282
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Low HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) Score Increases the Risk of Post-Stroke Cognitive Impairment: A Multicenter Cohort Study

, , , , , ORCID Icon, , ORCID Icon, , , & show all
Pages 81-92 | Received 28 Jul 2023, Accepted 24 Nov 2023, Published online: 09 Jan 2024

References

  • Blackburn DJ, Bafadhel L, Randall M, et al. Cognitive screening in the acute stroke setting. Age Ageing. 2013;42(1):113–116. doi:10.1093/ageing/afs116
  • Fischer U, Baumgartner A, Arnold M, et al. What is a minor stroke? Stroke. 2010;41(4):661–666. doi:10.1161/STROKEAHA.109.572883
  • Tsutsumiuchi K, Wakabayashi H, Maeda K, et al. Impact of malnutrition on post-stroke cognitive impairment in convalescent rehabilitation ward inpatients. Eur Geriatr Med. 2021;12(1):167–174. doi:10.1007/s41999-020-00393-0
  • Clark C, Richiardi J, Maréchal B, et al. Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people. J Neuroinflammation. 2022;19(1):127. doi:10.1186/s12974-022-02473-3
  • Zou F, Wang J, Han B, et al. Early neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke after successful revascularization. World Neurosurg. 2022;157:e401–e409. doi:10.1016/j.wneu.2021.10.097
  • Ren X, Akiyoshi K, Dziennis S, et al. Regulatory b cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci. 2011;31(23):8556–8563. doi:10.1523/JNEUROSCI.1623-11.2011
  • Lux D, Alakbarzade V, Bridge L, et al. The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke. J Neuroinflammation. 2020;17(1):60. doi:10.1186/s12974-020-01739-y
  • Zhu B, Pan Y, Jing J, et al. Neutrophil counts, neutrophil ratio, and new stroke in minor ischemic stroke or tia. Neurology. 2018;90(21):e1870–e1878. doi:10.1212/WNL.0000000000005554
  • Zhao Q, Gao R, Liu C, et al. Dynamic change of lymphocyte-to-monocyte is associated with the occurrence of pocd after cardiovascular surgery: a prospective observational study. Front Behav Neurosci. 2021;15:646528. doi:10.3389/fnbeh.2021.646528
  • Chen C, Gu L, Chen L, et al. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of prognosis in acute ischemic stroke. Front Neurol. 2020;11:525621. doi:10.3389/fneur.2020.525621
  • Massiot N, Lareyre F, Voury-Pons A, et al. High neutrophil to lymphocyte ratio and platelet to lymphocyte ratio are associated with symptomatic internal carotid artery stenosis. J Stroke Cerebrovascular Dis. 2019;28(1):76–83. doi:10.1016/j.jstrokecerebrovasdis.2018.09.001
  • Yang M, Pan Y, Li Z, et al. Platelet count predicts adverse clinical outcomes after ischemic stroke or tia: subgroup analysis of cnsr ii. Front Neurol. 2019;10:370. doi:10.3389/fneur.2019.00370
  • Du L, Hu X, Zhang B, et al. The relationship of platelet-to-lymphocyte ratio with cognitive decline in t2dm. Diabetol Metab Syndr. 2021;13(1):151. doi:10.1186/s13098-021-00772-y
  • Kirkpatrick AC, Stoner JA, Dale GL, et al. Higher coated-platelet levels in acute stroke are associated with lower cognitive scores at three months post infarction. J Stroke Cerebrovasc Dis. 2019;28(9):2398–2406. doi:10.1016/j.jstrokecerebrovasdis.2019.06.033
  • Gu Y, Wang F, Gong L, et al. A nomogram incorporating red blood cell indices to predict post-stroke cognitive impairment in the intracerebral hemorrhage population. Front Aging Neurosci. 2022;14:985386. doi:10.3389/fnagi.2022.985386
  • Zhang X, Le W. Pathological role of hypoxia in Alzheimer’s disease. Exp Neurol. 2010;223(2):299–303. doi:10.1016/j.expneurol.2009.07.033
  • Jeong SM, Shin DW, Lee JE, et al. Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons. Alzheimers Res Ther. 2017;9(1):94. doi:10.1186/s13195-017-0322-2
  • Ruan Y, Yuan C, Liu Y, et al. High fibrinogen-to-albumin ratio is associated with hemorrhagic transformation in acute ischemic stroke patients. Brain Behav. 2021;11(1):e01855. doi:10.1002/brb3.1855
  • Lee M, Lim JS, Kim Y, et al. Association between geriatric nutritional risk index and post-stroke cognitive outcomes. Nutrients. 2021;13(6):1776.
