556.6e
   PubMed Web of Science ®Google Scholar
• Koumaras C, Tziomalos K, Stavrinou E, et al. Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness. Am Soc Hypertens. 2014;8(2):74–82. doi:10.1016/j.jash.2013.09.001
   PubMed Web of Science ®Google Scholar
• Theodorakopoulou M, Loutradis C, Bikos A, et al. The effects of nebivolol and irbesartan on ambulatory aortic blood pressure and arterial stiffness in hemodialysis patients with intradialytic hypertension. Blood Purif. 2021;50(1):73–83. doi:10.1159/000507913
   PubMed Web of Science ®Google Scholar
• Schram MT, Henry RM, van Dijk RA, et al. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: the Hoorn Study. Hypertension. 2004;43(2):176–181. doi:10.1161/01.HYP.0000111829.46090.92
   PubMed Web of Science ®Google Scholar
• Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med. 1995;46:223–234. doi:10.1146/annurev.med.46.1.223
   PubMed Web of Science ®Google Scholar
• Wan Y, Liu Z, Wu A, et al. Hyperglycemia Promotes Endothelial Cell Senescence through AQR/PLAU Signaling Axis. Int J Mol Sci. 2022;23(5):2879. doi:10.3390/ijms23052879
   PubMed Web of Science ®Google Scholar
• Tian J, Wen Y, Yan L, et al. Vascular endothelial dysfunction in patients with newly diagnosed type 2 diabetes and effects of 2-year and 5-year multifactorial intervention. Echocardiography. 2011;28(10):1133–1140. doi:10.1111/j.1540-8175.2011.01514.x
   PubMed Web of Science ®Google Scholar
• Singh TP, Groehn H, Kazmers A. Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol. 2003;41(4):661–665. doi:10.1016/S0735-1097(02)02894-2
   PubMed Web of Science ®Google Scholar
• Cameron JD, Bulpitt CJ, Pinto ES, Rajkumar C. The aging of elastic and muscular arteries: a comparison of diabetic and nondiabetic subjects. Diabetes Care. 2003;26(7):2133–2138. doi:10.2337/diacare.26.7.2133
   PubMed Web of Science ®Google Scholar
• de la Cruz-Ares S, Cardelo MP, Gutiérrez-Mariscal FM, et al. Endothelial dysfunction and advanced glycation end products in patients with newly diagnosed versus established diabetes: from the CORDIOPREV study. Nutrients. 2020;12(1):238. doi:10.3390/nu12010238
   PubMed Web of Science ®Google Scholar
• Dayem SM, Battah AA, El Bohy AE. Assessment of increase in aortic and carotid intimal medial thickness in type 1 diabetic patients. Open Access Maced J Med Sci. 2016;4(4):630–635. doi:10.3889/oamjms.2016.118
   PubMedGoogle Scholar
• Abdelgawad IY, Agostinucci K, Sadaf B, Grant MKO, Zordoky BN. Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells. Front Aging. 2023;4:1170434. doi:10.3389/fragi.2023.1170434
   PubMedGoogle Scholar
• Timmons JG, Greenlaw N, Boyle JG, et al. Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes: the REMOVAL trial. Diabet Obes Metab. 2021;23(6):1371–1378. doi:10.1111/dom.14350
   PubMed Web of Science ®Google Scholar
• Sardu C, Paolisso P, Sacra C, et al. Effects of metformin therapy on coronary endothelial dysfunction in patients with prediabetes with stable angina and nonobstructive coronary artery stenosis: the CODYCE multicenter prospective study. Diabet Care. 2019;42(10):1946–1955. doi:10.2337/dc18-2356
   PubMed Web of Science ®Google Scholar
• Lunder M, Janić M, Japelj M, Juretič A, Janež A, Šabovič M. Empagliflozin on top of metformin treatment improves arterial function in patients with type 1 diabetes mellitus. Cardiovasc Diabetol. 2018;17(1):153. doi:10.1186/s12933-018-0797-6
   PubMed Web of Science ®Google Scholar
• Agarwal N, Rice SP, Bolusani H, et al. Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial. J Clin Endocrinol Metab. 2010;95(2):722–730. doi:10.1210/jc.2009-1985
   PubMed Web of Science ®Google Scholar
• Minamikawa J, Tanaka S, Yamauchi M, Inoue D, Koshiyama H. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab. 1998;83(5):1818–1820. doi:10.1210/jcem.83.5.4932
