Association Between Medication Adherence and Risk of COPD in Adult Asthma Patients: A Retrospective Cohort Study in Canada

References

• Statistics Canada. Asthma; 2014. Available from: https://www150.statcan.gc.ca/n1/pub/82-625-x/2015001/article/14179-eng.htm. Accessed February 11, 2021.
   Google Scholar
• Soriano JB, Abajobir AA, Abate KH, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017;5(9):691–706. doi:10.1016/S2213-2600(17)30293-X
   PubMed Web of Science ®Google Scholar
• Ekström M, Nwaru BI, Wiklund F, Telg G, Janson C. Risk of Rehospitalization and Death in Patients Hospitalized Due to Asthma. J Allergy Clin Immunol Pract. 2021;9(5):1960–1968.e4. doi:10.1016/j.jaip.2020.12.030
   PubMed Web of Science ®Google Scholar
• Gonzalez-Barcala FJ, Aboal J, Valdes L, et al. Trends in adult asthma hospitalization: gender-age effect. Multidiscip Respir Med. 2011;6(2):82–86. doi:10.1186/2049-6958-6-2-82
   PubMed Web of Science ®Google Scholar
• de Araujo Cardoso T, Roncada C, da Silva ER, et al. The impact of asthma in Brazil: a longitudinal analysis of data from a Brazilian national database system. J Bras Pneumol. 2017;43(3):163–168. doi:10.1590/S1806-37562016000000352
   Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention (Updated 2022). Global Initiative for Asthma (GINA);2022.
   Google Scholar
• Yang CL, Hicks EA, Mitchell P, et al. Canadian Thoracic Society 2021 Guideline update: diagnosis and management of asthma in preschoolers, children and adults. Can J Respir Crit Care Sleep Med. 2021;5(6):348–361. doi:10.1080/24745332.2021.1945887
   Web of Science ®Google Scholar
• Bateman E, Hurd S. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31:143–178. doi:10.1183/09031936.00138707
   PubMed Web of Science ®Google Scholar
• Bidwal M, Lor K, Yu J, Ip E. Evaluation of asthma medication adherence rates and strategies to improve adherence in the underserved population at a Federally Qualified Health Center. Res Soc Adm Pharm. 2017;13(4):759–766. doi:10.1016/j.sapharm.2016.07.007
   PubMed Web of Science ®Google Scholar
• Murphy A, Proeschal A, Brightling C, et al. The relationship between clinical outcomes and medication adherence in difficult-to-control asthma. Thorax. 2012;67:751–753. doi:10.1136/thoraxjnl-2011-201096
   PubMed Web of Science ®Google Scholar
• Engelkes M, Janssens HM, De Jongste JC, Sturkenboom MCJM, Verhamme KMC. Medication adherence and the risk of severe asthma exacerbations: a systematic review. Eur Respir J. 2015;45(2):396–407. doi:10.1183/09031936.00075614
   PubMed Web of Science ®Google Scholar
• Guo J, Kelton C, Tsai K, Cai B, Bian B, Wigle P. Inhaled corticosteroid and long-acting beta-agonist medication compliance in patients with moderate and severe asthma. Respir Related Dis. 2012;15:A57.
