References
- MiniñoAMDeath in the United States, 2011NCHS Data Brief20131151823742756
- WernerCACensus 2010 Brief C2010BR-09: The Older Population: 2010Washington, DCUS Department of Commerce2011 Available at: http://www.census.gov/prod/cen2010/briefs/c2010br-09.pdfAccessed May 28, 2013
- BartynskiWSHellerMTGrahovacSZRothfusWEKurs-LaskyMSevere thoracic kyphosis in the older patient in the absence of vertebral fracture: association of extreme curve with ageAJNR Am J Neuroradiol20052682077208516155162
- SharmaGGoodwinJEffect of aging on respiratory system physiology and immunologyClin Interv Aging20061325326018046878
- EnsrudKEBlackDMHarrisFEttingerBCummingsSRCorrelates of kyphosis in older women. The Fracture Intervention Trial Research GroupJ Am Geriatr Soc19974566826879180660
- FonGTPittMJThiesACJrThoracic kyphosis: range in normal subjectsAJR Am J Roentgenol198013459799836768276
- LombardiIJrOliveiraLMMayerAFJardimJRNatourJEvaluation of pulmonary function and quality of life in women with osteoporosisOsteoporosis Int2005161012471253
- CulhamEGJimenezHAKingCEThoracic kyphosis, rib mobility, and lung volumes in normal women and women with osteoporosisSpine19941911125012558073317
- AroraNSRochesterDFEffect of body weight and muscularity on human diaphragm muscle mass, thickness, and areaJ Appl Physiol198252164707061279
- BrownMHasserEMComplexity of age-related change in skeletal muscleJ Gerontol A Biol Sci Med Sci1996512B117B1238612095
- FreitasFSIbiapinaCCAlvimCGBrittoRRParreiraVFRelationship between cough strength and functional level in elderlyRev Bras Fisioter201014647047621340240
- DeslerCHansenTLFrederiksenJBMarckerMLSinghKKJuel RasmussenLIs there a link between mitochondrial reserve respiratory capacity and aging?J Aging Res20122012 Article ID 192503
- SevranskyJEHaponikEFRespiratory failure in elderly patientsClin Geriatr Med200319120522412735123
- McCoolFDGlobal physiology and pathophysiology of cough: ACCP evidence-based clinical practice guidelinesChest2006129Suppl 148S53S16428691
- HeglandKWTrocheMSDavenportPWCough expired volume and airflow rates during sequential induced coughFront Physiol2013416723847546
- KimJDavenportPSapienzaCEffect of expiratory muscle strength training on elderly cough functionArch Gerontol Geriatr200948336136618457885
- PolkeyMIHarrisMLHughesPDThe contractile properties of the elderly human diaphragmAm J Respir Crit Care Med19971555156015649154857
- TolepKHigginsNMuzaSCrinerGKelsenSGComparison of diaphragm strength between healthy adult elderly and young menAm J Respir Crit Care Med199515226776827633725
- ChenHIKuoCSRelationship between respiratory muscle function and age, sex, and other factorsJ Appl Physiol19896629439482708222
- BerryJKVitaloCALarsonJLPatelMKimMJRespiratory muscle strength in older adultsNurs Res19964531541598637796
- FaulknerJABrooksSVZerbaESkeletal muscle weakness and fatigue in old age: underlying mechanismsAnnu Rev Gerontol Geriatr1990101471662102709
- MobasheriAMendesAFPhysiology and pathophysiology of musculoskeletal aging: current research trends and future prioritiesFront Physiol201347323576994
- WannerAClinical aspects of mucociliary transportAm Rev Respir Dis1977116173125327882
- ChilversMAO’CallaghanCLocal mucociliary defence mechanismsPaediatr Respir Rev200011273416263440
- de Oliveira-MaulJPde CarvalhoHBMiyuki GotoDAging, diabetes, and hypertension are associated with decreased nasal mucociliary clearanceChest201314341091109723100111
- SvartengrenMFalkRPhilipsonKLong-term clearance from small airways decreases with ageEur Respir J200526460961516204590
- AgiusAMSmallmanLAPahorALAge, smoking and nasal ciliary beat frequencyClin Otolaryngol Allied Sci19982332272309669071
- PandaAArjonaASapeyEHuman innate immunosenescence: causes and consequences for immunity in old ageTrends Immunol200930732533319541535
- KovacsEJGrabowskiKADuffnerLAPlackettTPGregoryMSSurvival and cell mediated immunity after burn injury in aged miceJ Am Aging Assoc20022513923604885
- GomezCRNomelliniVBailaHOshimaKKovacsEJComparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administrationShock200931217818418636046
- GómezCRAcuña-CastilloCNishimuraSSerum from aged F344 rats conditions the activation of young macrophagesMech Ageing Dev2006127325726316343598
