Patterns of Multimorbidity and Differences in Healthcare Utilization and Complexity Among Acutely Hospitalized Medical Patients (≥65 Years) – A Latent Class Approach

References

• Hughes LD, McMurdo MET, Guthrie B. Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing. 2013;42(1):62–69. doi:10.1093/ageing/afs10022910303
   PubMed Web of Science ®Google Scholar
• Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu AW. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716–724. doi:10.1001/jama.294.6.71616091574
   PubMed Web of Science ®Google Scholar
• Søndergaard E, Willadsen TG, Guassora AD, et al. Problems and challenges in relation to the treatment of patients with multimorbidity: general practitioners’ views and attitudes. Scand J Prim Health Care. 2015;33(2):121–126. doi:10.3109/02813432.2015.104182826158584
   PubMed Web of Science ®Google Scholar
• van den AM, Buntinx F, Knottnerus JA. Comorbidity or multimorbidity. Eur J General Pract. 1996;2(2):65–70. doi:10.3109/13814789609162146
   Google Scholar
• Nicholson K, Makovski TT, Griffith LE, Raina P, Stranges S, van den Akker M. Multimorbidity and comorbidity revisited: refining the concepts for international health research. J Clin Epidemiol. 2018. doi:10.1016/j.jclinepi.2018.09.008
   Web of Science ®Google Scholar
• Moffat K, Mercer SW. Challenges of managing people with multimorbidity in today’s healthcare systems. BMC Fam Pract. 2015;16(1):129. doi:10.1186/s12875-015-0344-426462820
   PubMed Web of Science ®Google Scholar
• Millar E, Stanley J, Gurney J, et al. Effect of multimorbidity on health service utilisation and health care experiences. J Prim Health Care. 2018;10(1):44–53. doi:10.1071/HC1707430068451
   PubMed Web of Science ®Google Scholar
• McGilton KS, Vellani S, Yeung L, et al. Identifying and understanding the health and social care needs of older adults with multiple chronic conditions and their caregivers: a scoping review. BMC Geriatr. 2018;18. doi:10.1186/s12877-018-0925-x
   Web of Science ®Google Scholar
• Schiøtz ML, Høst D, Frølich A. Involving patients with multimorbidity in service planning: perspectives on continuity and care coordination. J Comorb. 2016;6(2):95–102. doi:10.15256/joc.2016.6.8129090180
   PubMedGoogle Scholar
• Rosbach M, Andersen JS. Patient-experienced burden of treatment in patients with multimorbidity - A systematic review of qualitative data. PLoS One. 2017;12(6):e0179916. doi:10.1371/journal.pone.017991628644877
   PubMed Web of Science ®Google Scholar
• Boyd CM, Landefeld CS, Counsell SR, et al. Recovery of activities of daily living in older adults after hospitalization for acute medical illness. J Am Geriatr Soc. 2008;56(12):2171–2179. doi:10.1111/j.1532-5415.2008.02023.x19093915
   PubMed Web of Science ®Google Scholar
• Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in disability after hospitalization or restricted activity in older persons. JAMA. 2010;304(17):1919–1928. doi:10.1001/jama.2010.156821045098
   PubMed Web of Science ®Google Scholar
• Juul-Larsen HG, Petersen J, Sivertsen DM, Andersen O. Prevalence and overlap of Disease Management Program diseases in older hospitalized patients. Eur J Ageing. 2017;14(3):283–293. doi:10.1007/s10433-017-0412-928936138
   PubMed Web of Science ®Google Scholar
• de Gelder J, Lucke JA, Heim N, et al. Predicting mortality in acutely hospitalized older patients: a retrospective cohort study. Intern Emerg Med. 2016;11:587–594. doi:10.1007/s11739-015-1381-726825335
   PubMed Web of Science ®Google Scholar
• Bodilsen AC, Klausen HH, Petersen J, et al. Prediction of mobility limitations after hospitalization in older medical patients by simple measures of physical performance obtained at admission to the emergency department. PLoS One. 2016;11(5):e0154350. doi:10.1371/journal.pone.015435027195499
   PubMed Web of Science ®Google Scholar
• Juul-Larsen HG, Andersen O, Bandholm T, et al. Differences in function and recovery profiles between patterns of multimorbidity among older medical patients the first year after an acute admission – an exploratory latent class analysis [Submitted]. Archiv Gerontol Geriatr. 2020;86:103956. doi:10.1016/j.archger.2019.103956
   Web of Science ®Google Scholar
• Palladino R, Tayu Lee J, Ashworth M, Triassi M, Millett C. Associations between multimorbidity, healthcare utilisation and health status: evidence from 16 European countries. Age Ageing. 2016;45(3):431–435. doi:10.1093/ageing/afw04427013499
   PubMed Web of Science ®Google Scholar
