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Review

Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis

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Pages 4881-4890 | Published online: 24 Oct 2018

References

  • FranciosiMLucisanoGLapiceEStrippoliGFPellegriniFNicolucciAMetformin therapy and risk of cancer in patients with type 2 diabetes: systematic reviewPLoS One201388e7158323936520
  • LarssonSCOrsiniNWolkADiabetes mellitus and risk of colorectal cancer: a meta-analysisJ Natl Cancer Inst200597221679168716288121
  • FribergEOrsiniNMantzorosCSWolkADiabetes mellitus and risk of endometrial cancer: a meta-analysisDiabetologia20075071365137417476474
  • BaroneBBYehHCSnyderCFLong-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysisJAMA2008300232754276419088353
  • DowlingRJGoodwinPJStambolicVUnderstanding the benefit of metformin use in cancer treatmentBMC Med201193321470407
  • KoritzinskyMMetformin: a novel biological modifier of tumor response to radiation therapyInt J Radiat Oncol Biol Phys201593245446426383681
  • PollakMNInvestigating metformin for cancer prevention and treatment: the end of the beginningCancer Discov20122977879022926251
  • EvansJMDonnellyLAEmslie-SmithAMAlessiDRMorrisADMetformin and reduced risk of cancer in diabetic patientsBMJ200533075031304130515849206
  • YuHYinLJiangXEffect of metformin on cancer risk and treatment outcome of prostate cancer: a meta-analysis of epidemiological observational studiesPLoS One2014912e11632725545701
  • StopsackKHZiehrDRRiderJRGiovannucciELMetformin and prostate cancer mortality: a meta-analysisCancer Causes Control201627110511326537119
  • NevadunskyNSvan ArsdaleAStricklerHDMetformin use and endometrial cancer survivalGynecol Oncol2014132123624024189334
  • MemmottRMMercadoJRMaierCRKawabataSFoxSDDennisPAMetformin prevents tobacco carcinogen—induced lung tumorigenesisCancer Prev Res20103910661076
  • Ben SahraILaurentKLoubatAThe antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 levelOncogene200827253576358618212742
  • StorozhukYHopmansSNSanliTMetformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPKBr J Cancer2013108102021203223632475
  • LinAMaityAMolecular pathways: a novel approach to targeting hypoxia and improving radiotherapy efficacy via reduction in oxygen demandClin Cancer Res20152191995200025934887
  • HillRPBristowRGFylesAKoritzinskyMMilosevicMWoutersBGHypoxia and predicting radiation responseSemin Radiat Oncol201525426027226384274
  • SamsuriNABLeechMMarignolLMetformin and improved treatment outcomes in radiation therapy—a reviewCancer Treat Rev20175515016228399491
  • LiDMWangLMuQXSunXCEffect of prognosis of metformin on limited stage small cell lung cancer treated with concurrent chemoradiotherapyActa Universitatis Medicinalis Nanjing (Natural Science)2016356841843
  • AdebergSBernhardtDBen HarrabiSMetformin influences progression in diabetic glioblastoma patientsStrahlenther Onkol20151911292893526329695
  • ZaorskyNGShaikhTRuthKProstate cancer patients with unmanaged diabetes or receiving insulin experience inferior outcomes and toxicities after treatment with radiation therapyClin Genitourin Cancer201715232633527789181
  • ChangPHYehKYWangCHImpact of metformin on patients with advanced head and neck cancer undergoing concurrent chemoradiotherapyHead Neck20173981573157728449193
  • SkinnerHDCraneCHGarrettCRMetformin use and improved response to therapy in rectal cancerCancer Med2013219910724133632
  • OhBYParkYAHuhJWMetformin enhances the response to radiotherapy in diabetic patients with rectal cancerJ Cancer Res Clin Oncol201614261377138527011019
  • AhmedIFerroACohlerAImpact of metformin use on survival in locally-advanced, inoperable non-small cell lung cancer treated with definitive chemoradiationJ Thorac Dis20157334635525922712
  • WinkKCBelderbosJSDielemanEMImproved progression free survival for patients with diabetes and locally advanced non-small cell lung cancer (NSCLC) using metformin during concurrent chemoradiotherapyRadiother Oncol2016118345345926861738
  • JangWIKimMSLimJSSurvival advantage associated with metformin usage in hepatocellular carcinoma patients receiving radiotherapy: a propensity score matching analysisAnticancer Res20153595047505426254406
  • SprattDEZhangCZumstegZSPeiXZhangZZelefskyMJMetformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortalityEur Urol201363470971623287698
  • ZannellaVEdal PraAMuaddiHReprogramming metabolism with metformin improves tumor oxygenation and radiotherapy responseClin Cancer Res201319246741675024141625
  • TairaAVMerrickGSGalbreathRWMorrisMButlerWMAdamovichEMetformin is not associated with improved biochemical free survival or cause-specific survival in men with prostate cancer treated with permanent interstitial brachytherapyJ Contemp Brachytherapy20146325426125337126
  • SkinnerHDMccurdyMREcheverriaAEMetformin use and improved response to therapy in esophageal adenocarcinomaActa Oncol20135251002100922950385
  • Spierings LEAMMLagardeSMvan OijenMGHMetformin use during treatment of potentially curable esophageal cancer patients is not associated with better outcomesAnn Surg Oncol201522S3766771
  • van de VoordeLJanssenLLarueRCan metformin improve ‘the tomorrow’ of patients treated for oesophageal cancer?Eur J Surg Oncol201541101333133926091848
  • SkinnerHDSandulacheVCOwTJTP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescenceClin Cancer Res201218129030022090360
  • SprattDEBeadleBMZumstegZSThe influence of diabetes mellitus and metformin on distant metastases in oropharyngeal cancer: a multicenter studyInt J Radiat Oncol Biol Phys201694352353126867881
  • American Diabetes AssociationStandards of medical care in diabetes-2016 abridged for primary care providersClin Diabetes201634132126807004
  • BojkovaBOrendasPGarajovaMMetformin in chemically-induced mammary carcinogenesis in ratsNeoplasma200956326927419309231
  • GandiniSPuntoniMHeckman-StoddardBMMetformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confoundersCancer Prev Res201479867885
  • LevyADoyenJMetformin for non-small cell lung cancer patients: opportunities and pitfallsCrit Rev Oncol Hematol2018125414729650275
  • CerezoMTomicTBallottiRRocchiSIs it time to test biguanide metformin in the treatment of melanoma?Pigment Cell Melanoma Res201528182024862830
  • LinYCWuMHWeiTTMetformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stressOncotarget20145129830824457597
  • RiekenMXylinasEKluthLAssociation of diabetes mellitus and metformin use with oncological outcomes of patients with non-muscle-invasive bladder cancerBJU Int201311281105111224053906
  • ZhangTZhangLZhangTMetformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivoRadiat Res2014181664164924844651
  • KimEHKimMSChoCKJungWGJeongYKJeongJHLow and high linear energy transfer radiation sensitization of HCC cells by metforminJ Radiat Res201455343244224375278
  • VousdenKHLaneDPp53 in health and diseaseNat Rev Mol Cell Biol20078427528317380161
  • MullerPAVousdenKHp53 mutations in cancerNat Cell Biol20131512823263379
  • FasihAElbazHAHüttemannMKonskiAAZielskeSPRadiosensitization of pancreatic cancer cells by metformin through the AMPK pathwayRadiat Res20141821505924909911