Calcium channel α2δ1 subunit (CACNA2D1) enhances radioresistance in cancer stem-like cells in non-small cell lung cancer cell lines

Xin Sui1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China, [email protected]

Jian-Hao Geng1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China, [email protected]

Yong-Heng Li1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China, [email protected]

Guang-Ying Zhu2 Department of Radiation Oncology, National Clinical Research Center for Respiratory Disease, Center for Respiratory Disease, Lung Cancer Center, China-Japan Friendship Hospital, Peking University Health Science Center, Beijing, China, [email protected]Correspondence[email protected]

Wei-Hu Wang1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China, [email protected]Correspondence[email protected]

Pages 5009-5018 | Published online: 26 Oct 2018

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BrunnerTBKunz-SchughartLAGrosse-GehlingPBaumannMCancer stem cells as a predictive factor in radiotherapySemin Radiat Oncol201222215117422385922
PubMed Web of Science ®Google Scholar
BaumannMKrauseMHillRExploring the role of cancer stem cells in radioresistanceNat Rev Cancer20088754555418511937
PubMed Web of Science ®Google Scholar
ClarkeMFDickJEDirksPBCancer stem cells: perspectives on current status and future directions: AACR Workshop on cancer stem cellsCancer Res200666199339934416990346
PubMedGoogle Scholar
BoeschMZeimetAGReimerDThe side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristicsOncotarget20145167027703925216521
PubMedGoogle Scholar
BaoSWuQMclendonREGlioma stem cells promote radioresistance by preferential activation of the DNA damage responseNature2006444712075676017051156
PubMed Web of Science ®Google Scholar
WangWJWuSPLiuJBMYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cellsCancer Res20137331219123123269272
PubMed Web of Science ®Google Scholar
DiehnMChoRWLoboNAAssociation of reactive oxygen species levels and radioresistance in cancer stem cellsNature2009458723978078319194462
PubMed Web of Science ®Google Scholar
Gomez-CasalRBhattacharyaCGaneshNNon-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypesMol Cancer20131219423947765
PubMed Web of Science ®Google Scholar
MihatschJToulanyMBareissPMSelection of radioresistant tumor cells and presence of ALDH1 activity in vitroRadiother Oncol201199330030621704411
PubMed Web of Science ®Google Scholar
ZhaoWWangLHanH1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunitCancer Cell201323454155623597567
PubMed Web of Science ®Google Scholar
LanLHanHZuoHUpregulation of myosin Va by Snail is involved in cancer cell migration and metastasisInt J Cancer20101261536419521958
PubMed Web of Science ®Google Scholar
CahuJBustanySSolaBSenescence-associated secretory phenotype favors the emergence of cancer stem-like cellsCell Death Dis20123e44623254289
PubMed Web of Science ®Google Scholar
LavinMFKozlovSDNA damage-induced signalling in ataxia-telangiectasia and related syndromesRadiother Oncol200783323123717512070
PubMed Web of Science ®Google Scholar
JeterCRYangTWangJChaoHPTangDGConcise Review: NANOG in cancer stem cells and tumor development: an update and outstanding questionsStem Cells20153382381239025821200
PubMed Web of Science ®Google Scholar
GaspariniPLovatFFassanMProtective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiationProc Natl Acad Sci U S A2014111124536454124616504
PubMed Web of Science ®Google Scholar
SpiraABeaneJEShahVAirway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancerNat Med200713336136617334370
PubMed Web of Science ®Google Scholar
EramoALottiFSetteGIdentification and expansion of the tumorigenic lung cancer stem cell populationCell Death Differ200815350451418049477
PubMed Web of Science ®Google Scholar
ZhangWCShyh-ChangNYangHGlycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesisCell20121481–225927222225612
PubMed Web of Science ®Google Scholar
LeungELFiscusRRTungJWNon-small cell lung cancer cells expressing CD44 are enriched for stem cell-like propertiesPLoS One2010511e1406221124918
PubMed Web of Science ®Google Scholar
SullivanJPSpinolaMDodgeMAldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signalingCancer Res201070239937994821118965
PubMed Web of Science ®Google Scholar
LundholmLHåågPZongDResistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrestCell Death Dis20134e47823370278
PubMed Web of Science ®Google Scholar
YuDHolmRGoscinskiMATropeCGNeslandJMSuoZPrognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective studyAm J Cancer Res2016692088209727725913
PubMed Web of Science ®Google Scholar
RuanJLiuXXiongXmiR-107 promotes the erythroid differentiation of leukemia cells via the downregulation of Cacna2d1Mol Med Rep20151121334133925373460
PubMed Web of Science ®Google Scholar
KuoSSSaadAHKoongACHahnGMGiacciaAJPotassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cellsProc Natl Acad Sci U S A19939039089128430104
PubMed Web of Science ®Google Scholar
PalmeDMisovicMSchmidEKv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cellsPflugers Arch201346581209122123443853
PubMed Web of Science ®Google Scholar
HeiseNPalmeDMisovicMNon-selective cation channel-mediated Ca2+-entry and activation of Ca2+/calmodulin-dependent kinase II contribute to G2/M cell cycle arrest and survival of irradiated leukemia cellsCell Physiol Biochem2010264–559760821063097
PubMedGoogle Scholar
YuJWangSZhaoWMechanistic exploration of cancer stem cell marker voltage-dependent calcium channel α2δ1 subunitmediated chemotherapy resistance in small-cell lung cancerClin Cancer Res20182492148215829437792
PubMed Web of Science ®Google Scholar
LiLHaoXQinJAntibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in miceGastroenterology201414641108111824397969
PubMed Web of Science ®Google Scholar

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Calcium channel α2δ1 subunit (CACNA2D1) enhances radioresistance in cancer stem-like cells in non-small cell lung cancer cell lines

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Calcium channel α2δ1 subunit (CACNA2D1) enhances radioresistance in cancer stem-like cells in non-small cell lung cancer cell lines

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