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Original Research

Nitrate in Drinking Water and Time to Pregnancy or Medically Assisted Reproduction in Women and Men: A Nationwide Cohort Study in the Danish National Birth Cohort

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Pages 475-487 | Published online: 13 Apr 2022

References

  • European Society of Human Reproduction and Embryology. ART fact sheet. 2020 data 2016–2020. Available from: file:///C:/Users/au631982/Downloads/ESHRE_ARTFactSheet_2022.pdf. Accessed October 31, 2021.
  • Segal TR, Giudice LC. Before the beginning: environmental exposures and reproductive and obstetrical outcomes. Fertil Steril. 2019;112(4):613–621. doi:10.1016/j.fertnstert.2019.08.001
  • Zegers-Hochschild F, Adamson GD, Dyer S, et al. The international glossary on infertility and fertility care, 2017. Hum Reprod. 2017;32:1786–1801. doi:10.1093/humrep/dex234
  • Vander Borght M, Wyns C. Fertility and infertility: definition and epidemiology. Clin Biochem. 2018;62:2–10. doi:10.1016/j.clinbiochem.2018.03.012
  • Hansen B, Thorling L, Kim H, Blicher-Mathiesen G. Long-term nitrate response in shallow groundwater to agricultural N regulations in Denmark. J Environ Manage. 2019;240:66–74.
  • van Grinsven HJ, Rabl A, de Kok TM. Estimation of incidence and social cost of colon cancer due to nitrate in drinking water in the EU: a tentative cost-benefit assessment. Environ Health. 2010;9:58. doi:10.1186/1476-069X-9-58
  • Anderson LM, Giner-Sorolla A, Ebeling D. Effects of imipramine, nitrite, and dimethylnitrosamine on reproduction in mice. Res Commun Chem Pathol Pharmacol. 1978;19:311–327.
  • Anderson LM, Giner-Sorolla A, Haller IM, Budinger JM. Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure. Cancer Res. 1985;45:3561–3566.
  • Greenlee AR, Ellis TM, Berg RL. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environ Health Perspect. 2004;112:703–709. doi:10.1289/ehp.6774
  • National Toxicology Program. Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser. 2001;495:7–273.
  • Sund JM, Wright MJ, Simon J. Weeds containing nitrates cause abortion in cattle. Agron J. 1957;49:278–279. doi:10.2134/agronj1957.00021962004900050019x
  • Aly HA, Mansour AM, Abo-Salem OM, Abd-Ellah HF, Abdel-Naim AB. Potential testicular toxicity of sodium nitrate in adult rats. Food Chem Toxicol. 2010;48:572–578. doi:10.1016/j.fct.2009.11.034
  • Pant N, Srivastava SP. Testicular and spermatotoxic effect of nitrate in mice. Hum Exp Toxicol. 2002;21:37–41. doi:10.1191/0960327102ht206oa
  • Ward MH, Jones RR, Brender JD, et al. Drinking water nitrate and human health: an updated review. Int J Environ Res Public Health. 2018;15:1557. doi:10.3390/ijerph15071557
  • Coffman VR, Jensen AS, Trabjerg BB, et al. Prenatal exposure to nitrate from drinking water and markers of fetal growth restriction: a population-based study of nearly one million Danish-born children. Environ Health Perspect. 2021;129:27002. doi:10.1289/EHP7331
  • Water and health in Europe. A joint report from the European Environment Agency and the WHO Regional Office for Europe. WHO Reg Publ Eur Ser. 2002;III-XXIII:1–222.
  • Clausen HS, Ebdrup NH, Barsoe IM, et al. Association between drinking water nitrate and adverse reproductive outcomes: a systematic PRISMA review. Water. 2020;12:2287. doi:10.3390/w12082287
  • Panesar NS, Chan KW. Decreased steroid hormone synthesis from inorganic nitrite and nitrate: studies in vitro and in vivo. Toxicol Appl Pharmacol. 2000;169:222–230. doi:10.1006/taap.2000.9079
  • De Groef B, Decallonne BR, Van der Geyten S, Darras VM, Bouillon R. Perchlorate versus other environmental sodium/iodide symporter inhibitors: potential thyroid-related health effects. Eur J Endocrinol. 2006;155:17–25. doi:10.1530/eje.1.02190
  • Edwards TM, Hamlin HJ. Reproductive endocrinology of environmental nitrate. Gen Comp Endocrinol. 2018;265:31–40. doi:10.1016/j.ygcen.2018.03.021
  • Blaisdell J, Turyk ME, Almberg KS, Jones RM, Stayner LT. Prenatal exposure to nitrate in drinking water and the risk of congenital anomalies. Environ Res. 2019;176:108553. doi:10.1016/j.envres.2019.108553
  • Greer FR, Shannon M;, Committee on Environmental Health. Infant methemoglobinemia: the role of dietary nitrate in food and water. Pediatrics. 2005;116:784–786. doi:10.1542/peds.2005-1497
  • Schmitz JT. Methemoglobinemia–a cause of abortions? Preliminary report. Obstet Gynecol. 1961;17:413–415.
