The Relationship Between Social Isolation and Cognitive Frailty Among Community-Dwelling Older Adults: The Mediating Role of Depressive Symptoms

References

• Kelaiditi E, Cesari M, Canevelli M, et al. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group. J Nutr Health Aging. 2013;17(9):726–734. doi:10.1007/s12603-013-0367-2
   PubMed Web of Science ®Google Scholar
• Tang KF, Teh PL, Lee SWH. Cognitive Frailty and Functional Disability Among Community-Dwelling Older Adults: a Systematic Review. Innov Aging. 2023;7(1):igad005. doi:10.1093/geroni/igad005
   PubMed Web of Science ®Google Scholar
• Chen B, Wang M, He Q, et al. Impact of frailty, mild cognitive impairment and cognitive frailty on adverse health outcomes among community-dwelling older adults: a systematic review and meta-analysis. Front Med Lausanne. 2022:9. doi:10.3389/fmed.2022.1009794
   Web of Science ®Google Scholar
• Solfrizzi V, Scafato E, Lozupone M, et al. Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: the Italian Longitudinal Study on Aging. Am J Geriatric Psychiatry. 2017;25(11):1236–1248. doi:10.1016/j.jagp.2017.05.018
   PubMed Web of Science ®Google Scholar
• Corral-Pérez J, Casals C, Ávila-Cabeza-de-Vaca L, et al. Health factors associated with cognitive frailty in older adults living in the community. Front Aging Neurosci. 2023:15. doi:10.3389/fnagi.2023.1232460
   Google Scholar
• Lu S, Xu Q, Yu J, et al. Prevalence and possible factors of cognitive frailty in the elderly with hypertension and diabetes. Front Cardiovasc Med. 2022:9. doi:10.3389/fcvm.2022.1054208
   Web of Science ®Google Scholar
• Nicholson NR. Social isolation in older adults: an evolutionary concept analysis. J Adv Nurs. 2009;65(6):1342–1352. doi:10.1111/j.1365-2648.2008.04959.x
   PubMed Web of Science ®Google Scholar
• Tragantzopoulou P, Giannouli V. Social isolation and loneliness in old age: exploring their role in mental and physical health. Psychiatriki. 2021;32(1):59–66. doi:10.22365/jpsych.2021.009
   PubMedGoogle Scholar
• Uno C, Okada K, Matsushita E, et al. Friendship-related social isolation is a potential risk factor for the transition from robust to prefrailty among healthy older adults: a 1-year follow-up study. Eur Geriatr Med. 2021;12(2):285–293. doi:10.1007/s41999-020-00422-y
   PubMed Web of Science ®Google Scholar
• Pan C. Bidirectional Relationships and Mediating Effects Between Social Isolation, Loneliness, and Frailty in Chinese Older Adults. Innov Aging. 2024;8(3):igae019. doi:10.1093/geroni/igae019
   PubMed Web of Science ®Google Scholar
• Nie Y, Richards M, Kubinova R, et al. Social networks and cognitive function in older adults: findings from the HAPIEE study. BMC Geriatr. 2021;21(1):570. doi:10.1186/s12877-021-02531-0
   PubMed Web of Science ®Google Scholar
• Lara E, Caballero FF, Rico‐Uribe LA, et al. Are loneliness and social isolation associated with cognitive decline? Int J Geriatr Psychiatry. 2019;34(11):1613–1622. doi:10.1002/gps.5174
   PubMed Web of Science ®Google Scholar
• Holt-Lunstad J, Steptoe A. Social isolation: an underappreciated determinant of physical health. Curr Opin Psychol. 2022;43:232–237. doi:10.1016/j.copsyc.2021.07.012
   PubMed Web of Science ®Google Scholar
• Noguchi T, Saito M, Aida J, et al. Association between social isolation and depression onset among older adults: a cross-national longitudinal study in England and Japan. BMJ Open. 2021;11(3):e045834. doi:10.1136/bmjopen-2020-045834
   PubMed Web of Science ®Google Scholar
• Ditzen B, Heinrichs M. Psychobiology of social support: the social dimension of stress buffering. Restor Neurol Neurosci. 2014;32(1):149–162. doi:10.3233/RNN-139008
   PubMed Web of Science ®Google Scholar
• Herbolsheimer F, Ungar N, Peter R. Why Is Social Isolation Among Older Adults Associated with Depressive Symptoms? The Mediating Role of Out-of-Home Physical Activity. Int J Behav Med. 2018;25(6):649–657. doi:10.1007/s12529-018-9752-x
   PubMed Web of Science ®Google Scholar
• Zhang T, Ren Y, Shen P, et al. Prevalence and Associated Risk Factors of Cognitive Frailty: a Systematic Review and Meta-Analysis. Front Aging Neurosci. 2022;13:755926. doi:10.3389/fnagi.2021.755926
   PubMed Web of Science ®Google Scholar
• Zhou Q, Zhou J, Min K, et al. The prevalence and determinants of cognitive frailty among institutionalized older adults. J Nurs Sci. 2020;35(09):88–92.
