106
Views
21
CrossRef citations to date
0
Altmetric
Original Research

Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

, , , , , , , & show all
Pages 95-105 | Published online: 20 Dec 2018

References

  • SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
  • ChenWZhengRBaadePDCancer statistics in China, 2015CA Cancer J Clin201666211513226808342
  • CersosimoRJManagement of advanced colorectal cancer, Part 1Am J Health Syst Pharm201370539540623413162
  • MurilloGPengXTorresKEMehtaRGDeguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathwayCancer Prev Res (Phila)200921194295019861542
  • LeeHYOhSHWooJKChemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesisJ Natl Cancer Inst200597221695169916288123
  • YanBZhaoDYaoYBaoZLuGZhouJDeguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1Int J Biol Sci201612785086027313498
  • BoreddySRSrivastavaSKDeguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic modelOncogene201332343980399122986522
  • LeeHYSuhYAKosmederJWPezzutoJMHongWKKurieJMDeguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cellsClin Cancer Res20041031074107914871987
  • MemmottRMDennisPAThe role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesisClin Cancer Res201016141020028747
  • OhSHWooJKJinQIdentification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alphaInt J Cancer2008122151417764071
  • SuhYAKimJHSungMAA novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancerCancer Lett2013332110210923348700
  • KangHWKimJMChaMYJungHCSongISKimJSDeguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in miceDig Dis Sci201257112873288222623043
  • JinQMenterDGMaoLHongWKLeeHYSurvivin expression in normal human bronchial epithelial cells: an early and critical step in tumorigenesis induced by tobacco exposureCarcinogenesis20082981614162218635526
  • LooDTIn situ detection of apoptosis by the TUNEL assay: an overview of techniquesMethods Mol Biol201168231321057916
  • OlsonJMHallahanARp38 MAP kinase: a convergence point in cancer therapyTrends Mol Med200410312512915102355
  • CuadradoANebredaARMechanisms and functions of p38 MAPK signallingBiochem J2010429340341720626350
  • XiaYShenSVermaIMNF-κB, an active player in human cancersCancer Immunol Res20142982383025187272
  • HsuYCChiangJHYuCSAntitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts modelEnviron Toxicol2017321849826592500
  • MarianiMZannoniGFSioleticSGender influences the class III and V β-tubulin ability to predict poor outcome in colorectal cancerClin Cancer Res201218102964297522438565
  • TammIWangYSausvilleEIAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugsCancer Res19985823531553209850056
  • CorySAdamsJMThe Bcl2 family: regulators of the cellular life-or-death switchNat Rev Cancer20022964765612209154
  • AdamsJMCorySThe Bcl-2 apoptotic switch in cancer development and therapyOncogene20072691324133717322918
  • MerinoDLokSWVisvaderJELindemanGJTargeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancerOncogene201635151877188726257067
  • BelmokhtarCAHillionJSégal-BendirdjianEStaurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanismsOncogene200120263354336211423986
  • Pozo-GuisadoEMerinoJMMulero-NavarroSResveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaBInt J Cancer20051151748415688415
  • GrossiVPesericoATezilTSimoneCp38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistanceWorld J Gastroenterol201420299744975825110412
  • ShinDYLeeWSLuJNInduction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPKInt J Oncol2009356149950419885574
  • PangHCaiLYangYChenXSuiGZhaoCKnockdown of osteopontin chemosensitizes MDA-MB-231 cells to cyclophosphamide by enhancing apoptosis through activating p38 MAPK pathwayCancer Biother Radiopharm201126216517321539449
  • LouXZhouQYinYZhouCShenYInhibition of the met receptor tyrosine kinase signaling enhances the chemosensitivity of glioma cell lines to CDDP through activation of p38 MAPK pathwayMol Cancer Ther2009851126113619435873
  • GanLWangJXuHYangXResistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signalingProstate201171111158116621656826
  • PereiraLIgeaACanovasBDoladoINebredaARInhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNKEMBO Mol Med20135111759177424115572