Highly elevated soluble Tim-3 levels correlate with increased hepatocellular carcinoma risk and poor survival of hepatocellular carcinoma patients in chronic hepatitis B virus infection

References

• MokdadAALopezADShahrazSLiver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysisBMC Med20141214525242656
   PubMed Web of Science ®Google Scholar
• MittalSEl-SeragHBEpidemiology of hepatocellular carcinoma: consider the populationJ Clin Gastroenterol201347SupplS2S623632345
   PubMed Web of Science ®Google Scholar
• StanawayJDFlaxmanADNaghaviMThe global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013Lancet2016388100491081108827394647
   PubMed Web of Science ®Google Scholar
• European Association for the Study of the LiverEASL 2017 clinical practice guidelines on the management of hepatitis B virus infectionJ Hepatol201767237039828427875
   PubMed Web of Science ®Google Scholar
• ThimmeRWielandSSteigerCCD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infectionJ Virol2003771687612477811
   PubMed Web of Science ®Google Scholar
• PhillipsSChokshiSRivaAEvansAWilliamsRNaoumovNVCD8(+) T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functionsJ Immunol2010184128729519949099
   PubMed Web of Science ®Google Scholar
• GuidottiLGChisariFVImmunobiology and pathogenesis of viral hepatitisAnnu Rev Pathol20061236118039107
   PubMed Web of Science ®Google Scholar
• WherryEJT cell exhaustionNat Immunol201112649249921739672
   PubMed Web of Science ®Google Scholar
• WielandDHofmannMThimmeROvercoming CD8+ T-cell exhaustion in viral hepatitis: lessons from the mouse model and clinical perspectivesDig Dis201735433433828468011
   PubMed Web of Science ®Google Scholar
• BoniCFisicaroPValdattaCCharacterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infectionJ Virol20078184215422517287266
   PubMed Web of Science ®Google Scholar
• DinneyCMZhaoLDConradCDRegulation of HBV-specific CD8(+) T cell-mediated inflammation is diversified in different clinical presentations of HBV infectionJ Microbiol2015531071872426428923
   PubMed Web of Science ®Google Scholar
• LiHWuKTaoKTim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinomaHepatology20125641342135122505239
   PubMed Web of Science ®Google Scholar
• NebbiaGPeppaDSchurichAUpregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infectionPLoS One2012710e4764823112829
   PubMed Web of Science ®Google Scholar
• WuWShiYLiJChenFChenZZhengMTim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infectionVirol J2011811321392402
   PubMed Web of Science ®Google Scholar
• LiZLiNLiFImmune checkpoint proteins PD-1 and TIM-3 are both highly expressed in liver tissues and correlate with their gene polymorphisms in patients with HBV-related hepatocellular carcinomaMedicine (Baltimore)20169552e574928033288
   PubMed Web of Science ®Google Scholar
• WangLZhaoCPengQShiJGuGExpression levels of CD28, CTLA-4, PD-1 and Tim-3 as novel indicators of T-cell immune function in patients with chronic hepatitis B virus infectionBiomed Rep20142227027424649109
   PubMedGoogle Scholar
• WuWShiYLiSBlockade of Tim-3 signaling restores the virus-specific CD8+ T-cell response in patients with chronic hepatitis BEur J Immunol20124251180119122539292
   PubMed Web of Science ®Google Scholar
• RongYHWanZHSongHTim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis BTissue Antigens2014832768124397461
   PubMedGoogle Scholar
• SabatosCAChakravartiSChaEInteraction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral toleranceNat Immunol20034111102111014556006
   PubMed Web of Science ®Google Scholar
• GengHZhangGMLiDSoluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune responseJ Immunol200617631411142016424168
   PubMed Web of Science ®Google Scholar
• Möller-HackbarthKDewitzCSchweigertOA disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)J Biol Chem201328848345293454424121505
   PubMed Web of Science ®Google Scholar
• HansenJAHanashSMTabelliniLA novel soluble form of Tim-3 associated with severe graft-versus-host diseaseBiol Blood Marrow Transplant20131991323133023791624
