137
Views
0
CrossRef citations to date
0
Altmetric
Review

Reducing rectal injury in men receiving prostate cancer radiation therapy: current perspectives

, &
Pages 339-350 | Published online: 28 Jul 2017

References

  • EmamiBLymanJBrownATolerance of normal tissue to therapeutic irradiationInt J Radiat Oncol Biol Phys19912111091222032882
  • Hauer-JensenMWangJDenhamJWBowel injury: current and evolving management strategiesSemin Radiat Oncol200313335737112903023
  • BuchiKRadiation proctitis: therapy and prognosisJAMA1991265911801996006
  • HasletonPSCarrNSchofieldPFVascular changes in radiation bowel diseaseHistopathology1985955175344007790
  • FajardoLFThe pathology of ionizing radiation as defined by morphologic patternsActa Oncol2005441132215848902
  • ZelefskyMJFuksZHappersettLClinical experience with intensity modulated radiation therapy (IMRT) in prostate cancerRadiother Oncol200055324124910869739
  • ZietmanALDeSilvioMLSlaterJDComparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trialJAMA2005294101233123916160131
  • MerrickGSWallnerKEButlerWMBlaskoJCPermanent prostate brachytherapy: is supplemental external-beam radiation therapy necessary?Oncology (Williston Park)2006205514522 discussion 522–52516739748
  • MorrisWJTyldesleySRoddaSAndrogen suppression combined with elective nodal and dose escalated radiation therapy (the ASCENDE-RT Trial): an analysis of survival endpoints for a randomized trial comparing a low-dose-rate brachytherapy boost to a dose-escalated external beam boost for high- and intermediate-risk prostate cancerInt J Radiat Oncol Biol Phys201798227528528262473
  • GiordanoSHLeeAKuoYFFreemanJGoodwinJSLate gastrointestinal toxicity after radiation for prostate cancerCancer2006107242343216779795
  • Al-MamganiAvan PuttenWLHeemsbergenWDUpdate of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancerInt J Radiat Oncol Biol Phys200872498098818495377
  • DearnaleyDPSydesMRGrahamJDRT01 collaboratorsEscalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trialLancet Oncol20078647548717482880
  • KubanDATuckerSLDongLLong-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancerInt J Radiat Oncol Biol Phys2008701677417765406
  • ZelefskyMJLevinEJHuntMIncidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancerInt J Radiat Oncol Biol Phys20087041124112918313526
  • AlicikusZAYamadaYZhangZTen-year outcomes of high-dose, intensity-modulated radiotherapy for localized prostate cancerCancer201111771429143721425143
  • PeetersSTHeemsbergenWDvan PuttenWLAcute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 GyInt J Radiat Oncol Biol Phys20056141019103415752881
  • BoyerALAntonukLFensterAA review of electronic portal imaging devices (EPIDs)Med Phys19921911161620036
  • KesslerMLMcShanDLFraassBAA computer-controlled conformal radiotherapy system. III: graphical simulation and monitoring of treatment deliveryInt J Radiat Oncol Biol Phys1995335117311807493842
  • JaffrayDASiewerdsenJHWongJWMartinezAAFlat-panel cone-beam computed tomography for image-guided radiation therapyInt J Radiat Oncol Biol Phys20025351337134912128137
  • LuWOliveraGHChenQDeformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapyPhys Med Biol200651174357437416912386
  • ShiratoHHaradaTHarabayashiTFeasibility of insertion/implantation of 2.0-mm-diameter gold internal fiducial markers for precise setup and real-time tumor tracking in radiotherapyInt J Radiat Oncol Biol Phys200356124024712694845
  • BalterJMWrightJNNewellLJAccuracy of a wireless localization system for radiotherapyInt J Radiat Oncol Biol Phys200561393393715708277
  • RajendranRRPlastarasJPMickRMcMichael KohlerDKassaeeAVapiwalaNDaily isocenter correction with electromagnetic-based localization improves target coverage and rectal sparing during prostate radiotherapyInt J Radiat Oncol Biol Phys20107641092109919625136
  • ChungHTXiaPChanLWPark-SomersERoachM3rdDoes image-guided radiotherapy improve toxicity profile in whole pelvic-treated high-risk prostate cancer? Comparison between IG-IMRT and IMRTInt J Radiat Oncol Biol Phys2009731536018501530
