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Review

Single-Fraction Radiotherapy (SFRT) For Bone Metastases: Patient Selection And Perspectives

, , ORCID Icon, &
Pages 9397-9408 | Published online: 05 Nov 2019

References

  • Bruera ED, Portenoy RK, eds, Cancer Pain: Assessment and Management. New York (NY): Cambridge University Press; 2003:413–428.
  • Smith HS. Painful osseous metastases. Pain Physician. 2011;14(4):E373–403.21785487
  • Mundy GR. Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2(8):584–593. doi:10.1038/nrc86712154351
  • Weinfurt KP, Li Y, Castel LD, et al. The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol. 2005;16(4):579–584. doi:10.1093/annonc/mdi12215734776
  • Decroisette C, Monnet I, Berard H, et al. Epidemiology and treatment costs of bone metastases from lung cancer: a French prospective, observational, multicentre study (GFPC 0601). J Thorac Oncol. 2011;6(3):576–582. doi:10.1097/JTO.0b013e318206a1e321270669
  • Lutz S, Balboni T, Jones J, et al. Palliative radiation therapy for bone metastases: update of an ASTRO evidence-based guideline. Pract Radiat Oncol. 2017;7(1):4–12. doi:10.1016/j.prro.2016.08.00127663933
  • Rich SE, Chow R, Raman S, et al. Update of the systematic review of palliative radiation therapy fractionation for bone metastases. Radiother Oncol. 2018;126(3):547–557. doi:10.1016/j.radonc.2018.01.00329397209
  • Huisman M, van Den Bosch MA, Wijlemans JW, et al. Effectiveness of reirradiation for painful bone metastases: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys. 2012;84(1):8–14. doi:10.1016/j.ijrobp.2011.10.08022300568
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. doi:10.3322/caac.v69.130620402
  • Barzilai O, Versteeg AL, Sahgal A, et al. Survival, local control, and health-related quality of life in patients with oligometastatic and polymetastatic spinal tumors: a multicenter, international study. Cancer. 2019;125(5):770–778. doi:10.1002/cncr.3187030489634
  • Sprave T, Verma V, Förster R, et al. Randomized phase II trial evaluating pain response in patients with spinal metastases following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy. Radiother Oncol. 2018;128(2):274–282. doi:10.1016/j.radonc.2018.04.03029843899
  • van der Velden JM, Verkooijen HM, Seravalli E, et al. Comparing conVEntional radiotherapy with stereotactIC body radiotherapy in patients with spinAL metastases: study protocol for an randomized controlled trial following the cohort multiple randomized controlled trial design. BMC Cancer. 2016;16(1):909. doi:10.1186/s12885-016-2947-027871280
  • Ryu S, Pugh SL, Gerszten PC, et al. RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1-3) spine metastases: phase 2 results. Pract Radiat Oncol. 2014;4(2):76–81. doi:10.1016/j.prro.2013.05.00124890347
  • Palma DA, Olson R, Harrow S, et al. Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2,open-label trial. Lancet. 2019;393(10185):2051–2058. doi:10.1016/S0140-6736(18)32487-530982687
  • Katsoulakis E, Laufer I, Bilsky M, et al. Pathological characteristics of spine metastases treated with high-dose single-fraction stereotactic radiosurgery. Neurosurg Focus. 2017;42(1):E7. doi:10.3171/2016.10.FOCUS16368
  • van Den Hout WB, van der Linden YM, Steenland E. Single- versus multiple-fraction radiotherapy in patients with painful bone metastases: cost-utility analysis based on a randomized trial. J Natl Cancer Inst. 2003;95(3):222–229. doi:10.1093/jnci/95.3.22212569144
  • Klimo P Jr, Schmidt MH. Surgical management of spinal metastases. Oncologist. 2004;9(2):188–196. doi:10.1634/theoncologist.9-2-18815047923
