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Original Research

Antiemetic Prescription Fills in Pregnancy: A Drug Utilization Study Among 762,437 Pregnancies in Norway

ORCID Icon & ORCID Icon
Pages 161-174 | Published online: 26 Feb 2021

References

  • Einarson TR, Piwko C, Koren G. Quantifying the global rates of nausea and vomiting of pregnancy: a meta analysis. J Popul Ther Clin Pharmacol. 2013;20(2):e171–e183.23863575
  • Gazmararian JA, Petersen R, Jamieson DJ, et al. Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002;100(1):94–100. doi:10.1016/s0029-7844(02)02024-012100809
  • Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin No. 189: nausea and vomiting of pregnancy. Obstet Gynecol. 2018;131(1):e15–e30. doi:10.1097/AOG.000000000000245629266076
  • Veenendaal MVE, van Abeelen AFM, Painter RC, van der Post JAM, Roseboom TJ. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG. 2011;118(11):1302–1313. doi:10.1111/j.1471-0528.2011.03023.x21749625
  • Heitmann K, Nordeng H, Havnen GC, Solheimsnes A, Holst L. The burden of nausea and vomiting during pregnancy: severe impacts on quality of life, daily life functioning and willingness to become pregnant again - results from a cross-sectional study. BMC Pregnancy Childbirth. 2017;17(1):75. doi:10.1186/s12884-017-1249-028241811
  • Tan A, Lowe S, Henry A. Nausea and vomiting of pregnancy: effects on quality of life and day-to-day function. Aust N Z J Obstet Gynaecol. 2018;58(3):278–290. doi:10.1111/ajo.1271428949009
  • Tsakiridis I, Mamopoulos A, Athanasiadis A, Dagklis T. The management of nausea and vomiting of pregnancy: synthesis of national guidelines. Obstet Gynecol Surv. 2019;74(3):161–169. doi:10.1097/OGX.000000000000065431634919
  • Campbell K, Rowe H, Azzam H, Lane CA. The management of nausea and vomiting of pregnancy. J Obstet Gynaecol Can. 2016;38(12):1127–1137. doi:10.1016/j.jogc.2016.08.00927986189
  • Royal College of Obstetricians & Gynaecologists. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum. Green-top guidelines no 69; 2016. Available from: https://www.rcog.org.uk/globalassets/documents/guidelines/green-top-guidelines/gtg69-hyperemesis.pdf. Accessed 1221, 2020.
  • Fiaschi L, Nelson-Piercy C, Deb S, King R, Tata LJ. Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population-based study. BJOG. 2019;126(10):1201–1211. doi:10.1111/1471-0528.1566230786126
  • Taylor LG, Bird ST, Sahin L, et al. Antiemetic use among pregnant women in the United States: the escalating use of ondansetron. Pharmacoepidemiol Drug Saf. 2017;26(5):592–596. doi:10.1002/pds.418528220993
  • Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V. Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2018;31(18):2492–2505. doi:10.1080/14767058.2017.134280528614956
  • Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation. 11th ed. Philadelphia: Lippincott Williams & Wilkins; 2017.
  • The Norwegian Society of Obstetrics and Gynecology. Veileder i fødselshjelp [Obstetric guidelines issued by the Norwegian Society of Obstetrics and Gynaecology]; 2014. Available from: https://www.legeforeningen.no/foreningsledd/fagmed/norsk-gynekologisk-forening/veiledere/veileder-i-fodselshjelp-2014/7.-emesis-og-hyperemesis-gravidarum/. Accessed 1221, 2020. Norwegian.
  • Quinlan JD Nausea and vomiting in pregnancy. BMJ Best Practice. 2020. Available from: https://bestpractice.bmj.com/topics/en-gb/999. Accessed 1221, 2020.
  • Schaefer C, Peters PWJ, Miller RK. Drugs During Pregnancy and Lactation. 3rd ed. London: Academic Press; 2015.
  • Smith JA, Fox KA, Clark SM Nausea and vomiting of pregnancy: treatment and outcome. UpToDate 2020.
  • European Medicines Agency. PRAC recommendations on signals; 2019. Available from: https://www.ema.europa.eu/en/documents/prac-recommendation/prac-recommendations-signals-adopted-8-11-july-2019-prac-meeting_en.pdf. Accessed 1221, 2020.
