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REVIEW

Future Perspectives to Improve CHA2DS2VASc Score: The Role of Left Atrium Remodelling, Inflammation and Genetics in Anticoagulation of Atrial Fibrillation

ORCID Icon, , , , ORCID Icon &
Pages 1737-1748 | Received 26 Jun 2023, Accepted 07 Oct 2023, Published online: 18 Oct 2023

References

  • Lyth J, Svennberg E, Bernfort L, et al. Cost-effectiveness of population screening for atrial fibrillation: the STROKESTOP study. Europ Heart J. 2022;00:1–10.
  • Boriani G, Laroche C, Diemberger I, et al. Asymptomatic atrial fibrillation: clinical correlates, management, and outcomes in the EORP-AF Pilot General Registry. Am J Med. 2015;128(5):509–18.e2. PMID: 25534423. doi:10.1016/j.amjmed.2014.11.026
  • Lip GYH, Laroche C, Popescu MI, et al. Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational research programme-atrial fibrillation general registry pilot phase (EORP-AF Pilot registry). Europ Heart J. 2014;35(47):3365. doi:10.1093/eurheartj/ehu374
  • Boriani G, Laroche C, Diemberger I, et al. Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes. Sci Rep. 2016;6:30271. doi:10.1038/srep30271
  • Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for cardio-thoracic surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European society of cardiology (ESC) developed with the special contribution of the European heart rhythm association (EHRA) of the ESC. Europ Heart J. 2021;42(5):373–498. doi:10.1093/eurheartj/ehaa612
  • Marston NA, Garfinkel AC, Kamanu FK, et al. A polygenic risk score predicts atrial fibrillation in cardiovascular disease. Europ Heart J. 2023;44(3):221–231. doi:10.1093/eurheartj/ehac460
  • Skrebelyte-Strøm L, Morten Rønning O, DahL FA, Steine K, Kjekshus H. Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA. Europace. 2022;24:1881–1888. doi:10.1093/europace/eu
  • Andrade JG, Deyell MW, Macle L, et al. Healthcare utilization and quality of life for atrial fibrillation burden: the CIRCA-DOSE study. Europ Heart J. 2023;44(9):765–776. doi:10.1093/eurheartj/ehac692
  • Svennberg E, Friberg L, Frykman V, Al-Khalili F, Engdahl J, Rosenqvist M. Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial. Lancet. 2021;398(10310):1498–1506. PMID: 34469764. doi:10.1016/S0140-6736(21)01637-8
  • Lowe I. Critique of warfarin dosing: the use of nudging to adjust the load. Academia Letters. 2022;2022:2–8.
  • Thomas FL. Unresolved issues of anticoagulation in atrial fibrillation: age, BMI, reduced dose, and ethnicity. Europ Heart J. 2019;40:1477–1481. doi:10.1093/eurheartj/ehz302
  • Lee J-D, Kuo Y-W, Lee C-P, Huang Y-C, Lee M, Lee T-H. Development and validation of a novel score for predicting paroxysmal atrial fibrillation in acute ischemic stroke. Int J Environ Res. 2022;19:7277. doi:10.3390/ijerph19127277
  • Edmiston MK, Lewis WR. Bleeding risk scores in atrial fibrillation: helpful or harmful? J Am Heart Assoc. 2018;7(18):e010582. PMID: 30371216; PMCID: PMC6222951. doi:10.1161/JAHA.118.010582
  • Zheng Y, Li TYW, Goh FQ, et al. Abnormal left atrial strain is associated with eventual diagnosis of atrial fibrillation in patients with embolic stroke of undetermined source. Europ Heart J. 2023;44:ehac779–002. doi:10.1093/eurheartj/ehac779.002
  • Hijazi Z, Benz AP, Lindbäck J, et al. Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation. Europ Heart J. 2023;44(3):208–218. doi:10.1093/eurheartj/ehac632
  • De Caterina R, Prisco D, Eikelboom JW. Factor XI inhibitors: cardiovascular perspectives. Europ Heart J. 2023;44(4):280–292. doi:10.1093/eurheartj/ehac464