  • Hamilton AJ, Lulu BA, Fosmire H, Stea B, Cassady JR. Preliminary clinical experience with linear accelerator-based spinal stereotactic radiosurgery. Neurosurgery. 1995;36(2):311–319. doi:10.1227/00006123-199502000-00107731511
  • Ryu S, Fang Yin F, Rock J, et al. Image-guided and intensity-modulated radiosurgery for patients with spinal metastasis. Cancer. 2003;97(8):2013–2018. doi:10.1002/cncr.1129612673732
  • Garg AK, Shiu AS, Yang J, et al. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012;118(20):5069–5077. doi:10.1002/cncr.2753022511344
  • Ryu S, Rock J, Rosenblum M, Kim JH. Patterns of failure after single-dose radiosurgery for spinal metastasis. J Neurosurg. 2004;101(S3):402–405. doi:10.3171/sup.2004.101.supplement3.0402
  • Leeman JE, Bilsky M, Laufer I, et al. Stereotactic body radiotherapy for metastatic spinal sarcoma: a detailed patterns-of-failure study. J Neurosurg Spine. 2016;25(1):52–58. doi:10.3171/2015.11.SPINE15105926943256
  • Gerszten PC, Burton SA, Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila Pa 1976). 2007;32(2):193–199. doi:10.1097/01.brs.000251863.76595.a217224814
  • Bishop AJ, Tao R, Guadagnolo BA, et al. Spine stereotactic radiosurgery for metastatic sarcoma: patterns of failure and radiation treatment volume considerations. J Neurosurg Spine. 2017;27(3):303–311. doi:10.3171/2017.1.SPINE16104528644075
  • Yamada Y, Katsoulakis E, Laufer I, et al. The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery. Neurosurg Focus. 2017;42(1):E6. doi:10.3171/2016.9.FOCUS16369
  • Jahaveri PM, Teh BS, Paulino AC, et al. A dose-response relationship for time to bone pain resolution after stereotactic body radiotherapy (SBRT) for renal cell carcinoma (RCC) bony metastases. Acta Oncol. 2012;51(5):584–588. doi:10.3109/0284186X.2011.65274122248089
  • Rose PS, Laufer I, Boland PJ, et al. Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol. 2009;27(30):5075–5079. doi:10.1200/JCO.2008.19.350819738130
  • Garcia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science. 2003;300(5622):1155–1159. doi:10.1126/science.108250412750523
  • Steverink JG, Willems SM, Philippens MEP, et al. Early tissue effects of stereotactic body radiation therapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2018;100(5):1254–1258. doi:10.1016/j.ijrobp.2018.01.00529439885
  • Heron DE, Rajagopalan MS, Stone B, et al. Single-session and multisession CyberKnife radiosurgery for spine metastases-University of Pittsburgh and Georgetown University experience. J Neurosurg Spine. 2012;17(1):11–18. doi:10.3171/2012.4.SPINE11902
  • Ghia AJ, Chang EL, Bishop AJ, et al. Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials. J Neurosurg Spine. 2016;24(5):829–836. doi:10.3171/2015.8.SPINE1584426799117
  • Folkert MR, Bilsky MH, Tom AK, et al. Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine. Int J Radiat Oncol Biol Phys. 2014;88(5):1085–1091. doi:10.1016/j.ijrobp.2013.12.04224661662
  • Ning MS, Deegan BJ, Ho JC, et al. Low incidence of late failure and toxicity after spine stereotactic radiosurgery: secondary analysis of phase I/II trials with long-term follow-up. Radiother Oncol. 2019;138:80–85. doi:10.1016/j.radonc.2019.06.00331252298
  • Yoo GS, Park HC, Yu JI, et al. Stereotactic ablative body radiotherapy for spinal metastasis from hepatocellular carcinoma: its oncologic outcomes and risk of vertebral compression fracture. Oncotarget. 2017;8(42):72860–72871. doi:10.18632/oncotarget.v8i4229069831
  • Ling DC, Flickinger JC, Burton SA, et al. Long-term outcomes after stereotactic radiosurgery for spine metastases: radiation dose-response for late toxicity. Int J Radiat Oncol Biol Phys. 2018;101(3):602–609. doi:10.1016/j.ijrobp.2018.02.03529678526
