137
Views
18
CrossRef citations to date
0
Altmetric
Review

Clinical utility of fulvestrant in the treatment of breast cancer: a report on the emerging clinical evidence

, , , &
Pages 3083-3099 | Published online: 30 Aug 2018

References

  • International Agency for Research on Cancer. [webpage on the Internet]Cancer Today2016 Available from: http://gco.iarc.fr/todayAccessed December 12, 2017
  • Cancer Genome Atlas NetworkComprehensive molecular portraits of human breast tumoursNature20124907418617023000897
  • PerouCMSørlieTEisenMBMolecular portraits of human breast tumoursNature2000406679774775210963602
  • SorlieTTibshiraniRParkerJRepeated observation of breast tumor subtypes in independent gene expression data setsProc Natl Acad Sci U S A2003100148418842312829800
  • BrentonJDCareyLAAhmedAACaldasCMolecular classification and molecular forecasting of breast cancer: ready for clinical application?J Clin Oncol200523297350736016145060
  • AdesFZardavasDBozovic-SpasojevicILuminal B breast cancer: molecular characterization, clinical management, and future perspectivesJ Clin Oncol201432252794280325049332
  • GoldhirschAWinerEPCoatesASPersonalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013Ann Oncol20132492206222323917950
  • CardosoFCostaASenkusE3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)Ann Oncol2017281163328177437
  • MusgroveEASutherlandRLBiological determinants of endocrine resistance in breast cancerNat Rev Cancer20099963164319701242
  • MillerTWRexerBNGarrettJTArteagaCLMutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancerBreast Cancer Res201113622422114931
  • FrogneTJepsenJSLarsenSSFogCKBrockdorffBLLykkes-feldtAEAntiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growthEndocr Relat Cancer200512359961416172194
  • YamnikRLHolzMKmTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylationFEBS Lett2010584112412819925796
  • HuiRFinneyGLCarrollJSLeeCSMusgroveEASutherlandRLConstitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cellsCancer Res200262236916692312460907
  • AlvesCLEliasDLyngMHigh CDK6 protects cells from fulvestrant-mediated apoptosis and is a predictor of resistance to fulvestrant in estrogen receptor-positive metastatic breast cancerClin Cancer Res201622225514552627252418
  • ThangavelCDeanJLErtelATherapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancerEndocr Relat Cancer201118333334521367843
  • JeselsohnRBuchwalterGde AngelisCBrownMSchiffRESR1 mutations: a mechanism for acquired endocrine resistance in breast cancerNat Rev Clin Oncol2015121057358326122181
  • WakelingAEDukesMBowlerJA potent specific pure antiestrogen with clinical potentialCancer Res19915115386738731855205
  • OsborneCKSchiffREstrogen-receptor biology: continuing progress and therapeutic implicationsJ Clin Oncol20052381616162215755967
  • JordanVCO’MalleyBWSelective estrogen-receptor modulators and antihormonal resistance in breast cancerJ Clin Oncol200725365815582417893378
  • OsborneCKWakelingANicholsonRIFulvestrant: an oestrogen receptor antagonist with a novel mechanism of actionBr J Cancer200490Suppl 1S2S615094757
  • KumarVGreenSStackGBerryMJinJRChambonPFunctional domains of the human estrogen receptorCell19875169419513690665
  • KatoSEndohHMasuhiroYActivation of the estrogen receptor through phosphorylation by mitogen-activated protein kinaseScience19952705241149114947491495
  • FawellSEWhiteRHoareSSydenhamMPageMParkerMGInhibition of estrogen receptor-DNA binding by the “pure” antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerizationProc Natl Acad Sci U S A19908717688368872395882
  • DauvoisSWhiteRParkerMGThe antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttlingJ Cell Sci1993106Pt 4137713888126115
  • WakelingAEUse of pure antioestrogens to elucidate the mode of action of oestrogensBiochem Pharmacol19954911154515497786294
  • MoralesLNevenPTimmermanDProspective assessment of the endometrium in postmenopausal breast cancer patients treated with fulvestrantBreast Cancer Res Treat20091171778119048370
  • PeekhausNTChangTHayesECDistinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-α and -β in the breast cancer cell line MCF-7J Mol Endocrinol200432398799515171727
  • MishraAKAbrahamssonADabrosinCFulvestrant inhibits growth of triple negative breast cancer and synergizes with tamoxifen in ERα positive breast cancer by up-regulation of ERβOncotarget2016735568765688827486755
