Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?

References

• TorreLABrayFSiegelRLFerlayJLortet-TieulentJJemalAGlobal cancer statistics, 2012CA Cancer J Clin2015658710825651787
   PubMed Web of Science ®Google Scholar
• SinghGParmarPKatariaSPKatariaSPSinghSSenRSpectrum of acute and chronic leukemia at a tertiary care hospital, Haryana, IndiaInt J Res Med Sci2016411151118
   Google Scholar
• DöhnerHEsteyEHAmadoriSDiagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia NetBlood201011545347419880497
   PubMed Web of Science ®Google Scholar
• KantarjianHO’BrienSCortesJResults of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndromeCancer20061061090109816435386
   PubMed Web of Science ®Google Scholar
• LerchEEspeliVZuccaEPrognosis of acute myeloid leukemia in the general population: data from southern SwitzerlandTumori20099530331019688968
   PubMed Web of Science ®Google Scholar
• BahlASharmaARainaVLong-term outcomes for patients with acute myeloid leukemia: a single-center experience from AIIMS, IndiaAsia Pac J Clin Oncol20151124225225639656
   PubMed Web of Science ®Google Scholar
• WeltermannAFonatschCHaasOAImpact of cytogenetics on the prognosis of adults with de novo AML in first relapseLeukemia20041829330214671635
   PubMed Web of Science ®Google Scholar
• UllahKAhmedPRazaSManagement of acute myeloid leukaemia-5 years experience at Armed Forces Bone Marrow Transplant Centre, RawalpindiJ Pak Med Assoc20075743443918072636
   PubMedGoogle Scholar
• MaynadiéMDe AngelisRMarcos-GrageraRSurvival of European patients diagnosed with myeloid malignancies: a HAEMACARE studyHaematologica20139823023822983589
   PubMed Web of Science ®Google Scholar
• SchimmerADPedersenIMKitadaSFunctional blocks in caspase activation pathways are common in leukemia and predict patient response to induction chemotherapyCancer Res2003631242124812649183
   PubMed Web of Science ®Google Scholar
• OlaMSNawazMAhsanHRole of Bcl-2 family proteins and caspases in the regulation of apoptosisMol Cell Biochem2011351415821210296
   PubMed Web of Science ®Google Scholar
• JanumyanYCuiQYanLSansamCGValentinMYangEG0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulationJ Biol Chem2008283341083412018818203
   PubMed Web of Science ®Google Scholar
• YouleRJStrasserAThe BCL-2 protein family: opposing activities that mediate cell deathNat Rev Mol Cell Biol20089475918097445
   PubMed Web of Science ®Google Scholar
• WongRSApoptosis in cancer: from pathogenesis to treatmentJ Exp Clin Cancer Res2011308721943236
   PubMed Web of Science ®Google Scholar
• ProkopAWiederTSturnIRelapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivoLeukemia2000141606161310995007
   PubMed Web of Science ®Google Scholar
• MatsumotoHWadaTFukunagaKYoshihiroSMatsuyamaHNaitoKBax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder cancerJpn J Clin Oncol20043412413015078907
   PubMed Web of Science ®Google Scholar
• KhorLYMoughanJAl-SaleemTBcl-2 and Bax expression predict prostate cancer outcome in men treated with androgen deprivation and radiotherapy on radiation therapy oncology group protocol 92-02Clin Cancer Res2007133585359017575222
   PubMed Web of Science ®Google Scholar
• KatkooriVRSuarez-CuervoCShanmugamCBax expression is a candidate prognostic and predictive marker of colorectal cancerJ Gastrointest Oncol20101768922811811
   PubMedGoogle Scholar
• SinghLPushkerNSainiNExpression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins in human retinoblastomaClin Exp Ophthalmol20154325926725132102
   PubMed Web of Science ®Google Scholar
• AppelMLEdelweissMIFleckJP53 and BCL-2 as prognostic markers in endometrial carcinomaPathol Oncol Res200814233018398703
   PubMed Web of Science ®Google Scholar
• PalmerJESant CassiaLJIrwinCJMorrisAGRollasonTPP53 and bcl-2 assessment in serous ovarian carcinomaInt J Gynecol Cancer20081824124818334006
   PubMed Web of Science ®Google Scholar
• PaoluzziLGonenMBhagatGThe BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignanciesBlood20081122906291618591385
   PubMed Web of Science ®Google Scholar
• KhawSLMérinoDAndersonMABoth leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective Pharmacological inhibition of prosurvival Bcl-2 with ABT-199Leukemia2014281207121524402163