  • Sahgal A, Atenafu EG, Chao S, et al. Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol. 2013;31(27):3426–3431. doi:10.1200/JCO.2013.50.141123960179
  • Napieralska A, Miszczyk L, Stapor-Fudzinska M. CyberKnife stereotactic radiosurgery and stereotactic ablative radiation therapy of patients with prostate cancer bone metastases. Neoplasma. 2016;63(2):304–312. doi:10.4149/218_150807N43526774153
  • Boyce-Fappiano D, Elibe E, Schultz L, et al. Analysis of the factors contributing to vertebral compression fractures after spine stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2017;97(2):236–245. doi:10.1016/j.ijrobp.2016.09.00728068232
  • Thibault I, Whyne CM, Zhou S, et al. Volume of lytic vertebral body metastatic disease quantified using computed tomography-based image segmentation predicts fracture risk after spine stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2017;97(1):75–81. doi:10.1016/j.ijrobp.2016.09.02927843032
  • Tseng CL, Soliman H, Myrehaug S, et al. Imaging-based outcomes for 24 Gy in 2 daily fractions for patients with de novo spinal metastases treated with spine stereotactic body radiation therapy (SBRT). Int J Radiat Oncol Biol Phys. 2018;102(3):499–507. doi:10.1016/j.ijrobp.2018.06.04730003994
  • Jawad MS, Fahim DK, Gerszten PC, et al. Vertebral compression fractures after stereotactic body radiation therapy: a large, multi-institutional, multinational evaluation. J Neurosurg Spine. 2016;24(6):928–936. doi:10.3171/2015.10.SPINE14126126895526
  • Thibault I, Al-Omair A, Masucci GL, et al. Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture. J Neurosurg Spine. 2014;21(5):711–718. doi:10.3171/2014.7.SPINE1389525170656
  • Boehling NS, Grosshans DR, Allen PK, et al. Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases. J Neurosurg Spine. 2012;16(4):379–386. doi:10.3171/2011.11.SPINE11622225488
  • Kelley KD, Racareanu R, Sison CP, et al. Outcomes in the radiosurgical management of metastatic spine disease. Adv Radiat Oncol. 2018;4(2):283–293. doi:10.1016/j.adro.2018.10.00731011673
  • Fisher CG, DiPaola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spine (Phila Pa 1976). 2010;35(22):E1221–9. doi:10.1097/BRS.0b013e3181e16ae220562730
  • Lee SH, Tatsui CE, Ghia AJ, et al. Can the spinal instability neoplastic score prior to spinal radiosurgery predict compression fractures following stereotactic spinal radiosurgery for metastatic spinal tumor?: a post hoc analysis of prospective phase II single-institution trials. J Neurooncol. 2016;126(3):509–517. doi:10.1007/s11060-015-1990-z26643804
  • Kassamali RH, Ganeshan A, Hoey ET, Crowe PM, Douis H, Henderson J. Pain management in spinal metastases: the role of percutaneous vertebral augmentation. Ann Oncol. 2011;22(4):782–786. doi:10.1093/annonc/mdq60520966180
  • Wardak Z, Bland R, Ahn C, et al. A phase 2 clinical trial of SABR followed by immediate vertebroplasty for spine metastases. Int J Radiat Oncol Biol Phys. 2019;104(1):83–89. doi:10.1016/j.ijrobp.2019.01.07230684664
  • Ozdemir Y, Torun N, Guler OC, et al. Local control and vertebral compression fractures following stereotactic body radiotherapy for spine metastases. J Bone Oncol. 2019;15:100218. doi:10.1016/j.jbo.2019.10021830815342
  • Pichon B, Campion L, Delpon G, et al. High-dose hypofractionated radiation therapy for noncompressive vertebral metastases in combination with zoledronate: a phase 1 study. Int J Radiat Oncol Biol Phys. 2016;96(4):840–847. doi:10.1016/j.ijrobp.2016.07.02727663759
