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Clinical Epidemiology Volume 14, 2022 - Issue
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Original Research

Unraveling COVID-19: A Large-Scale Characterization of 4.5 Million COVID-19 Cases Using CHARYBDIS

Kristin Kostka1 IQVIA, Cambridge, MA, USA;2 OHDSI Center at The Roux Institute, Northeastern University, Portland, ME, USAORCID Iconhttps://orcid.org/0000-0003-2595-8736View further author information
ORCID Icon,
Talita Duarte-Salles3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, SpainORCID Iconhttps://orcid.org/0000-0002-8274-0357View further author information
ORCID Icon,
Albert Prats-Uribe4 Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UKORCID Iconhttps://orcid.org/0000-0003-1202-9153View further author information
ORCID Icon,
Anthony G Sena5 Janssen Research & Development, Titusville, NJ, USA;6 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The NetherlandsView further author information
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Andrea Pistillo3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, SpainORCID Iconhttps://orcid.org/0000-0002-4467-0220View further author information
ORCID Icon,
Sara Khalid4 Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UKView further author information
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Lana Y H Lai7 School of Medical Sciences, University of Manchester, Manchester, UKView further author information
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Asieh Golozar8 Regeneron Pharmaceuticals, Tarrytown, NY, USA;9 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAView further author information
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Thamir M Alshammari10 College of Pharmacy, Riyadh Elm University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-5630-2468View further author information
ORCID Icon,
Dalia M Dawoud11 National Institute for Health and Care Excellence, London, UKView further author information
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Fredrik Nyberg12 School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0003-0892-5668View further author information
ORCID Icon,
Adam B Wilcox13 Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA;14 Unviersity of Washington Medicine, Seattle, WA, USAView further author information
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Alan Andryc5 Janssen Research & Development, Titusville, NJ, USAORCID Iconhttps://orcid.org/0000-0002-2663-2298View further author information
ORCID Icon,
Andrew Williams15 Tufts Institute for Clinical Research and Health Policy Studies, Boston, MA, USAView further author information
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Anna Ostropolets16 Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USAView further author information
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Carlos Areia17 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKView further author information
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Chi Young Jung18 Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu, South KoreaView further author information
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Christopher A Harle19 University of Florida Health, Gainesville, FL, USAView further author information
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Christian G Reich1 IQVIA, Cambridge, MA, USA;2 OHDSI Center at The Roux Institute, Northeastern University, Portland, ME, USAORCID Iconhttps://orcid.org/0000-0002-3641-055XView further author information
ORCID Icon,
Clair Blacketer5 Janssen Research & Development, Titusville, NJ, USA;6 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The NetherlandsView further author information
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Daniel R Morales20 Division of Population Health and Genomics, University of Dundee, Dundee, UKView further author information
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David A Dorr21 Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USAView further author information
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Edward Burn3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain;4 Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UKORCID Iconhttps://orcid.org/0000-0002-9286-1128View further author information
ORCID Icon,
Elena Roel3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain;22 Universitat Autònoma de Barcelona, Barcelona, SpainView further author information
,
Eng Hooi Tan4 Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UKView further author information
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Evan Minty23 O’Brien Institute for Public Health, Faculty of Medicine, University of Calgary, Calgary, CanadaView further author information
,
Frank DeFalco5 Janssen Research & Development, Titusville, NJ, USAView further author information
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Gabriel de Maeztu24 IOMED, Barcelona, SpainView further author information
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Gigi Lipori19 University of Florida Health, Gainesville, FL, USAView further author information
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Hiba Alghoul25 Faculty of Medicine, Islamic University of Gaza, Gaza, PalestineORCID Iconhttps://orcid.org/0000-0001-8234-5843View further author information
ORCID Icon,
Hong Zhu26 Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaView further author information
,
Jason A Thomas13 Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USAView further author information
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Jiang Bian19 University of Florida Health, Gainesville, FL, USAView further author information
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Jimyung Park27 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, South KoreaORCID Iconhttps://orcid.org/0000-0002-6998-2546View further author information
ORCID Icon,
Jordi Martínez Roldán28 Director of Innovation and Digital Transformation, Hospital del Mar, Barcelona, SpainView further author information
,
Jose D Posada29 Department of Medicine, School of Medicine, Stanford University, Redwood City, CA, USAView further author information
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Juan M Banda30 Georgia State University, Department of Computer Science, Atlanta, GA, USAORCID Iconhttps://orcid.org/0000-0001-8499-824XView further author information
ORCID Icon,
