Search in:

Advanced search

Cancer Management and Research Volume 10, 2018 - Issue

Submit an article Journal homepage

Open access

Views

CrossRef citations to date

Altmetric

Original Research

Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations

Xinrui Yang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Jinlong Shi2 Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing 100853, China

Xinpei Zhang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Gaoqi Zhang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Jilei Zhang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Siyuan Yang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Jing Wang1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Xiaoyan Ke1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]

Lin Fu1 Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing 100191, China, [email protected]Correspondence[email protected]

show all

Pages 2489-2497 | Published online: 07 Aug 2018

Cite this article
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

References

DohnerHWeisdorfDJBloomfieldCDAcute myeloid leukemiaN Engl J Med2015373121136115226376137
PubMed Web of Science ®Google Scholar
EstellerMEpigenetics in cancerN Engl J Med2008358111148115918337604
PubMed Web of Science ®Google Scholar
LeyTJDingLWalterMJDNMT3A mutations in acute myeloid leukemiaN Engl J Med2010363252424243321067377
PubMed Web of Science ®Google Scholar
LinNFuWZhaoCLiBYanXLiYBiologico-clinical significance of DNMT3A variants expression in acute myeloid leukemiaBiochem Biophys Res Commun20174941–227027729024628
PubMed Web of Science ®Google Scholar
TholFDammFLudekingAIncidence and prognostic influence of DNMT3A mutations in acute myeloid leukemiaJ Clin Oncol201129212889289621670448
PubMed Web of Science ®Google Scholar
GaidzikVIWeberDPaschkaPGerman-Austrian Acute Myeloid Leukemia Study Group (AMLSG)DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemiaLeukemia2017321303728643785
PubMed Web of Science ®Google Scholar
SunYShenHXuTPersistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remissionLeuk Res20164910210727626217
PubMed Web of Science ®Google Scholar
TieRZhangTFuHAssociation between DNMT3A mutations and prognosis of adults with de novo acute myeloid leukemia: a systematic review and meta-analysisPLoS One201496e9335324936645
PubMed Web of Science ®Google Scholar
ShivarovVGueorguievaRStoimenovATiuRDNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patientsLeuk Res201337111445145023962568
PubMed Web of Science ®Google Scholar
LiYZhuBAcute myeloid leukemia with DNMT3A mutationsLeuk Lymphoma20145592002201224283755
PubMed Web of Science ®Google Scholar
YuanXQPengLZengWJJiangBYLiGCChenXPDNMT3A R882 mutations predict a poor prognosis in AML: a meta-analysis from 4474 patientsMedicine (Baltimore)20169518e351927149454
PubMed Web of Science ®Google Scholar
BerensteinRBlauIWSuckertNQuantitative detection of DNMT3A R882H mutation in acute myeloid leukemiaJ Exp Clin Cancer Res2015345525994761
PubMed Web of Science ®Google Scholar
YoheSMolecular genetic markers in acute myeloid leukemiaJ Clin Med20154346047826239249
PubMed Web of Science ®Google Scholar
ElGDTaalabMMGhazyHFEneenAFDNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndromeBlood Cells Mol Dis2014531–2616624512939
PubMed Web of Science ®Google Scholar
GaleRELambKAllenCSimpson’s paradox and the impact of different DNMT3A mutations on outcome in younger adults with acute myeloid leukemiaJ Clin Oncol201533182072208325964253
PubMed Web of Science ®Google Scholar
LeyTJMillerCDingLCancer Genome Atlas Research NetworkGenomic and epigenomic landscapes of adult de novo acute myeloid leukemiaN Engl J Med2013368222059207423634996
PubMed Web of Science ®Google Scholar
ZhouJDYaoDMLiXXKRAS overexpression independent of RAS mutations confers an adverse prognosis in cytogenetically normal acute myeloid leukemiaOncotarget2017839660876609729029494
PubMedGoogle Scholar
OhgamiRSMaLMerkerJDNext-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutationsMod Pathol201528570671425412851
PubMed Web of Science ®Google Scholar
AndradeFGNoronhaEPBrissonGDBrazilian Study Group of Childhood Acute Myeloid Leukemia (IMol-AMLBSG) as coauthorsMolecular characterization of pediatric acute myeloid leukemia: results of a multicentric study in BrazilArch Med Res201647865666728476193
PubMed Web of Science ®Google Scholar
BacherUHaferlachTSchochCKernWSchnittgerSImplications of NRAS mutations in AML: a study of 2502 patientsBlood2006107103847385316434492
PubMed Web of Science ®Google Scholar
TholFBollinRGehlhaarMMutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implicationsBlood2014123691492024335498
PubMed Web of Science ®Google Scholar
HolmbergOKNisterMLindstromMSLoss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcriptionJ Biol Chem201428950346013461925349213
PubMed Web of Science ®Google Scholar
XuYSunYShenHAllogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutationsAm J Hematol2015901199299726223865
PubMed Web of Science ®Google Scholar
FrohlingSSchlenkRFBreitruckJAML Study Group UlmAcute myeloid leukemia. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group UlmBlood2002100134372438012393388
PubMed Web of Science ®Google Scholar
TangSShenHMaoXFLT3-ITD with DNMT3A R882 double mutation is a poor prognostic factor in Chinese patients with acute myeloid leukemia after chemotherapy or allogeneic hematopoietic stem cell transplantationInt J Hematol2017106455256128616699
PubMed Web of Science ®Google Scholar

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations

References

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date