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Review

Apathy and depressive symptoms in older people and incident myocardial infarction, stroke, and mortality: a systematic review and meta-analysis of individual participant data

Lisa SM Eurelings1 Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands [email protected]

Jan Willem van Dalen1 Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands [email protected]Correspondence[email protected]

Gerben ter Riet2 Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Eric P Moll van Charante2 Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

Edo Richard1 Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands [email protected];3 Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Centre, Nijmegen, the Netherlands

Willem A van Gool1 Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands [email protected]

Osvaldo P Almeida4 Department of Psychiatry and Clinical Neurosciences, Royal Perth Hospital, University of Western Australia, Perth, Australia;5 Harry Perkins Institute for Medical Research, Western Australian Centre for Health & Ageing, Royal Perth Hospital, University of Western Australia, Perth, Australia

, MD, PhD,

Tiago S Alexandre6 Department of Gerontology, Center for Biological and Health Sciences, Federal University of São Carlos, São Carlos, Brazil

, PhD,

Bernhard T Baune7 Discipline of Psychiatry, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia

, MD, PhD,

Horst Bickel8 Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany

, PhD,

Francesco Cacciatore9 Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy;10 Salvatore Maugeri Foundation, Scientific Institute of Telese Terme, Telese Terme, Italy

, MD, PhD,

Cyrus Cooper11 Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK;12 National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK;13 National Institute for Health Research Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK

, FMedSci,

Ton AJM de Craen14 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

, PhD,

Jean-Marie Degryse15 Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven, Belgium;16 Institut de Recherche Santé et Société, Université Catholique de Louvain, Brussels, Belgium

, MD, PhD,

Mauro Di Bari17 Department of Experimental and Clinical Medicine, Research Unit of Medicine of Aging, University of Florence, Florence, Italy;18 Department of Geriatrics, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy

, MD, PhD,

Yeda A Duarte19 Department of Medical-Surgical Nursing, University of São Paulo, São Paulo, Brazil

, PhD,

Liang Feng20 Department of Health Sciences and System Research, Duke NUS Medical School, National University of Singapore, Singapore;21 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

, PhD,

Nicola Ferrara9 Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy;10 Salvatore Maugeri Foundation, Scientific Institute of Telese Terme, Telese Terme, Italy

, MD,

Leon Flicker22 Centre Medical Research, Western Australian Centre for Health & Ageing, University of Western Australia, Perth, Australia;23 Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia;24 School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

, MB, BS, PhD, FRACP,

Maurizio Gallucci25 Cognitive Impairment Center, Health District of Treviso, Local Health Authority 9 of Treviso, Treviso, Italy;26 Interdisciplinary Geriatric Research Foundation, Treviso, Italy

, MD,

Antonio Guaita27 Golgi Cenci Foundation, Abbiategrasso, Italy

, MD,

Stephanie L Harrison28 Department of Epidemiology and Biostatistics, California Pacific Medical Center Research Institute, University of California, San Francisco, CA, USA

, MPH,

Mindy J Katz29 Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA

, MPH,

Maria L Lebrão30 Department of Epidemiology, Faculty of Public Health, University of São Paulo, São Paulo, Brazil

, PhD,

Jason Leung31 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong

, MSc,

Richard B Lipton29 Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA;32 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA;29 Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA;34 Department of Psychiatry and Behavioral Science, Albert Einstein College of Medicine, New York, NY, USA

, MD,

Marta Mengoni17 Department of Experimental and Clinical Medicine, Research Unit of Medicine of Aging, University of Florence, Florence, Italy

, MD, PhD,

Tze Pin Ng21 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

, MD, PhD,

Truls Østbye35 Center for Aging Research and Education, Duke NUS Medical School, Singapore;36 Duke Global Health Institute, Duke University, Durham, NC, USA

, MD, PhD,

Francesco Panza37 Department of Basic Medicine, Neuroscience, and Sense Organs, Neurodegenerative Disease Unit, Pia Fondazione Cardinale G Panico, University of Bari Aldo Moro, Tricase, Italy

, MD, PhD,

Letizia Polito27 Golgi Cenci Foundation, Abbiategrasso, Italy

, PhD,

Dirk Sander38 Department of Neurology, Benedictus Krankenhaus Tutzing, Technische Universität München, Tutzing, Germany

, MD, PhD,

Vincenzo Solfrizzi39 Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unit, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, University of Bari Aldo Moro, Bari, Italy

, MD, PhD,

Holly E Syddall11 Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

, PhD,

Roos C van der Mast40 Department of Psychiatry, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium;41 Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands

, MD, PhD,

Bert Vaes15 Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven, Belgium;16 Institut de Recherche Santé et Société, Université Catholique de Louvain, Brussels, Belgium

, MD, PhD,

Jean Woo42 Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong

, MD,

Kristine Yaffe30 Department of Epidemiology, Faculty of Public Health, University of São Paulo, São Paulo, Brazil;43 Departments of Psychiatry and Neurology, University of California, San Francisco, CA, USA

, MD, ICARA Study Group,

, PhD,

, PhD,

, PhD,

, MSc,

, PhD &

Frederick W. Unverzagt