   PubMed Web of Science ®Google Scholar
• Sidhu JS, Kaposzta Z, Markus HS, Kaski JC. Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus. Arterioscler Thromb Vasc Biol. 2004;24(5):930–934. doi:10.1161/01.ATV.0000124890.40436.77
   PubMed Web of Science ®Google Scholar
• Hetzel J, Balletshofer B, Rittig K, et al. Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers. Arterioscler Thromb Vasc Biol. 2005;25(9):1804–1809. doi:10.1161/01.ATV.0000176192.16951.9a
   PubMed Web of Science ®Google Scholar
• Satoh N, Ogawa Y, Usui T, et al. Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabet Care. 2003;26(9):2493–2499. doi:10.2337/diacare.26.9.2493
   PubMed Web of Science ®Google Scholar
• Liu L, Ni YQ, Zhan JK, Liu YS. The role of SGLT2 INHIBITORS IN VASCULAR AGING. Aging Dis. 2021;12(5):1323–1336. doi:10.14336/AD.2020.1229
   PubMed Web of Science ®Google Scholar
• Solini A, Giannini L, Seghieri M, et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol. 2017;16(1):138. doi:10.1186/s12933-017-0621-8
   PubMed Web of Science ®Google Scholar
• Solini A, Seghieri M, Giannini L, et al. The effects of dapagliflozin on systemic and renal vascular function display an epigenetic signature. J Clin Endocrinol Metab. 2019;104(10):4253–4263. doi:10.1210/jc.2019-00706
   PubMed Web of Science ®Google Scholar
• Koren S, Shemesh-Bar L, Tirosh A, et al. The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients. Diabet Technol Ther. 2012;14(7):561–567. doi:10.1089/dia.2011.0296
   PubMed Web of Science ®Google Scholar
• Cosenso-Martin LN, Giollo-Júnior LT, Fernandes LAB, et al. Effect of vildagliptin versus glibenclamide on endothelial function and arterial stiffness in patients with type 2 diabetes and hypertension: a randomized controlled trial. Acta Diabetol. 2018;55(12):1237–1245. doi:10.1007/s00592-018-1204-1
   PubMed Web of Science ®Google Scholar
• Nagayama D, Saiki A, Endo K, et al. Improvement of cardio-ankle vascular index by glimepiride in type 2 diabetic patients. Int J Clin Pract. 2010;64(13):1796–1801. doi:10.1111/j.1742-1241.2010.02399.x
   PubMed Web of Science ®Google Scholar
• Chen LL, Yu F, Zeng TS, Liao YF, Li YM, Ding HC. Effects of gliclazide on endothelial function in patients with newly diagnosed type 2 diabetes. Eur J Pharmacol. 2011;659(2–3):296–301. doi:10.1016/j.ejphar.2011.02.044
   PubMed Web of Science ®Google Scholar
• Fava D, Cassone-Faldetta M, Laurenti O, De Luca O, Ghiselli A, De Mattia G. Gliclazide improves anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes. Diabet Med. 2002;19(9):752–757. doi:10.1046/j.1464-5491.2002.00762.x
   PubMed Web of Science ®Google Scholar
• Kraaijenhof J, Muskiet MHA, Tonneijck L, et al. Effects of dipeptidyl peptidase-4 inhibitor linagliptin versus sulphonylurea glimepiride on systemic haemodynamics in overweight patients with type 2 diabetes: a secondary analysis of an 8-week, randomized, controlled, double-blind trial. Diabetes Obes Metab. 2020;22(10):1847–1856. doi:10.1111/dom.14107
   PubMed Web of Science ®Google Scholar
• van Bommel EJM, Smits MM, Ruiter D, et al. Effects of dapagliflozin and gliclazide on the cardiorenal axis in people with type 2 diabetes. J Hypertens. 2020;38(9):1811–1819. doi:10.1097/HJH.0000000000002480
   PubMed Web of Science ®Google Scholar
• Tamura H, Kondo Y, Ito K, Hasebe M, Satoh S, Terauchi Y. Comparison of the effects of empagliflozin and glimepiride on endothelial function in patients with type 2 diabetes: a randomized controlled study. PLoS One. 2022;17(2):e0262831. doi:10.1371/journal.pone.0262831
   PubMed Web of Science ®Google Scholar