• Marengoni A, Vetrano DL, Onder G. Target population for clinical trials on multimorbidity: is disease count enough? J Am Med Dir Assoc. 2019;20(2):113–114. doi:10.1016/j.jamda.2018.10.01230503590
   PubMed Web of Science ®Google Scholar
• Islam MM, Valderas JM, Yen L, Dawda P, Jowsey T, McRae IS. Multimorbidity and comorbidity of chronic diseases among the senior australians: prevalence and patterns. PLoS One. 2014;9(1):e83783. doi:10.1371/journal.pone.008378324421905
   PubMed Web of Science ®Google Scholar
• Ng SK, Tawiah R, Sawyer M, Scuffham P. Patterns of multimorbid health conditions: a systematic review of analytical methods and comparison analysis. Int J Epidemiol. 2018;47(5):1687–1704. doi:10.1093/ije/dyy13430016472
   PubMed Web of Science ®Google Scholar
• Olaya B, Moneta MV, Caballero FF, et al. Latent class analysis of multimorbidity patterns and associated outcomes in Spanish older adults: a prospective cohort study. BMC Geriatr. 2017;17. doi:10.1186/s12877-017-0586-1
   Web of Science ®Google Scholar
• Dong H-J, Wressle E, Marcusson J. Multimorbidity patterns of and use of health services by Swedish 85-year-olds: an exploratory study. BMC Geriatr. 2013;13:120. doi:10.1186/1471-2318-13-12024195643
   PubMed Web of Science ®Google Scholar
• Buja A, Rivera M, De Battisti E, et al. Multimorbidity and hospital admissions in high-need, high-cost elderly patients. J Aging Health. 2018:898264318817091. doi:10.1177/089826431881709130522388
   PubMed Web of Science ®Google Scholar
• Collerton J, Jagger C, Yadegarfar ME, et al. Deconstructing complex multimorbidity in the very old: findings from the newcastle 85+ study. Biomed Res Int. 2016;2016:8745670. doi:10.1155/2016/874567026885519
   PubMed Web of Science ®Google Scholar
• Juul-Larsen HG, Christensen LD, Andersen O, Bandholm T, Kaae S, Petersen J. Development of the “chronic condition measurement guide”: a new tool to measure chronic conditions in older people based on ICD-10 and ATC-codes. Eur Geriatr Med. 2019;10:431–444. doi:10.1007/s41999-019-00188-y
   Web of Science ®Google Scholar
• von Elm E, Altman DG, Egger M, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806–808. doi:10.1136/bmj.39335.541782.AD17947786
   PubMed Web of Science ®Google Scholar
• Thygesen LC, Daasnes C, Thaulow I, Brønnum-Hansen H. Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving. Scand J Public Health. 2011;39(7_suppl):12–16. doi:10.1177/140349481139995621898916
   PubMed Web of Science ®Google Scholar
• Pedersen CB. The Danish civil registration system. Scand J Public Health. 2011;39(7 Suppl):22–25. doi:10.1177/140349481038796521775345
   PubMed Web of Science ®Google Scholar
• Lynge E, Sandegaard JL, Rebolj M. The Danish national patient register. Scand J Public Health. 2011;39(7 Suppl):30–33. doi:10.1177/140349481140148221775347
   PubMed Web of Science ®Google Scholar
• Helweg-Larsen K. The Danish register of causes of death. Scand J Public Health. 2011;39(7 Suppl):26–29. doi:10.1177/1403494811399958
   PubMed Web of Science ®Google Scholar
• Kildemoes HW, Sørensen HT, Hallas J. The Danish national prescription registry. Scand J Public Health. 2011;39(7 Suppl):38–41. doi:10.1177/140349481039471721775349
   PubMed Web of Science ®Google Scholar
• Andersen JS, Olivarius NDF, Krasnik A. The Danish national health service register. Scand J Public Health. 2011;39(7 Suppl):34–37. doi:10.1177/140349481039471821775348
   PubMed Web of Science ®Google Scholar
• Jensen VM, Rasmussen AW. Danish education registers. Scand J Public Health. 2011;39(7Suppl):91–94. doi:10.1177/140349481039471521775362
   PubMed Web of Science ®Google Scholar
• Norredam M, Kastrup M, Helweg-Larsen K. Register-based studies on migration, ethnicity, and health. Scand J Public Health. 2011;39(7 Suppl):201–205. doi:10.1177/140349481039656121775384
   PubMed Web of Science ®Google Scholar
• Schram MT, Frijters D, van de Lisdonk EH, et al. Setting and registry characteristics affect the prevalence and nature of multimorbidity in the elderly. J Clin Epidemiol. 2008;61(11):1104–1112. doi:10.1016/j.jclinepi.2007.11.02118538993
   PubMed Web of Science ®Google Scholar
• Fortin M, Bravo G, Hudon C, Vanasse A, Lapointe L. Prevalence of multimorbidity among adults seen in family practice. Ann Fam Med. 2005;3(3):223–228. doi:10.1370/afm.27215928225
   PubMed Web of Science ®Google Scholar
• Hagenaars JA, ed. Applied Latent Class Analysis. Cambridge: Cambridge University Press; 2009.