Juan P Horcajada31 Department of Infectious Diseases, Hospital del Mar, Institut Hospital del Mar d’Investigació Mèdica (IMIM), Universitat Autònoma de Barcelona, Universitat Pompeu Fabra, Barcelona, SpainORCID Iconhttps://orcid.org/0000-0001-9873-5459View further author information
ORCID Icon,
Julianna Kohler32 United States Agency for International Development, Washington, DC, USAView further author information
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Karishma Shah33 Botnar Research Centre, NDORMS, University of Oxford, Oxford, UKView further author information
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Karthik Natarajan16 Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA;34 New York-Presbyterian Hospital, New York, NY, USAORCID Iconhttps://orcid.org/0000-0002-9066-9431View further author information
ORCID Icon,
Kristine E Lynch35 VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA;36 Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USAView further author information
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Li Liu37 Biomedical Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5265-4159View further author information
ORCID Icon,
Lisa M Schilling38 Data Science to Patient Value Program, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information
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Martina Recalde3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain;22 Universitat Autònoma de Barcelona, Barcelona, SpainView further author information
,
Matthew Spotnitz14 Unviersity of Washington Medicine, Seattle, WA, USAView further author information
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Mengchun Gong39 Institute of Health Management, Southern Medical University, Guangzhou, People’s Republic of ChinaView further author information
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Michael E Matheny40 Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN, USA;41 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USAView further author information
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Neus Valveny42 Real-World Evidence, TFS, Barcelona, SpainORCID Iconhttps://orcid.org/0000-0003-1105-5018View further author information
ORCID Icon,
Nicole G Weiskopf21 Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USAView further author information
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Nigam Shah29 Department of Medicine, School of Medicine, Stanford University, Redwood City, CA, USAView further author information
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Osaid Alser43 Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAView further author information
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Paula Casajust42 Real-World Evidence, TFS, Barcelona, SpainORCID Iconhttps://orcid.org/0000-0003-2733-5436View further author information
ORCID Icon,
Rae Woong Park27 Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, South Korea;44 Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, South KoreaView further author information
,
Robert Schuff21 Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USAView further author information
,
Sarah Seager1 IQVIA, Cambridge, MA, USAView further author information
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Scott L DuVall35 VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA;36 Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USAORCID Iconhttps://orcid.org/0000-0002-4898-3865View further author information
ORCID Icon,
Seng Chan You45 Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South KoreaView further author information
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Seokyoung Song46 Department of Anesthesiology and Pain Medicine, Catholic University of Daegu, School of Medicine, Daegu, South KoreaORCID Iconhttps://orcid.org/0000-0002-5653-7005View further author information
ORCID Icon,
Sergio Fernández-Bertolín3 Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, SpainView further author information
,
Stephen Fortin5 Janssen Research & Development, Titusville, NJ, USAView further author information
,
Tanja Magoc19 University of Florida Health, Gainesville, FL, USAORCID Iconhttps://orcid.org/0000-0001-8213-2266View further author information
ORCID Icon,
Thomas Falconer16 Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USAORCID Iconhttps://orcid.org/0000-0001-6904-1394View further author information
ORCID Icon,
Vignesh Subbian47 College of Engineering, The University of Arizona, Tucson, AZ, USAView further author information
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Vojtech Huser48 National Library of Medicine, National Institutes of Health, Bethesda, MD, USAView further author information
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Waheed-Ul-Rahman Ahmed33 Botnar Research Centre, NDORMS, University of Oxford, Oxford, UK;49 College of Medicine and Health, University of Exeter, St Luke’s Campus, Exeter, UKORCID Iconhttps://orcid.org/0000-0003-0880-0355View further author information
ORCID Icon,
William Carter38 Data Science to Patient Value Program, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USAORCID Iconhttps://orcid.org/0000-0001-5346-3453View further author information
ORCID Icon,
Yin Guan50 DHC Technologies Co. Ltd., Beijing, People’s Republic of ChinaView further author information
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Yankuic Galvan19 University of Florida Health, Gainesville, FL, USAView further author information
,
Xing He19 University of Florida Health, Gainesville, FL, USAView further author information
,
Peter R Rijnbeek6 Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The NetherlandsView further author information
,
George Hripcsak16 Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USA;34 New York-Presbyterian Hospital, New York, NY, USAView further author information
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Patrick B Ryan5 Janssen Research & Development, Titusville, NJ, USA;16 Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY, USAView further author information
,
Marc A Suchard51 Departments of Biostatistics, Computational Medicine, and Human Genetics, University of California, Los Angeles, CA, USAORCID Iconhttps://orcid.org/0000-0001-9818-479XView further author information
ORCID Icon &
Daniel Prieto-Alhambra4 Centre for Statistics in Medicine, NDORMS, University of Oxford, Oxford, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3950-6346View further author information
ORCID Icon show all
Pages 369-384 | Published online: 22 Mar 2022

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