   Google Scholar
• Ismaila A, Corriveau D, Vaillancourt J, Parsons D, Standford R, Sampalis JS. Impact of adherence to treatment with fluticasone propionate/salmeterol in asthma patients. Curr Med Res Opin. 2014;30(7):1417–1425. doi:10.1185/03007995.2014.908827
   PubMed Web of Science ®Google Scholar
• Kang H-R, Song HJ, Nam JH, et al. Risk factors of asthma exacerbation based on asthma severity: a nationwide population-based observational study in South Korea. BMJ Open. 2018;8:1–9. doi:10.1136/bmjopen-2017-020825
   Web of Science ®Google Scholar
• Fitzgerald JM, Lemiere C, Lougheed MD, et al. Recognition and management of severe asthma: a Canadian Thoracic Society position statement. Int J Med. 2017;1(4):199–221. doi:10.1080/24745332.2017.1395250
   Web of Science ®Google Scholar
• Lommatzsch M, Virchow J. Severe Asthma: definition, Diagnosis and Treatment. Dtsch Arztebl Int. 2014;111:847–855. doi:10.3238/arztebl.2014.0847
   PubMed Web of Science ®Google Scholar
• Bakakos A, Vogli S, Dimakou K, Hillas G. Asthma with Fixed Airflow Obstruction: from Fixed to Personalized Approach. J Pers Med. 2022;12(3):1–15. doi:10.3390/jpm12030333
   Web of Science ®Google Scholar
• Shifren A, Witt C, Christie C, Castro M. Mechanisms of Remodeling in Asthmatic Airways. J Allergy. 2012;2012:1–12. doi:10.1155/2012/316049
   Google Scholar
• Asamoah-Boaheng M, Acheampong L, Tenkorang EY, Farrell J, Oyet A, Midodzi WK. Association between early history of asthma and COPD diagnosis in later life: a systematic review and meta-analysis. Int J Epidemiol. 2018;47(6):1865–1876. doi:10.1093/ije/dyy207
   PubMed Web of Science ®Google Scholar
• Chongmelaxme B, Chaiyakunapruk N, Dilokthornsakul P. Association between adherence and severe asthma exacerbation: a systematic review and meta-analysis. J Am Pharm Assoc. 2020;60(5):669–685.e2. doi:10.1016/j.japh.2020.02.010
   Google Scholar
• Bedouch P, Marra C, FitzGerald J, Lynd L, Sedatsafavi M. Trends in Asthma related direct medical costs from 2002 to 2007 in British Columbia, Canada: a population based-cohort study. PLoS One. 2012;7(12):1–8. doi:10.1371/journal.pone.0050949
   Web of Science ®Google Scholar
• Population Data BC (PopData BC). Population Data British Columbia; 2021. Available from: https://www.popdata.bc.ca/. Accessed October 11, 2022.
   Google Scholar
• Canadian Institute for Health Information (CIHI) [creator]. Discharge Abstract Database (Hospital Separations). V2. Population Data BC [Publisher]. Data Extract. MOH(2020); 2019. Available from: http://www.popdata.bc.ca/data. Accessed October 11, 2022.
   Google Scholar
• British Columbia Ministry of Health (BC MOH) [creator]. Consolidation File (MSP Registration & Premium Billing). V2. Population Data BC [Publisher]. Data Extract. MOH(2020); 2020. Available from: http://www.popdata.bc.ca/data. Accessed October 11, 2022.
   Google Scholar
• British Columbia Ministry of Health (BC MOH) [creator]. PharmaNet. V2. Population Data BC [Publisher]. Data Extract. Data Stewardship Committee (2020); 2020. Available from: http://www.popdata.bc.ca/data. Accessed October 11, 2022.
   Google Scholar
• Population Data BC(PopData BC). Data available; 2021. Available from: https://www.popdata.bc.ca/data. Accessed October 11, 2022.