  • Andreotti F, Geisler T, Collet J-P, et al. Acute, periprocedural and long term antithrombotic therapy in older adults: 2022 Update by the ESC working group on thrombosis. Europ Heart J. 2023;44(4):262–279. doi:10.1093/eurheartj/ehac515
  • Andreotti F, Rocca B, Husted S, et al. Antithrombotic therapy in the elderly: expert position paper of the European society of cardiology working group on thrombosis. Europ Heart J. 2015;36:3238–3249. doi:10.1093/eurheartj/ehv304
  • Pennlert J, Overholser R, Asplund K, et al. Optimal timing of anticoagulant treatment after intracerebral hemorrhage in patients with atrial fibrillation. Stroke. 2016;48:314–320. doi:10.1161/STROKEAHA.116.014643
  • Al-Kaisey AM, Kalman JM. Atrial arrhythmia recurrence post-catheter ablation: when perfect is the enemy of good. Europ Heart J. 2023;44(9):777–779. doi:10.1093/eurheartj/ehac736
  • Vincenti A, Genovesi S, Sonaglioni A, et al. Mechanical atrial recovery after cardioversion in persistent atrial fibrillation evaluated by bidimensional speckle tracking echocardiography. J Cardiovasc Med. 2019;20(11):745–751. PMID: 31483328. doi:10.2459/JCM.0000000000000864
  • Freeman JV, Varosy P, Price MJ, et al. The NCDR left atrial appendage occlusion registry. J Am Coll Cardiol. 2020;75(13):1503–1518. PMID: 32238316; PMCID: PMC7205034. doi:10.1016/j.jacc.2019.12.040
  • Manjunath CN, Srinivasa KH, Ravindranath KS, et al. Balloon mitral valvotomy in patients with mitral stenosis and left atrial thrombus. Catheter Cardiovasc Interv. 2009;74(4):653–661. PMID: 19777604. doi:10.1002/ccd.22176
  • Sonaglioni A, Vincenti A, Lombardo M, Anzà C. Left atrial cavity thrombus and fatal systemic embolization in a stroke patient with nonvalvular atrial fibrillation: a caveat against left atrial appendage closure for stroke prevention. J Cardiovasc Echogr. 2020;30(1):41–43. PMID: 32766107; PMCID: PMC7307615. doi:10.4103/jcecho.jcecho_46_19
  • Floria M, Radu S, Gosav EM, et al. Left Atrial structural remodelling in non-valvular atrial fibrillation: what have we learnt from CMR? Diagnostics. 2020;10(3):137. PMID: 32131455; PMCID: PMC7151417. doi:10.3390/diagnostics10030137
  • Cozma D, Streian CG, Vacarescu C, Mornos C. Back to sinus rhythm from atrial flutter or fibrillation: dabigatran is safe without transoesophageal control. Kardiol Pol. 2016;74(5):425–430. PMID: 26502941. doi:10.5603/KP.a2015.0209
  • Luca CT, Crisan S, Cozma D, et al. Arterial hypertension: individual therapeutic approaches-from DNA sequencing to gender differentiation and new therapeutic targets. Pharmaceutics. 2021;13(6):856. PMID: 34207606; PMCID: PMC8229802. doi:10.3390/pharmaceutics13060856
  • Cozma D, Streian CG, Petrescu L, Mornos C. Subclinical left atrium remodelling in patients with frequent premature ventricular contractions. Kardiol Pol. 2014;72(11):1141–1147. PMID: 25522754. doi:10.5603/KP.a2014.0133
  • Douglas PS, Carabello BA, Lang RM, et al. 2019 ACC/AHA/ASE key data elements and definitions for transthoracic echocardiography: a report of the American college of cardiology/American heart association task force on clinical data standards (writing committee to develop cardiovascular endpoints data standards) and the American society of echocardiography. Circ Cardiovasc Imaging. 2019;12(7):e000027. PMID: 31233331. doi:10.1161/HCI.0000000000000027
  • Birnie D, Hudnall H, Lemke B, et al. Continuous optimization of cardiac resynchronization therapy reduces atrial fibrillation in heart failure patients: results of the adaptive cardiac resynchronization therapy trial. Heart Rhythm. 2017;14(12):1820–1825. PMID: 28893549. doi:10.1016/j.hrthm.2017.08.017