   Google Scholar
• Zou C, Yu Q, Wang C, et al. Association of depression with cognitive frailty: a systematic review and meta-analysis. J Affect Disord. 2023;320:133–139. doi:10.1016/j.jad.2022.09.118
   PubMed Web of Science ®Google Scholar
• Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a Brief Screening Tool For Mild Cognitive Impairment. J Am Geriatr Soc. 2005;53(4):695–699. doi:10.1111/j.1532-5415.2005.53221.x
   PubMed Web of Science ®Google Scholar
• Wang X, Zhang J, Chen C, et al. The association between physical activity and cognitive function in the elderly in rural areas of northern China. Front Aging Neurosci. 2023:15. doi:10.3389/fnagi.2023.1168892
   Google Scholar
• Morris JC. Clinical Dementia Rating: a Reliable and Valid Diagnostic and Staging Measure for Dementia of the Alzheimer Type. Int Psychogeriatr. 1997;9(S1):173–176. doi:10.1017/S1041610297004870
   PubMedGoogle Scholar
• van Kan GA, Rolland YM, Morley JE, et al. Frailty: toward a Clinical Definition. J Am Med Dir Assoc. 2008;9(2):71–72. doi:10.1016/j.jamda.2007.11.005
   PubMed Web of Science ®Google Scholar
• Dong L, Qiao X, Tian X, et al. Cross-Cultural Adaptation and Validation of the FRAIL Scale in Chinese Community-Dwelling Older Adults. J Am Med Dir Assoc. 2018;19(1):12–17. doi:10.1016/j.jamda.2017.06.011
   PubMed Web of Science ®Google Scholar
• Ruan Q, Yu Z, Chen M, et al. Cognitive frailty, a novel target for the prevention of elderly dependency. Ageing Res Rev. 2015;20:1–10. doi:10.1016/j.arr.2014.12.004
   PubMed Web of Science ®Google Scholar
• Lubben J, Blozik E, Gillmann G, et al. Performance of an Abbreviated Version of the Lubben Social Network Scale Among Three European Community-Dwelling Older Adult Populations. Gerontologist. 2006;46(4):503–513. doi:10.1093/geront/46.4.503
   PubMed Web of Science ®Google Scholar
• Chang Q, Sha F, Chan CH, et al. Validation of an abbreviated version of the Lubben Social Network Scale (“LSNS-6”) and its associations with suicidality among older adults in China. PLoS One. 2018;13(8):e0201612. doi:10.1371/journal.pone.0201612
   PubMed Web of Science ®Google Scholar
• Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17(1):37–49. doi:10.1016/0022-3956(82)90033-4
   PubMed Web of Science ®Google Scholar
• Jea W. The prevalence of depressive symptoms and predisposing factors in an elderly Chinese population. Acta Psychiatr Scand. 1994;89(1):8–13. doi:10.1111/j.1600-0447.1994.tb01478.x
   PubMed Web of Science ®Google Scholar
• Hou D, Sun Y, Liu Z, et al. A longitudinal study of factors associated with cognitive frailty in middle-aged and elderly population based on the health ecology model. J Affect Disord. 2024;352:410–418. doi:10.1016/j.jad.2024.02.014
   PubMed Web of Science ®Google Scholar
• Ge L, Yap CW, Heng BH. Associations of social isolation, social participation, and loneliness with frailty in older adults in Singapore: a panel data analysis. BMC Geriatr. 2022;22(1):26. doi:10.1186/s12877-021-02745-2
   PubMed Web of Science ®Google Scholar
• Fang F, Hughes TF, Weinstein A, et al. Social Isolation and Loneliness in a Population Study of Cognitive Impairment: the MYHAT Study. J Appl Gerontol. 2023;42(12):2313–2324. doi:10.1177/07334648231192053
   PubMed Web of Science ®Google Scholar
• Hou P, Xue H, Zhang Y, et al. Mediating Effect of Loneliness in the Relationship between Depressive Symptoms and Cognitive Frailty in Community-Dwelling Older Adults. Brain Sci. 2022;12(10):1341. doi:10.3390/brainsci12101341
   PubMed Web of Science ®Google Scholar
• Zhang C, Zhang H, Zhao M, et al. Reliability, Validity, and Factor Structure of Pittsburgh Sleep Quality Index in Community-Based Centenarians. Front Psychiatry. 2020:11. doi:10.3389/fpsyt.2020.573530
   PubMed Web of Science ®Google Scholar
• Mackinnon DP, Dwyer JH. Estimating Mediated Effects in Prevention Studies. Eval Rev. 1993;17(2):144–158. doi:10.1177/0193841X9301700202
   Web of Science ®Google Scholar
• Kong LL, Xie W, Dong ZY, et al. Cognitive frailty and its association with disability among Chinese community-dwelling older adults: a cross-sectional study. BMC Geriatr. 2024;24(1):189. doi:10.1186/s12877-024-04773-0