  • McClellandRAGeeJMFrancisABShort-term effects of pure anti-oestrogen ICI 182780 treatment on oestrogen receptor, epidermal growth factor receptor and transforming growth factor-alpha protein expression in human breast cancerEur J Cancer199632A34134168814683
  • InoueAYoshidaNOmotoYDevelopment of cDNA microarray for expression profiling of estrogen-responsive genesJ Mol Endocrinol200229217519212370120
  • dos SantosEGDieudonneMNPecqueryRle MoalVGiudicelliYLacasaDRapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytesEndocrinology2002143393094011861515
  • HuXFVeroniMde LuiseMCircumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780Int J Cancer19935558738768244585
  • LykkesfeldtAEMadsenMWBriandPAltered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1Cancer Res1994546158715958137264
  • de CupisANoonanDPiraniPFerreraAClericoLFavoniREComparison between novel steroid-like and conventional nonste-roidal antioestrogens in inhibiting oestradiol- and IGF-I-induced proliferation of human breast cancer-derived cellsBr J Pharmacol19951165239124008581274
  • LykkesfeldtAELarsenSSBriandPHuman breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatmentInt J Cancer19956145295347759159
  • OsborneCKCoronado-HeinsohnEBHilsenbeckSGComparison of the effects of a pure steroidal antiestrogen with those of tamoxifen in a model of human breast cancerJ Natl Cancer Inst199587107467507563152
  • DowsettMNicholsonRIPietrasRJBiological characteristics of the pure antiestrogen fulvestrant: overcoming endocrine resistanceBreast Cancer Res Treat200593Suppl 1S11S1816247595
  • DeFriendDJHowellANicholsonRIInvestigation of a new pure antiestrogen (ICI 182780) in women with primary breast cancerCancer Res19945424084148275477
  • RobertsonJFNicholsonRIBundredNJComparison of the short-term biological effects of 7α-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17β-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancerCancer Res200161186739674611559545
  • AgrawalARobertsonJFCheungKLBiological effects of fulvestrant on estrogen receptor positive human breast cancer: short, medium and long-term effects based on sequential biopsiesInt J Cancer2016138114615926178788
  • KuterIGeeJMHeggRDose-dependent change in biomarkers during neoadjuvant endocrine therapy with fulvestrant: results from NEWEST, a randomized phase II studyBreast Cancer Res Treat2012133123724622286314
  • DeeksEDFulvestrant: a review in advanced breast cancer not previously treated with endocrine therapyDrugs201878113113729270913
  • HowellADeFriendDRobertsonJBlameyRWaltonPResponse to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancerLancet1995345894129307799704
  • HowellADeFriendDJRobertsonJFPharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancerBr J Cancer19967423003088688341
  • RobertsonJFEriksteinBOsborneKCPharmacokinetic profile of intramuscular fulvestrant in advanced breast cancerClin Pharmacokinet200443852953815170367
  • RobertsonJFOdling-SmeeWHolcombeCKohlhardtSRHarrisonMPPharmacokinetics of a single dose of fulvestrant prolonged-release intramuscular injection in postmenopausal women awaiting surgery for primary breast cancerClin Ther20032551440145212867220
  • RobertsonJFHarrisonMPEquivalent single-dose pharmacokinetics of two different dosing methods of prolonged-release fulvestrant (‘Faslodex’) in postmenopausal women with advanced breast cancerCancer Chemother Pharmacol200352434634812879276
  • RobertsonJFFulvestrant (Faslodex): how to make a good drug betterOncologist200712777478417673609
  • OhnoSRaiYIwataHThree dose regimens of fulvestrant in postmenopausal Japanese women with advanced breast cancer: results from a double-blind, phase II comparative study (FINDER1)Ann Oncol201021122342234720494961
  • PritchardKIRolskiJPapaiZResults of a phase II study comparing three dosing regimens of fulvestrant in postmenopausal women with advanced breast cancer (FINDER2)Breast Cancer Res Treat2010123245346120632084
  • ChiaSGradisharWMauriacLDouble-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECTJ Clin Oncol200826101664167018316794
  • McCormackPSapunarFPharmacokinetic profile of the fulvestrant loading dose regimen in postmenopausal women with hormone receptor-positive advanced breast cancerClin Breast Cancer20088434735118757262
  • OakmanCMorettiESantarpiaLDi LeoAFulvestrant in the management of postmenopausal women with advanced, endocrine-responsive breast cancerFuture Oncol20117217318621345137
  • LeeCIGoodwinAWilckenNFulvestrant for hormone-sensitive metastatic breast cancerCochrane Database Syst Rev20171CD01109328043088