  • Vacarescu C, Luca CT, Feier H, et al. Beta blockers and ivabradine titration according to exercise test in LV only fusion CRT pacing. Diagnostics. 2022;12(5):1096. PMID: 35626251; PMCID: PMC9139204. doi:10.3390/diagnostics12051096
  • Goanță EV, Luca CT, Vacarescu C, et al. Non-ischemic super-responders in fusion CRT pacing with normal atrioventricular conduction. Diagnostics. 2022;12(9):2032. PMID: 36140434; PMCID: PMC9497644. doi:10.3390/diagnostics12092032
  • Arboix A, Martí L, Dorison S, Sánchez MJ. Bayés syndrome and acute cardioembolic ischemic stroke. World J Clin Cases. 2017;5(3):93–101. PMID: 28352633. doi:10.12998/wjcc.v5.i3.93
  • Guo Y, Lip GY, Apostolakis S. Inflammation in atrial fibrillation. J Am Coll Cardiol. 2012;60(22):2263–2270. PMID: 23194937. doi:10.1016/j.jacc.2012.04.063
  • Nso N, Bookani KR, Metzl M, Radparvar F. Role of inflammation in atrial fibrillation: a comprehensive review of current knowledge. J Arrhythm. 2020;37(1):1–10. PMID: 33664879; PMCID: PMC7896450. doi:10.1002/joa3.12473
  • Schnabel RB, Larson MG, Yamamoto JF, et al. Relation of multiple inflammatory biomarkers to incident atrial fibrillation. Am J Cardiol. 2009;104(1):92–96. doi:10.1016/j.amjcard.2009.02.053
  • Goette A, Honeycutt C, Langberg JJ. Electrical remodeling in atrial fibrillation. Time course and mechanisms. Circulation. 1996;94(11):2968–2974. doi:10.1161/01.CIR.94.11.2968
  • Karam BS, Chavez‐Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc Diabetol. 2017;16(1):1–9. doi:10.1186/s12933-017-0604-9
  • Korantzopoulos P, Letsas KP, Tse G, Fragakis N, Goudis CA, Liu T. Inflammation and atrial fibrillation: a comprehensive review. J Arrhythm. 2018;34(4):394–401. PMID: 30167010; PMCID: PMC6111477. doi:10.1002/joa3.12077
  • Acampa M, Lazzerini PE, Guideri F, Tassi R, Lo monaco A, Martini G. Inflammation and atrial electrical remodelling in patients with embolic strokes of undetermined source. Heart Lung Circ. 2019;28(6):917–922. PMID: 29887417. doi:10.1016/j.hlc.2018.04.294
  • Lazzerini PE, Laghi-Pasini F, Acampa M, et al. Systemic inflammation rapidly induces reversible atrial electrical remodeling: the role of interleukin-6-mediated changes in connexin expression. J Am Heart Assoc. 2019;8(16):e011006. PMID: 31423933; PMCID: PMC6759884. doi:10.1161/JAHA.118.011006
  • Varghese B, Feldman DI, Chew C, et al. Inflammation, atrial fibrillation, and the potential role for colchicine therapy. Heart Rhythm. 2021;2(3):298–303. PMID: 34337581; PMCID: PMC8322795. doi:10.1016/j.hroo.2021.03.011
  • Ang YS, Rajamani S, Haldar SM, Hüser J. A new therapeutic framework for atrial fibrillation drug development. Circ Res. 2020;127(1):184–201. PMID: 32717173. doi:10.1161/CIRCRESAHA.120.316576
  • Roselli C, Rienstra M, Ellinor PT. Genetics of atrial fibrillation in 2020: GWAS, genome sequencing, polygenic risk, and beyond. Circ Res. 2020;127(1):21–33. PMID: 32716721; PMCID: PMC7388073. doi:10.1161/CIRCRESAHA.120.316575
  • Andersen JH, Andreasen L, Olesen MS. Atrial fibrillation-a complex polygenetic disease. Eur J Hum Genet. 2021;29(7):1051–1060. PMID: 33279945; PMCID: PMC8298566. doi:10.1038/s41431-020-00784-8
  • Lee SP, Ashley EA, Homburger J, et al. SHaRe investigators. incident atrial fibrillation is associated with myh7 sarcomeric gene variation in hypertrophic cardiomyopathy. Circ Heart Fail. 2018;11(9):e005191. PMID: 30354366. doi:10.1161/CIRCHEARTFAILURE.118.005191