  • Huybrechts KF, Hernández-Díaz S, Straub L, et al. Association of maternal first-trimester ondansetron use with cardiac malformations and oral clefts in offspring. JAMA. 2018;320(23):2429–2437. doi:10.1001/jama.2018.1830730561479
  • Lemon LS, Bodnar LM, Garrard W, et al. Ondansetron use in the first trimester of pregnancy and the risk of neonatal ventricular septal defect. Int J Epidemiol. 2020;49(2):648–656. doi:10.1093/ije/dyz25531860078
  • Parker SE, Van Bennekom C, Anderka M, Mitchell AA. National birth defects prevention study. Ondansetron for treatment of nausea and vomiting of pregnancy and the risk of specific birth defects. Obstet Gynecol. 2018;132(2):385–394. doi:10.1097/AOG.000000000000267929995744
  • Zambelli-Weiner A, Via C, Yuen M, Weiner DJ, Kirby RS. First trimester ondansetron exposure and risk of structural birth defects. Reprod Toxicol. 2019;83:14–20. doi:10.1016/j.reprotox.2018.10.01030385129
  • Huybrechts KF, Hernández-Díaz S, Bateman BT. Contextualizing potential risks of medications in pregnancy for the newborn-the case of ondansetron. JAMA Pediatr. 2020;174(8):747–748. doi:10.1001/jamapediatrics.2020.132532478805
  • Damkier P, Kaplan YC, Shechtman S, et al. Ondansetron should never be used in pregnancy: against: ondansetron in pregnancy revisited. BJOG. 2021;128(1):111–112. doi:10.1111/1471-0528.1647632991063
  • Irgens LM. The medical birth registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand. 2000;79(6):435–439.10857866
  • Furu K. Establishment of the nationwide Norwegian Prescription Database (NorPD) – new opportunities for research in pharmacoepidemiology in Norway. Nor Epidemiol. 2008;18(2):129–136.
  • WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index 2021; 2020. Available from: https://www.whocc.no/atc_ddd_index/. Accessed 1221, 2020.
  • Elseviers M, Wettermark B, Almarsdóttir AB, et al. Drug Utilization Research: Methods and Applications. Toronto: Wiley-Blackwell; 2016.
  • Bateman BT, Mhyre JM, Hernandez-Diaz S, et al. Development of a comorbidity index for use in obstetric patients. Obstet Gynecol. 2013;122(5):957–965. doi:10.1097/AOG.0b013e3182a603bb24104771
  • Havnen GC, Truong MB, Do MH, Heitmann K, Holst L, Nordeng H. Women’s perspectives on the management and consequences of hyperemesis gravidarum - a descriptive interview study. Scand J Prim Health Care. 2019;37(1):30–40. doi:10.1080/02813432.2019.156942430822254
  • Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ. 2009;338(jun18 1):b2255. doi:10.1136/bmj.b225519541696
  • Heitmann K, Holst L, Lupattelli A, Maltepe C, Nordeng H. Treatment of nausea in pregnancy: a cross-sectional multinational web-based study of pregnant women and new mothers. BMC Pregnancy Childbirth. 2015;15(1):321. doi:10.1186/s12884-015-0746-226628289
  • Van den Heuvel JM, Farzan N, van Hoek M, Maitland-van der Zee AH, Ahmadizar F. Mining treatment patterns of glucose-lowering medications for type 2 diabetes in the Netherlands. BMJ Open Diabetes Res Care. 2020;8(1):e000767. doi:10.1136/bmjdrc-2019-000767
  • European Medicines Agency. Assessment report: metoclopramide only containing medicinal products; 2013. Available from: https://www.ema.europa.eu/en/documents/referral/assessment-report-metoclopramide-containing-medicines_en.pdf. Accessed 1221, 2020.
