Identifying Individual Medications Affecting Pulmonary Outcomes When Multiple Medications are Present

Yisha Li1 Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Ran Dai2 Department of Biostatistics, School of Public Health, University of Nebraska Medical Center, Omaha, NE, USAView further author information

Yeongjin Gwon2 Department of Biostatistics, School of Public Health, University of Nebraska Medical Center, Omaha, NE, USA

Stephen I Rennard3 Division of Pulmonary, Critical Care and Sleep Medicine, University of Nebraska Medical Center, Omaha, NE, USAView further author information

Barry J Make4 Department of Medicine, National Jewish Health, Denver, CO, USA

Dinah Foer5 Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USAView further author information

Matthew J Strand4 Department of Medicine, National Jewish Health, Denver, CO, USAView further author information

Erin Austin6 Mathematical and Statistical Sciences, University of Colorado Denver, Denver, CO, USAView further author information

Kendra A Young1 Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

John E Hokanson1 Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information

Katherine A Pratte7 Department of Biostatistics, National Jewish Health, Denver, CO, USAView further author information

Rebecca Conway1 Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USAView further author information

Gregory L Kinney1 Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USACorrespondence[email protected]

References

Negewo NA, Gibson PG, McDonald VM. COPD and its comorbidities: impact, measurement and mechanisms. Respirology. 2015;20(8):1160–1171. doi:10.1111/resp.12642
PubMed Web of Science ®Google Scholar
Barber RF, Candès EJ. Controlling the false discovery rate via knockoffs. Ann Stat. 2015;43(5):2055–2085, 2031. doi:10.1214/15-AOS1337
Web of Science ®Google Scholar
Dai Ran ZC. Multiple testing for composite null with FDR control guarantee. arXiv preprint arXiv. 2021. doi:10.48550/arXiv.2106.12719
Google Scholar
Regan EA, Hokanson JE, Murphy JR, et al. Genetic epidemiology of COPD (COPDGene) study design. Copd. 2010;7(1):32–43. doi:10.3109/15412550903499522
PubMedGoogle Scholar
Li Y, Ragland M, Austin E, et al. Co-morbidity patterns identified using latent class analysis of medications predict all-cause mortality independent of other known risk factors: the COPDGene(®) Study. Clin Epidemiol. 2020;12:1171–1181. doi:10.2147/CLEP.S279075
Web of Science ®Google Scholar
Shen A, Fu H, He K, Jiang H. False discovery rate control in cancer biomarker selection using knockoffs. Cancers. 2019;11(6):744. doi:10.3390/cancers11060744
Web of Science ®Google Scholar
Polverino F, Wu TD, Rojas-Quintero J, et al. Metformin: experimental and clinical evidence for a potential role in emphysema treatment. Am J Respir Crit Care Med. 2021;204(6):651–666. doi:10.1164/rccm.202012-4510OC
Web of Science ®Google Scholar