  • Aschengrau A, Zierler S, Cohen A. Quality of community drinking water and the occurrence of spontaneous abortion. Arch Environ Health. 1989;44:283–290. doi:10.1080/00039896.1989.9935895
  • Migeot V, Albouy-Llaty M, Carles C, et al. Drinking-water exposure to a mixture of nitrate and low-dose atrazine metabolites and small-for-gestational age (SGA) babies: a historic cohort study. Environ Res. 2013;122:58–64. doi:10.1016/j.envres.2012.12.007
  • Sherris AR, Baiocchi M, Fendorf S, Luby SP, Yang W, Shaw GM. Nitrate in drinking water during pregnancy and spontaneous preterm birth: a retrospective within-mother analysis in California. Environ Health Perspect. 2021;129:57001. doi:10.1289/EHP8205
  • Bukowski J, Somers G, Bryanton J. Agricultural contamination of groundwater as a possible risk factor for growth restriction or prematurity. J Occup Environ Med. 2001;43:377–383. doi:10.1097/00043764-200104000-00016
  • Stayner LT, Almberg K, Jones R, Graber J, Pedersen M, Turyk M. Atrazine and nitrate in drinking water and the risk of preterm delivery and low birth weight in four Midwestern states. Environ Res. 2017;152:294–303. doi:10.1016/j.envres.2016.10.022
  • Croen LA, Todoroff K, Shaw GM. Maternal exposure to nitrate from drinking water and diet and risk for neural tube defects. Am J Epidemiol. 2001;153:325–331. doi:10.1093/aje/153.4.325
  • Dorsch MM, Scragg RK, McMichael AJ, Baghurst PA, Dyer KF. Congenital malformations and maternal drinking water supply in rural South Australia: a case-control study. Am J Epidemiol. 1984;119:473–486. doi:10.1093/oxfordjournals.aje.a113764
  • Radikova Z, Tajtakova M, Kocan A, et al. Possible effects of environmental nitrates and toxic organochlorines on human thyroid in highly polluted areas in Slovakia. Thyroid. 2008;18:353–362. doi:10.1089/thy.2007.0182
  • van Grinsven HJ, Ward MH, Benjamin N, de Kok TM. Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water? Environ Health. 2006;5:26. doi:10.1186/1476-069X-5-26
  • Schullehner J, Hansen B, Thygesen M, Pedersen CB, Sigsgaard T. Nitrate in drinking water and colorectal cancer risk: a nationwide population-based cohort study. Int J Cancer. 2018;143:73–79. doi:10.1002/ijc.31306
  • Olsen J, Melbye M, Olsen SF, et al. The Danish national birth cohort–its background, structure and aim. Scand J Public Health. 2001;29:300–307. doi:10.1177/14034948010290040201
  • Danish National Birth Cohort (DNBC). Interview 1-4. Available from: https://www.dnbc.dk/data-available/interviews-1—4. Accessed October 2020.