  • Buchtele N, Schwameis M, Gilbert JC, Schörgenhofer C, Jilma B. Targeting von Willebrand factor in ischaemic stroke: focus on clinical evidence. Thromb Haemost. 2018;118(6):959–978. PMID: 29847840; PMCID: PMC6193403. doi:10.1055/s-0038-1648251
  • Wysokinski WE, Cohoon KP, Konik EA, et al. Effect of atrial fibrillation duration on plasma von Willebrand factor level. Eur J Haematol. 2017;99(6):569–576. PMID: 28952167; PMCID: PMC6310225. doi:10.1111/ejh.12975
  • Ding WY, Harrison S, Gupta D, Lip GYH, Lane DA. Stroke and bleeding risk assessments in patients with atrial fibrillation: concepts and controversies. Front Med. 2020;7:54. PMID: 32154260; PMCID: PMC7047213. doi:10.3389/fmed.2020.00054
  • Gairolla J, Ahluwalia J, Khullar M, et al. Clopidogrel response in ischemic stroke patients: is polymorphism or gender more important? Results of the CRISP study. J Clin Neurosci. 2020;76:81–86. PMID: 32317191. doi:10.1016/j.jocn.2020.04.038
  • Al-Eitan LN, Almasri AY, Khasawneh RH. Impact of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in Jordanian cardiovascular patients during the initiation therapy. Genes. 2018;9(12):578. PMID: 30486437; PMCID: PMC6316567. doi:10.3390/genes9120578
  • Jorgensen AL, FitzGerald RJ, Oyee J, Pirmohamed M, Williamson PR. Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis. PLoS One. 2012;7(8):e44064. PMID: 22952875; PMCID: PMC3430615. doi:10.1371/journal.pone.0044064
  • Arboix A, García-Eroles L, Massons J, Oliveres M, Targa C. Lacunar infarcts in patients aged 85 years and older. Acta Neurol Scand. 2000;101(1):25–29. PMID: 10660148. doi:10.1034/j.1600-0404.2000.00005.x
  • Chung H, Lee JM. Left atrial remodeling and thromboembolic risk in patients with atrial fibrillation. Int J Heart Fail. 2022;4(1):26–28. PMID: 36262196; PMCID: PMC9383338. doi:10.36628/ijhf.2022.0006
  • Sahin T, Acar E, Celikyurt U, et al. Relation of hs-CRP and BNP levels with the atrial spontaneous echo contrast and thrombi in permanent atrial fibrillation patients with different etiologies. Med Sci Monit. 2012;18(2):CR78–87. PMID: 22293881; PMCID: PMC3560580. doi:10.12659/msm.882461
  • Christophersen IE, Rienstra M, Roselli C, et al. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017;49(6):946–952. PMID: 28416818; PMCID: PMC5585859. doi:10.1038/ng.3843
  • Jansen HJ, Bohne LJ, Gillis AM, Rose RA. Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease. Heart Rhythm. 2020;1(2):147–159. PMID: 34113869; PMCID: PMC8183954. doi:10.1016/j.hroo.2020.05.002
  • Chen YC, Voskoboinik A, Gerche A, Marwick TH, McMullen JR. Prevention of pathological atrial remodeling and atrial fibrillation: JACC state-of-the-art review. J Am Coll Cardiol. 2021;77(22):2846–2864. PMID: 34082914. doi:10.1016/j.jacc.2021.04.012
  • Jumeau C, Rupin A, Chieng-Yane P, et al. Direct thrombin inhibitors prevent left atrial remodeling associated with heart failure in rats. JACC Basic Transl Sci. 2016;1(5):328–339. PMID: 27642643; PMCID: PMC5012373. doi:10.1016/j.jacbts.2016.05.002
  • Marott SC, Nordestgaard BG, Zacho J, et al. Does elevated C-reactive protein increase atrial fibrillation risk? A Mendelian randomization of 47,000 individuals from the general population. J Am Coll Cardiol. 2010;56(10):789–795. PMID: 20797493. doi:10.1016/j.jacc.2010.02.066
  • Fu T, Chen M, Xu L, et al. Association of the MYH6 gene polymorphism with the risk of atrial fibrillation and warfarin anticoagulation therapy. Genet Test Mol Biomarkers. 2021;25(9):590–599. PMID: 34515533. doi:10.1089/gtmb.2021.0025