• Nomoto H, Miyoshi H, Furumoto T, et al. A comparison of the effects of the GLP-1 analogue liraglutide and insulin glargine on endothelial function and metabolic parameters: a randomized, controlled trial Sapporo Athero-Incretin Study 2 (SAIS2). PLoS One. 2015;10(8):e0135854. doi:10.1371/journal.pone.0135854
   PubMed Web of Science ®Google Scholar
• Gurkan E, Tarkun I, Sahin T, Cetinarslan B, Canturk Z. Evaluation of exenatide versus insulin glargine for the impact on endothelial functions and cardiovascular risk markers. Diabet Res Clin Pract. 2014;106(3):567–575. doi:10.1016/j.diabres.2014.09.046
   PubMed Web of Science ®Google Scholar
• Irace C, De Luca S, Shehaj E, et al. Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: results from an observational research. Diab Vasc Dis Res. 2013;10(1):72–77. doi:10.1177/1479164112449562
   PubMed Web of Science ®Google Scholar
• Koska J, Sands M, Burciu C, et al. Exenatide protects against glucose- and lipid-induced endothelial dysfunction: evidence for direct vasodilation effect of GLP-1 receptor agonists in humans. Diabetes. 2015;64(7):2624–2635. doi:10.2337/db14-0976
   PubMed Web of Science ®Google Scholar
• Song X, Jia H, Jiang Y, et al. Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 Diabetes Mellitus: a meta-analysis. Sci Rep. 2015;5:10202. doi:10.1038/srep10202
   PubMed Web of Science ®Google Scholar
• Scalzo RL, Moreau KL, Ozemek C, et al. Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes. J Diabetes Complications. 2017;31(2):449–455. doi:10.1016/j.jdiacomp.2016.10.003
   PubMed Web of Science ®Google Scholar
• Hong JY, Park KY, Kim BJ, Hwang WM, Kim DH, Lim DM. Effects of short-term exenatide treatment on regional fat distribution, glycated hemoglobin levels, and aortic pulse wave velocity of obese type 2 diabetes mellitus patients. Endocrinol Metab. 2016;31(1):80–85. doi:10.3803/EnM.2016.31.1.80
   Google Scholar
• Patti AM, Nikolic D, Magan-Fernandez A, et al. Exenatide once-weekly improves metabolic parameters, endothelial dysfunction and carotid intima-media thickness in patients with type-2 diabetes: an 8-month prospective study. Diabet Res Clin Pract. 2019;149:163–169. doi:10.1016/j.diabres.2019.02.006
   PubMed Web of Science ®Google Scholar
• Franklin VL, Khan F, Kennedy G, Belch JJ, Greene SA. Intensive insulin therapy improves endothelial function and microvascular reactivity in young people with type 1 diabetes. Diabetologia. 2008;51(2):353–360. doi:10.1007/s00125-007-0870-2
   PubMed Web of Science ®Google Scholar
• Vehkavaara S, Yki-Järvinen H. 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2004;24(2):325–330. doi:10.1161/01.ATV.0000113817.48983.c5
   PubMed Web of Science ®Google Scholar
• Makino H, Tanaka A, Hosoda H, et al. Effect of basal insulin therapy on vascular endothelial function and adipokine profiles in people with Type 2 diabetes. Diabet Med. 2016;33(12):1737–1743. doi:10.1111/dme.13151
   PubMed Web of Science ®Google Scholar
• Pirro M, Schillaci G, Paltriccia R, et al. Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2006;26(11):2530–2535. doi:10.1161/01.ATV.0000243941.72375.15
   PubMed Web of Science ®Google Scholar
• Reiner Ž, Simental-Mendía LE, Ruscica M, et al. Pulse wave velocity as a measure of arterial stiffness in patients with familial hypercholesterolemia: a systematic review and meta-analysis. Arch Med Sci. 2019;15(6):1365–1374. doi:10.5114/aoms.2019.89450
   PubMed Web of Science ®Google Scholar
• Braamskamp M, Langslet G, McCrindle BW, et al. Effect of rosuvastatin on carotid intima-media thickness in children with heterozygous familial hypercholesterolemia: the CHARON Study (Hypercholesterolemia in children and adolescents taking rosuvastatin open label). Circulation. 2017;136(4):359–366. doi:10.1161/CIRCULATIONAHA.116.025158
   PubMed Web of Science ®Google Scholar
