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Original Research

A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction

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Pages 3069-3082 | Published online: 29 Aug 2018

References

  • JemalABrayFCenterMMFerlayJWardEFormanDGlobal cancer statisticsCA Cancer J Clin2011612699021296855
  • SiegelRLMillerKDJemalACancer statistics, 2017CA Cancer J Clin201767173028055103
  • SakashitaSSakashitaMTsaoMSGenes and pathology of non-small cell lung carcinomaSemin Oncol2014411283924565579
  • da Cunha SantosGShepherdFATsaoMSEGFR mutations and lung cancerAnnu Rev Pathol20116496920887192
  • ZhouCWuYLChenGErlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 studyLancet Oncol201112873574221783417
  • RosellRCarcerenyEGervaisRErlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialLancet Oncol201213323924622285168
  • MitsudomiTMoritaSYatabeYGefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trialLancet Oncol201011212112820022809
  • LynchTJBellDWSordellaRActivating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinibN Engl J Med2004350212129213915118073
  • PaezJGJannePALeeJCEGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyScience200430456761497150015118125
  • PaoWMillerVZakowskiMEGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinibProc Natl Acad Sci U S A200410136133061331115329413
  • PaoWMillerVAPolitiKAAcquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainPLoS Med200523e7315737014
  • BalakMNGongYRielyGJNovel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitorsClin Cancer Res200612216494650117085664
  • YuHATianSKDrilonAEAcquired resistance of EGFR-mutant lung cancer to a T790M-specific EGFR inhibitor: emergence of a third mutation (C797S) in the EGFR tyrosine kinase domainJAMA Oncol20151798298426181354
  • SongHNJungKSYooKHAcquired C797S mutation upon treatment with a T790M-specific third-generation EGFR inhibitor (HM61713) in non-small cell lung cancerJ Thorac Oncol2016114e45e4726749488
  • HilemanEOLiuJAlbitarMKeatingMJHuangPIntrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivityCancer Chemother Pharmacol200453320921914610616
  • ToyokuniSOkamotoKYodoiJHiaiHPersistent oxidative stress in cancerFEBS Lett19953581137821417
  • SoignetSLMaslakPWangZGComplete remission after treatment of acute promyelocytic leukemia with arsenic trioxideN Engl J Med199833919134113489801394
  • NiuCYanHYuTStudies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patientsBlood199994103315332410552940
  • ZhangJFengZWangCCurcumin derivative WZ35 efficiently suppresses colon cancer progression through inducing ROS production and ER stress-dependent apoptosisAm J Cancer Res20177227528828337376
  • ZhangXChenMZouPCurcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cellsBMC Cancer20151586626546056
  • ZouPZhangJXiaYROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancerOncotarget2015685860587625714022
  • ChenWZouPZhaoZSelective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activationOncotarget2016713165931660926919094
  • ZouPChenMJiJAuranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancerOncotarget2015634365053652126431378
  • ShiYVattemKMSoodRIdentification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlMol Cell Biol19981812749975099819435
  • LeeESYoonCHKimYSBaeYSThe double-strand RNA-dependent protein kinase PKR plays a significant role in a sustained ER stress-induced apoptosisFEBS Lett2007581224325433217716668
  • WalterPRonDThe unfolded protein response: from stress pathway to homeostatic regulationScience201133460591081108622116877
  • TabasIRonDIntegrating the mechanisms of apoptosis induced by endoplasmic reticulum stressNat Cell Biol201113318419021364565
  • MatsumotoMMinamiMTakedaKSakaoYAkiraSEctopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cellsFEBS Lett19963952–31431478898082
  • GotohTOyadomariSMoriKMoriMNitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOPJ Biol Chem200227714123431235011805088
  • MaytinEVUbedaMLinJCHabenerJFStress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanismsExp Cell Res2001267219320411426938
  • ParkSHBlackstoneCFurther assembly required: construction and dynamics of the endoplasmic reticulum networkEMBO Rep201011751552120559323
  • PennoAHackenbroichGThieleCPhospholipids and lipid dropletsBiochim Biophys Acta20131831358959423246574
  • PintonPGiorgiCSivieroRZecchiniERizzutoRCalcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosisOncogene200827506407641818955969
  • WangQWangHJiaYPanHDingHLuteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastomaCancer Chemother Pharmacol20177951031104128393257
  • FabrizioGDi PaolaSStillaAARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responsesCell Mol Life Sci20157261209122525292337
  • CampERSummyJBauerTWLiuWGallickGEEllisLMMolecular mechanisms of resistance to therapies targeting the epidermal growth factor receptorClin Cancer Res200511139740515671571
  • KobayashiSBoggonTJDayaramTEGFR mutation and resistance of non-small-cell lung cancer to gefitinibN Engl J Med2005352878679215728811
  • EngelmanJAZejnullahuKMitsudomiTMET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingScience200731658271039104317463250
  • LeungELFanXXWongMPTargeting tyrosine kinase inhibitor-resistant non-small cell lung cancer by inducing epidermal growth factor receptor degradation via methionine 790 oxidationAntioxid Redox Signal201624526327926528827
  • AcharyaADasIChandhokDSahaTRedox regulation in cancer: a double-edged sword with therapeutic potentialOxid Med Cell Longev201031233420716925
  • CairnsRAHarrisISMakTWRegulation of cancer cell metabolismNat Rev Cancer2011112859521258394
  • TrachoothamDAlexandreJHuangPTargeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Nat Rev Drug Discov20098757959119478820
  • NogueiraVHayNMolecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapyClin Cancer Res201319164309431423719265
  • RajLIdeTGurkarAUSelective killing of cancer cells by a small molecule targeting the stress response to ROSNature2011475735523123421753854
  • SamoylenkoAHossainJAMennerichDKellokumpuSHiltunenJKKietzmannTNutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidenceAntioxid Redox Signal201319172157219623458328
  • SharmaVAndersonDDhawanAZinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)Apoptosis201217885287022395444