  • FiorinoCValdagniRRancatiTSanguinetiGDose-volume effects for normal tissues in external radiotherapy: pelvisRadiother Oncol200993215316719765845
  • JacksonASkwarchukMWZelefskyMJLate rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histogramsInt J Radiat Oncol Biol Phys200149368569811172950
  • FiorinoCCozzariniCVavassoriVRelationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer: analysis of a large group of patients pooled from three institutionsRadiother Oncol200264111212208568
  • FiorinoCSanguinetiGCozzariniCRectal dose-volume constraints in high-dose radiotherapy of localized prostate cancerInt J Radiat Oncol Biol Phys200357495396214575825
  • RancatiTFiorinoCGagliardiGFitting late rectal bleeding data using different NTCP models: results from an Italian multi-centric study (AIROPROS0101)Radiother Oncol2004731213215465142
  • VargasCMartinezAKestinLLDose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapyInt J Radiat Oncol Biol Phys20056251297130816029785
  • SöhnMYanDLiangJMeldolesiEVargasCAlberMIncidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability modelsInt J Radiat Oncol Biol Phys20076741066107317258870
  • FiorinoCFellinGRancatiTClinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: preliminary results of a multicenter prospective studyInt J Radiat Oncol Biol Phys20087041130113717881142
  • StoreyMRPollackAZagarsGSmithLAntolakJRosenIComplications from radiotherapy dose escalation in prostate cancer: preliminary results of a randomized trialInt J Radiat Oncol Biol Phys200048363564211020558
  • HuangEHPollackALevyLLate rectal toxicity: dose-volume effects of conformal radiotherapy for prostate cancerInt J Radiat Oncol Biol Phys20025451314132112459352
  • van der LaanHPvan den BerghASchilstraCVlasmanRMeertensHLangendijkJAGrading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancerInt J Radiat Oncol Biol Phys20087041138114517931794
  • PeetersSTHoogemanMSHeemsbergenWDHartAAKoperPCLebesqueJVRectal bleeding, fecal incontinence, and high stool frequency after conformal radiotherapy for prostate cancer: normal tissue complication probability modelingInt J Radiat Oncol Biol Phys2006661111916757129
  • MichalskiJMWinterKPurdyJAToxicity after three-dimensional radiotherapy for prostate cancer with RTOG 9406 dose level IVInt J Radiat Oncol Biol Phys200458373574214967428
  • PeetersSTHoogemanMSHeemsbergenWDVolume and hormonal effects for acute side effects of rectum and bladder during conformal radiotherapy for prostate cancerInt J Radiat Oncol Biol Phys20056341142115215939547
  • SchaakeWvan der SchaafAvan DijkLVBongaertsAHvan den BerghACLangendijkJANormal tissue complication probability (NTCP) models for late rectal bleeding, stool frequency and fecal incontinence after radiotherapy in prostate cancer patientsRadiother Oncol2016119338138727157889
  • MirjoletCWalkerPMGauthierMAbsolute volume of the rectum and AUC from rectal DVH between 25Gy and 50Gy predict acute gastrointestinal toxicity with IG-IMRT in prostate cancerRadiat Oncol201611114527814726
  • DréanGAcostaOOspinaJDIdentification of a rectal subregion highly predictive of rectal bleeding in prostate cancer IMRTRadiother Oncol2016119338839727173457
  • BrennerDJMartinezAAEdmundsonGKMitchellCThamesHDArmourEPDirect evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissueInt J Radiat Oncol Biol Phys200252161311777617
  • MiralbellRRobertsSAZubizarretaEHendryJHDose-fractionation sensitivity of prostate cancer deduced from radiotherapy outcomes of 5,969 patients in seven international institutional datasets: α/β = 1.4 (0.9–2.2) GyInt J Radiat Oncol Biol Phys2012821e17e2421324610
  • ThamesHDBentzenSMTuressonIOvergaardMVan den BogaertWTime-dose factors in radiotherapy: a review of the human dataRadiother Oncol19901932192352281152
  • DearnaleyDSyndikusIMossopHCHHiP InvestigatorsConventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trialLancet Oncol20161781047106027339115
  • LeeWRDignamJJAminMBRandomized phase III oninferiority study comparing two radiotherapy fractionation schedules in patients with low-risk prostate cancerJ Clin Oncol201634202325233227044935