• Masoura C, Pitsavos C, Aznaouridis K, Skoumas I, Vlachopoulos C, Stefanadis C. Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis. Atherosclerosis. 2011;214(1):129–138. doi:10.1016/j.atherosclerosis.2010.10.008
   PubMed Web of Science ®Google Scholar
• John S, Schneider MP, Delles C, Jacobi J, Schmieder RE. Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. Am Heart J. 2005;149(3):473. doi:10.1016/j.ahj.2004.06.027
   PubMed Web of Science ®Google Scholar
• Smilde TJ, van Wissen S, Wollersheim H, Trip MD, Kastelein JJ, Stalenhoef AF. Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolaemia (ASAP): a prospective, randomised, double-blind trial. Lancet. 2001;357(9256):577–581. doi:10.1016/S0140-6736(00)04053-8
   PubMed Web of Science ®Google Scholar
• Smilde TJ, van den Berkmortel FW, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef AF. The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest. 2000;30(6):473–480. doi:10.1046/j.1365-2362.2000.00654.x
   PubMed Web of Science ®Google Scholar
• Garcia MM, Varela CG, Silva PF, et al. Endothelial effect of statin therapy at a high dose versus low dose associated with ezetimibe. Arq Bras Cardiol. 2016;106(4):279–288. doi:10.5935/abc.20160048
   PubMed Web of Science ®Google Scholar
• Takase S, Matoba T, Nakashiro S, et al. Ezetimibe in combination with statins ameliorates endothelial dysfunction in coronary arteries after stenting: the CuVIC Trial (Effect of cholesterol absorption inhibitor usage on target vessel dysfunction after coronary stenting), a multicenter randomized controlled trial. Arterioscler Thromb Vasc Biol. 2017;37(2):350–358. doi:10.1161/ATVBAHA.116.308388
   PubMed Web of Science ®Google Scholar
• Upala S, Wirunsawanya K, Jaruvongvanich V, Sanguankeo A. Effects of statin therapy on arterial stiffness: a systematic review and meta-analysis of randomized controlled trial. Int J Cardiol. 2017;227:338–341. doi:10.1016/j.ijcard.2016.11.073
   PubMed Web of Science ®Google Scholar
• Nechyporenko A, Tedla YG, Korcarz C, Tattersall MC, Greenland P, Gepner AD. Association of statin therapy with progression of carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis (Mesa). Hypertens Res. 2023;46(3):679–687. doi:10.1038/s41440-022-01095-9
   PubMed Web of Science ®Google Scholar
• Castejon R, Castañeda A, Sollet A, et al. Short-term atorvastatin therapy improves arterial stiffness of middle-aged systemic lupus erythematosus patients with pathological pulse wave velocity. Lupus. 2017;26(4):355–364. doi:10.1177/0961203316662719
   PubMed Web of Science ®Google Scholar
• Cavero-Redondo I, Deeks JJ, Alvarez-Bueno C, et al. Comparative effect of physical exercise versus statins on improving arterial stiffness in patients with high cardiometabolic risk: a network meta-analysis. PLoS Med. 2021;18(2):e1003543. doi:10.1371/journal.pmed.1003543
   PubMed Web of Science ®Google Scholar
• Gepner AD, Lazar K, Hulle CV, Korcarz CE, Asthana S, Carlsson CM. Effects of simvastatin on augmentation index are transient: outcomes from a randomized controlled trial. J Am Heart Assoc. 2019;8(20):e009792. doi:10.1161/JAHA.118.009792
   PubMed Web of Science ®Google Scholar
• Jankowski J, Floege J, Fliser D, Böhm M, Marx N. Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options. Circulation. 2021;143(11):1157–1172. doi:10.1161/CIRCULATIONAHA.120.050686
   PubMed Web of Science ®Google Scholar
• Fassett RG, Robertson IK, Ball MJ, Geraghty DP, Sharman JE, Coombes JS. Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial. J Atheroscler Thromb. 2010;17(3):235–241. doi:10.5551/jat.2683
   PubMed Web of Science ®Google Scholar
• Kontopoulos AG, Athyros VG, Pehlivanidis AN, Demitriadis DS, Papageorgiou AA, Boudoulas H. Long-term treatment effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients. Curr Med Res Opin. 2003;19(1):22–27. doi:10.1185/030079902125001290