  • IngleJNSumanVJRowlandKMFulvestrant in women with advanced breast cancer after progression on prior aromatase inhibitor therapy: North Central Cancer Treatment Group Trial N0032J Clin Oncol20062471052105616505423
  • PereyLParidaensRHawleHClinical benefit of fulvestrant in postmenopausal women with advanced breast cancer and primary or acquired resistance to aromatase inhibitors: final results of phase II Swiss Group for Clinical Cancer Research Trial (SAKK 21/00)Ann Oncol2007181646917030543
  • FrancoSPerezATan-ChiuEFrankelCVogelCLResponse to fulvestrant in heavily pretreated postmenopausal women: a single-center experienceBreast Cancer Res Treat200488210310815564793
  • StegerGGBartschRWenzelCFulvestrant (‘Faslodex’) in pre-treated patients with advanced breast cancer: a single-centre experienceEur J Cancer200541172655266116230005
  • HowellARobertsonJFAlbanoJQFulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatmentJ Clin Oncol200220163396340312177099
  • OsborneCKPippenJJonesSEDouble-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trialJ Clin Oncol200220163386339512177098
  • RobertsonJFOsborneCKHowellAFulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trialsCancer200398222923812872340
  • MauriacLPippenJEAlbanoJQGertlerSZOsborneCKFulvestrant (Faslodex) versus anastrozole for the second-line treatment of advanced breast cancer in subgroups of postmenopausal women with visceral and non-visceral metastases: combined results from two multicentre trialsEur J Cancer20033991228123312763210
  • HowellAPippenJElledgeRMFulvestrant versus anastrozole for the treatment of advanced breast carcinoma: a prospectively planned combined survival analysis of two multicenter trialsCancer2005104223623915937908
  • HowellARobertsonJFAbramPComparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trialJ Clin Oncol20042291605161315117982
  • Di LeoAJerusalemGPetruzelkaLResults of the CONFIRM phase III trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancerJ Clin Oncol201028304594460020855825
  • Di LeoAJerusalemGPetruzelkaLFinal overall survival: fulvestrant 500 mg vs 250 mg in the randomized CONFIRM trialJ Natl Cancer Inst20141061djt33724317176
  • Di LeoAJerusalemGTorresRFirst-line vs second-line fulvestrant for hormone receptor-positive advanced breast cancer: a post-hoc analysis of the CONFIRM studyBreast20183814414929324303
  • JeselsohnRBarryWTMigliaccioITransCONFIRM: identification of a genetic signature of response to fulvestrant in advanced hormone receptor-positive breast cancerClin Cancer Res201622235755576427185372
  • RobertsonJFLlombart-CussacARolskiJActivity of ful-vestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST studyJ Clin Oncol200927274530453519704066
  • RobertsonJFLindemannJPLlombart-CussacAFulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: follow-up analysis from the randomized ‘FIRST’ studyBreast Cancer Res Treat2012136250351123065000
  • EllisMJLlombart-CussacAFeltlDFulvestrant 500 mg versus anastrozole 1 mg for the first-line treatment of advanced breast cancer: overall survival analysis from the phase II FIRST studyJ Clin Oncol201533323781378726371134
  • RobertsonJFBondarenkoIMTrishkinaEFulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trialLancet2016388100632997300527908454
  • YoungOERenshawLMacaskillEJEffects of fulvestrant 750mg in premenopausal women with oestrogen-receptor-positive primary breast cancerEur J Cancer200844339139918083023
  • MasciGGandiniCZuradelliMFulvestrant for advanced male breast cancer patients: a case seriesAnn Oncol201122498521447621
  • ZagouriFSergentanisTNChrysikosDDimopoulosMAPsaltopoulouTFulvestrant and male breast cancer: a pooled analysisBreast Cancer Res Treat2015149126927525519043
  • JelovacDMacedoLGoloubevaOGHandrattaVBrodieAMAdditive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer modelCancer Res200565125439544415958593
  • RobertsonJFDixonJMSibberingDMA randomized trial to assess the biological activity of short-term (pre-surgical) fulvestrant 500 mg plus anastrozole versus fulvestrant 500 mg alone or anastrozole alone on primary breast cancerBreast Cancer Res2013152R1823497452
  • BerghJJönssonPELidbrinkEKFACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancerJ Clin Oncol201230161919192522370325
  • MehtaRSBarlowWEAlbainKSCombination anastrozole and fulvestrant in metastatic breast cancerN Engl J Med2012367543544422853014