  • CattonCNLukkaHGuCSRandomized trial of a hypofractionated radiation regimen for the treatment of localized prostate cancerJ Clin Oncol201735171884189028296582
  • IncrocciLWortelRCAlemayehuWGHypofractionated versus conventionally fractionated radiotherapy for patients with localised prostate cancer (HYPRO): final efficacy results from a randomised, multicentre, open-label, phase 3 trialLancet Oncol20161781061106927339116
  • BenjaminLCTreeACDearnaleyDPThe role of hypofractionated radiotherapy in prostate cancerCurr Oncol Rep20171943028343352
  • D’AmicoAVManolaJLoffredoMA practical method to achieve prostate gland immobilization and target verification for daily treatmentInt J Radiat Oncol Biol Phys20015151431143611728704
  • McGaryJETehBSButlerEBGrantW3rdProstate immobilization using a rectal balloonJ Appl Clin Med Phys20023161111817999
  • TehBSWooSYMaiWYClinical experience with intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of rectal balloon for prostate immobilizationMed Dosim200227210511312074461
  • van LinENvan der VightLPWitjesJAHuismanHJLeerJWVisserAGThe effect of an endorectal balloon and off-line correction on the interfraction systematic and random prostate position variations: a comparative studyInt J Radiat Oncol Biol Phys200561127828815629621
  • El-BassiouniMDavisJBEl-AttarIStuderGMLütolfUMCiernikIFTarget motion variability and on-line positioning accuracy during external-beam radiation therapy of prostate cancer with an endorectal balloon deviceStrahlenther Onkol2006182953153616944375
  • WachterSGerstnerNDornerDThe influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancerInt J Radiat Oncol Biol Phys20025219110011777626
  • HilleASchmidbergerHTöwsNWeissEVorwerkHHessCFThe impact of varying volumes in rectal balloons on rectal dose sparing in conformal radiation therapy of prostate cancer. A prospective three-dimensional analysisStrahlenther Onkol20051811170971616254706
  • ElsayedHBöllingTMoustakisCOrgan movements and dose exposures in teletherapy of prostate cancer using a rectal balloonStrahlenther Onkol20071831161762417960337
  • PatelRROrtonNTomeWAChappellRRitterMARectal dose sparing with a balloon catheter and ultrasound localization in conformal radiation therapy for prostate cancerRadiother Oncol200367328529412865176
  • van LinENHoffmannALvan KollenburgPLeerJWVisserAGRectal wall sparing effect of three different endorectal balloons in 3D conformal and IMRT prostate radiotherapyInt J Radiat Oncol Biol Phys200563256557616168848
  • van LinENKristinssonJPhilippensMEReduced late rectal mucosal changes after prostate three-dimensional conformal radiotherapy with endorectal balloon as observed in repeated endoscopyInt J Radiat Oncol Biol Phys200767379981117161552
  • SchutzerMEOrioPFBiagioliMCAsherDALomasHMoghanakiDA review of rectal toxicity following permanent low dose-rate prostate brachytherapy and the potential value of biodegradable rectal spacersProstate Cancer Prostatic Dis20151829610325687401
  • PradaPJGonzalezHMenéndezCTransperineal injection of hyaluronic acid in the anterior perirectal fat to decrease rectal toxicity from radiation delivered with low-dose-rate brachytherapy for prostate cancer patientsBrachytherapy20098221021719213607
  • NoyesWRHosfordCCSchultzSEHuman collagen injections to reduce rectal dose during radiotherapyInt J Radiat Oncol Biol Phys20128251918192221514738
  • MelchertCGezEBohlenGInterstitial biodegradable balloon for reduced rectal dose during prostate radiotherapy: results of a virtual planning investigation based on the pre- and post-implant imaging data of an international multicenter studyRadiother Oncol2013106221021423484879
  • SusilRCMcNuttTRDeWeeseTLSongDEffects of prostate-rectum separation on rectal dose from external beam radiotherapyInt J Radiat Oncol Biol Phys20107641251125819939577
  • StromTJWilderRBFernandezDCA dosimetric study of polyethylene glycol hydrogel in 200 prostate cancer patients treated with high-dose rate brachytherapy±intensity modulated radiation therapyRadiother Oncol2014111112613124746567