   PubMed Web of Science ®Google Scholar
• Gomez-Sanchez M, Gomez-Sanchez L, Patino-Alonso MC, et al. Vascular aging and its relationship with lifestyles and other risk factors in the general Spanish population: early Vascular Ageing Study. J Hypertens. 2020;38(6):1110–1122. doi:10.1097/HJH.0000000000002373
   PubMed Web of Science ®Google Scholar
• DeSouza CA, Shapiro LF, Clevenger CM, et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000;102(12):1351–1357. doi:10.1161/01.CIR.102.12.1351
   PubMed Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Kurisu S, et al. Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium-derived nitric oxide. Circulation. 1999;100(11):1194–1202. doi:10.1161/01.CIR.100.11.1194
   PubMed Web of Science ®Google Scholar
• Golbidi S, Laher I. Exercise and the aging endothelium. J Diabetes Res. 2013;2013:789607. doi:10.1155/2013/789607
   PubMed Web of Science ®Google Scholar
• Higashi Y, Sasaki S, Sasaki N, et al. Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension. Hypertension. 1999;33(1 Pt 2):591–597. doi:10.1161/01.HYP.33.1.591
   PubMed Web of Science ®Google Scholar
• Sugawara J, Tomoto T, Noda N, et al. Effects of endothelin-related gene polymorphisms and aerobic exercise habit on age-related arterial stiffening: a 10-yr longitudinal study. J Appl Physiol. 2018;124(2):312–320. doi:10.1152/japplphysiol.00697.2017
   PubMed Web of Science ®Google Scholar
• Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102(11):1270–1275. doi:10.1161/01.CIR.102.11.1270
   PubMed Web of Science ®Google Scholar
• Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol. 2002;92(4):1458–1464. doi:10.1152/japplphysiol.00824.2001
   PubMed Web of Science ®Google Scholar
• Popovic M, Puchner S, Endler G, Foraschik C, Minar E, Bucek RA. The effects of endurance and recreational exercise on subclinical evidence of atherosclerosis in young adults. Am J Med Sci. 2010;339(4):332–336. doi:10.1097/MAJ.0b013e3181cefbb9
   PubMed Web of Science ®Google Scholar
• Moreau KL, Donato AJ, Seals DR, et al. Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol. 2002;283(4):H1409–H1417. doi:10.1152/ajpheart.00035.2002
   PubMed Web of Science ®Google Scholar
• Moreau KL, Silver AE, Dinenno FA, Seals DR. Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. Eur J Cardiovasc Prev Rehabil. 2006;13(5):805–811. doi:10.1097/01.hjr.0000230103.55653.42
   PubMedGoogle Scholar
• Dinenno FA, Tanaka H, Monahan KD, et al. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol. 2001;534(Pt 1):287–295. doi:10.1111/j.1469-7793.2001.00287.x
   PubMed Web of Science ®Google Scholar
• Thijssen DH, Cable NT, Green DJ. Impact of exercise training on arterial wall thickness in humans. Clin Sci. 2012;122(7):311–322. doi:10.1042/CS20110469
   Web of Science ®Google Scholar
• Miyachi M, Donato AJ, Yamamoto K, et al. Greater age-related reductions in central arterial compliance in resistance-trained men. Hypertension. 2003;41(1):130–135. doi:10.1161/01.HYP.0000047649.62181.88
   PubMed Web of Science ®Google Scholar
• Jennings A, Berendsen AM, de Groot L, et al. Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults. Hypertension. 2019;73(3):578–586. doi:10.1161/HYPERTENSIONAHA.118.12259
   PubMed Web of Science ®Google Scholar
• Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278(20):1682–1686. doi:10.1001/jama.1997.03550200058032
   PubMed Web of Science ®Google Scholar
• Davis CR, Hodgson JM, Woodman R, Bryan J, Wilson C, Murphy KJ. A Mediterranean diet lowers blood pressure and improves endothelial function: results from the MedLey randomized intervention trial. Am J Clin Nutr. 2017;105(6):1305–1313. doi:10.3945/ajcn.116.146803
   PubMed Web of Science ®Google Scholar