   Google Scholar
• Nylund KL, Asparouhov T, Muthén BO. Deciding on the number of classes in latent class analysis and growth mixture modeling: a monte carlo simulation study. Struct Equ Modeling. 2007;14(4):535–569. doi:10.1080/10705510701575396
   Web of Science ®Google Scholar
• Bakk Z, Kuha J. Two-step estimation of models between latent classes and external variables. Psychometrika. 2018;83(4):871–892. doi:10.1007/s11336-017-9592-729150817
   PubMed Web of Science ®Google Scholar
• Balakumar P, Maung-U K, Jagadeesh G. Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol Res. 2016;113:600–609. doi:10.1016/j.phrs.2016.09.04027697647
   PubMed Web of Science ®Google Scholar
• Inoue D, Watanabe R, Okazaki R. COPD and osteoporosis: links, risks, and treatment challenges. Int J Chron Obstruct Pulmon Dis. 2016;11:637–648. doi:10.2147/COPD.S7963827099481
   PubMed Web of Science ®Google Scholar
• Whitson HE, Johnson KS, Sloane R, et al. Identifying patterns of multimorbidity in older americans: application of latent class analysis. J Am Geriatr Soc. 2016;64(8):1668–1673. doi:10.1111/jgs.1420127309908
   PubMed Web of Science ®Google Scholar
• Filipčić I, Šimunović Filipčić I, Grošić V, et al. Patterns of chronic physical multimorbidity in psychiatric and general population. J Psychosom Res. 2018;114:72–80. doi:10.1016/j.jpsychores.2018.09.01130314582
   PubMed Web of Science ®Google Scholar
• Nguyen QD, Wu C, Odden MC, Kim DH. Multimorbidity patterns, frailty, and survival in community-dwelling older adults. J Gerontol a Biol Sci Med Sci. 2018. doi:10.1093/gerona/gly205
   Web of Science ®Google Scholar
• Gonsoulin ME, Durazo-Arvizu RA, Goldstein KM, et al. A health profile of senior-aged women veterans: a latent class analysis of condition clusters. Innov Aging. 2017;1(2). doi:10.1093/geroni/igx024
   Web of Science ®Google Scholar
• Buja A, Claus M, Perin L, et al. Multimorbidity patterns in high-need, high-cost elderly patients. PLoS One. 2018;13(12):e0208875. doi:10.1371/journal.pone.020887530557384
   PubMed Web of Science ®Google Scholar
• Gellert P, von Berenberg P, Zahn T, Neuwirth J, Kuhlmey A, Dräger D. Multimorbidity profiles in german centenarians: a latent class analysis of health insurance data. J Aging Health. 2019;31(4):580–594. doi:10.1177/089826431773789429254430
   PubMed Web of Science ®Google Scholar
• Osika Friberg I, Krantz G, Määttä S, Järbrink K. Sex differences in health care consumption in Sweden: a register-based cross-sectional study. Scand J Public Health. 2016;44(3):264–273. doi:10.1177/140349481561884326647097
   PubMed Web of Science ®Google Scholar
• Statistics Denmark [statistikbanken.dk/HISB7] In Danish. 2019 Available from: https://www.statistikbanken.dk/statbank5a/default.asp?w=1280. Accessed 118, 2020.
   Google Scholar
• Wong SL, Gilmour H, Ramage-Morin PL. Parkinson’s disease: prevalence, diagnosis and impact. Health Reports. 2014;25(11):7.
   Web of Science ®Google Scholar
• Capital region, Denmark. [Forløbsprogram for diabetes Type 2]. In Danish. 2009 Available from: https://www.regionh.dk/til-fagfolk/Sundhed/kronisk-sygdom/PublishingImages/Sider/Forloebsprogram-for-type-2-diabetes/Forl%C3%B8bsprogrammet%20for%20type%202-diabetes.pdf. Accessed 118, 2020.
