Fat Embolism Syndrome and in-Hospital Mortality Rates According to Patient Age: A Large Nationwide Retrospective Study

References

• Sevitt S. Fat embolism in patients with fractured hips. Br Med J. 1972 Apr 29;2(5808):257-62. doi: 10.1136/bmj.2.5808.257
   Google Scholar
• Gauss H. The pathology of fat embolism. Arch. Surg. 1924;9(593):593. doi:10.1001/archsurg.1924.01120090110007
   Google Scholar
• Lempert M, Halvachizadeh S, Ellanti P, et al. Incidence of fat embolism syndrome in femur fractures and its associated risk factors over time-a systematic review. J Clin Med Res. 2021;10:2733.
   Google Scholar
• Bulger EM, Smith DG, Maier RV, Jurkovich GJ. Fat embolism syndrome. A 10-year review. Arch Surg. 1997;132:435–439. doi:10.1001/archsurg.1997.01430280109019
   PubMed Web of Science ®Google Scholar
• Tzioupis CC, Giannoudis PV. Fat embolism syndrome: what have we learned over the years? Traumatology. 2011;13:259–281.
   Google Scholar
• Mellor A, Soni N. Fat embolism. Anaesthesia. 2001;56:145–154. doi:10.1046/j.1365-2044.2001.01724.x
   PubMed Web of Science ®Google Scholar
• Rothberg DL, Makarewich CA. Fat embolism and fat embolism syndrome. J Am Acad Orthop Surg. 2019;27:e346–e355. doi:10.5435/JAAOS-D-17-00571
   PubMed Web of Science ®Google Scholar
• Kosova E, Bergmark B, Piazza G. Fat embolism syndrome. Circulation. 2015;131:317–320. doi:10.1161/CIRCULATIONAHA.114.010835
   Web of Science ®Google Scholar
• Chan KM, Tham KT, Chiu HS, Chow YN, Leung PC. Post-traumatic fat embolism—its clinical and subclinical presentations. J Trauma Injury, Infect Crit Care. 1984;24:45–49. doi:10.1097/00005373-198401000-00007
   PubMedGoogle Scholar
• Gupta B, D’souza N, Sawhney C, et al. Analyzing fat embolism syndrome in trauma patients at AIIMS Apex Trauma Center, New Delhi, India. J Emerg Trauma Shock. 2011;4:337–341. doi:10.4103/0974-2700.83859
   PubMedGoogle Scholar
• George J, George R, Dixit R, Gupta RC, Gupta N. Fat embolism syndrome. Lung India. 2013;30:47–53. doi:10.4103/0970-2113.106133
   Google Scholar
• Newbigin K, Souza CA, Torres C, et al. Fat embolism syndrome: state-of-the-art review focused on pulmonary imaging findings. Respir Med. 2016;113:93–100. doi:10.1016/j.rmed.2016.01.018
   Web of Science ®Google Scholar
• Lackner I, Weber B, Baur M, et al. Complement activation and organ damage after trauma-differential immune response based on surgical treatment strategy. Front. Immunol. 2020;11(64). doi:10.3389/fimmu.2020.00064
   Web of Science ®Google Scholar
• Sears BW, Stover MD, Callaci J. Pathoanatomy and clinical correlates of the immunoinflammatory response following orthopaedic trauma. J Am Acad Orthop Surg. 2009;17:255–265. doi:10.5435/00124635-200904000-00006
   Web of Science ®Google Scholar
• Godoy DA, Di Napoli M, Rabinstein AA. Cerebral fat embolism: recognition, complications, and prognosis. Neurocrit Care. 2018;29:358–365. doi:10.1007/s12028-017-0463-y
   Web of Science ®Google Scholar
• Bone LB, Johnson KD, Weigelt J, Scheinberg R. Early versus delayed stabilization of femoral fractures. A prospective randomized study. J Bone Joint Surg Am. 1989;71:336–340. doi:10.2106/00004623-198971030-00004
   PubMed Web of Science ®Google Scholar
• Shaikh N. Emergency management of fat embolism syndrome. J Emerg Trauma Shock. 2009;2:29–33. doi:10.4103/0974-2700.44680
   PubMedGoogle Scholar
• He Z, Shi Z, Li C, et al. Single-case metanalysis of fat embolism syndrome. Int. J. Cardiol. 2021;345:111–117. doi:10.1016/j.ijcard.2021.10.151
