Density of CD8+ lymphocytes in biopsy samples combined with the circulating lymphocyte ratio predicts pathologic complete response to chemoradiotherapy for rectal cancer

References

• BossetJFColletteLCalaisGEORTC Radiotherapy Group Trial 22921Chemotherapy with preoperative radiotherapy in rectal cancerN Engl J Med200635511111416971718
   PubMed Web of Science ®Google Scholar
• Habr-GamaAPerezRONadalinWOperative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term resultsAnn Surg20042404717718
   Web of Science ®Google Scholar
• LambregtsDMJMaasMBakersFCHLong-term follow-up features on rectal MRI during a wait-and-see approach after a clinical complete response in patients with rectal cancer treated with chemo-radiotherapyDis Colon Rectum201154121521152822067180
   PubMed Web of Science ®Google Scholar
• SmithJDRubyJAGoodmanKANonoperative management of rectal cancer with complete clinical response after neoadjuvant therapyAnn Surg2012256696597223154394
   PubMed Web of Science ®Google Scholar
• CarlomagnoCPepeSD’ArmientoFPPredictive factors of complete response to neoadjuvant chemoradiotherapy in patients with rectal cancerOncology2010785–636937520798559
   PubMed Web of Science ®Google Scholar
• KaladyMFde CamposlobatoLFStocchiLPredictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancerAnn Surg2009250458219710605
   PubMed Web of Science ®Google Scholar
• ZengWLiangJWangZClinical parameters predicting pathologic complete response following neoadjuvant chemoradiotherapy for rectal cancerChin J Cancer2015341046847426268466
   PubMedGoogle Scholar
• JungSWParkIJOhSHAssociation of immunologic markers from complete blood counts with the response to preoperative chemoradiotherapy and prognosis in locally advanced rectal cancerOncotarget2017835597575976528938679
   PubMedGoogle Scholar
• FreyBRubnerYKulzerLAntitumor immune responses induced by ionizing irradiation and further immune stimulationCancer Immunol Immunother2014631293624052136
   PubMed Web of Science ®Google Scholar
• LorimoreSACoatesPJScobieGEMilneGWrightEGInflammatory- type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects?Oncogene200120487085709511704832
   PubMed Web of Science ®Google Scholar
• PerezCAFuAOnishkoHHallahanDEGengLRadiation induces an antitumour immune response to mouse melanomaInt J Radiat Biol200985121126113619995238
   PubMed Web of Science ®Google Scholar
• YasudaKNireiTSunamiENagawaHKitayamaJDensity of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancerRadiat Oncol2011614921575175
   PubMed Web of Science ®Google Scholar
• DouXWangRYanHCirculating lymphocytes as predictors of sensitivity to preoperative chemoradiotherapy in rectal cancer casesAsian Pac J Cancer Prev20131463881388523886201
   PubMedGoogle Scholar
• KitayamaJYasudaKKawaiKSunamiENagawaHCirculating lymphocyte number has a positive association with tumor response in neoadjuvant chemoradiotherapy for advanced rectal cancerRadiat Oncol2010514720525293
   PubMed Web of Science ®Google Scholar
• MandardAMDalibardFMandardJCPathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Clinicopathologic correlationsCancer19947311268026868194005
   PubMed Web of Science ®Google Scholar
• TengFMuDMengXTumor infiltrating lymphocytes (TILs) before and after neoadjuvant chemoradiotherapy and its clinical utility for rectal cancerAm J Cancer Res2015562064207426269765
   PubMed Web of Science ®Google Scholar
• GalonJType, density, and location of immune cells within human colorectal tumors predict clinical outcomeScience200631357951960196417008531
   PubMed Web of Science ®Google Scholar
• MalietzisGGiacomettiMAskariAA preoperative neutrophil to lymphocyte ratio of 3 predicts disease-free survival after curative elective colorectal cancer surgeryAnn Surg2014260228729224096764
   PubMed Web of Science ®Google Scholar
• LewisCEPollardJWDistinct role of macrophages in different tumor microenvironmentsCancer Res200666260561216423985
   PubMed Web of Science ®Google Scholar
• HoughtonMGRzymkiewiczDMJiHNeutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growthNat Med201016221922320081861
   PubMed Web of Science ®Google Scholar
• SerugaBZhangHBernsteinLJCytokines and their relationship to the symptoms and outcome of cancerNat Rev Cancer200881188789918846100
   PubMed Web of Science ®Google Scholar
• MlecnikBBindeaGAngellHKIntegrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instabilityImmunity201644369871126982367
   PubMed Web of Science ®Google Scholar
• MlecnikBTosoliniMKirilovskyAHistopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reactionJ Clin Oncol201129661061821245428
   PubMed Web of Science ®Google Scholar
• KimIYYouSHKimYWNeutrophil-lymphocyte ratio predicts pathologic tumor response and survival after preoperative chemoradiation for rectal cancerBMC Surg2014149425406793
   PubMed Web of Science ®Google Scholar
• GrimmMFeyenOHofmannHImmunophenotyping of patients with oral squamous cell carcinoma in peripheral blood and associated tumor tissueTumor Biol201637338073816
   Google Scholar
• EmersonROSherwoodAMRiederMJHigh-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancerJ Pathol2013231443344024027095
   PubMed Web of Science ®Google Scholar
• ParkJWLimSBKimDYCarcinoembryonic antigen as a predictor of pathologic response and a prognostic factor in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and surgeryInt J Radiat Oncol Biol Phys200974381081719101093
   PubMed Web of Science ®Google Scholar
• WanSLaiYMyersREPreoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patientsJ Gastrointest Cancer201344329330423549858
   PubMedGoogle Scholar
• YasudaKSunamiEKawaiKNagawaHKitayamaJLaboratory blood data have a significant impact on tumor response and outcome in preoperative chemoradiotherapy for advanced rectal cancerJ Gastrointest Cancer201243223624321365477
   PubMedGoogle Scholar
• Garcia-AguilarJChowOSSmithDDTiming of Rectal Cancer Response to Chemoradiation ConsortiumEffect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trialLancet Oncol201516895796626187751
   PubMed Web of Science ®Google Scholar
• FarahRKhamisy FarahRAssociation of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infectionJ Clin Lab Anal201428321922324478129
   PubMed Web of Science ®Google Scholar
• BhatTTeliSRijalJNeutrophil to lymphocyte ratio and cardiovascular diseases: a reviewExpert Rev Cardiovasc Ther20131115523259445
   PubMedGoogle Scholar