Marker of proliferation Ki-67 expression is associated with transforming growth factor beta 1 and can predict the prognosis of patients with hepatic B virus-related hepatocellular carcinoma

References

• FerlayJSoerjomataramIDikshitRCancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Int J Cancer20151365E359E38625220842
   PubMed Web of Science ®Google Scholar
• ZhangWSunBImpact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER databaseOncotarget20156263325575810
   PubMedGoogle Scholar
• BruixJLlovetJMMajor achievements in hepatocellular carcinomaLancet2009373966461419231618
   PubMed Web of Science ®Google Scholar
• ShimozawaNHanazakiKLongterm prognosis after hepatic resection for small hepatocellular carcinomaJ Am Coll Surg2004198335614992736
   PubMed Web of Science ®Google Scholar
• MajumdarACurleySAWuXHepatic stem cells and transforming growth factor β in hepatocellular carcinomaNat Rev Gastroenterol Hepatol20129953053822710573
   PubMed Web of Science ®Google Scholar
• GiannelliGVillaELahnMTransforming growth factor-β as a therapeutic target in hepatocellular carcinomaCancer Res20147471890189424638984
   PubMed Web of Science ®Google Scholar
• MazzoccaAFransveaEDituriFLupoLAntonaciSGiannelliGDownregulation of connective tissue growth factor by inhibition of transforming growth factor β blocks the tumor–stroma cross-talk and tumor progression in hepatocellular carcinomaHepatology201051252353419821534
   PubMed Web of Science ®Google Scholar
• PengLZhouYDongLTGF-β1 upregulates the expression of triggering receptor expressed on myeloid cells 1 in murine lungsSci Rep201661894626738569
   PubMed Web of Science ®Google Scholar
• MassaguéJTGFβ in cancerCell2008134221523018662538
   PubMed Web of Science ®Google Scholar
• GiannelliGRaniBDituriFCaoYPalascianoGMoving towards personalised therapy in patients with hepatocellular carcinoma: the role of the microenvironmentGut201463101668167625053718
   PubMed Web of Science ®Google Scholar
• SasakiKMurakamiTKawasakiMTakahashiMThe cell cycle associated change of the Ki-67 reactive nuclear antigen expressionJ Cell Physiol198713335793121642
   PubMed Web of Science ®Google Scholar
• MaedaTTakenakaKAdachiESmall hepatocellular carcinoma of single nodular type: a specific reference to its surrounding cancerous area undetected radiologically and macroscopicallyJ Surg Oncol199560275797564384
   PubMed Web of Science ®Google Scholar
• NgIONaJLaiECFanSTNgMKi-67 antigen expression in hepatocellular carcinoma using monoclonal antibody MIB1. A comparison with proliferating cell nuclear antigenAm J Clin Pathol199510433137545866
   PubMed Web of Science ®Google Scholar
• ShirabeKKitamuraMTsutsuiSMaedaTMatsumataTSugimachiKA long-term survivor of ruptured hepatocellular carcinoma after hepatic resectionJ Gastroenterol Hepatol19951033517548817
   PubMed Web of Science ®Google Scholar
• LuoYRenFLiuYClinicopathological and prognostic significance of high Ki-67 labeling index in hepatocellular carcinoma patients: a meta-analysisInt J Clin Exp Med2015871023526379815
   PubMed Web of Science ®Google Scholar
• GlazerESWelshEPimientoJMTeerJKMalafaMPTGFβ1 overexpression is associated with improved survival and low tumor cell proliferation in patients with early-stage pancreatic ductal adenocarcinomaOncotarget201781999100627895310
   PubMedGoogle Scholar
• gepia.cancer-pku. cn [homepage on the Internet]ChinaBIOPIC, School of Life Sciences, Peking University2017 [updated April 12, 2017]. Available from: http://gepia.cancer-pku.cn/Accessed November 25, 2017
   Google Scholar
• xena.ucsc.edu [homepage on the Internet]Americathe University of California, Santa Cruz2017 [updated November 2, 2017]. Available from: https://xenabrowser.net/datapages/?hub=https://tcga.xenahubs.net:443Accessed November 24, 2017
   Google Scholar
• RoesslerSJiaH-LBudhuAA unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patientsCancer Res20107024102021021221159642
   PubMed Web of Science ®Google Scholar
• SubramanianATamayoPMoothaVKGene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesProc Natl Acad Sci USA200510243155451555016199517