   Google Scholar
• Prosser RJ, Carleton BC, Smith MA. Identifying persons with treated asthma using administrative data via latent class modelling. Health Serv Res. 2008;43(2):733–754. doi:10.1111/j.1475-6773.2007.00775.x
   PubMed Web of Science ®Google Scholar
• Averell CM, Stanford RH, Laliberté F, Wu JW, Germain G, Duh MS. Medication adherence in patients with asthma using once-daily versus twice-daily ICS/LABAs. J Asthma. 2019;1–10. doi:10.1080/02770903.2019.1663429
   Web of Science ®Google Scholar
• Makhinova T, Barner JC, Richards KM, Rascati KL. Asthma controller medication adherence, risk of exacerbation, and use of rescue agents among Texas Medicaid patients with persistent asthma. J Manag Care Pharm. 2015;21(12):1124–1132. doi:10.18553/jmcp.2015.21.12.1124
   PubMed Web of Science ®Google Scholar
• Serhal S, Saini B, Bosnic-Anticevich S, Krass I, Wilson F, Armour C. Medication Adherence in a Community Population with Uncontrolled Asthma. Pharmacy. 2020;8(4):183. doi:10.3390/pharmacy8040183
   Web of Science ®Google Scholar
• Friedman HS, Navaratnam P, McLaughlin J. Treatment and outcomes - Adherence and asthma control with mometasone furoate versus fluticasone propionate in adolescents and young adults with mild asthma. J Asthma. 2010;47(9):994–1000. doi:10.1080/02770903.2010.513076
   PubMed Web of Science ®Google Scholar
• Chang A. A SAS Macro to Calculate the PDC Adjustment of Inpatient Stays. SAS Global Forum Proce. 2015;3560.
   Google Scholar
• Choudhry NK, Shrank WH, Levin RL, et al. Measuring concurrent adherence to multiple related medications. Am J Manag Care. 2009;15(7):457–464.
   PubMed Web of Science ®Google Scholar
• Asamoah-Boaheng M, Farrell J, Osei Bonsu K, Midodzi WK. Determining the optimal threshold for medication adherence in adult asthma patients: an analysis of British Columbia administrative health database in Canada. J Asthma. 2021;1–12. doi:10.1080/02770903.2021.2014862
   Web of Science ®Google Scholar
• Asamoah-boaheng M, Farrell J, Oyet A, Midodzi WK. Measuring Medication Adherence in a Population-Based Asthma Administrative Pharmacy Database: a Systematic Review and Meta-Analysis. Clin Epidemiol. 2021;13:981–1010. doi:10.2147/CLEP.S333534
   PubMed Web of Science ®Google Scholar
• Firoozi F, Lemière C, Beauchesne MF, Forget A, Blais L. Development and validation of database indexes of asthma severity and control. Thorax. 2007;62(7):581–587. doi:10.1136/thx.2006.061572
   PubMed Web of Science ®Google Scholar
• Chen W, FitzGerald JM, Sin DD, Sadatsafavi M. Excess economic burden of comorbidities in COPD: a 15-year population-based study. Eur Respir J. 2017;50(1):1–10. doi:10.1183/13993003.00393-2017
   Web of Science ®Google Scholar
• Antoniou T, Yao Z, Raboud J, Gershon AS. Incidence of chronic obstructive pulmonary disease in people with HIV in Ontario, 1996-2015: a retrospective population-based cohort study. C Open. 2020;8(1):E83–E89. doi:10.9778/cmajo.20190028
   Google Scholar
• To T, Zhu J, Gray N, et al. Asthma and chronic obstructive pulmonary disease overlap in women incidence and risk factors. Ann Am Thorac Soc. 2018;15(11):1304–1310. doi:10.1513/AnnalsATS.201802-078OC
   PubMed Web of Science ®Google Scholar
• To T, Zhu J, Larsen K, et al. Progression from asthma to chronic obstructive pulmonary disease is air pollution a risk factor? Am J Respir Crit Care Med. 2016;194(4):429–438. doi:10.1164/rccm.201510-1932OC
   PubMed Web of Science ®Google Scholar
• Charlson M, Pompei P, Ales K, MacKenzie C. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383. doi:10.1016/0021-9681(87)90171-8
   PubMedGoogle Scholar
• Núñez JE, Núñez E, Fácila L, et al. Prognostic Value of Charlson Comorbidity Index at 30 Days and 1 Year After Acute Myocardial Infarction. Rev Esp Cardiol. 2004;57(9):842–849. doi:10.1016/S0300-8932(04)77204-8