  • Cong L, Hu L. The value of the combination of hemoglobin, albumin, lymphocyte and platelet in predicting platinum-based chemoradiotherapy response in male patients with esophageal squamous cell carcinoma. Int Immunopharmacol. 2017;46:75–79. doi:10.1016/j.intimp.2017.02.027
  • Peng D, Zhang CJ, Gong YQ, et al. Prognostic significance of halp (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy. Sci Rep. 2018;8(1):794. doi:10.1038/s41598-018-19146-y
  • Xu SS, Li S, Xu HX, et al. Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer. World J Gastroenterol. 2020;26(8):828–838. doi:10.3748/wjg.v26.i8.828
  • Tian M, Li Y, Wang X, et al. The hemoglobin, albumin, lymphocyte, and platelet (halp) score is associated with poor outcome of acute ischemic stroke. Front Neurol. 2020;11:610318. doi:10.3389/fneur.2020.610318
  • Buckinx F, Reginster JY, Petermans J, et al. Relationship between frailty, physical performance and quality of life among nursing home residents: the senior cohort. Aging Clin Exp Res. 2016;28(6):1149–1157. doi:10.1007/s40520-016-0616-4
  • Blodgett JM, Theou O, Howlett SE, et al. A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes. Age Ageing. 2016;45(4):463–468. doi:10.1093/ageing/afw054
  • Elkind MSV, Boehme AK, Smith CJ, et al. Infection as a stroke risk factor and determinant of outcome after stroke. Stroke. 2020;51(10):3156–3168. doi:10.1161/STROKEAHA.120.030429
  • Brainin M, Teuschl Y. Poststroke neurocognitive disorders are mostly defined by strategic lesions. Stroke. 2018;49(11):2563–2564. doi:10.1161/STROKEAHA.118.023090
  • Wang Y, Jing J, Meng X, et al. The third China national stroke registry (cnsr-iii) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics. Stroke Vasc Neurol. 2019;4(3):158–164. doi:10.1136/svn-2019-000242
  • Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the who task force on stroke and other cerebrovascular disorders. Stroke. 1989;20(10):1407–1431. doi:10.1161/01.STR.20.10.1407
  • Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke. 2009;40(6):2276–2293. doi:10.1161/STROKEAHA.108.192218
  • Chen XL, Xue L, Wang W, et al. Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study. Oncotarget. 2015;6(38):41370–41382. doi:10.18632/oncotarget.5629
  • Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal cognitive assessment, moca: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x
  • Zuo L, Dong Y, Zhu R, et al. Screening for cognitive impairment with the Montreal cognitive assessment in Chinese patients with acute mild stroke and transient ischaemic attack: a validation study. BMJ Open. 2016;6(7):e011310. doi:10.1136/bmjopen-2016-011310
  • Myint PK, O. Bachmann M, Loke YK, et al. Important factors in predicting mortality outcome from stroke: findings from the Anglia Stroke Clinical Network Evaluation Study. Age Ageing. 2017;46(1):83–90. doi:10.1093/ageing/afw175
  • Munthe-Kaas R, Aam S, Saltvedt I, et al. Is frailty index a better predictor than pre-stroke modified rankin scale for neurocognitive outcomes 3-months post-stroke? BMC Geriatr. 2022;22(1):139. doi:10.1186/s12877-022-02840-y
  • Atif F, Yousuf S, Espinosa-Garcia C, et al. Post-ischemic stroke systemic inflammation: immunomodulation by progesterone and vitamin d hormone. Neuropharmacology. 2020;181:108327. doi:10.1016/j.neuropharm.2020.108327
  • Evans LE, Taylor JL, Smith CJ, et al. Cardiovascular comorbidities, inflammation, and cerebral small vessel disease. Cardiovasc Res. 2021;117(13):2575–2588. doi:10.1093/cvr/cvab284
