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Original Research

Elevated Uric Acid Mediates the Effect of Obesity on Hypertension Development: A Causal Mediation Analysis in a Prospective Longitudinal Study

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Pages 463-473 | Published online: 11 Apr 2022

References

  • Garrison RJ, Kannel WB, Stokes J, Castelli WP. Incidence and precursors of hypertension in young adults: the Framingham Offspring Study. Prev Med. 1987;16:235–251. doi:10.1016/0091-7435(87)90087-9
  • Sjostrom L, Lindroos AK, Peltonen M, et al.; Swedish Obese Subjects Study Scientific G. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–2693. doi:10.1056/NEJMoa035622
  • Furuhashi M, Matsumoto M, Murase T, et al. Independent links between plasma xanthine oxidoreductase activity and levels of adipokines. J Diabetes Investig. 2019;10(4):1059–1067. doi:10.1111/jdi.12982
  • Furuhashi M, Matsumoto M, Tanaka M, et al. Plasma xanthine oxidoreductase activity as a novel biomarker of metabolic disorders in a general population. Circ J. 2018;82(7):1892–1899. doi:10.1253/circj.CJ-18-0082
  • Washio KW, Kusunoki Y, Murase T, et al. Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans. Metabolism. 2017;70:51–56. doi:10.1016/j.metabol.2017.01.031
  • Russo E, Leoncini G, Esposito P, Garibotto G, Pontremoli R, Viazzi F. Fructose and uric acid: major mediators of cardiovascular disease risk starting at pediatric age. Int J Mol Sci. 2020;21:4479.
  • Ali N, Miah R, Hasan M, et al. Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults. Sci Rep. 2020;10(1):7841. doi:10.1038/s41598-020-64884-7
  • Haque T, Rahman S, Islam S, Molla NH, Ali N. Assessment of the relationship between serum uric acid and glucose levels in healthy, prediabetic and diabetic individuals. Diabetol Metab Syndr. 2019;11(1):49. doi:10.1186/s13098-019-0446-6
  • Ali N, Rahman S, Islam S, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord. 2019;19(1):42. doi:10.1186/s12872-019-1026-2
  • Costa TEM, Lauar JC, Innecchi MLR, Coelho VA, Moyses RMA, Elias RM. Hyperuricemia is associated with secondary hyperparathyroidism in patients with chronic kidney disease. Int Urol Nephrol. 2022. doi:10.1007/s11255-022-03116-5
  • Molla NH, Kathak RR, Sumon AH, et al. Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults. Sci Rep. 2021;11(1):20114. doi:10.1038/s41598-021-99623-z
  • Duan Y, Liang W, Zhu L, et al. Association between serum uric acid levels and obesity among university students (China). Nutr Hosp. 2015;31(6):2407–2411. doi:10.3305/nh.2015.31.6.8734
  • Kang T, Hu Y, Huang X, Amoah AN, Lyu Q. Serum uric acid level and all-cause and cardiovascular mortality in peritoneal dialysis patients: a systematic review and dose-response meta-analysis of cohort studies. PLoS One. 2022;17(2):e0264340. doi:10.1371/journal.pone.0264340
  • Ndrepepa G. Uric acid and cardiovascular disease. Clin Chim Acta. 2018;484:150–163. doi:10.1016/j.cca.2018.05.046
  • Wei F, Sun N, Cai C, et al. Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study. J Transl Med. 2016;14(1):110. doi:10.1186/s12967-016-0866-0
  • Yu J, Sun H, Zhu J, et al. Asymptomatic hyperuricemia and metabolically unhealthy obesity: a cross-sectional analysis in the tianning cohort. Diabetes Metab Syndr Obes. 2021;14:1367–1374. doi:10.2147/DMSO.S301363
  • Masuo K, Kawaguchi H, Mikami H, Ogihara T, Tuck ML. Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation. Hypertension. 2003;42(4):474–480. doi:10.1161/01.HYP.0000091371.53502.D3
  • Han T, Meng X, Shan R, et al. Temporal relationship between hyperuricemia and obesity, and its association with future risk of type 2 diabetes. Int J Obes. 2018;42(7):1336–1344. doi:10.1038/s41366-018-0074-5
  • Zhu Y, Zhang Y, Choi HK. The serum urate-lowering impact of weight loss among men with a high cardiovascular risk profile: the multiple risk factor intervention trial. Rheumatology. 2010;49(12):2391–2399. doi:10.1093/rheumatology/keq256
  • Nicholls A, Scott JT. Effect of weight-loss on plasma and urinary levels of uric acid. Lancet. 1972;300(7789):1223–1224. doi:10.1016/S0140-6736(72)92271-4
  • Yamashita S, Matsuzawa Y, Tokunaga K, Fujioka S, Tarui S. Studies on the impaired metabolism of uric acid in obese subjects: marked reduction of renal urate excretion and its improvement by a low-calorie diet. Int J Obes. 1986;10(4):255–264.
  • Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008;300(8):924–932. doi:10.1001/jama.300.8.924