• Rallidis LS, Lekakis J, Kolomvotsou A, et al. Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity. Am J Clin Nutr. 2009;90(2):263–268. doi:10.3945/ajcn.2008.27290
   PubMed Web of Science ®Google Scholar
• Esposito K, Marfella R, Ciotola M, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004;292(12):1440–1446. doi:10.1001/jama.292.12.1440
   PubMed Web of Science ®Google Scholar
• Khoo J, Piantadosi C, Duncan R, et al. Comparing effects of a low-energy diet and a high-protein low-fat diet on sexual and endothelial function, urinary tract symptoms, and inflammation in obese diabetic men. J Sex Med. 2011;8(10):2868–2875. doi:10.1111/j.1743-6109.2011.02417.x
   PubMed Web of Science ®Google Scholar
• Phillips SA, Jurva JW, Syed AQ, et al. Benefit of low-fat over low-carbohydrate diet on endothelial health in obesity. Hypertension. 2008;51(2):376–382. doi:10.1161/HYPERTENSIONAHA.107.101824
   PubMed Web of Science ®Google Scholar
• Pirro M, Schillaci G, Savarese G, et al. Attenuation of inflammation with short-term dietary intervention is associated with a reduction of arterial stiffness in subjects with hypercholesterolaemia. Eur J Cardiovasc Prev Rehabil. 2004;11(6):497–502. doi:10.1097/01.hjr.0000152243.51327.2a
   PubMedGoogle Scholar
• Steffen LM, Jacobs DR Jr, Stevens J, Shahar E, Carithers T, Folsom AR. Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003;78(3):383–390. doi:10.1093/ajcn/78.3.383
   PubMed Web of Science ®Google Scholar
• Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM. Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr. 2007;85(6):1495–1502. doi:10.1093/ajcn/85.6.1495
   PubMed Web of Science ®Google Scholar
• Brock DW, Davis CK, Irving BA, et al. A high-carbohydrate, high-fiber meal improves endothelial function in adults with the metabolic syndrome. Diabetes Care. 2006;29(10):2313–2315. doi:10.2337/dc06-0917
   PubMed Web of Science ®Google Scholar
• Whisner CM, Angadi SS, Weltman NY, et al. Effects of low-fat and high-fat meals, with and without dietary fiber, on postprandial endothelial function, triglyceridemia, and glycemia in adolescents. Nutrients. 2019;11(11):11. doi:10.3390/nu11112626
   Web of Science ®Google Scholar
• Katz DL, Nawaz H, Boukhalil J, et al. Effects of oat and wheat cereals on endothelial responses. Prev Med. 2001;33(5):476–484. doi:10.1006/pmed.2001.0918
   PubMed Web of Science ®Google Scholar
• Edwards DG, Farquhar WB. Vascular effects of dietary salt. Curr Opin Nephrol Hypertens. 2015;24(1):8–13. doi:10.1097/MNH.0000000000000089
   PubMed Web of Science ®Google Scholar
• Tzemos N, Lim PO, Wong S, Struthers AD, MacDonald TM. Adverse cardiovascular effects of acute salt loading in young normotensive individuals. Hypertension. 2008;51(6):1525–1530. doi:10.1161/HYPERTENSIONAHA.108.109868
   PubMed Web of Science ®Google Scholar
• DuPont JJ, Greaney JL, Wenner MM, et al. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens. 2013;31(3):530–536. doi:10.1097/HJH.0b013e32835c6ca8
   PubMed Web of Science ®Google Scholar
• Todd AS, Macginley RJ, Schollum JB, et al. Dietary salt loading impairs arterial vascular reactivity. Am J Clin Nutr. 2010;91(3):557–564. doi:10.3945/ajcn.2009.28645
   PubMed Web of Science ®Google Scholar
• Gates PE, Tanaka H, Hiatt WR, Seals DR. Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension. Hypertension. 2004;44(1):35–41. doi:10.1161/01.HYP.0000132767.74476.64
   PubMed Web of Science ®Google Scholar
• Avolio AP, Clyde KM, Beard TC, Cooke HM, Ho KK, O’Rourke MF. Improved arterial distensibility in normotensive subjects on a low salt diet. Arteriosclerosis. 1986;6(2):166–169. doi:10.1161/01.ATV.6.2.166
   PubMedGoogle Scholar
• Nicoll R, Henein MY. Caloric restriction and its effect on blood pressure, heart rate variability and arterial stiffness and dilatation: a review of the evidence. Int J Mol Sci. 2018;19(3):751. doi:10.3390/ijms19030751