  • Ito K, Ogawa H, Shimizuguchi T, et al. Stereotactic body radiotherapy for spinal metastases: clinical experience in 134 cases from a single Japanese institution. Technol Cancer Res Treat. 2018;17:1533033818806472. doi:10.1177/153303381880647230355246
  • Chang JH, Gandhidasan S, Finnigan R, et al. Stereotactic ablative body radiotherapy for the treatment of spinal oligometastases. Clin Oncol (R Coll Radiol). 2017;29(7):e119–e125. doi:10.1016/j.clon.2017.02.00428237218
  • Guckenberger M, Mantel F, Gerszten PC, et al. Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis. Radiat Oncol. 2014;9:226. doi:10.1186/s13014-014-0226-225319530
  • Nuyttens JJ, Moiseenko V, McLaughlin M, Jain S, Herbert S, Grimm J. Esophageal dose tolerance in patients treated with stereotactic body radiation therapy. Semin Radiat Oncol. 2016;26(2):120–128. doi:10.1016/j.semradonc.2015.11.00627000508
  • Abelson JA, Murphy JD, Loo BW Jr, et al. Esophageal tolerance to high-dose stereotactic ablative radiotherapy. Dis Esophagus. 2012;25(7):623–629. doi:10.1111/dote.2012.25.issue-722168251
  • Cox BW, Jackson A, Hunt M, Bilsky M, Yamada Y. Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2012;83(5):e661–7. doi:10.1016/j.ijrobp.2012.01.08022572079
  • Onimaru R, Shirato H, Shimizu S, et al. Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys. 2003;56(1):126–135. doi:10.1016/S0360-3016(03)00095-612694831
  • Hellman S, Weichselbaum RR. Oligometastases. J Clin Oncol. 1995;13(1):8–10. doi:10.1200/JCO.1995.13.1.87799047
  • Salama JK, Hasselle MD, Chmura SJ, et al. Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease. Cancer. 2012;118(11):2962–2970. doi:10.1002/cncr.2661122020702
  • Ho JC, Tang C, Deegan BJ, et al. The use of spine stereotactic radiosurgery for oligometastatic disease. J Neurosurg Spine. 2016;25(2):239–247. doi:10.3171/2016.1.SPINE15116627035507
  • Silva SR, Gliniewicz A, Martin B, et al. Oligometastatic disease state is associated with improved local control in patients undergoing three or five fraction spine stereotactic body radiotherapy. World Neurosurg. 2019;122:e342–e348. doi:10.1016/j.wneu.2018.10.04430326310
  • Loi M, Desideri I, Greto D, et al. Radiotherapy in the age of cancer immunology: current concepts and future developments. Crit Rev Oncol Hematol. 2017;112:1–10. doi:10.1016/j.critrevonc.2017.02.00228325250
  • Laufer I, Rubin DG, Lis E, et al. The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 2013;18(6):744–751. doi:10.1634/theoncologist.2012-029323709750
  • Tang C, Hess K, Bishop AJ, et al. Creation of a prognostic index for spine metastasis to stratify survival in patients treated with spinal stereotactic radiosurgery: secondary analysis of mature prospective trials. Int J Radiat Oncol Biol Phys. 2015;93(1):118–125. doi:10.1016/j.ijrobp.2015.04.05026130231
  • Spratt DE, Beeler WH, de Moraes FY, et al. An integrated multidisciplinary algorithm for the management of spinal metastases: an International Spine Oncology Consortium report. Lancet Oncol. 2017;18(12):e720–e730. doi:10.1016/S1470-2045(17)30612-529208438
  • Cox BW, Spratt DE, Lovelock M, et al. International Spine Radiosurgery Consortium consensus guidelines fortarget volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2012;83(5):e597–e605. doi:10.1016/j.ijrobp.2012.03.00922608954
  • Ito K, Shimizuguchi T, Nihei K, et al. Patterns of intraosseous recurrence after stereotactic body radiation therapy for coxal bone metastasis. Int J Radiat Oncol Biol Phys. 2018;100(1):159–161. doi:10.1016/j.ijrobp.2017.08.04529066121