  • Borgi L, McMullan C, Wohlhueter A, Curhan GC, Fisher ND, Forman JP. Effect of uric acid-lowering agents on endothelial function: a randomized, double-blind, placebo-controlled trial. Hypertension. 2017;69(2):243–248. doi:10.1161/HYPERTENSIONAHA.116.08488
  • Kuwabara M, Niwa K, Hisatome I, et al. Asymptomatic hyperuricemia without comorbidities predicts cardiometabolic diseases: five-year Japanese cohort study. Hypertension. 2017;69(6):1036–1044. doi:10.1161/HYPERTENSIONAHA.116.08998
  • Jiang Y, Yu J, Zhang Q, et al. Microalbuminuria mediates the association between serum uric acid and elevation of blood pressure: a longitudinal analysis in the Gusu cohort. J Hypertens. 2020;38(4):625–632. doi:10.1097/HJH.0000000000002316
  • Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origins of hypertension. J Pediatr. 2013;162(5):896–902. doi:10.1016/j.jpeds.2012.12.078
  • Richiardi L, Bellocco R, Zugna D. Mediation analysis in epidemiology: methods, interpretation and bias. Int J Epidemiol. 2013;42(5):1511–1519. doi:10.1093/ije/dyt127
  • Liu Y, Peng H, Zhang Q, et al. Association between serum soluble corin and hyperglycaemia: a cross-sectional study among Chinese adults. BMJ Open. 2015;5:e009085.
  • Zhou BF; Cooperative Meta-Analysis Group of the Working Group on Obesity in C. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults–study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002;15(1):83–96.
  • Zhang ML, Gao YX, Wang X, Chang H, Huang GW. Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults. J Clin Biochem Nutr. 2013;52(1):38–42. doi:10.3164/jcbn.12-65
  • Lenfant C, Chobanian AV, Jones DW, Roccella EJ. Seventh report of the Joint National Committee on the prevention, detection, evaluation, and treatment of high blood pressure (JNC 7) resetting the hypertension sails. Hypertension. 2003;41(6):1178–1179. doi:10.1161/01.HYP.0000075790.33892.AE
  • Rosseel Y. lavaan: an R package for structural equation modeling. J Stat Softw. 2012;48(2):1–36. doi:10.18637/jss.v048.i02
  • Tingley D, Yamamoto T, Hirose K, Keele L, Imai K. mediation: r Package for Causal Mediation Analysis. J Stat Softw. 2014;59. doi: 10.18637/jss.v059.i05
  • Ali N, Perveen R, Rahman S, et al. Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: a study on Bangladeshi adults. PLoS One. 2018;13(11):e0206850. doi:10.1371/journal.pone.0206850
  • Rathmann W, Haastert B, Icks A, Giani G, Roseman JM. Ten-year change in serum uric acid and its relation to changes in other metabolic risk factors in young black and white adults: the CARDIA study. Eur J Epidemiol. 2007;22(7):439–445. doi:10.1007/s10654-007-9132-3
  • Dalbeth N, Chen P, White M, et al. Impact of bariatric surgery on serum urate targets in people with morbid obesity and diabetes: a prospective longitudinal study. Ann Rheum Dis. 2014;73(5):797–802. doi:10.1136/annrheumdis-2013-203970
  • Dessein PH, Shipton EA, Stanwix AE, Joffe BI, Ramokgadi J. Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Ann Rheum Dis. 2000;59(7):539–543. doi:10.1136/ard.59.7.539
  • Ali N, Mahmood S, Islam F, et al. Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults. Sci Rep. 2019;9(1):9061. doi:10.1038/s41598-019-45680-4
  • Gunawardhana L, McLean L, Punzi HA, Hunt B, Palmer RN. Whelton A, Feig DI. effect of febuxostat on ambulatory blood pressure in subjects with hyperuricemia and hypertension: a phase 2 randomized placebo-controlled study. J Am Heart Assoc. 2017;6:e006683.
  • de Oliveira EP, Burini RC. High plasma uric acid concentration: causes and consequences. Diabetol Metab Syndr. 2012;4(1):12. doi:10.1186/1758-5996-4-12
  • Li C, Hsieh MC, Chang SJ. Metabolic syndrome, diabetes, and hyperuricemia. Curr Opin Rheumatol. 2013;25(2):210–216. doi:10.1097/BOR.0b013e32835d951e
  • Bagheri B, Zargari M, Meshkini F, et al. Uric acid and coronary artery disease, two sides of a single coin: a determinant of antioxidant system or a factor in metabolic syndrome. J Clin Diagn Res. 2016;10(2):OC27–OC31. doi:10.7860/JCDR/2016/16335.7281
  • Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system. J Hypertens. 2008;26(2):269–275. doi:10.1097/HJH.0b013e3282f240bf
  • Fantin F, Giani A, Zoico E, Rossi AP, Mazzali G, Zamboni M. Weight loss and hypertension in obese subjects. Nutrients. 2019;11:1667.
  • Bosello O, Zamboni M. Visceral obesity and metabolic syndrome. Obes Rev. 2000;1(1):47–56. doi:10.1046/j.1467-789x.2000.00008.x