149
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Genetically Predicted Circulating Concentrations of Alanine and Alanine Aminotransferase Were Associated with Prostate Cancer Risk

, , , , , , , & ORCID Icon show all
Pages 1255-1264 | Received 12 Jul 2022, Accepted 07 Oct 2022, Published online: 28 Oct 2022

References

  • Ferlay J, Colombet M, Soerjomataram I, et al. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021;149(4):778–789. doi:10.1002/ijc.33588
  • Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Schaid DJ. The complex genetic epidemiology of prostate cancer. Hum Mol Genet. 2004;13(90001):R103–R121. doi:10.1093/hmg/ddh072
  • Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343(2):78–85. doi:10.1056/NEJM200007133430201
  • Nakagawa H, Akamatsu S, Takata R, Takahashi A, Kubo M, Nakamura Y. Prostate cancer genomics, biology, and risk assessment through genome-wide association studies. Cancer Sci. 2012;103(4):607–613. doi:10.1111/j.1349-7006.2011.02193.x
  • Thapar R, Titus MA. Recent advances in metabolic profiling and imaging of prostate cancer. Curr Metabolomics. 2014;2(1):53–69. doi:10.2174/2213235X02666140301002510
  • Huang J, Mondul AM, Weinstein SJ, et al. Prospective serum metabolomic profiling of lethal prostate cancer. Int J Cancer. 2019;145(12):3231–3243. doi:10.1002/ijc.32218
  • Miyagi Y, Higashiyama M, Gochi A, et al. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One. 2011;6(9):e24143. doi:10.1371/journal.pone.0024143
  • Qader G, Aali M, Smail SW, et al. Cardiac, hepatic and renal dysfunction and IL-18 Polymorphism in breast, colorectal, and prostate cancer patients. Asian Pac J Cancer Prev. 2021;22(1):131–137. doi:10.31557/APJCP.2021.22.1.131
  • Zhou J, He Z, Ma S, Liu R. AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer. Cancer Med. 2020;9(15):5672–5677. doi:10.1002/cam4.3086
  • Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med. 2008;27(8):1133–1163. doi:10.1002/sim.3034
  • Schumacher FR, Al Olama AA, Berndt SI, et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat Genet. 2018;50(7):928–936. doi:10.1038/s41588-018-0142-8
  • Lotta LA, Pietzner M, Stewart ID, et al. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet. 2021;53(1):54–64. doi:10.1038/s41588-020-00751-5
  • Pazoki R, Vujkovic M, Elliott J, et al. Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Nat Commun. 2021;12(1):2579. doi:10.1038/s41467-021-22338-2
  • Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–665. doi:10.1002/gepi.21758
  • Greco MF, Minelli C, Sheehan NA, Thompson JR. Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med. 2015;34(21):2926–2940. doi:10.1002/sim.6522
  • Greenland S. Quantitative methods in the review of epidemiologic literature. Epidemiol Rev. 1987;9:1–30. doi:10.1093/oxfordjournals.epirev.a036298
  • Zhao Q, Bowden J. Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score. Anna Statist. .2019;48(3):1742–1769. doi:10.1214/19-aos1866
  • Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–698. doi:10.1038/s41588-018-0099-7
  • Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–525. doi:10.1093/ije/dyv080
  • Burgess S, Thompson SG, Collaboration CCG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–764. doi:10.1093/ije/dyr036
  • van der Meij BS, Teleni L, Engelen M, Deutz NEP. Amino acid kinetics and the response to nutrition in patients with cancer. Int J Radiat Biol. 2019;95(4):480–492. doi:10.1080/09553002.2018.1466209
  • Manig F, Kuhne K, von Neubeck C, et al. The why and how of amino acid analytics in cancer diagnostics and therapy. J Biotechnol. 2017;242:30–54. doi:10.1016/j.jbiotec.2016.12.001
  • Shingyoji M, Iizasa T, Higashiyama M, et al. The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer. BMC Cancer. 2013;13:77. doi:10.1186/1471-2407-13-77
  • Plewa S, Horala A, Derezinski P, et al. Usefulness of amino acid profiling in ovarian cancer screening with special emphasis on their role in cancerogenesis. Int J Mol Sci. 2017;18(12):2727. doi:10.3390/ijms18122727
  • Gao P, Zhou C, Zhao L, Zhang G, Zhang Y. Tissue amino acid profile could be used to differentiate advanced adenoma from colorectal cancer. J Pharm Biomed Anal. 2016;118:349–355. doi:10.1016/j.jpba.2015.11.007
  • Siminska E, Koba M. Amino acid profiling as a method of discovering biomarkers for early diagnosis of cancer. Amino Acids. 2016;48(6):1339–1345. doi:10.1007/s00726-016-2215-2
  • Derezinski P, Klupczynska A, Sawicki W, Palka JA, Kokot ZJ. Amino acid profiles of serum and urine in search for prostate cancer biomarkers: a pilot study. Int J Med Sci. 2017;14(1):1–12. doi:10.7150/ijms.15783
  • Hammarsten J, Hogstedt B. Clinical, haemodynamic, anthropometric, metabolic and insulin profile of men with high-stage and high-grade clinical prostate cancer. Blood Press. 2004;13(1):47–55. doi:10.1080/08037050310025735
  • Liu Z, Que S, Xu J, Peng T. Alanine aminotransferase-old biomarker and new concept: a review. Int J Med Sci. 2014;11(9):925–935. doi:10.7150/ijms.8951
  • Lee MH, Yang HI, Lu SN, et al. Hepatitis C virus seromarkers and subsequent risk of hepatocellular carcinoma: long-term predictors from a community-based cohort study. J Clin Oncol. 2010;28(30):4587–4593. doi:10.1200/JCO.2010.29.1500
  • Zhang C, Wang H, Ning Z, et al. Serum liver enzymes serve as prognostic factors in patients with intrahepatic cholangiocarcinoma. Onco Targets Ther. 2017;10:1441–1449. doi:10.2147/OTT.S124161
  • Aktas G, Kus T, Balkan A, Metin T, Gulsen MT, Abali H. Prognostic factors in patients with advanced extrahepatic cholangiocarcinoma: a single center experience. Medicine. 2019;98(8):e14556. doi:10.1097/MD.0000000000014556
  • Katzke V, Johnson T, Sookthai D, Husing A, Kuhn T, Kaaks R. Circulating liver enzymes and risks of chronic diseases and mortality in the prospective EPIC-Heidelberg case-cohort study. BMJ Open. 2020;10(3):e033532. doi:10.1136/bmjopen-2019-033532
  • Kunutsor SK, Apekey TA, Van Hemelrijck M, Calori G, Perseghin G. Gamma glutamyltransferase, alanine aminotransferase and risk of cancer: systematic review and meta-analysis. Int J Cancer. 2015;136(5):1162–1170. doi:10.1002/ijc.29084
  • Hodgson MJ. Alanine aminotransferase in clinical practice. Arch Intern Med. 1992;152(1):208. doi:10.1001/archinte.1992.00400130196033
  • Banez LL, Loftis RM, Freedland SJ, et al. The influence of hepatic function on prostate cancer outcomes after radical prostatectomy. Prostate Cancer Prostatic Dis. 2010;13(2):173–177. doi:10.1038/pcan.2010.3
  • Katan MB. Commentary: Mendelian Randomization, 18 years on. Int J Epidemiol. 2004;33(1):10–11. doi:10.1093/ije/dyh023
  • Davies NM, Holmes MV, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362:k601. doi:10.1136/bmj.k601