Advanced search
Publication Cover
Cancer Management and Research Volume 10, 2018 - Issue
Submit an article Journal homepage
64
Views
14
CrossRef citations to date
0
Altmetric
Original Research

An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients

Wen-Zhuo He1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Qian-Kun Xie1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Wan-Ming Hu2 Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China;3 Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People’s Republic of China;4 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
,
Peng-fei Kong1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Lin Yang1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Yuan-Zhong Yang2 Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Chang Jiang1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Chen-Xi Yin1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Hui-Juan Qiu1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Hui-Zhong Zhang2 Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
,
Bei Zhang1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of China
&
Liang-Ping Xia1 VIP Region, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 1597-1604 | Published online: 18 Jun 2018

References

  • BaxterNNVirnigDJRothenbergerDALymph node evaluation in colorectal cancer patients: a population-based studyJ Natl Cancer Inst200597321922515687365
  • WuSGWangYZhouJNumber of negative lymph nodes should be considered for incorporation into staging for breast cancerAm J Cancer Res20155284485325973321
  • WangQXCaiYFChenYYAdditional prognostic value of lymph node ratio (LNR) and number of negative lymph nodes (NLNs) in Chinese patients with triple negative breast cancerAnn Clin Lab Sci2017471687528249920
  • LeDTDurhamJNSmithKNMismatch repair deficiency predicts response of solid tumors to PD-1 blockadeScience2017357634940941328596308
  • ZhuoCYingMLinRWuXGuanSYangCNegative lymph node count is a significant prognostic factor in patient with stage IV gastric cancer after palliative gastrectomyOncotarget2017841711977120529050356
  • LiXZhangWZhangXThe prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapyOncotarget2017829469464695428159939
  • ZhuZChenHYuWNumber of negative lymph nodes is associated with survival in thoracic esophageal squamous cell carcinoma patients undergoing three-field lymphadenectomyAnn Surg Oncol20142192857286324740827
  • ChenYZhangLTianJRenXHaoQCombining the negative lymph nodes count with the ratio of positive and removed lymph nodes can better predict the postoperative survival in cervical cancer patientsCancer Cell Int2013131623374254
  • JohnsonPMPorterGARicciardiRBaxterNNIncreasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancerJ Clin Oncol200624223570357516877723
  • LiQLiangLJiaHNegative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancerOncotarget2016744722907229927474167
  • LiXLuHXuKNegative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapyBMC Cancer201717122728351352
  • OginoSNoshoKIraharaNNegative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reactionAm J Gastroenterol2010105242043319809407
  • KlintrupKMakinenJMKauppilaSInflammation and prognosis in colorectal cancerEur J Cancer200541172645265416239109
  • MeskerWEJunggeburtJMSzuhaiKThe carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stageCell Oncol200729538739817726261
  • ParkJHPowellAGRoxburghCSMismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environmentBr J Cancer2016114556257026859693
  • HuhJWKimYJKimHRDistribution of lymph node metastases is an independent predictor of survival for sigmoid colon and rectal cancerAnn Surg20122551707822133895
  • OginoSGalonJFuchsCSDranoffGCancer immunology–analysis of host and tumor factors for personalized medicineNat Rev Clin Oncol201181271171921826083
  • AkagiYAdachiYKinugasaTLymph node evaluation and survival in colorectal cancer: review of population-based, prospective studiesAnticancer Res20133372839284723780968
  • GleisnerALMogalHDodsonRNodal status, number of lymph nodes examined, and lymph node ratio: what defines prognosis after resection of colon adenocarcinoma?J Am Coll Surg201321761090110024045143
  • AhmadiOStringerMDBlackMAMcCallJLClinico-pathological factors influencing lymph node yield in colorectal cancer and impact on survival: analysis of New Zealand Cancer Registry dataJ Surg Oncol2015111445145825663298
  • TsaiHLHuangCWYehYSFactors affecting number of lymph nodes harvested and the impact of examining a minimum of 12 lymph nodes in stage I-III colorectal cancer patients: a retrospective single institution cohort study of 1167 consecutive patientsBMC Surg2016161727079509
  • ZhangZYGaoWLuoQFA nomogram improves AJCC stages for colorectal cancers by introducing CEA, modified lymph node ratio and negative lymph node countSci Rep201663902827941905
  • GeorgeSPrimroseJTalbotRWill Rogers revisited: prospective observational study of survival of 3592 patients with colorectal cancer according to number of nodes examined by pathologistsBr J Cancer200695784184716969342
  • GuinneyJDienstmannRWangXThe consensus molecular subtypes of colorectal cancerNat Med201521111350135626457759
  • DienstmannRVermeulenLGuinneyJConsensus molecular subtypes and the evolution of precision medicine in colorectal cancerNat Rev Cancer2017172799228050011

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.