   Web of Science ®Google Scholar
• Friedman HS, Navaratnam P, McLaughlin J. Treatment and outcomes - Adherence and asthma control with mometasone furoate versus fluticasone propionate in adolescents and young adults with mild asthma. J Asthma. 2010;47(9):994. doi:10.1080/02770903.2010.513076
   PubMed Web of Science ®Google Scholar
• Nwaru BI, Ekström M, Hasvold P, Wiklund F, Telg G, Janson C. Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. Eur Respir J. 2020;55(4):1–11. doi:10.1183/13993003.01872-2019
   Web of Science ®Google Scholar
• Wiley LK, Shah A, Xu H, Bush WS. ICD-9 tobacco use codes are effective identifiers of smoking status. J Am Med Informatics Assoc. 2013;20(4):652–658. doi:10.1136/amiajnl-2012-001557
   Web of Science ®Google Scholar
• Hernan M, Brumback B, Robins J. Marginal structural models to estimate the joint causal effect of nonrandomized treatments. J Am Stat Assoc. 2001;96(454):440–448. doi:10.1198/016214501753168154
   Web of Science ®Google Scholar
• Faries DE, Obenchain R, Haro JM, Leon AC Analysis of observational health care data using SAS. Published online 2010. Available from: https://www.sas.com/store/books/categories/usage-and-reference/analysis-of-observational-health-care-data-using-sas-/prodBK_61876_en.html. Accessed October 11, 2022.
   Google Scholar
• Williams L, Xi MP. Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. J Allergy Clin Immunol. 2004;114:1288–1293. doi:10.1016/j.jaci.2004.09.028
   PubMed Web of Science ®Google Scholar
• Harrison B, Stephenson P, Mohan G, et al. An ongoing confidential enquiry into asthma deaths in the Eastern Region of the UK, 2001-2003. Prim Care Respir J. 2005;14:303–313. doi:10.1016/j.pcrj.2005.08.004
   PubMedGoogle Scholar
• Delea TE, Standford RH, Hagiwara M, Stempel DA. Association between adherence with fixed dose combination fluticasone propionate/salmeterol on asthma outcomes and costs. Curr Med Res Opin. 2008;24(12):3435–3442. doi:10.1185/03007990802557344
   PubMed Web of Science ®Google Scholar
• Williams L, Peterson E, Wells K, et al. Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroids non-adherence. J Allergy Clin Immunol. 2011;128(6):1185–1191. doi:10.1016/j.jaci.2011.09.011
   PubMed Web of Science ®Google Scholar
• Terzikhan N, Verhamme K, Hofman A, Stricker B, Brusselle G, Lahousse L. Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study. Eur J Epidemiol. 2016;31(8):785–792. doi:10.1007/s10654-016-0132-z
   PubMed Web of Science ®Google Scholar
• Kosse RC, Bouvy ML, de Vries TW, Koster ES. Effect of a mHealth intervention on adherence in adolescents with asthma: a randomized controlled trial. Respir Med. 2019;149(February):45–51. doi:10.1016/j.rmed.2019.02.009
   Web of Science ®Google Scholar
• Normansell R, Kew KM, Stovold E. Interventions to improve adherence to inhaled steroids for asthma. Cochrane Database Syst Rev. 2017;2017(4). doi:10.1002/14651858.CD012226.pub2
   Web of Science ®Google Scholar
• Braido F, Chrystyn H, Baiardini I, et al. “Trying, but failing”–the role of inhaler technique and mode of delivery in respiratory medication adherence. J Allergy Clin Immunol. 2016;4:823–832. doi:10.1016/j.jaip.2016.03.002
   Web of Science ®Google Scholar
• Hudson M, Rahme E, Richard H, Pilote L. Comparison of measures of medication persistency using a prescription drug database. Am Hear J. 2007;153(1):59–65. doi:10.1016/j.ahj.2006.10.018
   Web of Science ®Google Scholar
• Guenette L, Moisan J, Preville M, Boyer R. Measures of adherence based on self-report exhibited poor agreement with those based on pharmacy records. J Clin Epidemiol. 2005;58(9):924–933. doi:10.1016/j.jclinepi.2005.02.002
   Web of Science ®Google Scholar