352
Views
173
CrossRef citations to date
0
Altmetric
Review

IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis

, , , &
Pages 6685-6693 | Published online: 05 Dec 2018

References

  • BalkwillFMantovaniAInflammation and cancer: back to Virchow?Lancet2001357925553954511229684
  • ChatterjeeMStühmerTHerrmannPBommertKDörkenBBargouRCCombined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cellsBlood2004104123712372115297310
  • GascheJAHoffmannJBolandCRGoelAInterleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cellsInt J Cancer201112951053106321710491
  • GrivennikovSKarinETerzicJIL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerCancer Cell200915210311319185845
  • BeckerCFantiniMCWirtzSIL-6 signaling promotes tumor growth in colorectal cancerCell Cycle20054221722015655344
  • IsobeASawadaKKinoseYInterleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancerPLoS One2015102e011808025658637
  • GopinathanGMilagreCPearceOMInterleukin-6 stimulates defective angiogenesisCancer Res201575153098310726081809
  • CowardJKulbeHChakravartyPInterleukin-6 as a therapeutic target in human ovarian cancerClin Cancer Res201117186083609621795409
  • SainiUNaiduSElNaggarACElevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic targetOncogene201736216818127292260
  • ColomiereMWardACRileyCCross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomasBr J Cancer2009100113414419088723
  • ObataNHTamakoshiKShibataKKikkawaFTomodaYEffects of interleukin-6 on in vitro cell attachment, migration and invasion of human ovarian carcinomaAnticancer Res1997171A3373429066674
  • RathKSFunkHMBowlingMCRichardsWEDrewAFExpression of soluble interleukin-6 receptor in malignant ovarian tissueAm J Obstet Gynecol20102033230e1e820471626
  • SiegelRLMillerKDJemalACancer statistics, 2016CA Cancer J Clin201666173026742998
  • WangYLiLGuoXInterleukin-6 signaling regulates anchorage-independent growth, proliferation, adhesion and invasion in human ovarian cancer cellsCytokine201259222823622595649
  • American Cancer SocietyCancer Facts & Figures 2016American Cancer SocietyAtlanta, GA, USA2016 Available from: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2016/cancer-facts-and-figures-2016.pdfAccessed November 28, 2018
  • SiegelRLMillerKDJemalACancer statistics, 2018CA Cancer J Clin201868173029313949
  • NezhatFRApostolRNezhatCPejovicTNew insights in the pathophysiology of ovarian cancer and implications for screening and preventionAm J Obstet Gynecol2015213326226725818671
  • McCluggageWGMorphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesisPathology201143542043221716157
  • KurmanRJShih I eMThe dualistic model of ovarian carcinogenesis: revisited, revised, and expandedAm J Pathol2016186473374727012190
  • PradeepSKimSWWuSYHematogenous metastasis of ovarian cancer: rethinking mode of spreadCancer Cell2014261779125026212
  • LengyelEOvarian cancer development and metastasisAm J Pathol201017731053106420651229
  • ImanishiYHuBJarzynkaMJAngiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathwayCancer Res20076794254426317483337
  • WangENgalameYPanelliMCPeritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancerClin Cancer Res200511111312215671535
  • ZhangYTangHCaiJOvarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasionCancer Lett20113031475521310528
  • GiridharPVFunkHMGalloCAInterleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cellsClin Exp Metastasis201128888789721887537
  • SaidNSochaMJOlearczykJJElmarakbyAAImigJDMotamedKNormalization of the ovarian cancer microenvironment by SPARCMol Cancer Res20075101015103017951402
  • SavantSSSriramkumarSO’HaganHMThe role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancerCancers (Basel)2018108E25130061485
  • NilssonMBLangleyRRFidlerIJInterleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokineCancer Res20056523107941080016322225
  • HideshimaTNakamuraNChauhanDAndersonKCBiologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myelomaOncogene200120425991600011593406
  • KulbeHThompsonRWilsonJLThe inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cellsCancer Res200767258559217234767
  • MacciòAMadedduCInflammation and ovarian cancerCytokine201258213314722349527
  • WuDChengJSunGp70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinomaOncotarget2016724365393655027174914
  • KishimotoTIL-6: from its discovery to clinical applicationsInt Immunol201022534735220410258
  • HeinrichPCBehrmannIHaanSHermannsHMMüller-NewenGSchaperFPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationBiochem J2003374Pt 112012773095
  • WangZWuPWuDPrognostic and clinicopathological significance of serum interleukin-6 expression in colorectal cancer: a systematic review and meta-analysisOnco Targets Ther201583793380126719707
  • AbubakerKLuworRBEscalonaRTargeted disruption of the JAK2/STAT3 pathway in combination with systemic administration of paclitaxel inhibits the priming of ovarian cancer stem cells leading to a reduced tumor burdenFront Oncol201447524782986
  • DuanZFosterRBellDASignal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancerClin Cancer Res200612175055506316951221
  • KimGDavidsonBHenningRAdhesion molecule protein signature in ovarian cancer effusions is prognostic of patient outcomeCancer201211861543155322009736
  • HoCMChengWFLinMCPrognostic and predictive values of E-cadherin for patients of ovarian clear cell adenocarcinomaInt J Gynecol Cancer20102091490149721119364
  • SilverDLNaoraHLiuJChengWMontellDJActivated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motilityCancer Res200464103550355815150111
  • WenWWuJLiuLSynergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancerMol Cancer20151410025928246
  • MoLBachelderREKennedyMSyngeneic murine ovarian cancer model reveals that ascites enriches for ovarian cancer stem-like cells expressing membrane GRP78Mol Cancer Ther201514374775625589495
  • ErroiASironiMChiaffarinoFChenZGMengozziMMantovaniAIL-1 and IL-6 release by tumor-associated macrophages from human ovarian carcinomaInt J Cancer19894457958012583859
  • Chaluvally-RaghavanPJeongKJPradeepSDirect upregulation of STAT3 by microRNA-551b-3p deregulates growth and metastasis of ovarian cancerCell Rep20161571493150427160903
  • SoKAMinKJHongJHLeeJKInterleukin-6 expression by interactions between gynecologic cancer cells and human mesenchymal stem cells promotes epithelial-mesenchymal transitionInt J Oncol20154741451145926316317
  • AnsieauSBastidJDoreauAInduction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescenceCancer Cell2008141798918598946
  • MorelAPHinkalGWThomasCEMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic micePLoS Genet201285e100272322654675
  • VergaraDMerlotBLucotJPEpithelial-mesenchymal transition in ovarian cancerCancer Lett20102911596619880243
  • StefaniaDVergaraDThe many-faced program of epithelial-Mesenchymal transition: a system biology-based viewFront Oncol2017727429181337
  • WellnerUSchubertJBurkUCThe EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAsNat Cell Biol200911121487149519935649
  • GuoLChenCShiMStat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transitionOncogene201332455272528223318420
  • De CraeneBBerxGRegulatory networks defining EMT during cancer initiation and progressionNat Rev Cancer20131329711023344542
  • CookeVGLeBleuVSKeskinDPericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathwayCancer Cell2012211668122264789
  • AuerspergNPanJGroveBDE-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epitheliumProc Natl Acad Sci U S A199996116249625410339573
  • ZhangYFanNYangJExpression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell linesMol Med Rep20151233393339925975373
  • YoshidaTOzawaYKimuraTEribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) statesBr J Cancer201411061497150524569463
  • YeasminSNakayamaKRahmanMTLoss of MKK4 expression in ovarian cancer: a potential role for the epithelial to mesenchymal transitionInt J Cancer201112819410420309881
  • TerauchiMKajiyamaHYamashitaMPossible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinomaClin Exp Metastasis200724532933917487558
  • KeskinDKimJCookeVGTargeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2Cell Rep20151071066108125704811
  • NaylorMSStampGWDaviesBDBalkwillFRExpression and activity of MMPS and their regulators in ovarian cancerInt J Cancer199458150568014015
  • KoHSParkBJChoiSKSTAT3 and ERK signaling pathways are implicated in the invasion activity by oncostatin m through induction of matrix metalloproteinases 2 and 9Yonsei Med J201657376176826996579
  • PiuraBMedinaLRabinovichADyominVHuleihelMThalidomide distinctly affected TNF-α, IL-6 and MMP secretion by an ovarian cancer cell line (SKOV-3) and primary ovarian cancer cellsEur Cytokine Netw201324312212924284039
  • LiLNZhouXGuYYanJPrognostic value of MMP-9 in ovarian cancer: a meta-analysisAsian Pac J Cancer Prev20131474107411323991961
  • HuXLiDZhangWZhouJTangBLiLMatrix metalloproteinase-9 expression correlates with prognosis and involved in ovarian cancer cell invasionArch Gynecol Obstet201228661537154322832979
  • RabinovichAMedinaLPiuraBSegalSHuleihelMRegulation of ovarian carcinoma SKOV-3 cell proliferation and secretion of MMPs by autocrine IL-6Anticancer Res2007271A26727217352242
  • MaYZhangXXuXSTAT3 decoy oligodeoxynucleotides-loaded solid lipid nanoparticles induce cell death and inhibit invasion in ovarian cancer cellsPLoS One2015104e012492425923701
  • TangYJSunZLWuWGInhibitor of signal transducer and activator of transcription 3 (STAT3) suppresses ovarian cancer growth, migration and invasion and enhances the effect of cisplatin in vitroGenet Mol Res20151412450246025867391
  • AngevinETaberneroJElezEA phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumorsClin Cancer Res20142082192220424563479
  • van KruchtenMde VriesEFArtsHJAssessment of estrogen receptor expression in epithelial ovarian cancer patients using 16α-18F-fluoro-17β-estradiol PET/CTJ Nucl Med2015561505525476534
  • GearingDPComeauMRFriendDJThe IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptorScience19922555050143414371542794
  • MosleyBDe ImusCFriendDDual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activationJ Biol Chem19962715132635326438999038
  • LiuJModrellBAruffoAScharnowskeSShoyabMInteractions between oncostatin M and the IL-6 signal transducer, gp130Cytokine1994632722788054483
  • GrenierADehouxMBouttenAOncostatin M production and regulation by human polymorphonuclear neutrophilsBlood1999934141314219949186
  • WestNRMurrayJIWatsonPHOncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancerOncogene201433121485149423584474
  • DavidEGuihardPBrounaisBDirect anti-cancer effect of oncostatin M on chondrosarcomaInt J Cancer201112881822183521344373
  • DavidETirodeFBaud’huinMOncostatin M is a growth factor for Ewing sarcomaAm J Pathol201218151782179522982441
  • RyanREMartinBMellorLOncostatin M binds to extracellular matrix in a bioactive conformation: implications for inflammation and metastasisCytokine2015721718525622278