   PubMed Web of Science ®Google Scholar
• TungEKKMakCKMFatimaSClinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinomaLiver Int201131101494150421955977
   PubMed Web of Science ®Google Scholar
• AbnaofKMallelaNWalendaGTGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription levelBMC Syst Biol2014815524886091
   PubMedGoogle Scholar
• YangCkWangXkLiaoXwAldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinomaPLoS One2017128e018220828792511
   PubMed Web of Science ®Google Scholar
• YangC-KYuT-DHanC-YGenome-wide association study of MKI67 expression and its clinical implications in HBV-related hepatocellular carcinoma in Southern ChinaCell Physiol Biochem20174241342135728700999
   PubMedGoogle Scholar
• HarrellFEJrrms: Regression Modeling Strategies. R package version 4.0.02013
   Google Scholar
• r-projectorg [homepage on the Internet]AustriaR Foundation for Statistical Computing, Vienna2017 [updated March 10, 2018]. Available from: https://mirrors.ustc.edu.cn/CRAN/Accessed November 14, 2017
   Google Scholar
• IasonosASchragDRajGVPanageasKSHow to build and interpret a nomogram for cancer prognosisJ Clin Oncol20082681364137018323559
   PubMed Web of Science ®Google Scholar
• LiangWZhangLJiangGDevelopment and validation of a nomogram for predicting survival in patients with resected non-small-cell lung cancerJ Clin Oncol201533886186925624438
   PubMed Web of Science ®Google Scholar
• PickupMNovitskiySMosesHLThe roles of TGFβ in the tumour microenvironmentNat Rev Cancer2013131178824132110
   PubMed Web of Science ®Google Scholar
• PrincipeDRDollJABauerJTGF-β: duality of function between tumor prevention and carcinogenesisJ Natl Cancer Inst20141062djt36924511106
   PubMedGoogle Scholar
• DerynckRAkhurstRJBalmainATGF-β signaling in tumor suppression and cancer progressionNat Genet200129211712911586292
   PubMed Web of Science ®Google Scholar
• MeulmeesterETen DijkePThe dynamic roles of TGF-β in cancerJ Pathol20112232206219
   Web of Science ®Google Scholar
• DewidarBSoukupovaJFabregatIDooleySTGF-β in hepatic stellate cell activation and liver fibrogenesis: updatedCurr Pathobiol Rep201534291305
   Google Scholar
• BissellDMChronic liver injury, TGF-[beta], and cancerExp Mol Med200133417911795478
   PubMed Web of Science ®Google Scholar
• GiannelliGMazzoccaAFransveaELahnMAntonaciSInhibiting TGF-β signaling in hepatocellular carcinomaBiochim Biophys Acta20111815221422321129443
   PubMed Web of Science ®Google Scholar
• van ZijlFMallSMachatGA human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progressionMol Cancer Ther201110585086021364009
   PubMed Web of Science ®Google Scholar
• FuchsBCFujiiTDorfmanJDEpithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cellsCancer Res20086872391239918381447
   PubMed Web of Science ®Google Scholar
• LinT-HShaoY-YChanS-YHuangC-YHsuC-HChengA-LHigh serum transforming growth factor-β1 levels predict outcome in hepatocellular carcinoma patients treated with SorafenibClin Cancer Res201521163678368425977342
   PubMed Web of Science ®Google Scholar
• PengLYuanX-QZhangC-YHigh TGF-β1 expression predicts poor disease prognosis in hepatocellular carcinoma patientsOncotarget20178213438728415739
   PubMedGoogle Scholar
• DituriFSerioGFilanninoDCirculating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scoresCancer Lett2014353226427125088578
   PubMed Web of Science ®Google Scholar
• WeberABoegeYReisingerFHeikenwälderMChronic liver inflammation and hepatocellular carcinoma: persistence mattersSwiss Med Wkly201114118w1319721557112
   PubMedGoogle Scholar
• LiuNJiaoTHuangYLiuWLiZYeXHepatitis B virus regulates apoptosis and tumorigenesis through the microRNA-15a-Smad7-transforming growth factor beta pathwayJ Virol20158952739274925540364
   PubMed Web of Science ®Google Scholar
• SerovaMTijeras-RaballandADos SantosCEffects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patientsOncotarget20156252161426057634
   PubMedGoogle Scholar
• ZhangXFanQLiYTransforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signalingOncotarget20178182978528076850
   PubMedGoogle Scholar