   PubMed Web of Science ®Google Scholar
• Kim H, Awata S, Watanabe Y, et al. Cognitive frailty in community-dwelling older Japanese people: prevalence and its association with falls. Geriatr Gerontol Int. 2019;19(7):647–653. doi:10.1111/ggi.13685
   PubMed Web of Science ®Google Scholar
• Malek Rivan NF, Shahar S, Rajab NF, et al. Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study. Clin Interv Aging. 2019;14:1343–1352. doi:10.2147/CIA.S211027
   PubMed Web of Science ®Google Scholar
• Corral-Pérez J, Casals C, Ávila-Cabeza-de-Vaca L, et al. Health factors associated with cognitive frailty in older adults living in the community. Front Aging Neurosci. 2023;15:1232460. doi:10.3389/fnagi.2023.1232460
   PubMed Web of Science ®Google Scholar
• Bu Z, Huang A, Xue M, et al. Cognitive frailty as a predictor of adverse outcomes among older adults: a systematic review and meta-analysis. Brain Behav. 2021;11(1):e01926. doi:10.1002/brb3.1926
   PubMed Web of Science ®Google Scholar
• Makri E, Giannouli V. Cross-cultural cognitive and affective differences in aging: can culture shape the expression and perception of psychopathology in old age? ENCEPHALOS. 2022;59:34–43.
   Google Scholar
• Teo RH, Cheng WH, Cheng LJ, et al. Global prevalence of social isolation among community-dwelling older adults: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2023;107:104904. doi:10.1016/j.archger.2022.104904
   PubMed Web of Science ®Google Scholar
• Yang J, Huang J, Yang X, et al. The association of living alone and social isolation with sarcopenia: a systematic review and meta-analysis. Ageing Res Rev. 2023;91:102043. doi:10.1016/j.arr.2023.102043
   PubMed Web of Science ®Google Scholar
• Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015;22(9):411–416. doi:10.1101/lm.037291.114
   PubMed Web of Science ®Google Scholar
• Bennett DA, Schneider JA, Tang Y, et al. The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006;5:406–412. doi:10.1016/S1474-4422(06)70417–3
   PubMed Web of Science ®Google Scholar
• Luo J, Hendryx M. Mediation analysis of social isolation and mortality by health behaviors. Prev Med (Baltim). 2022;154:106881. doi:10.1016/j.ypmed.2021.106881
   Web of Science ®Google Scholar
• Harasemiw O, Newall N, Shooshtari S, et al. From Social Integration to Social Isolation: the Relationship Between Social Network Types and Perceived Availability of Social Support in a National Sample of Older Canadians. Res Aging. 2018;40(8):715–739. doi:10.1177/0164027517734587
   PubMed Web of Science ®Google Scholar
• Litwin H. The association between social network relationships and depressive symptoms among older Americans: what matters most? International Psychogeriatrics. 2011;23(6):930–940. doi:10.1017/S1041610211000251
   PubMed Web of Science ®Google Scholar
• Cudjoe TKM, Selvakumar S, Chung SE, et al. Getting under the skin: social isolation and biological markers in the National Health and Aging Trends Study. J Am Geriatr Soc. 2022;70(2):408–414. doi:10.1111/jgs.17518
   PubMed Web of Science ®Google Scholar
• Diniz BS, Lima-Costa MF, Peixoto SV, et al. Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality. Am J Geriatr Psychiatry. 2022;30(7):825–833. doi:10.1016/j.jagp.2022.01.012
   PubMed Web of Science ®Google Scholar
• Panza F, Solfrizzi V, Sardone R, et al. Depressive and Biopsychosocial Frailty Phenotypes: impact on Late-life Cognitive Disorders. J Alzheimers Dis. 2023;94(3):879–898. doi:10.3233/JAD-230312
   PubMed Web of Science ®Google Scholar
• Ibarra F, Baez M, Cernuzzi L, et al. A Systematic Review on Technology-Supported Interventions to Improve Old-Age Social Wellbeing: loneliness, Social Isolation, and Connectedness. J Healthc Eng. 2020;2020:2036842. doi:10.1155/2020/2036842
   PubMed Web of Science ®Google Scholar
• Gadbois EA, Jimenez F, Brazier JF, et al. Findings From Talking Tech: a Technology Training Pilot Intervention to Reduce Loneliness and Social Isolation Among Homebound Older Adults. Innov Aging. 2022;6(5):igac040. doi:10.1093/geroni/igac040
   PubMed Web of Science ®Google Scholar