Clinical and biological implications of IDH1/2 in acute myeloid leukemia with DNMT3A^mut

References

• VardimanJWThieleJArberDAThe 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changesBlood2009114593795119357394
   PubMed Web of Science ®Google Scholar
• ArberDAOraziAHasserjianRThe 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemiaBlood2016127202391240527069254
   PubMed Web of Science ®Google Scholar
• KavanaghSMurphyTLawAEmerging therapies for acute myeloid leukemia: translating biology into the clinicJCI Insight2017218e95679
   PubMed Web of Science ®Google Scholar
• SehgalARGimottyPAZhaoJDNMT3A mutational status affects the results of dose-escalated induction therapy in acute myelogenous leukemiaClin Cancer Res20152171614162025609058
   PubMed Web of Science ®Google Scholar
• LeyTJDingLWalterMJDNMT3A mutations in acute myeloid leukemiaN Engl J Med2010363252424243321067377
   PubMed Web of Science ®Google Scholar
• HájkováHMarkováJHaškovecCDecreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylationLeuk Res20123691128113322749068
   PubMed Web of Science ®Google Scholar
• TholFDammFLüdekingAIncidence and prognostic influence of DNMT3A mutations in acute myeloid leukemiaJ Clin Oncol201129212889289621670448
   PubMed Web of Science ®Google Scholar
• GaleRELambKAllenCSimpson’s paradox and the impact of different DNMT3A mutations on outcome in younger adults with acute myeloid leukemiaJ Clin Oncol201533182072208325964253
   PubMed Web of Science ®Google Scholar
• HouHAKuoYYLiuCYDNMT3A mutations in acute myeloid leukemia: Stability during disease evolution and clinical implicationsBlood2012119255956822077061
   PubMed Web of Science ®Google Scholar
• RakhejaDKonoplevSMedeirosLJChenWIDH mutations in acute myeloid leukemiaHum Pathol201243101541155122917530
   PubMed Web of Science ®Google Scholar
• DiNardoCDRavandiFAgrestaSCharacteristics, clinical outcome, and prognostic significance of IDH mutations in AMLAm J Hematol201590873273626016821
   PubMed Web of Science ®Google Scholar
• WardPSPatelJWiseDRThe common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarateCancer Cell201017322523420171147
   PubMed Web of Science ®Google Scholar
• ImAPSehgalARCarrollMPDNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategiesLeukemia20142891774178324699305
   PubMed Web of Science ®Google Scholar
• UpadhyayVABrunnerAMFathiATIsocitrate dehydrogenase (IDH) inhibition as treatment of myeloid malignancies: Progress and future directionsPharmacol Ther201717712312828315358
   PubMed Web of Science ®Google Scholar
• FigueroaMEAbdel-WahabOLuCLeukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationCancer Cell201018655356721130701
   PubMed Web of Science ®Google Scholar
• XuQLiYLvNCorrelation between isocitrate dehydrogenase gene aberrations and prognosis of patients with acute myeloid leukemia: A systematic review and meta-analysisClin Cancer Res201723154511452228246275
   PubMed Web of Science ®Google Scholar
• The Cancer Genome Atlas Research NetworkGenomic and epigenomic landscapes of adult de novo acute myeloid leukemiaN Engl J Med2013368222059207423634996
   PubMed Web of Science ®Google Scholar
• WangMLindbergJKlevebringDValidation of risk stratification models in acute myeloid leukemia using sequencing-based molecular profilingLeukemia201731102029203628167833
   PubMed Web of Science ®Google Scholar
• WahlinABillströmRBjörOResults of risk-adapted therapy in acute myeloid leukaemia. A long-term population-based follow-up studyEur J Haematol20098329910719385987
   PubMed Web of Science ®Google Scholar
• PatelJPGönenMFigueroaMEPrognostic relevance of integrated genetic profiling in acute myeloid leukemiaN Engl J Med2012366121079108922417203
   PubMed Web of Science ®Google Scholar
• ZhouJ-DYaoD-MLiX-XKRAS overexpression independent of RAS mutations confers an adverse prognosis in cytogenetically normal acute myeloid leukemiaOncotarget2017839660876609729029494
   PubMedGoogle Scholar
• BacherUHaferlachTSchochCKernWSchnittgerSImplications of NRAS mutations in AML: A study of 2502 patientsBlood2006107103847385316434492
   PubMed Web of Science ®Google Scholar
• KadiaTMKantarjianHKornblauSClinical and proteomic characterization of acute myeloid leukemia with mutated RASCancer2012118225550555922569880
   PubMed Web of Science ®Google Scholar
• TholFBollinRGehlhaarMMutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implicationsBlood2014123691492024335498
   PubMed Web of Science ®Google Scholar
• AndradeFGNoronhaEPBrissonGDMolecular characterization of pediatric acute myeloid leukemia: Results of a multicentric study in BrazilArch Med Res201647865666728476193
   PubMed Web of Science ®Google Scholar
• OhgamiRSMaLMerkerJDNext-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutationsMod Pathol201528570671425412851
   PubMed Web of Science ®Google Scholar
• SunQYDingLWTanKTOrdering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)Leukemia201731111027389053
   PubMed Web of Science ®Google Scholar
• TangSShenHMaoXFLT3-ITD with DNMT3A R882 double mutation is a poor prognostic factor in Chinese patients with acute myeloid leukemia after chemotherapy or allogeneic hematopoietic stem cell transplantationInt J Hematol2017106455256128616699
   PubMed Web of Science ®Google Scholar
• PaschkaPSchlenkRFGaidzikVIIDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplicationJ Clin Oncol201028223636364320567020
   PubMed Web of Science ®Google Scholar
• XuYSunYShenHAllogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutationsAm J Hematol2015901199299726223865
   PubMed Web of Science ®Google Scholar
• SteinEMDiNardoCDPollyeaDAEnasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemiaBlood2017130672273128588020
   PubMed Web of Science ®Google Scholar
• AmatangeloMDQuekLShihAEnasidenib induces acute myeloid leukemia cell differentiation to promote clinical responseBlood2017130673274128588019
   PubMed Web of Science ®Google Scholar