References
- SiegelRLMillerKDJemalACancer statistics, 2017CA Cancer J Clin201767173028055103
- ChenWZhengRBaadePDCancer statistics in China, 2015CA Cancer J Clin201666211513226808342
- XingLShiQZhengKUltrasound-mediated microbubble destruction (UMMD) facilitates the delivery of CA19-9 targeted and paclitaxel loaded mPEG-PLGA-PLL nanoparticles in pancreatic cancerTheranostics20166101573158727446491
- MahajanUMTellerSSendlerMTumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancerGut201665111838184927196585
- LeeHJZhuangGCaoYDuPKimHJSettlemanJDrug resistance via feedback activation of Stat3 in oncogene-addicted cancer cellsCancer Cell201426220722125065853
- ZhaoCLiHLinHJYangSLinJLiangGFeedback activation of STAT3 as a cancer drug-resistance mechanismTrends Pharmacol Sci2016371476126576830
- YinFHuKChenYSiRNA delivery with PEGylated graphene oxide nanosheets for combined photothermal and genetherapy for pancreatic cancerTheranostics2017751133114828435453
- YuHPardollDJoveRSTATs in cancer inflammation and immunity: a leading role for STAT3Nat Rev Cancer200991179880919851315
- YuHLeeHHerrmannABuettnerRJoveRRevisiting STAT3 signalling in cancer: new and unexpected biological functionsNat Rev Cancer2014141173674625342631
- HerrmannAPricemanSJSwiderskiPCTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cellsJ Clin Invest201512562547
- JungKHYooWStevensonHLMulti-functional effects of a small-molecule STAT3 inhibitor on NASH and HCC in miceClin Cancer Res201723185537554628533225
- SahuNChanEChuFCo-targeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocarcinomaMol Cancer Ther20171691729173828619758
- LongKBTookerGTookerEIL-6 receptor blockade enhances chemotherapy efficacy in pancreatic ductal adenocarcinomaMol Cancer Ther20171691898190828611107
- ZhangZWangFDuCBRM/SMARCA2 promotes the proliferation and chemoresistance of pancreatic cancer cells by targeting JAK2/STAT3 signalingCancer Lett201740221322428602977
- HuminieckiLHorbanczukJAtanasovAGThe functional genomic studies of curcuminSemin Cancer Biol20174610711828392463
- NelsonKMDahlinJLBissonJGrahamJPauliGFWaltersMAThe essential medicinal chemistry of curcuminJ Med Chem20176051620163728074653
- BakerMDeceptive curcumin offers cautionary tale for chemistsNature2017541763614414528079090
- ZhaoCLiuZLiangGPromising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs)Curr Pharm Des201319112114213523116317
- LinLHutzenBZuoMNovel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cellsCancer Res20107062445245420215512
- WuJPatmoreDMJousmaEEGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumorsOncogene201433217318023318430
- MaceTAAmeenZCollinsAPancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent mannerCancer Res201373103007301823514705
- BillMANicholasCMaceTAStructurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell linesPLoS One201278e4072422899991
- CenLHutzenBBallSNew structural analogues of curcumin exhibit potent growth suppressive activity in human colorectal carcinoma cellsBMC Cancer200999919331692
- RathKSNaiduSKLataPHO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancerCancer Res20147482316232724590057
- LiangGShaoLWangYExploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agentsBioorg Med Chem20091762623263119243951
- TrottOOlsonAJAutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingJ Comput Chem201031245546119499576
- BeckerSGronerBMullerCWThree-dimensional structure of the Stat3beta homodimer bound to DNANature199839466891451519671298
- SannerMFPython: a programming language for software integration and developmentJ Mol Graph Model1999171576110660911
- HubbardJMGrotheyANapabucasin: an update on the first-in-class cancer stemness inhibitorDrugs201777101091110328573435
- AgrawalPFontanals-CireraBSokolovaEA systems biology approach identifies FUT8 as a driver of melanoma metastasisCancer Cell2017316804.e819.e28609658
- LiuYLiPKLiCLinJInhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cellsJ Biol Chem201028535274292743920562100
- WuZGabrielsonAHwangJJPhase II study of lapatinib and capecitabine in second-line treatment for metastatic pancreatic cancerCancer Chemother Pharmacol20157661309131426507197
- LiHLiuAZhaoZFragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3)J Med Chem201154155592559621678971
- LiHMultiple Ligand Simultaneous Docking (MLSD) and Its Applications to Fragment Based Drug Design and Drug Repositioning [Electronic Thesis or Dissertation]Ohio State University2012 Available from: https://etd.ohiolink.edu/Accessed February 6, 2018
- YuWLiCZhangWDiscovery of an orally selective inhibitor of signal transducer and activator of transcription 3 using advanced multiple ligand simultaneous dockingJ Med Chem20176072718273128245116
- VenninCChinVTWarrenSCTransient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasisSci Transl Med20179384eaai850428381539
- ZengHQuJJinNFeedback activation of leukemia inhibitory factor receptor limits response to histone deacetylase inhibitors in breast cancerCancer Cell201630345947327622335
- ZhangZDuanQZhaoHGemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-kappaB/STAT3 signaling cascadeCancer Lett20163821536327576197
- JonkerDJNottLYoshinoTA randomized phase III study of napabucasin [BBI608] (NAPA) vs placebo (PBO) in patients (pts) with pretreated advanced colorectal cancer (ACRC): the CCTG/AGITG CO.23 trialAnn Oncol201627454O26685010
- GrotheyATebbuttNVan CutsemECanStem303C trial: a phase III study of BBI-608 (napabucasin) in combination with 5-fluorouracil (5-FU), leucovorin, irinotecan (FOLFIRI) in adult patients with previously treated metastatic colorectal cancer (mCRC)Ann Oncol20163527
- BaoGQShenBYPanCPZhangYJShiMMPengCHAndrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancerToxicol Lett20132221233523845849