   PubMed Web of Science ®Google Scholar
• Weiss EP, Fontana L. Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol. 2011;301(4):H1205–H1219. doi:10.1152/ajpheart.00685.2011
   PubMed Web of Science ®Google Scholar
• Sasaki S, Higashi Y, Nakagawa K, et al. A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension. Am J Hypertens. 2002;15(4 Pt 1):302–309. doi:10.1016/S0895-7061(01)02322-6
   PubMed Web of Science ®Google Scholar
• Raitakari M, Ilvonen T, Ahotupa M, et al. Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose. Arterioscler Thromb Vasc Biol. 2004;24(1):124–128. doi:10.1161/01.ATV.0000109749.11042.7c
   PubMed Web of Science ®Google Scholar
• Clifton PM, Keogh JB, Foster PR, Noakes M. Effect of weight loss on inflammatory and endothelial markers and FMD using two low-fat diets. Int J Obes. 2005;29(12):1445–1451. doi:10.1038/sj.ijo.0803039
   Web of Science ®Google Scholar
• Di Daniele N, Marrone G, Di Lauro M, et al. Effects of Caloric restriction diet on arterial hypertension and endothelial dysfunction. Nutrients. 2021;13(1):274. doi:10.3390/nu13010274
   PubMed Web of Science ®Google Scholar
• Guo Y, Luo S, Ye Y, Yin S, Fan J, Xia M. Intermittent fasting improves cardiometabolic risk factors and alters gut microbiota in metabolic syndrome patients. J Clin Endocrinol Metab. 2021;106(1):64–79. doi:10.1210/clinem/dgaa644
   PubMed Web of Science ®Google Scholar
• Azemi AK, Siti-Sarah AR, Mokhtar SS, Rasool AHG. Time-Restricted feeding improved vascular endothelial function in a high-fat diet-induced obesity rat model. Vet Sci. 2022;9(5). doi:10.3390/vetsci9050217
   PubMedGoogle Scholar
• Petersen KS, Clifton PM, Lister N, Keogh JB. Effect of weight loss induced by energy restriction on measures of arterial compliance: a systematic review and meta-analysis. Atherosclerosis. 2016;247:7–20. doi:10.1016/j.atherosclerosis.2016.01.042
   PubMed Web of Science ®Google Scholar
• Petersen KS, Blanch N, Keogh JB, Clifton PM. Effect of weight loss on pulse wave velocity: systematic review and meta-analysis. Arterioscler Thromb Vasc Biol. 2015;35(1):243–252. doi:10.1161/ATVBAHA.114.304798
   PubMed Web of Science ®Google Scholar
• Nordstrand N, Gjevestad E, Hertel JK, et al. Arterial stiffness, lifestyle intervention and a low-calorie diet in morbidly obese patients-a nonrandomized clinical trial. Obesity. 2013;21(4):690–697. doi:10.1002/oby.20099
   PubMed Web of Science ®Google Scholar
• Van Schinkel LD, Bakker LE, Jonker JT, et al. Cardiovascular flexibility in middle-aged overweight South Asians vs white Caucasians: response to short-term caloric restriction. Nutr Metab Cardiovasc Dis. 2015;25(4):403–410. doi:10.1016/j.numecd.2014.12.007
   PubMed Web of Science ®Google Scholar
• Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571(7764):183–192. doi:10.1038/s41586-019-1365-2
   PubMed Web of Science ®Google Scholar
• Pignolo RJ, Passos JF, Khosla S, Tchkonia T, Kirkland JL. Reducing Senescent Cell Burden in Aging and Disease. Trends Mol Med. 2020;26(7):630–638. doi:10.1016/j.molmed.2020.03.005
   PubMed Web of Science ®Google Scholar
• Khosla S, Farr JN, Tchkonia T, Kirkland JL. The role of cellular senescence in ageing and endocrine disease. Nat Rev Endocrinol. 2020;16(5):263–275. doi:10.1038/s41574-020-0335-y
   PubMed Web of Science ®Google Scholar
• Roos CM, Zhang B, Palmer AK, et al. Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. Aging Cell. 2016;15(5):973–977. doi:10.1111/acel.12458
   PubMed Web of Science ®Google Scholar
• Childs BG, Gluscevic M, Baker DJ, et al. Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov. 2017;16(10):718–735. doi:10.1038/nrd.2017.116
   PubMed Web of Science ®Google Scholar