   Web of Science ®Google Scholar
• Kainoh T, Iriyama H, Komori A, et al. Risk factors of fat embolism syndrome after trauma: a nested case-control study with the use of a nationwide trauma registry in Japan. Chest. 2021;159:1064–1071. doi:10.1016/j.chest.2020.09.268
   Web of Science ®Google Scholar
• Vetrugno L, Bignami E, Deana C, et al. Cerebral fat embolism after traumatic bone fractures: a structured literature review and analysis of published case reports. Scand J Trauma Resusc Emerg Med. 2021;29(1). doi:10.1186/s13049-021-00861-x
   Web of Science ®Google Scholar
• Tsai I-T, Hsu C-J, Chen Y-H, et al. Fat embolism syndrome in long bone fracture—clinical experience in a tertiary referral center in Taiwan. J. Chin. Med. Assoc. 2010;73:407–410. doi:10.1016/S1726-4901(10)70088-5
   Web of Science ®Google Scholar
• Gurd AR. Fat embolism: an aid to diagnosis. J Bone Joint Surg Br. 1970;52:732–737. doi:10.1302/0301-620X.52B4.732
   PubMedGoogle Scholar
• Stein PD, Yaekoub AY, Matta F, Kleerekoper M. Fat embolism syndrome. Am J Med Sci. 2008;336:472–477. doi:10.1097/MAJ.0b013e318172f5d2
   PubMed Web of Science ®Google Scholar
• Lynch MJ. Nephrosis and fat embolism in acute hemorrhagic pancreatitis. AMA Arch Intern Med. 1954;94:709–717. doi:10.1001/archinte.1954.00250050023004
   Google Scholar
• Scroggins C, Barson PK. Fat embolism syndrome in a case of abdominal lipectomy with liposuction. Md Med J. 1999;48:116–118.
   PubMedGoogle Scholar
• Taviloglu K, Yanar H. Fat embolism syndrome. Surg Today. 2007;37:5–8. doi:10.1007/s00595-006-3307-5
   Web of Science ®Google Scholar
• Blacker E, Tsitsikas D. Fat embolism syndrome in sickle cell disease: a case series. Br J Soc Econ Res. 2018;181:124.
   Google Scholar
• Macmahon HE, Weiss S. Carbon tetrachloride poisoning with macroscopic fat in the pulmonary artery. Am J Pathol. 1929;5:623–630.
   Google Scholar
• Lindeque BG, Schoeman HS, Dommisse GF, Boeyens MC, Vlok AL. Fat embolism and the fat embolism syndrome. A double-blind therapeutic study. J Bone Joint Surg. 1987;69-B:128–131. doi:10.1302/0301-620X.69B1.3818718
   Web of Science ®Google Scholar
• Schonfeld SA, Ploysongsang Y, Dilisio RA, et al. Fat embolism prophylaxis with corticosteroids. A prospective study in high-risk patients. Ann Intern Med. 1983;99:438–443. doi:10.7326/0003-4819-99-4-438
   PubMed Web of Science ®Google Scholar
• Victorino GP, Chong TJ, Pal JD. Trauma in the elderly patient. Arch Surg. 2003;138:1093–1098. doi:10.1001/archsurg.138.10.1093
   PubMedGoogle Scholar
• Hashmi ZG, Kaji AH, Nathens AB. Practical guide to surgical data sets: National Trauma Data Bank (NTDB). JAMA Surg. 2018;153:852–853. doi:10.1001/jamasurg.2018.0483
   Web of Science ®Google Scholar
• Pigott TD. A Review of Methods for Missing Data. Educ Res Eval. 2001;7:353–383. doi:10.1076/edre.7.4.353.8937
   Google Scholar
• Haider AH, Hashmi ZG, Zafar SN, et al. Developing best practices to study trauma outcomes in large databases: an evidence-based approach to determine the best mortality risk adjustment model. J. Trauma Acute Care Surg. 2014;76:1061–1069. doi:10.1097/TA.0000000000000182
   PubMed Web of Science ®Google Scholar
• Pfeifer R, Heussen N, Michalewicz E, Hilgers R-D, Pape H-C. Incidence of adult respiratory distress syndrome in trauma patients: a systematic review and meta-analysis over a period of three decades. J Trauma Acute Care Surg. 2017;83:496–506. doi:10.1097/TA.0000000000001571
   Web of Science ®Google Scholar