- ErshlerWBKellerETAge-associated increased interleukin-6 gene expression, late-life diseases, and frailtyAnnu Rev Med20005124527010774463
- RenZGayRThomasAEffect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 miceJ Med Microbiol200958Pt 121559156719729455
- MurcianoCYáñezAO’ConnorJEGozalboDGilMLInfluence of aging on murine neutrophil and macrophage function against Candida albicansFEMS Immunol Med Microbiol200853221422118445021
- Shaik-DasthagirisahebYBKantarciAGibsonFCImmune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalisImmun Ageing201071521114831
- MurcianoCVillamónEYáñezAO’ConnorJEGozalboDGilMLImpaired immune response to Candida albicans in aged miceJ Med Microbiol200655Pt 121649165617108267
- van DuinDMohantySThomasVAge-associated defect in human TLR-1/2 functionJ Immunol2007178297097517202359
- ChelvarajanRLLiuYPopaDMolecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophagesJ Leukoc Biol20067961314132716603589
- GomezCRGoralJRamirezLKopfMKovacsEJAberrant acute-phase response in aged interleukin-6 knockout miceShock200625658158516721265
- GomezCRKaravitisJPalmerJLInterleukin-6 contributes to age-related alteration of cytokine production by macrophagesMediators Inflamm2010201047513920671912
- OlivieriFRippoMRMonsurroVMicroRNAs linking inflamm-aging, cellular senescence and cancerAgeing Res Rev Epub5172013
- OlivieriFLazzariniRRecchioniRMiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodellingAge (Dordr)20133541157117222692818
- MaresCAOjedaSSLiQMorrisEGCoalsonJJTealeJMAged mice display an altered pulmonary host response to Francisella tularensis live vaccine strain (LVS) infectionsExp Gerontol2010452919619825409
- ItoYBetsuyakuTNasuharaYNishimuraMLipopolysaccharide-induced neutrophilic inflammation in the lungs differs with ageExp Lung Res200733737538417849263
- BruunsgaardHAndersen-RanbergKHjelmborgJvPedersenBKJeuneBElevated levels of tumor necrosis factor alpha and mortality in centenariansAm J Med2003115427828312967692
- CarusoCLioDCavalloneLFranceschiCAging, longevity, inflammation, and cancerAnn N Y Acad Sci2004102811315915584
- TurrentineFEWangHSimpsonVBJonesRSSurgical risk factors, morbidity, and mortality in elderly patientsJ Am Coll Surg2006203686587717116555
- ButcherSKKillampalliVChahalHKaya AlparELordJMEffect of age on susceptibility to post-traumatic infection in the elderlyBiochem Soc Trans200331244945112653659
- RenshawMRockwellJEnglemanCGewirtzAKatzJSambharaSCutting edge: impaired Toll-like receptor expression and function in agingJ Immunol200216994697470112391175
- ChelvarajanRLCollinsSMVan WilligenJMBondadaSThe unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage functionJ Leukoc Biol200577450351215629885
- BoehmerEDMeehanMJCutroBTKovacsEJAging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathwayMech Ageing Dev2005126121305131316154177
- MoriyamaCBetsuyakuTItoYAging enhances susceptibility to cigarette smoke-induced inflammation through bronchiolar chemokinesAm J Respir Cell Mol Biol201042330431119491340
- SunilVRPatelKJMainelisGPulmonary effects of inhaled diesel exhaust in aged miceToxicol Appl Pharmacol2009241328329319729031
- McLachlanJASerkinCDMorreyKMBakoucheOAntitumoral properties of aged human monocytesJ Immunol199515428328437814887
- DaceDSApteRSEffect of senescence on macrophage polarization and angiogenesisRejuvenation Res200811117718518279031
- TasatDRMancusoRO’ConnorSMolinariBAge-dependent change in reactive oxygen species and nitric oxide generation by rat alveolar macrophagesAging cell20032315916412882408
- KissinETomasiMMcCartney-FrancisNGibbsCLSmithPDAge-related decline in murine macrophage production of nitric oxideJ Infect Dis19971754100410079086170
- DingAHwangSSchwabREffect of aging on murine macrophages. Diminished response to IFN-gamma for enhanced oxidative metabolismJ Immunol19941535214621527519641
- PolignanoATortorellaCVeneziaAJirilloEAntonaciSAge-associated changes of neutrophil responsiveness in a human healthy elderly populationCytobios1994803221451537774287
- Grolleau-JuliusAHarningEKAbernathyLMYungRLImpaired dendritic cell function in aging leads to defective antitumor immunityCancer Res200868156341634918676859
- ZhaoJZhaoJLeggeKPerlmanSAge-related increases in PGD(2) expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in miceJ Clin Invest2011121124921493022105170