  • BeydounNBucciJAChinYSMaloufDEnariEPainterSDFirst report of transperineal polyethylene glycol hydrogel spacer use to curtail rectal radiation dose after permanent iodine-125 prostate brachytherapyBrachytherapy201312436837423453682
  • MahalBAZiehrDRHyattASUse of a rectal spacer with low-dose-rate brachytherapy for treatment of prostate cancer in previously irradiated patients: initial experience and short-term resultsBrachytherapy201413544244924880584
  • AlongiFCozziLArcangeliSLinac based SBRT for prostate cancer in 5 fractions with VMAT and flattening filter free beams: preliminary report of a phase II studyRadiat Oncol2013817123835141
  • UhlMvan TriestBEbleMJWeberDCHerfarthKDe WeeseTLLow rectal toxicity after dose escalated IMRT treatment of prostate cancer using an absorbable hydrogel for increasing and maintaining space between the rectum and prostate: results of a multi-institutional phase II trialRadiother Oncol2013106221521923333011
  • EckertFAlloussiSPaulsenFProspective evaluation of a hydro-gel spacer for rectal separation in dose-escalated intensity-modulated radiotherapy for clinically localized prostate cancerBMC Cancer2013132723336502
  • PinkawaMPirothMDHolyRQuality of life after intensity-modulated radiotherapy for prostate cancer with a hydrogel spacer. Matched-pair analysisStrahlenther Onkol20121881091792522933033
  • MadsenBLHsiRAPhamHTFowlerJFEsaguiLCormanJStereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial resultsInt J Radiat Oncol Biol Phys20076741099110517336216
  • McBrideSMWongDSDombrowskiJJHypofractionated stereotactic body radiotherapy in low-risk prostate adenocarcinoma: preliminary results of a multi-institutional phase 1 feasibility trialCancer2012118153681369022170628
  • KatzAKangJStereotactic body radiotherapy with or without external beam radiation as treatment for organ confined high-risk prostate carcinoma: a six year studyRadiat Oncol20149124382205
  • LoblawACheungPD’AlimonteLProstate stereotactic ablative body radiotherapy using a standard linear accelerator: toxicity, biochemical, and pathological outcomesRadiother Oncol2013107215315823647750
  • KangJKChoCKChoiCWImage-guided stereotactic body radiation therapy for localized prostate cancerTumori2011971434821528663
  • FreemanDEKingCRStereotactic body radiotherapy for low-risk prostate cancer: five-year outcomesRadiat Oncol20116321219625
  • KimDWChoLCStrakaCPredictors of rectal tolerance observed in a dose-escalated phase 1-2 trial of stereotactic body radiation therapy for prostate cancerInt J Radiat Oncol Biol Phys201489350951724929162
  • HamstraDAMariadosNSylvesterJContinued benefit to rectal separation for prostate radiation therapy: final results of a phase III trialInt J Radiat Oncol Biol Phys201797597698528209443
  • BoermaMBurtonGRWangJFinkLMMcGeheeREJrHauer-JensenMComparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibitionBlood Coagul Fibrinolysis200617317318016575254
  • GauglerMHVereycken-HollerVSquibanCVandammeMVozenin-BrotonsMCBenderitterMPravastatin limits endothelial activation after irradiation and decreases the resulting inflammatory and thrombotic responsesRadiat Res2005163547948715850408
  • NübelTDamrotJRoosWPKainaBFritzGLovastatin protects human endothelial cells from killing by ionizing radiation without impairing induction and repair of DNA double-strand breaksClin Cancer Res2006123 Pt 193393916467108
  • RikitakeYKawashimaSTakeshitaSAnti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbitsAtherosclerosis20011541879611137086
  • MorikawaSTakabeWMatakiCThe effect of statins on mRNA levels of genes related to inflammation, coagulation, and vascular constriction in HUVEC. Human umbilical vein endothelial cellsJ Atheroscler Thromb20029417818312226549
  • WaehreTDamåsJKGullestadLHydroxymethylglutaryl coenzyme a reductase inhibitors down-regulate chemokines and chemokine receptors in patients with coronary artery diseaseJ Am Coll Cardiol20034191460146712742282
  • UndasABrozekJMusialJAnti-inflammatory and antithrombotic effects of statins in the management of coronary artery diseaseClin Lab2002485–628729612071579
