Clofoctol and sorafenib inhibit prostate cancer growth via synergistic induction of endoplasmic reticulum stress and UPR pathways

References

• MillerKDSiegelRLLinCCCancer treatment and survivorship statistics, 2016CA Cancer J Clin201666427128927253694
   PubMed Web of Science ®Google Scholar
• FalchookADChenRCAdjuvant vs.salvage radiotherapy for patients at high risk for recurrence after radical prostatectomyUrol Oncol2015331145145526814331
   PubMed Web of Science ®Google Scholar
• ChungBHThe role of radical prostatectomy in high-risk prostate cancerProstate Int2013139510124223409
   PubMedGoogle Scholar
• BorgesAHDubrowRSilverbergMJFactors contributing to risk for cancer among HIV-infected individuals, and evidence that earlier combination antiretroviral therapy will alter this riskCurr Opin HIV AIDS201491344024225382
   PubMed Web of Science ®Google Scholar
• de WittPMaartensDJUldrickTSSissolakGTreatment outcomes in AIDS-related diffuse large B-cell lymphoma in the setting roll out of combination antiretroviral therapy in South AfricaJ Acquir Immune Defic Syndr2013641667323797692
   PubMed Web of Science ®Google Scholar
• ChouTCDrug combination studies and their synergy quantification using the Chou-Talalay methodCancer Res201070244044620068163
   PubMed Web of Science ®Google Scholar
• ZhouYYangJZhangRKopečekJCombination therapy of prostate cancer with HPMA copolymer conjugates containing PI3K/mTOR inhibitor and docetaxelEur J Pharm Biopharm20158910711525481033
   PubMed Web of Science ®Google Scholar
• WangMShimJSLiRJRjLIdentification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancerBr J Pharmacol2014171194478448924903412
   PubMed Web of Science ®Google Scholar
• LiuLCaoYChenCSorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5Cancer Res20066624118511185817178882
   PubMed Web of Science ®Google Scholar
• Delaunay-MoisanAAppenzeller-HerzogCThe antioxidant machinery of the endoplasmic reticulum: Protection and signalingFree Radic Biol Med20158334135125744411
   PubMed Web of Science ®Google Scholar
• VashisthaNNealSESinghACarrollSMHamptonRYDirect and essential function for Hrd3 in ER-associated degradationProc Natl Acad Sci U S A2016113215934593927170191
   PubMed Web of Science ®Google Scholar
• BernasconiRGalliCKokameKMolinariMAutoadaptive ER-associated degradation defines a preemptive unfolded protein response pathwayMol Cell201352678379324239290
   PubMed Web of Science ®Google Scholar
• RashidHOYadavRKKimHRChaeHJER stress: Autophagy induction, inhibition and selectionAutophagy201511111956197726389781
   PubMed Web of Science ®Google Scholar
• GuptaAHossainMMReadDEPERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein ResponseSci Rep201551830426674075
   PubMed Web of Science ®Google Scholar
• GuptaAReadDEGuptaSAssays for induction of the unfolded protein response and selective activation of the three major pathwaysMethods Mol Biol20151292193825804745
   PubMedGoogle Scholar
• YeJRawsonRBKomuroRER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsMol Cell2000661355136411163209
   PubMed Web of Science ®Google Scholar
• WeatherbeeJLKrausJLRossAHER stress in temozolomide-treated glioblastomas interferes with DNA repair and induces apoptosisOncotarget2016728438204383427286262
   PubMedGoogle Scholar
• HaywoodJYammaniRRFree fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cellsOsteoarthritis Cartilage201624594294526687823
   PubMed Web of Science ®Google Scholar
• BustanySCahuJGuardiolaPSolaBCyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathwayBMC Cancer20151526225881299
   PubMed Web of Science ®Google Scholar
• RahmaniMDavisEMCrabtreeTRThe kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stressMol Cell Biol200727155499551317548474
   PubMed Web of Science ®Google Scholar
• LiNSunCZhouBLow concentration of quercetin antagonizes the cytotoxic effects of anti-neoplastic drugs in ovarian cancerPLoS One201497e10031424999622
   PubMed Web of Science ®Google Scholar