- GruverALHudsonLLSempowskiGDImmunosenescence of ageingJ Pathol2007211214415617200946
- TimmJAThomanMLMaturation of CD4+ lymphocytes in the aged microenvironment results in a memory-enriched populationJ Immunol199916227117179916690
- PosnettDNSinhaRKabakSRussoCClonal populations of T-cells in normal elderly humans: the T-cell equivalent to “benign monoclonal gammapathy”J Exp Med199417926096188294871
- HongMSDanJMChoiJYKangIAge-associated changes in the frequency of naïve, memory and effector CD8+ T-cellsMech Ageing Dev2004125961561815491679
- ProvincialiMMoresiRDonniniALisaRMReference values for CD4+ and CD8+ T lymphocytes with naïve or memory phenotype and their association with mortality in the elderlyGerontology200955331432119190395
- KhanNShariffNCobboldMCytomegalovirus seropositivity drives the CD8 T-cell repertoire toward greater clonality in healthy elderly individualsJ Immunol200216941984199212165524
- MirzaNPollockKHoelzingerDBDominguezALLustgartenJComparative kinetic analyses of gene profiles of naive CD4+ and CD8+ T-cells from young and old animals reveal novel age-related alterationsAging Cell201110585386721711441
- FranceschiCBonafèMValensinSHuman immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological spaceVaccine200018161717172010689155
- MeyerKCErshlerWRosenthalNSLuXGPetersonKImmune dysregulation in the aging human lungAm J Respir Crit Care Med19961533107210798630547
- ZookECKrishackPAZhangSOverexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T-cellsBlood2011118225723573121908422
- SongHPricePWCernyJAge-related changes in antibody repertoire: contribution from T-cellsImmunol Rev199716055629476665
- BuistASMcBurnieMAVollmerWMBOLD Collaborative Research Group. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence studyLancet2007370958974175017765523
- FukuchiYNishimuraMIchinoseMCOPD in Japan: the Nippon COPD Epidemiology studyRespirology20049445846515612956
- MurrayCJLopezADAlternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease StudyLancet19973499064149815049167458
- van DurmeYMVerhammeKMStijnenTPrevalence, incidence, and lifetime risk for the development of COPD in the elderly: the Rotterdam studyChest2009135236837719201711
- SharmaGHananiaNAShimYMThe aging immune system and its relationship to the development of chronic obstructive pulmonary diseaseProc Am Thorac Soc20096757358019934352
- RabeKFHurdSAnzuetoAGlobal Initiative for Chronic Obstructive Lung DiseaseGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med2007176653255517507545
- BrandstetterRDKazemiHAging and the respiratory systemMed Clin North Am19836724194316827880
- DyerCThe interaction of ageing and lung diseaseChron Respir Dis201291636722308556
- OharJASadeghnejadAMeyersDADonohueJFBleeckerERDo symptoms predict COPD in smokers?Chest201013761345135320363841
- AgustiASorianoJBCOPD as a systemic diseaseCOPD20085213313818415812
- PauwelsRABuistASCalverleyPMJenkinsCRHurdSSGOLD Scientific CommitteeGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summaryAm J Respir Crit Care Med200116351256127611316667
- LandboCPrescottELangePVestboJAlmdalTPPrognostic value of nutritional status in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med199916061856186110588597
- NorwoodRJA review of etiologies of depression in COPDInt J Chron Obstruct Pulmon Dis20072448549118268923
- PettyTLBlissPLAmbulatory oxygen therapy, exercise, and survival with advanced chronic obstructive pulmonary disease (the Nocturnal Oxygen Therapy Trial revisited)Respir Care2000452204211 discussion 211–21310771792
- GrantIHeatonRKMcSweenyAJAdamsKMTimmsRMNeuropsychologic findings in hypoxemic chronic obstructive pulmonary diseaseArch Intern Med19821428147014767103628
- HungWWWisniveskyJPSiuALRossJSCognitive decline among patients with chronic obstructive pulmonary diseaseAm J Respir Crit Care Med2009180213413719423714
- KirkilGTugTOzelEBulutSTekatasAMuzMHThe evaluation of cognitive functions with P300 test for chronic obstructive pulmonary disease patients in attack and stable periodClin Neurol Neurosurg2007109755356017532116
- FillitHNashDTRundekTZuckermanACardiovascular risk factors and dementiaAm J Geriatr Pharmacother20086210011818675769
- ArmitageJMWilliamsSJInhaler technique in the elderlyAge Ageing19881742752783177088