  • Li J, Wang J, Wu B, et al. Association between early cognitive impairment and midterm functional outcomes among Chinese acute ischemic stroke patients: a longitudinal study. Front Neurol. 2020;11:20. doi:10.3389/fneur.2020.00020
  • Rawish E, Nording H, Münte T, et al. Platelets as mediators of neuroinflammation and thrombosis. Front Immunol. 2020;11:548631. doi:10.3389/fimmu.2020.548631
  • Sun YY, Wang MQ, Wang Y, et al. Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients. Front Immunol. 2022;13:1000626. doi:10.3389/fimmu.2022.1000626
  • Gong P, Liu Y, Gong Y, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in patients with acute ischemic stroke. J Neuroinflammation. 2021;18(1):51. doi:10.1186/s12974-021-02090-6
  • van der Willik KD, Koppelmans V, Hauptmann M, et al. Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study. Breast Cancer Res. 2018;20(1):135. doi:10.1186/s13058-018-1062-3
  • Zhang G, Pan Y, Zhang R, et al. Prevalence and prognostic significance of malnutrition risk in patients with acute ischemic stroke: results from the third China national stroke registry. Stroke. 2022;53(1):111–119. doi:10.1161/STROKEAHA.121.034366
  • Zielińska-Nowak E, Cichon N, Saluk-Bijak J, et al. Nutritional supplements and neuroprotective diets and their potential clinical significance in post-stroke rehabilitation. Nutrients. 2021;13(8):2704. doi:10.3390/nu13082704
  • Guo N, Zhu Y, Tian D, et al. Role of diet in stroke incidence: an umbrella review of meta-analyses of prospective observational studies. BMC Med. 2022;20(1):194. doi:10.1186/s12916-022-02381-6
  • Aquilani R, Scocchi M, Boschi F, et al. Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke. Nutr Neurosci. 2008;11(5):235–240. doi:10.1179/147683008X301586
  • Verhaar BJH, De Leeuw FA, Doorduijn AS, et al. Nutritional status and structural brain changes in Alzheimer’s disease: the nudad project. Alzheimers Dement. 2020;12:e12063.
  • He W, Ruan Y, Yuan C, et al. Hemoglobin, anemia, and poststroke cognitive impairment: a cohort study. Int J Geriatr Psychiatry. 2020;35(5):564–571. doi:10.1002/gps.5272
  • Xu M, Chen L, Hu Y, et al. The halp (hemoglobin, albumin, lymphocyte, and platelet) score is associated with early-onset post-stroke cognitive impairment. Neurol Sci. 2022;44(1):237–245.
  • Sapp DG, Cormier BM, Rockwood K, et al. The frailty index based on laboratory test data as a tool to investigate the impact of frailty on health outcomes: a systematic review and meta-analysis. Age Ageing. 2023;52(1). doi:10.1093/ageing/afac309
  • Blodgett JM, Theou O, Mitnitski A, et al. Associations between a laboratory frailty index and adverse health outcomes across age and sex. Aging Med. 2019;2(1):11–17. doi:10.1002/agm2.12055
  • Hubbard RE, Rockwood K. Frailty in older women. Maturitas. 2011;69(3):203–207. doi:10.1016/j.maturitas.2011.04.006
  • Bahat G, Tufan F, Bahat Z, et al. Observational cohort study on correlates of mortality in older community-dwelling outpatients: the value of functional assessment. Geriatr Gerontol Int. 2015;15(11):1219–1226. doi:10.1111/ggi.12422
  • Maraj M, Kuśnierz-Cabala B, Dumnicka P, et al. Malnutrition, inflammation, atherosclerosis syndrome (mia) and diet recommendations among end-stage renal disease patients treated with maintenance hemodialysis. Nutrients. 2018;10(1):69. doi:10.3390/nu10010069