  • JohnstonSRKilburnLSEllisPFulvestrant plus anastrozole or placebo versus exemestane alone after progression on non-steroidal aromatase inhibitors in postmenopausal patients with hormone-receptor-positive locally advanced or metastatic breast cancer (SoFEA): a composite, multicentre, phase 3 randomised trialLancet Oncol2013141098999823902874
  • FribbensCO’LearyBKilburnLPlasma ESR1 mutations and the treatment of estrogen receptor-positive advanced breast cancerJ Clin Oncol201634252961296827269946
  • RobertsonJFStegerGGNevenPActivity of fulvestrant in HER2-overexpressing advanced breast cancerAnn Oncol20102161246125319875750
  • Sonne-HansenKNorrieICEmdalKBBreast cancer cells can switch between estrogen receptor alpha and ErbB signaling and combined treatment against both signaling pathways postpones development of resistanceBreast Cancer Res Treat2010121360161319697122
  • ChenQWengZLuYAn experimental analysis of the molecular effects of trastuzumab (Herceptin) and fulvestrant (Falsodex), as single agents or in combination, on human HR+/HER2+ breast cancer cell lines and mouse tumor xenograftsPLoS One2017121e016896028045951
  • MassarwehSThamYLHuangJA phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancerBreast Cancer Res Treat2011129381982721792626
  • CarlsonRWO’NeillAVidaurreTGomezHLBadveSSSledgeGWA randomized trial of combination anastrozole plus gefitinib and of combination fulvestrant plus gefitinib in the treatment of postmenopausal women with hormone receptor positive metastatic breast cancerBreast Cancer Res Treat201213331049105622418699
  • BursteinHJCirrincioneCTBarryWTEndocrine therapy with or without inhibition of epidermal growth factor receptor and human epidermal growth factor receptor 2: a randomized, double-blind, placebo-controlled phase III trial of fulvestrant with or without lapatinib for postmenopausal women with hormone receptor-positive advanced breast cancer-CALGB 40302 (Alliance)J Clin Oncol201432353959396625348000
  • RobertsonJFFerreroJMBourgeoisHGanitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trialLancet Oncol201314322823523414585
  • FrogneTBenjaminsenRVSonne-HansenKActivation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrantBreast Cancer Res Treat200911422637518409071
  • ZamanKWinterhalderRMamotCFulvestrant with or without selumetinib, a MEK 1/2 inhibitor, in breast cancer progressing after aromatase inhibitor therapy: a multicentre randomized placebo-controlled double-blind phase II trial, SAKK 21/08Eur J Cancer201551101212122025892646
  • ZmajkovicovaKJesenbergerVCatalanottiFBaumgartnerCReyesGBaccariniMMEK1 is required for PTEN membrane recruitment, Akt regulation, and the maintenance of peripheral toleranceMol Cell2013501435523453810
  • BoschALiZBergamaschiAPI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancerSci Transl Med20157283283ra51
  • MillerTWBalkoJMFoxEMERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancerCancer Discov20111433835122049316
  • MaCXLuoJNaughtonMA phase I trial of BKM120 (bupar-lisib) in combination with fulvestrant in postmenopausal women with estrogen receptor-positive metastatic breast cancerClin Cancer Res20162271583159126563128
  • BaselgaJImSAIwataHBuparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trialLancet Oncol201718790491628576675
  • Di LeoAJohnstonSLeeKSBuparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trialLancet Oncol20181918710029223745
  • SunSYRosenbergLMWangXActivation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibitionCancer Res200565167052705816103051
  • KropIEMayerIAGanjuVPictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trialLancet Oncol201617681182127155741
  • JuricDRodonJTaberneroJPhosphatidylinositol 3-kinase α-selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors: results from the first-in-human studyJ Clin Oncol201836131291129929401002
  • JuricDKropIRamanathanRKPhase I dose-escalation study of taselisib, an oral PI3K Inhibitor, in patients with advanced solid tumorsCancer Discov20177770471528331003
  • BaselgaJDentSFCortésJPhase III study of taselisib (GDC-0032) + fulvestrant (FULV) v FULV in patients (pts) with estrogen receptor (ER)-positive, PIK3CA-mutant (MUT), locally advanced or metastatic breast cancer (MBC): Primary analysis from SANDPIPERJ Clin Oncol201836
  • MaCXSanchezCGaoFA phase I study of the Akt inhibitor MK-2206 in combination with hormonal therapy in postmenopausal women with estrogen receptor-positive metastatic breast cancerClin Cancer Res201622112650265826783290