   Google Scholar
• Capital region, Denmark. [Forløbsprogram for KOL]. In Danish. 2009 Available from: https://www.regionh.dk/til-fagfolk/Sundhed/kronisk-sygdom/PublishingImages/Sider/Forloebsprogram-for-KOL/Forloebsprogram_KOL_LR.pdf. Accessed 118, 2020.
   Google Scholar
• Bähler C, Huber CA, Brüngger B, Reich O. Multimorbidity, health care utilization and costs in an elderly community-dwelling population: a claims data based observational study. BMC Health Serv Res. 2015;15:23. doi:10.1186/s12913-015-0698-225609174
   PubMed Web of Science ®Google Scholar
• Hutchinson AF, Graco M, Rasekaba TM, Parikh S, Berlowitz DJ, Lim WK. Relationship between health-related quality of life, comorbidities and acute health care utilisation, in adults with chronic conditions. Health Qual Life Outcomes. 2015;13:69. doi:10.1186/s12955-015-0260-226021834
   PubMed Web of Science ®Google Scholar
• van den Bussche H, Schön G, Kolonko T, et al. Patterns of ambulatory medical care utilization in elderly patients with special reference to chronic diseases and multimorbidity–results from a claims data based observational study in Germany. BMC Geriatr. 2011;11:54. doi:10.1186/1471-2318-11-5421914191
   PubMed Web of Science ®Google Scholar
• Glynn LG, Valderas JM, Healy P, et al. The prevalence of multimorbidity in primary care and its effect on health care utilization and cost. Fam Pract. 2011;28(5):516–523. doi:10.1093/fampra/cmr01321436204
   PubMed Web of Science ®Google Scholar
• van Oostrom SH, Picavet HSJ, de Bruin SR, et al. Multimorbidity of chronic diseases and health care utilization in general practice. BMC Fam Pract. 2014;15:61. doi:10.1186/1471-2296-15-6124708798
   PubMed Web of Science ®Google Scholar
• Austad B, Hetlevik I, Mjølstad BP, Helvik A-S. Applying clinical guidelines in general practice: a qualitative study of potential complications. BMC Fam Pract. 2016;17:92. doi:10.1186/s12875-016-0490-327449959
   PubMed Web of Science ®Google Scholar
• Smith SM, O’Kelly S, O’Dowd T. GPs’ and pharmacists’ experiences of managing multimorbidity: a ‘Pandora’s box.’. Br J Gen Pract. 2010;60(576):e285–e294. doi:10.3399/bjgp10X514756
   PubMed Web of Science ®Google Scholar
• Vass M, Hendriksen C. Polypharmacy and older people–the GP perspective. Z Gerontol Geriatr. 2005;38(Suppl 1):I14–17. doi:10.1007/s00391-005-1104-116189730
   PubMed Web of Science ®Google Scholar
• Kouladjian L, Gnjidic D, Reeve E, Chen TF, Hilmer SN. Health care practitioners’ perspectives on deprescribing anticholinergic and sedative medications in older adults. Ann Pharmacother. 2016;50(8):625–636. doi:10.1177/106002801665299727257284
   PubMed Web of Science ®Google Scholar
• Frølich A, Olsen F, Kristensen I. [Hvidbog Om Multisygdom. Dokumentation Af Multisygdom i Det Danske Samfund - Fra Silotænkning Til Sammenhæng.] In Danish. 2017 Available from: http://Multisygdom.Dk/Wp-Content/Uploads/2017/03/Hvidbog-Til-Net_2_rettet1.Pdf. Accessed 118, 2020.
   Google Scholar
• Nunes BP, Flores TR, Mielke GI, Thumé E, Facchini LA. Multimorbidity and mortality in older adults: a systematic review and meta-analysis. Arch Gerontol Geriatr. 2016;67:130–138. doi:10.1016/j.archger.2016.07.00827500661
   PubMed Web of Science ®Google Scholar
• Bradshaw LE, Goldberg SE, Lewis SA, et al. Six-month outcomes following an emergency hospital admission for older adults with co-morbid mental health problems indicate complexity of care needs. Age Ageing. 2013;42(5):582–588. doi:10.1093/ageing/aft07423800454
   PubMed Web of Science ®Google Scholar
• Klausen HH, Petersen J, Bandholm T, et al. Association between routine laboratory tests and long-term mortality among acutely admitted older medical patients: a cohort study. BMC Geriatr. 2017;17:62. doi:10.1186/s12877-017-0434-328249621
   PubMed Web of Science ®Google Scholar