  • Schmidt M, Pedersen L, Sørensen HT. The Danish civil registration system as a tool in epidemiology. Eur J Epidemiol. 2014;29(8):541–549. doi:10.1007/s10654-014-9930-3
  • Pedersen CB. The Danish civil registration system. Scand J Public Health. 2011;39:22–25. doi:10.1177/1403494810387965
  • Schullehner J, Stayner L, Hansen B. Nitrate, nitrite, and ammonium variability in drinking water distribution systems. Int J Environ Res Public Health. 2017;14:276. doi:10.3390/ijerph14030276
  • Hansen B, Dalgaard T, Thorling L, Sorensen B, Erlandsen M. Regional analysis of groundwater nitrate concentrations and trends in Denmark in regard to agricultural influence. Biogeosciences. 2012;9:3277–3286. doi:10.5194/bg-9-3277-2012
  • Thomsen AML, Ramlau-Hansen CH, Schullehner J, et al. Prenatal nitrosatable prescription drug intake, drinking water nitrate, and the risk of stillbirth: a register- and population-based cohort of Danish pregnancies, 1997–2017. Environ Health. 2021;20:118. doi:10.1186/s12940-021-00805-z
  • Hansen M, Pjetursson B. Free, online Danish shallow geological data. Geol Surv Den Greenl Bull. 2011;23:53–56. doi:10.34194/geusb.v23.4842
  • Schullehner J, Hansen B. Nitrate exposure from drinking water in Denmark over the last 35 years. Environ Res Lett. 2014;9(9):095001. doi:10.1088/1748-9326/9/9/095001
  • Schullehner J, Jensen NL, Thygesen M, Hansen B, Sigsgaard T. Drinking water nitrate estimation at household-level in Danish population-based long-term epidemiologic studies. J Geochem Explor. 2017;183:178–186. doi:10.1016/j.gexplo.2017.03.006
  • Bonde JP, Joffe M, Sallmen M, et al. Validity issues relating to time-to-pregnancy studies of fertility. Epidemiology. 2006;17:347–349. doi:10.1097/01.ede.0000210239.80406.46
  • Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology. 1999;10:37–48. doi:10.1097/00001648-199901000-00008
  • Samuelsson K, Chen T-HK, Antonsen S, Brandt SA, Sabel C, Barthel S. Residential environments across Denmark have become both denser and greener over 20 years. Environ Res Lett. 2020;16:014022. doi:10.1088/1748-9326/abcf7a
  • Elias P. Occupational Classification (ISCO-88): Concepts, Methods, Reliability, Validity and Cross-National Comparability. OECD Labour Market and Social Policy Occasional Papers; 1997:20.
  • Jensen VM, Rasmussen AW. Danish education registers. Scand J Public Health. 2011;39:91–94. doi:10.1177/1403494810394715
  • Harrell FE. Regression Modeling Strategies. Second ed. Springer International Publishing Switzerland; 2015.
  • Bonde JP, Hjollund NH, Jensen TK, et al. A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners: design and methods. Reprod Toxicol. 1998;12:19–27. doi:10.1016/S0890-6238(97)00096-8
  • Gnoth C, Godehardt D, Godehardt E, Frank-Herrmann P, Freundl G. Time to pregnancy: results of the German prospective study and impact on the management of infertility. Hum Reprod. 2003;18:1959–1966. doi:10.1093/humrep/deg366
  • Gruener N, Shuval HI, Behroozi K, Cohen S, Shechter H. Methemoglobinemia induced by transplacental passage of nitrites in rats. Bull Environ Contam Toxicol. 1973;9:44–48. doi:10.1007/BF01856770
  • Inui N, Nishi Y, Taketomi M, et al. Transplacental mutagenesis of products formed in the stomach of golden hamsters given sodium nitrite and morpholine. Int J Cancer. 1979;24:365–372. doi:10.1002/ijc.2910240316
  • Poulsen R, Cedergreen N, Hayes T, Hansen M. Nitrate: an environmental endocrine disruptor? A review of evidence and research needs. Environ Sci Technol. 2018;52:3869–3887. doi:10.1021/acs.est.7b06419
  • Skrivan J. Methemoglobinemia in pregnancy (clinical and experimental study). Acta Univ Carol Med. 1971;17:123–161.