  • ShiJWangJZhengHStatins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulationBlood Coagul Fibrinolysis200314657558512960612
  • Pérez-GuerreroCAlvarez de SotomayorMJimenezLHerreraMDMarhuendaEEffects of simvastatin on endothelial function after chronic inhibition of nitric oxide synthase by L-NAMEJ Cardiovasc Pharmacol200342220421012883323
  • WedlakeLJSiliaFBentonBEvaluating the efficacy of statins and ACE-inhibitors in reducing gastrointestinal toxicity in patients receiving radiotherapy for pelvic malignanciesEur J Cancer201248142117212422386574
  • PalumboIMatroneFMontesiGStatins protect against acute RT-related rectal toxicity in patients with prostate cancer: an observational prospective studyAnticancer Res20173731453145728314317
  • AnscherMSChangMGMoghanakiDA phase II study to prevent radiation-induced rectal injury with lovastatinAm J Clin Oncol Epub2016719
  • SarosdyMFUrinary and rectal complications of contemporary permanent transperineal brachytherapy for prostate carcinoma with or without external beam radiation therapyCancer2004101475476015305406
  • AkimotoTMuramatsuHTakahashiMRectal bleeding after hypofractionated radiotherapy for prostate cancer: correlation between clinical and dosimetric parameters and the incidence of grade 2 or worse rectal bleedingInt J Radiat Oncol Biol Phys20046041033103915519772
  • LeeCMLeeRJHandrahanDLSauseWTComparison of late rectal toxicity from conventional versus three-dimensional conformal radiotherapy for prostate cancer: analysis of clinical and dosimetric factorsUrology200565111411915667875
  • SherertzTWallnerKMerrickGFactors predictive of rectal bleeding after 103Pd and supplemental beam radiation for prostate cancerBrachytherapy20043313013515533804
  • TuckerSLDongLCheungRComparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapyInt J Radiat Oncol Biol Phys20046051589160115590191
  • WatermanFMDickerAPProbability of late rectal morbidity in 125I prostate brachytherapyInt J Radiat Oncol Biol Phys200355234235312527047
  • YoshiokaYNoseTYoshidaKHigh-dose-rate brachytherapy as monotherapy for localized prostate cancer: a retrospective analysis with special focus on tolerance and chronic toxicityInt J Radiat Oncol Biol Phys200356121322012694841
  • AlbertMTempanyCMSchultzDLate genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapyCancer200398594995412942561
  • RyuJKWinterKMichalskiJMInterim report of toxicity from 3D conformal radiation therapy (3D-CRT) for prostate cancer on 3DOG/RTOG 9406, level III (79.2 Gy)Int J Radiat Oncol Biol Phys20025441036104612419429
  • SkwarchukMWJacksonAZelefskyMJLate rectal toxicity after conformal radiotherapy of prostate cancer (I): multivariate analysis and dose-responseInt J Radiat Oncol Biol Phys200047110311310758311
  • HoffmanKESkinnerHPughTJPatient-reported urinary, bowel, and sexual function after hypofractionated intensity-modulated radiation therapy for prostate cancer: results from a randomized trialAm J Clin Oncol Epub2016915
  • PollackAWalkerGHorwitzEMRandomized trial of hypo-fractionated external-beam radiotherapy for prostate cancerJ Clin Oncol201331313860386824101042
  • KatzAJKangJQuality of life and toxicity after SBRT for organ-confined prostate cancer, a 7-year studyFront Oncol2014430125389521
  • ChenLNSuySUhmSStereotactic body radiation therapy (SBRT) for clinically localized prostate cancer: the Georgetown University experienceRadiat Oncol201385823497695
  • KingCRBrooksJDGillHPrestiJCJrLong-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancerInt J Radiat Oncol Biol Phys201282287788221300474
  • World Endoscopy Organization [homepage on the Internet]Radiation proctitis2012 [cited December 25, 2012]. Available from: http://www.endoatlas.org/index.php?page=results_jquery&mstcat=3Accessed July 14, 2017
  • LangSRiestererOProgress in Physics: Modern Techniques in Radiation OncologySPG Mitteilungen201341361922
  • Augmenix, Inc. [homepage on the internet]Bedford, MA, USASpaceOAR® system – spacing organs at risk Available from: http://review.augmenix.com/products/spaceoar/Accessed April 5, 2017