References
- VignolaAMScichiloneNBousquetJBonsignoreGBelliaVAging and asthma: pathophysiological mechanismsAllergy200358316517512653790
- IdeKHayakawaHYagiTDecreased expression of Th2 type cytokine mRNA contributes to the lack of allergic bronchial inflammation in aged ratsJ Immunol1999163139640210384141
- GelfandEWJoethamACuiZHInduction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitizationJ Immunol200417321298130615240723
- HasegawaAMikiTHosokawaHImpaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging miceJ Immunol200617642546255416456016
- BussePJZhangTFSrivastavaKSchofieldBLiXMEffect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged miceClin Exp Allergy20073791392140317845421
- CarnieliDSYoshiokaESilvaLFInflammation and remodeling in infantile, juvenile, and adult allergic sensitized micePediatr Pulmonol201146765066521360835
- HananiaNAKingMJBramanSSAsthma in Elderly workshop participants. Asthma in the elderly: Current understanding and future research needs–a report of a National Institute on Aging (NIA) workshopJ Allergy Clin Immunol2011128Suppl 3S4S2421872730
- IlliSvon MutiusELauSPerennial allergen sensitisation early in life and chronic asthma in children: a birth cohort studyLancet2006368953776377016935687
- GosensRZaagsmaJMeursHHalaykoAJMuscarinic receptor signaling in the pathophysiology of asthma and COPDRespir Res200677316684353
- GwiltCRDonnellyLERogersDFThe non-neuronal cholinergic system in the airways: an unappreciated regulatory role in pulmonary inflammation?Pharmacol Ther2007115220822217597218
- OhtaSOdaNYokoeTEffect of tiotropium bromide on airway inflammation and remodelling in a mouse model of asthmaClin Exp Allerg y201040812661275
- KangJYRheeCKKimJSEffect of tiotropium bromide on airway remodeling in a chronic asthma modelAnn Allergy Asthma Immunol20121091293522727154
- RestrepoRDUse of inhaled anticholinergic agents in obstructive airway diseaseRespir Care200752783385117594728
- VinckenWvan NoordJAGreefhorstAPImproved health outcomes in patients with COPD during 1 yr’s treatment with tiotropiumEur Respir J200219220921611871363
- AnzuetoATashkinDMenjogeSKestenSOne-year analysis of longitudinal changes in spirometry in patients with COPD receiving tiotropiumPulm Pharmacol Ther2005182758115649848
- KerstjensHAEngelMDahlRTiotropium in asthma poorly controlled with standard combination therapyN Engl J Med2012367131198120722938706
- KerstjensHADisseBSchroder-BaboWTiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trialJ Allergy Clin Immunol2011128230831421636120
- NamHSLeeSYKimSJThe soluble tumor necrosis factor-alpha receptor suppresses airway inflammation in a murine model of acute asthmaYonsei Med J200950456957519718408
- MyouSLeffARMyoSBlockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominantnegative phosphoinositide 3-kinase-TATJ Exp Med2003198101573158214623911
- PadridPSnookSFinucaneTPersistent airway hyperresponsive-ness and histologic alterations after chronic antigen challenge in catsAm J Respir Crit Care Med199515111841937812551
- BussePJSchofieldBBirminghamNThe traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged miceAnn Allergy Asthma Immunol2010104323624620377113
- KitaHEosinophils: multifunctional and distinctive propertiesInt Arch Allergy Immunol2013161Suppl 23910.1159/000350662 Epub May 29, 201323711847
- ColemanJMNaikCHolguinFEpithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onsetThorax201267121061106623015684
- ChakirJShannonJMoletSAirway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expressionJ Allergy Clin Immunol200311161293129812789232
- AgacheICiobanuCAgacheCAnghelMIncreased serum IL-17 is an independent risk factor for severe asthmaRespir Med201010481131113720338742
- SilverpilELindénAIL-17 in human asthmaExpert Rev Respir Med20126217318622455490
- Alvarez-RodríguezLLópez-HoyosMMuñoz-CachoPMartínez-TaboadaVMAging is associated with circulating cytokine dysregulationCell Immunol2012273212413222316526
- BousquetJJefferyPKBusseWWJohnsonMVignolaAMAsthma. From bronchoconstriction to airways inflammation and remodelingAm J Respir Crit Care Med200016151720174510806180
- BouletLPSterkPJAirway remodelling: the futureEur Respir J200730583183417978153
- KistemakerLEOenemaTAMeursHGosensRRegulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPDLife Sci20129121–221126113322406302
- MeursHDekkersBGMaarsinghHHalaykoAJZaagsmaJGosensRMuscarinic receptors on airway mesenchymal cells: Novel findings for an ancient targetPulm Pharmacol Ther201326114515522842340
- GraingeCLLauLCWardJAEffect of bronchoconstriction on airway remodeling in asthmaN Engl J Med2011364212006201521612469
- LeeHKLimMYBokSMAge differences in cholinergic airway responsiveness in relation with muscarinic receptor subtypesLife Sci200781320420917568623
- WrightDBTrianTSiddiquiSPhenotype modulation of airway smooth muscle in asthmaPulm Pharmacol Ther2013261424922939888
- LadislasRCellular and molecular mechanisms of aging and age related diseasesPathol Oncol Res2000613910749581