   PubMed Web of Science ®Google Scholar
• SuzukiKKazuiTYoshidaMDrug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitroJpn J Clin Oncol19992932333110470656
   PubMed Web of Science ®Google Scholar
• SchmittgenTDLivakKJAnalyzing real-time PCR data by the comparative C(T) methodNat Protoc200831101110818546601
   PubMed Web of Science ®Google Scholar
• BekhetMMFouadNTAFatheyHEl-SayedEHendawyLMKhattabDPrognostic value of Bcl2-associated X protein (Bax) expression in adult Egyptian patients with acute myeloid leukemiaIndian J Med Res Pharm Sci2016317
   Google Scholar
• HogarthLAHallAGIncreased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemiaBlood1999932671267810194447
   PubMed Web of Science ®Google Scholar
• KöhlerTSchillCDeiningerMWHigh Bad and Bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML)Leukemia200216222911840259
   PubMed Web of Science ®Google Scholar
• KaparouMChoumerianouDPerdikogianniCMartimianakiGKalmantiMStiakakiEEnhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk featuresGenet Mol Biol20133671123569402
   PubMed Web of Science ®Google Scholar
• ArefSSalamaOAl-TonbaryYMansourAAssessment of bcl-2 expression as modulator of fas mediated apoptosis in acute leukemiaHematology2004911312115203866
   PubMedGoogle Scholar
• KornblauSMThallPFEstrovZThe prognostic impact of BCL2 protein expression in acute myelogenous leukemia varies with cytogeneticsClin Cancer Res199951758176610430080
   PubMed Web of Science ®Google Scholar
• SahuGJenaRKClinical significance of P53 and Bcl-2 in acute myeloid leukemia patients of Eastern IndiaHematol Rep20113e2822593819
   PubMedGoogle Scholar
• HuangQLiSChengPHigh expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: result of a meta-analysisWorld J Gastroenterol2017235018503328785155
   PubMed Web of Science ®Google Scholar
• HwangKTWooJWShinHCPrognostic influence of BCL2 expression in breast cancerInt J Cancer2012131E1109E111922418857
   PubMed Web of Science ®Google Scholar
• CasadoSFortezaJDominguezSPredictive value of P53, BCL-2, and BAX in advanced head and neck carcinomaAm J Clin Oncol20022558859012478005
   PubMed Web of Science ®Google Scholar
• SagarraRAAndradeLAMartinezEZP53 and Bcl-2 as prognostic predictors in epithelial ovarian cancerInt J Gynecol Cancer20021272072712445249
   PubMed Web of Science ®Google Scholar
• GarciaEJLawsonDCotsonisGHepatocellular carcinoma and markers of apoptosis (bcl-2, bax, bcl-x): prognostic significanceAppl Immunohistochem Mol Morphol20021021021712373145
   PubMedGoogle Scholar
• PierceRHVailMERalphLCampbellJSFaustoNBcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating fociAm J Pathol20021601555156012000706
   PubMed Web of Science ®Google Scholar
• Kasimir-BauerSBeelenDFlasshoveMNoppeneyRSeeberSScheulenMEImpact of the expression of P glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemiaExp Hematol2002301302130812423683
   PubMed Web of Science ®Google Scholar
• Del PoetaGVendittiADel PrincipeMIAmount of spontaneous apoptosis detected by Bax/Bcl-2 ratio predicts outcome in acute myeloid leukemia (AML)Blood20031012125213112424199
   PubMed Web of Science ®Google Scholar
• KhodapasandEJafarzadehNFarrokhiFKamalidehghanBHoushmandMIs Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer?Iran Biomed J201519697525864810
   PubMedGoogle Scholar
• BelmarJFesikSWSmall molecule Mcl-1 inhibitors for the treatment of cancerPharmacol Ther2015145768425172548
   PubMed Web of Science ®Google Scholar
• KimJHSimSHHaHJKoJJLeeKBaeJMCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell deathFEBS Lett20095832758276419683529
   PubMed Web of Science ®Google Scholar
• PlaczekWJWeiJKitadaSZhaiDReedJCPellecchiaMA survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapyCell Death Dis20101e4021364647
   PubMed Web of Science ®Google Scholar
• PeiróGDieboldJBarettonGBKimmigRLöhrsUCellular apoptosis susceptibility gene expression in endometrial carcinoma: correlation with Bcl-2, Bax, and caspase-3 expression and outcomeInt J Gynecol Pathol200120435936711603220
   PubMed Web of Science ®Google Scholar
• ScopaCDVagianosCKardamakisDKourelisTGKalofonosHPTsamandasACbcl-2/bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal cancerAppl Immunohistochem Mol Morphol2001932933411759059
   PubMedGoogle Scholar