  • KornblumNZhaoFManolaJRandomized Phase II Trial of Fulvestrant Plus Everolimus or Placebo in Postmenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Resistant to Aromatase Inhibitor Therapy: Results of PrE0102J Clin Oncol201836161556156329664714
  • FinnRSDeringJConklinDPD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitroBreast Cancer Res2009115R7719874578
  • TurnerNCRoJAndréFPalbociclib in hormone-receptor-positive advanced breast cancerN Engl J Med2015373320921926030518
  • CristofanilliMTurnerNCBondarenkoIFulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trialLancet Oncol201617442543926947331
  • LoiblSTurnerNCRoJPalbociclib combined with fulvestrant in premenopausal women with advanced breast cancer and prior progression on endocrine therapy: PALOMA-3 resultsOncologist20172291028103828652278
  • TurnerNCFinnRSMartinMClinical considerations of the role of palbociclib in the management of advanced breast cancer patients with and without visceral metastasesAnn Oncol201829366968029342248
  • VermaSBartlettCHSchnellPPalbociclib in combination with fulvestrant in women with hormone receptor-positive/HER2-negative advanced metastatic breast cancer: detailed safety analysis from a multicenter, randomized, placebo-controlled, phase III study (PALOMA-3)Oncologist201621101165117527368881
  • HarbeckNIyerSTurnerNQuality of life with palbociclib plus fulvestrant in previously treated hormone receptor-positive, HER2-negative metastatic breast cancer: patient-reported outcomes from the PALOMA-3 trialAnn Oncol20162761047105427029704
  • GianniLBisagniGColleoniMNeoadjuvant treatment with trastuzumab and pertuzumab plus palbociclib and fulvestrant in HER2-positive, ER-positive breast cancer (NA-PHER2): an exploratory, open-label, phase 2 studyLancet Oncol201819224925629326029
  • SledgeGWJrToiMNevenPMONARCH 2: abemaciclib in combination with fulvestrant in women with HR+/HER2− advanced breast cancer who had progressed while receiving endocrine therapyJ Clin Oncol201735252875288428580882
  • SlamonDJNevenPChiaSPhase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: MONALEESA-3J Clin Oncol Epub201863
  • Herrera-AbreuMTPalafoxMAsgharUEarly adaptation and acquired resistance to CDK4/6 inhibition in estrogen receptor-positive breast cancerCancer Res20167682301231327020857
  • O’BrienNADi TomasoEAyalaRIn vivo efficacy of combined targeting of CDK4/6, ER and PI3K signaling in ER+ breast cancerCancer Res20147419 Suppl4756
  • TolaneySMForero-TorresABoniVRibociclib + fulvestrant in postmenopausal women with HR+, HER2− advanced breast cancer (ABC)Cancer Res2017774 SupplP4-22-12
  • ForeroAHanHSDeesECPhase IB study to assess the safety, tolerability, and clinical activity of gedatolisib in combination with palbociclib and either letrozole or fulvestrant in women with metastatic or locally advanced/recurrent breast cancer (B2151009)Poster presented at: 2017 San Antonio Breast Cancer SymposiumDecember 6–10, 2017San Antonio, TX
  • MartínMLoiblSvon MinckwitzGPhase III trial evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for advanced breast cancer: the letrozole/fulvestrant and avastin (LEA) studyJ Clin Oncol20153391045105225691671
  • ClemonsMJCochraneBPondGRRandomised, phase II, placebo-controlled, trial of fulvestrant plus vandetanib in postmenopausal women with bone only or bone predominant, hormone-receptor-positive metastatic breast cancer (MBC): the OCOG ZAMBONEY studyBreast Cancer Res Treat2014146115316224924416
  • MusolinoACamponeMNevenPPhase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2– breast cancer that had progressed during or after prior endocrine therapyBreast Cancer Res20171911828183331
  • AdelsonKRamaswamyBSparanoJARandomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: a New York Cancer Consortium trialNPJ Breast Cancer201621603728721390
  • DolfiSCJägerAVMedinaDJHafftyBGYangJMHirshfieldKMFulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugsCancer Lett20143501–2526024747123
  • JiangDHuangYHanNFulvestrant, a selective estrogen receptor down-regulator, sensitizes estrogen receptor negative breast tumors to chemotherapyCancer Lett2014346229229924462822
  • SchwartzbergLSWangGSomerBGPhase II trial of fulves-trant with metronomic capecitabine for postmenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancerClin Breast Cancer2014141131924268206
  • RobertsonJFCheungKLNoguchiSHealth-related quality of life from the FALCON phase III randomised trial of fulvestrant 500 mg versus anastrozole for hormone receptor-positive advanced breast cancerEur J Cancer20189420621529574365