   PubMed Web of Science ®Google Scholar
• ClaytonKLDouglas-VailMBNur-ur RahmanAKSoluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progressionJ Virol20158973723373625609823
   PubMed Web of Science ®Google Scholar
• AveryLFildermanJSzymczak-WorkmanALKaneLPTim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustionProc Natl Acad Sci U S A2018115102455246029463725
   PubMed Web of Science ®Google Scholar
• SabinsNCChornoguzOLeanderKTIM-3 engagement promotes effector memory T cell differentiation of human antigen-specific CD8 T cells by activating mTORC1J Immunol2017199124091410229127145
   PubMed Web of Science ®Google Scholar
• ZhangHSongYYangHTumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axisOncogene Epub2018216
   Google Scholar
• RenFLiJJiangXPlasma soluble Tim-3 emerges as an inhibitor in sepsis: sepsis contrary to membrane Tim-3 on monocytesTissue Antigens201586532533226373631
   PubMedGoogle Scholar
• WuMZhuYZhaoJSoluble costimulatory molecule sTim3 regulates the differentiation of Th1 and Th2 in patients with unexplained recurrent spontaneous abortionInt J Clin Exp Med2015868812881926309533
   PubMed Web of Science ®Google Scholar
• ChibaMYanabaKHayashiMYoshiharaYNakagawaHClinical significance of serum soluble T-cell immunoglobulin and mucin domain 3 levels in systemic sclerosis: association with disease severityJ Der-matol2017442194197
   Google Scholar
• Abu ZaidMWuJWuCPlasma biomarkers of risk for death in a multicenter phase 3 trial with uniform transplant characteristics post-allogeneic HCTBlood2017129216217027827824
   PubMed Web of Science ®Google Scholar
• ZhangJZhangFLiQIncreased serum levels of soluble T cell immunoglobulin mucin molecule 3 and IL-4 and decreased IFN-γ in patients with pulmonary tuberculosisXi Bao Yu Fen Zi Mian Yi Xue Za Zhi2016327968971 Chinese27363280
   PubMedGoogle Scholar
• PengGLiSWuWTanXChenYChenZPD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patientsMol Immunol200845496397017868872
   PubMed Web of Science ®Google Scholar
• ShiFShiMZengZPD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patientsInt J Cancer2011128488789620473887
   PubMed Web of Science ®Google Scholar
• ZhangWJPengCHZhengSSProgrammed death 1 and programmed death ligand 1 expressions in patients with chronic hepatitis BHepatobiliary Pancreat Dis Int201312439439923924497
   PubMed Web of Science ®Google Scholar
• XuPChenYJChenHThe expression of programmed death-1 in circulating CD4+ and CD8+ T cells during hepatitis B virus infection progression and its correlation with clinical baseline characteristicsGut Liver20148218619524672661
   PubMed Web of Science ®Google Scholar
• BengschBMartinBThimmeRRestoration of HBV specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiationJ Hepatol20146161212121925016223
   PubMed Web of Science ®Google Scholar
• HsuPNYangTCKaoJTIncreased PD-1 and decreased CD28 expression in chronic hepatitis B patients with advanced hepatocellular carcinomaLiver Int20103091379138620738778
   PubMed Web of Science ®Google Scholar
• ChengHYKangPJChuangYHCirculating programmed death-1 as a marker for sustained high hepatitis B viral load and risk of hepatocellular carcinomaPLoS One2014911e9587025427199
   PubMed Web of Science ®Google Scholar
• LiNZhouZLiFCirculating soluble programmed death-1 levels may differentiate immune-tolerant phase from other phases and hepatocellular carcinoma from other clinical diseases in chronic hepatitis B virus infectionOncotarget2017828460204603328545019
   PubMedGoogle Scholar
• JinHTAndersonACTanWGCooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infectionProc Natl Acad Sci U S A201010733147331473820679213
   PubMed Web of Science ®Google Scholar
• SakuishiKApetohLSullivanJMBlazarBRKuchrooVKAndersonACTargeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunityJ Exp Med2010207102187219420819927
   PubMed Web of Science ®Google Scholar
• XiaoLWangDSunCEnhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in miceHum Vaccin Immunother201410372473324326266
   PubMed Web of Science ®Google Scholar