  • Sleight SD, Atallah OA. Reproduction in the Guinea pig as affected by chronic administration of potassium nitrate and potassium nitrite. Toxicol Appl Pharmacol. 1968;12:179–185. doi:10.1016/0041-008X(68)90029-X
  • Attia YA, Abd El Hamid EA, Ismaiel AM, El-Nagar A. The detoxication of nitrate by two antioxidants or a probiotic, and the effects on blood and seminal plasma profiles and reproductive function of New Zealand white rabbit bucks. Animal. 2013;7:591–601. doi:10.1017/S1751731112002054
  • Hansen PR, Taxvig C, Christiansen S, et al. Evaluation of endocrine disrupting effects of nitrate after in utero exposure in rats and of nitrate and nitrite in the H295R and T-screen assay. Toxicol Sci. 2009;108:437–444. doi:10.1093/toxsci/kfp023
  • Kuh D, Ben-Shlomo Y, Lynch J, Hallqvist J, Power C. Life course epidemiology. J Epidemiol Community Health. 2003;57:778–783. doi:10.1136/jech.57.10.778
  • Lanciotti L, Cofini M, Leonardi A, Penta L, Esposito S. Up-to-date review about minipuberty and overview on hypothalamic-pituitary-gonadal axis activation in fetal and neonatal life. Front Endocrinol. 2018;9. doi:10.3389/fendo.2018.00410
  • Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009;90:1–10. doi:10.3945/ajcn.2008.27131
  • Erlangsen A, Fedyszyn I. Danish nationwide registers for public health and health-related research. Scand J Public Health. 2015;43:333–339. doi:10.1177/1403494815575193
  • Wilcox AJ, Weinberg CR, O’Connor JF, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988;319:189–194. doi:10.1056/NEJM198807283190401
  • Wilcox AJ, Harmon Q, Doody K, Wolf DP, Adashi EY. Preimplantation loss of fertilized human ova: estimating the unobservable. Hum Reprod. 2020;35:743–750.
  • Danish Fertility Association. Annual report 2019. Danish. Available from: https://fertilitetsselskab.dk/wp-content/uploads/2020/10/dfs2019-til-hjemmesiden.pdf. Accessed October 31, 2021.
  • Leung M, Kioumourtzoglou MA, Raz R, Weisskopf MG. Bias due to selection on live births in studies of environmental exposures during pregnancy: a simulation study. Environ Health Perspect. 2021;129:47001. doi:10.1289/EHP7961
  • Liew Z, Olsen J, Cui X, Ritz B, Arah OA. Bias from conditioning on live birth in pregnancy cohorts: an illustration based on neurodevelopment in children after prenatal exposure to organic pollutants. Int J Epidemiol. 2015;44:345–354. doi:10.1093/ije/dyu249
  • Save-Soderbergh M, Toljander J, Mattisson I, Akesson A, Simonsson M. Drinking water consumption patterns among adults-SMS as a novel tool for collection of repeated self-reported water consumption. J Expo Sci Environ Epidemiol. 2018;28:131–139. doi:10.1038/jes.2017.8
  • Rygaard M, Arvin E, Binning PJ. The valuation of water quality: effects of mixing different drinking water qualities. Water Res. 2009;43:1207–1218. doi:10.1016/j.watres.2008.12.014
  • Union of European Soft Drinks Associations. Industry volume data: Denmark. Vol 2021. Available from: https://www.unesda.eu/consumption/. Accessed June 14, 2021.
  • Falba TA, Sindelar JL. Spousal concordance in health behavior change. Health Serv Res. 2008;43:96–116. doi:10.1111/j.1475-6773.2007.00754.x
  • Meyler D, Stimpson JP, Peek MK. Health concordance within couples: a systematic review. Soc Sci Med. 2007;64:2297–2310. doi:10.1016/j.socscimed.2007.02.007
  • Hvidtjorn D, Grove J, Schendel D, et al. Validation of self-reported data on assisted conception in the Danish national birth cohort. Hum Reprod. 2009;24:2332–2340. doi:10.1093/humrep/dep179
  • Cooney MA, Buck Louis GM, Sundaram R, McGuiness BM, Lynch CD. Validity of self-reported time to pregnancy. Epidemiology. 2009;20:56–59. doi:10.1097/EDE.0b013e31818ef47e
  • Hansen B, Sonnenborg TO, Moller I, et al. Nitrate vulnerability assessment of aquifers. Environ Earth Sci. 2016;75:999. doi:10.1007/s12665-016-5767-2
  • Moller H, Landt J, Pedersen E, Jensen P, Autrup H, Jensen OM. Endogenous nitrosation in relation to nitrate exposure from drinking water and diet in a Danish rural population. Cancer Res. 1989;49:3117–3121.
  • Chen SX, Rasmussen KM, Finkelstein J, Stovring H, Nohr EA, Kirkegaard H. Maternal reproductive history and premenopausal risk of hypertension and cardiovascular disease: a Danish cohort study. BMJ Open. 2019;9:e030702. doi:10.1136/bmjopen-2019-030702