• Triggle CR, Mohammed I, Bshesh K, et al. Metformin: is it a drug for all reasons and diseases? Metabolism. 2022;133:155223. doi:10.1016/j.metabol.2022.155223
   PubMed Web of Science ®Google Scholar
• Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017;60(9):1577–1585. doi:10.1007/s00125-017-4342-z
   PubMed Web of Science ®Google Scholar
• Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA. Metformin as a Tool to Target Aging. Cell Metab. 2016;23(6):1060–1065. doi:10.1016/j.cmet.2016.05.011
   PubMed Web of Science ®Google Scholar
• Campbell JM, Bellman SM, Stephenson MD, Lisy K. Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: a systematic review and meta-analysis. Ageing Res Rev. 2017;40:31–44. doi:10.1016/j.arr.2017.08.003
   PubMed Web of Science ®Google Scholar
• Podhorecka M, Ibanez B, Dmoszyńska A. Metformin - its potential anti-cancer and anti-aging effects. Postepy Hig Med Dosw. 2017;71:170–175. doi:10.5604/01.3001.0010.3801
   PubMed Web of Science ®Google Scholar
• Glossmann HH, Lutz OMD. Metformin and aging: a review. Gerontology. 2019;65(6):581–590. doi:10.1159/000502257
   PubMed Web of Science ®Google Scholar
• Soukas AA, Hao H, Wu L. Metformin as anti-aging therapy: is it for everyone? Trends Endocrinol Metab. 2019;30(10):745–755. doi:10.1016/j.tem.2019.07.015
   PubMed Web of Science ®Google Scholar
• Wang C, Chen B, Feng Q, Nie C, Li T. Clinical perspectives and concerns of metformin as an anti-aging drug. Aging Med. 2020;3(4):266–275. doi:10.1002/agm2.12135
   PubMedGoogle Scholar
• Kaeberlein M, Powers RW, Steffen KK, et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005;310(5751):1193–1196. doi:10.1126/science.1115535
   PubMed Web of Science ®Google Scholar
• Bjedov I, Toivonen JM, Kerr F, et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010;11(1):35–46. doi:10.1016/j.cmet.2009.11.010
   PubMed Web of Science ®Google Scholar
• Robida-Stubbs S, Glover-Cutter K, Lamming DW, et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012;15(5):713–724. doi:10.1016/j.cmet.2012.04.007
   PubMed Web of Science ®Google Scholar
• Wang R, Yu Z, Sunchu B, et al. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. Aging Cell. 2017;16(3):564–574. doi:10.1111/acel.12587
   PubMed Web of Science ®Google Scholar
• Lesniewski LA, Seals DR, Walker AE, et al. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017;16(1):17–26. doi:10.1111/acel.12524
   PubMed Web of Science ®Google Scholar
• Joannides R, Etienne I, Iacob M, et al. Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients. Transpl Int. 2010;23(11):1135–1143. doi:10.1111/j.1432-2277.2010.01122.x
   PubMed Web of Science ®Google Scholar
• Joannidès R, Monteil C, de Ligny BH, et al. Immunosuppressant regimen based on sirolimus decreases aortic stiffness in renal transplant recipients in comparison to cyclosporine. Am J Transplant. 2011;11(11):2414–2422. doi:10.1111/j.1600-6143.2011.03697.x
   PubMed Web of Science ®Google Scholar
• Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528–536. doi:10.1016/j.cmet.2011.08.014
   PubMed Web of Science ®Google Scholar
• Yoshida M, Satoh A, Lin JB, et al. Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice. Cell Metab. 2019;30(2):329–342.e325. doi:10.1016/j.cmet.2019.05.015
   PubMed Web of Science ®Google Scholar
• Das A, Huang GX, Bonkowski MS, et al. Impairment of an endothelial NAD(+)-H(2)S signaling network is a reversible cause of vascular aging. Cell. 2018;173(1):74–89.e20. doi:10.1016/j.cell.2018.02.008
   PubMed Web of Science ®Google Scholar
• de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522–530. doi:10.1111/acel.12461
   PubMed Web of Science ®Google Scholar
• Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. doi:10.1038/s41467-018-03421-7
   PubMedGoogle Scholar