• FoucquierJGuedjMAnalysis of drug combinations: current methodological landscapePharmacol Res Perspect201533e0014926171228
   PubMed Web of Science ®Google Scholar
• OrtholanCDurivaultJHannoun-LeviJMBevacizumab/docetaxel association is more efficient than docetaxel alone in reducing breast and prostate cancer cell growth: a new paradigm for understanding the therapeutic effect of combined treatmentEur J Cancer201046163022303620729074
   PubMed Web of Science ®Google Scholar
• WangCTaoHChengLLiuZNear-infrared light induced in vivo photodynamic therapy of cancer based on upconversion nanoparticlesBiomaterials201132266145615421616529
   PubMed Web of Science ®Google Scholar
• MeyerHBugMBremerSEmerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemNat Cell Biol201214211712322298039
   PubMed Web of Science ®Google Scholar
• NalbandianAGhimbovschiSWangZGlobal gene expression profiling in R155H knock-in murine model of VCP diseaseClin Transl Sci20158181625388089
   PubMed Web of Science ®Google Scholar
• LinYFLeeYFLiangPHTargeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca2+ entry, mitochondrial perturbation and caspase overactivationCell Death Dis20123e43423190606
   PubMed Web of Science ®Google Scholar
• BuysSSPartridgeEBlackAEffect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled TrialJAMA2011305222295230321642681
   PubMed Web of Science ®Google Scholar
• Segovia-MendozaMDíazLGonzález-GonzálezMECalcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cellsJ Steroid Biochem Mol Biol201514812213125510900
   PubMed Web of Science ®Google Scholar
• ChouTCTalalayPQuantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitorsAdv Enzyme Regul19842227556382953
   PubMedGoogle Scholar
• YamaguchiSIshiharaHYamadaTATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stressCell Metab20087326927618316032
   PubMed Web of Science ®Google Scholar
• MaJYangYRChenWFluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cellsOncol Rep201636267668427278525
   PubMed Web of Science ®Google Scholar
• CarpioMAMichaudMZhouWBCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stressProc Natl Acad Sci U S A2015112237201720626015568
   PubMed Web of Science ®Google Scholar
• LiuWZhuXWangQWangLHyperglycemia induces endoplasmic reticulum stress-dependent CHOP expression in osteoblastsExp Ther Med2013551289129223737866
   PubMed Web of Science ®Google Scholar
• SongQGouWLZhangRFAM3A attenuates ER stress-induced mitochondrial dysfunction and apoptosis via CHOP-Wnt pathwayNeurochem Int201694828926939760
   PubMed Web of Science ®Google Scholar
• GurloTRiveraJFButlerAECHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell ApoptosisMol Endocrinol201630444645426900721
   PubMedGoogle Scholar
• DaltonLEHealeyEIrvingJMarciniakSJPhosphoproteins in stress-induced diseaseProg Mol Biol Transl Sci201210618922122340719
   PubMed Web of Science ®Google Scholar
• BadiolaNPenasCMiñano-MolinaAInduction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12Cell Death Dis20112e14921525936
   PubMed Web of Science ®Google Scholar
• LeeGHKimHKChaeSWBax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygen-ase-1 expressionJ Biol Chem200728230216182162817526500
   PubMed Web of Science ®Google Scholar
• HommaTFujiiJHeat stress promotes the down-regulation of IRE1α in cells: An atypical modulation of the UPR pathwayExp Cell Res2016349112813827743894
   PubMed Web of Science ®Google Scholar
• GalindoIHernáezBMuñoz-MorenoRThe ATF6 branch of unfolded protein response and apoptosis are activated to promote African swine fever virus infectionCell Death Dis20123e34122764100
   PubMed Web of Science ®Google Scholar
• ZhangHLvMJiaJExpression of the 78 kD glucose-regulated protein is induced by endoplasmic reticulum stress in the development of hepatopulmonary syndromeGene2014537111511924334118
   PubMed Web of Science ®Google Scholar
• FrosJJMajorLDScholteFEMChikungunya virus non-structural protein 2-mediated host shut-off disables the unfolded protein responseJ Gen Virol201596Pt 358058925395592
   PubMedGoogle Scholar