• Mudd KL, Hunt A, Matherly RC, et al. Analysis of pulmonary fat embolism in blunt force fatalities. J Trauma Injury, Infect Crit Care. 2000;48:711–715. doi:10.1097/00005373-200004000-00020
   PubMedGoogle Scholar
• Neiman R. Antegrade nailing for midshaft femur fractures. J Orthop Trauma. 2020;34:S29–S30. doi:10.1097/BOT.0000000000001822
   Web of Science ®Google Scholar
• Elliott J, Beringer T, Kee F, et al. Predicting survival after treatment for fracture of the proximal femur and the effect of delays to surgery. J. Clin. Epidemiol. 2003;56:788–795. doi:10.1016/S0895-4356(03)00129-X
   PubMed Web of Science ®Google Scholar
• Arshi A, Su L, Lee C, et al. Comparison of complication profiles for femoral neck, intertrochanteric, and subtrochanteric geriatric Hip fractures. Arch Orthop Trauma Surg. 2021. doi:10.1007/s00402-021-03978-x
   Web of Science ®Google Scholar
• Lari A, Abdulshakoor A, Zogheib E, et al. How to save a life from macroscopic fat embolism: a narrative review of treatment options. Aesthet. Surg. J. 2020;40:1098–1107. doi:10.1093/asj/sjz277
   Web of Science ®Google Scholar
• Pape H-C, Halvachizadeh S, Leenen L, et al. Timing of major fracture care in polytrauma patients - An update on principles, parameters and strategies for 2020. Injury. 2019;50:1656–1670. doi:10.1016/j.injury.2019.09.021
   Web of Science ®Google Scholar
• Lévesque LE, Hanley JA, Kezouh A, Suissa S. Problem of immortal time bias in cohort studies: example using statins for preventing progression of diabetes. BMJ. 2010;340(b5087):b5087–b5087. doi:10.1136/bmj.b5087
   Web of Science ®Google Scholar
• Schmidutz F, Düll T, Voges O, et al. Secondary cement injection technique reduces pulmonary embolism in total Hip arthroplasty. Int. Orthop. 2012;36:1575–1581. doi:10.1007/s00264-012-1537-2
   Web of Science ®Google Scholar
• Högel F, Kamer L, Schlegel U, et al. Fat extravasation due to unreamed and experimentally reamed intramedullary nailing of the sheep femur. Injury. 2009;40:718–721. doi:10.1016/j.injury.2008.10.044
   Web of Science ®Google Scholar
• Högel F, Gerlach UV, Südkamp NP, Müller CA. Pulmonary fat embolism after reamed and unreamed nailing of femoral fractures. Injury. 2010;41:1317–1322. doi:10.1016/j.injury.2010.08.019
   Web of Science ®Google Scholar
• Pape H-C, Giannoudis P. The biological and physiological effects of intramedullary reaming. J Bone Joint Surg Br. 2007;89-B:1421–1426. doi:10.1302/0301-620X.89B11.19570
   Google Scholar
• Alobaidi AS, Al-Hassani A, El-Menyar A, et al. Early and late intramedullary nailing of femur fracture: a single center experience. Int J Crit Illn Inj Sci. 2016;6:143–147. doi:10.4103/2229-5151.190649
   Google Scholar
• Pape H-C, Tornetta P, Tarkin I, et al. Timing of fracture fixation in multitrauma patients: the role of early total care and damage control surgery. J Am Acad Orthop Surg. 2009;17:541–549. doi:10.5435/00124635-200909000-00001
   Web of Science ®Google Scholar
• Bosse MJ, Mackenzie EJ, Riemer BL, et al. Adult respiratory distress syndrome, pneumonia, and mortality following thoracic injury and a femoral fracture treated either with intramedullary nailing with reaming or with a plate. A Comparative Study*. J Bone Joint Surg. 1997;79:799–809. doi:10.2106/00004623-199706000-00001
   PubMed Web of Science ®Google Scholar
• El-Menyar A, Muneer M, Samson D, et al. Early versus late intramedullary nailing for traumatic femur fracture management: meta-analysis. J Orthop Surg Res. 2018;13(160):1.
   Google Scholar