  • Bakker MK, Jentink J, Vroom F, Van Den Berg PB, De Walle HEK, De Jong-van Den Berg LTW. Drug prescription patterns before, during and after pregnancy for chronic, occasional and pregnancy-related drugs in the Netherlands. BJOG. 2006;113(5):559–568. doi:10.1111/j.1471-0528.2006.00927.x16637899
  • Demailly R, Escolano S, Quantin C, Tubert-Bitter P, Ahmed I. Prescription drug use during pregnancy in France: a study from the national health insurance permanent sample. Pharmacoepidemiol Drug Saf. 2017;26(9):1126–1134. doi:10.1002/pds.426528758270
  • Bérard A, Sheehy O, Gorgui J, Zhao JP, Soares de Moura C, Bernatsky S. New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. J Clin Epidemiol. 2019;116:39–48. doi:10.1016/j.jclinepi.2019.07.01431352006
  • Schrager NL, Adrien N, Werler MM, Parker SE, Van Bennekom C, Mitchell AA. Trends in first-trimester nausea and vomiting of pregnancy and use of select treatments: findings from the national birth defects prevention study. Paediatr Perinat Epidemiol. 2021;35(1):57–64. doi:10.1111/ppe.12705
  • Colvin L, Gill AW, Slack-Smith L, Stanley FJ, Bower C. Off-label use of ondansetron in pregnancy in Western Australia. Biomed Res Int. 2013;2013:909860. doi:10.1155/2013/90986024396830
  • Fiaschi L, Nelson-Piercy C, Tata LJ. Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies. Hum Reprod. 2016;31(8):1675–1684. doi:10.1093/humrep/dew12827251205
  • Fejzo MS, Macgibbon KW, Romero R, Goodwin TM, Mullin PM. Recurrence risk of hyperemesis gravidarum. J Midwifery Womens Health. 2011;56(2):132–136. doi:10.1111/j.1542-2011.2010.00019.x21429077
  • Trogstad LIS, Stoltenberg C, Magnus P, Skjærven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. BJOG. 2005;112(12):1641–1645. doi:10.1111/j.1471-0528.2005.00765.x16305568
  • Fejzo MS, Ingles SA, Wilson M, et al. High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals. Eur J Obstet Gynecol Reprod Biol. 2008;141(1):13–17. doi:10.1016/j.ejogrb.2008.07.00318752885
  • Fejzo MS, Myhre R, Colodro-Conde L, et al. Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2). Mol Cell Endocrinol. 2017;439:308–316. doi:10.1016/j.mce.2016.09.01727663074
  • Fejzo MS, Sazonova OV, Sathirapongsasuti JF, et al. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018;9(1):1178. doi:10.1038/s41467-018-03258-029563502
  • Zhang Y, Cantor RM, MacGibbon K, et al. Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2011;204(3):230.e1–230.e7. doi:10.1016/j.ajog.2010.09.018
  • Kjeldgaard HK, Eberhard-Gran M, Benth JS, Nordeng H, Vikanes ÅV. History of depression and risk of hyperemesis gravidarum: a population-based cohort study. Arch Womens Ment Health. 2017;20(3):397–404. doi:10.1007/s00737-016-0713-628064341
  • Whitehead SA, Andrews PLR, Chamberlain GVP. Characterisation of nausea and vomiting in early pregnancy: a survey of 1000 women. J Obstet Gynaecol. 1992;12(6):364–369. doi:10.3109/01443619209025932
  • Heitmann K, Solheimsnes A, Havnen GC, Nordeng H, Holst L. Treatment of nausea and vomiting during pregnancy - a cross-sectional study among 712 Norwegian women. Eur J Clin Pharmacol. 2016;72(5):593–604. doi:10.1007/s00228-016-2012-626815908
  • Chortatos A, Haugen M, Iversen PO, Vikanes Å, Magnus P, Veierød MB. Nausea and vomiting in pregnancy: associations with maternal gestational diet and lifestyle factors in the Norwegian mother and child cohort study. BJOG. 2013;120(13):1642–1653. doi:10.1111/1471-0528.1240623962347
  • Koren G, Boskovic R, Hard M, Maltepe C, Navioz Y, Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am J Obstet Gynecol. 2002;186(5):S228–S231. doi:10.1067/mob.2002.12305412011891
  • Lacasse A, Rey E, Ferreira E, Morin C, Bérard A. Validity of a modified Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scoring index to assess severity of nausea and vomiting of pregnancy. Am J Obstet Gynecol. 2008;198(1):71.e1–71.e7. doi:10.1016/j.ajog.2007.05.051
  • National Institute for Health and Care Excellence. Evidence review: doxylamine/pyridoxine (Xonvea) for treating nausea and vomiting of pregnancy; 2019. Available from: https://www.nice.org.uk/advice/es20/evidence/evidence-review-pdf-6836042269. Accessed 1221, 2020.
  • Andrade SE, Bérard A, Nordeng HME, Wood ME, van Gelder MMHJ, Toh S. Administrative claims data versus augmented pregnancy data for the study of pharmaceutical treatments in pregnancy. Curr Epidemiol Rep. 2017;4(2):106–116. doi:10.1007/s40471-017-0104-129399433
  • WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment; 2020. Available from: https://www.whocc.no/filearchive/publications/2021_guidelines_web.pdf. Accessed 1221, 2020.