  • Yu T, Choi CW, Kim KS. Treatment outcomes of stereotactic ablative radiation therapy for non-spinal bone metastases: focus on response assessment and treatment indication. Br J Radiol. 2019;92(1099):20181048. doi:10.1259/bjr.2018104831075040
  • Erler D, Brotherston D, Sahgal A, et al. Local control and fracture risk following stereotactic body radiation therapy for non-spine bone metastases. Radiother Oncol. 2018;127(2):304–309. doi:10.1016/j.radonc.2018.03.03029706460
  • Owen D, Laack NN, Mayo CS. Outcomes and toxicities of stereotactic body radiation therapy for non-spine bone oligometastases. Pract Radiat Oncol. 2014;4(2):e143–e149. doi:10.1016/j.prro.2013.05.00624890360
  • van der Linden YM, Steenland E, van Houwelingen HC, et al. Patients with a favourable prognosis are equally palliated with single and multiple fraction radiotherapy: results on survival in the Dutch Bone Metastasis Study. Radiother Oncol. 2006;78(3):245–253. doi:10.1016/j.radonc.2006.02.00716545474
  • Gaze MN, Kelly CG, Kerr GR, et al. Pain relief and quality of life following radiotherapy for bone metastases: a randomised trial of two fractionation schedules. Radiother Oncol. 1997;45(2):109–116. doi:10.1016/S0167-8140(97)00101-19423999
  • Nguyen QN, Chun SG, Chow E, et al. Single-fraction stereotactic vs conventional multifraction radiotherapy for pain relief in patients with predominantly nonspine bone metastases: a randomized phase 2 trial. JAMA Oncol. 2019;5:872. doi:10.1001/jamaoncol.2019.019231021390
  • Loi M, Klass ND, De Vries KC, et al. Pain flare, complexity and analgesia in bone oligometastases treated with stereotactic body radiation therapy. Eur J Cancer Care (Engl). 2018;27(6):e12915. doi:10.1111/ecc.1291530246916
  • Chiang A, Zeng L, Zhang L, et al. Pain flare is a common adverse event in steroid-naïve patients after spine stereotactic body radiation therapy: a prospective clinical trial. Int J Radiat Oncol Biol Phys. 2013;86(4):638–642. doi:10.1016/j.ijrobp.2013.03.02223664326
  • Pan HY, Allen PK, Wang XS, et al. Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1/2 trials. Int J Radiat Oncol Biol Phys. 2014;90(4):870–876. doi:10.1016/j.ijrobp.2014.07.03725227497
  • Khan L, Chiang A, Zhang L, et al. Prophylactic dexamethasone effectively reduces the incidence of pain flare following spine stereotactic body radiotherapy (SBRT): a prospective observational study. Support Care Cancer. 2015;23(10):2937–2943. doi:10.1007/s00520-015-2659-z25752882
  • McGee HM, Carpenter TJ, Ozbek U, et al. Analysis of local control and pain control after spine stereotactic radiosurgery reveals inferior outcomes for hepatocellular carcinoma compared with other radioresistant histologies. Pract Radiat Oncol. 2019;9(2):89–97. doi:10.1016/j.prro.2018.11.00930543868
  • Mehta N, Zavitsanos PJ, Moldovan K, et al. Local failure and vertebral body fracture risk using multifraction stereotactic body radiation therapy for spine metastases. Adv Radiat Oncol. 2018;3(3):245–251. doi:10.1016/j.adro.2018.04.00230202794
  • Zeng KL, Myrehaug S, Soliman H, et al. Stereotactic body radiotherapy for spinal metastases at the extreme ends of the spine: imaging-based outcomes for cervical and sacral metastases. Neurosurgery. 2018. doi:10.1093/neuros/nyy393
  • Fanetti G, Marvaso G, Ciardo D, et al. Stereotactic body radiotherapy for castration-sensitive prostate cancer bone oligometastases. Med Oncol. 2018;35(5):75. doi:10.1007/s12032-018-1137-029671075
  • Guckenberger M, Sweeney RA, Hawkins M, et al. Dose-intensified hypofractionated stereotactic body radiation therapy for painful spinal metastases: results of a phase 2 study. Cancer. 2018;124(9):2001–2009. doi:10.1002/cncr.v124.929499073
  • Bernard V, Bishop AJ, Allen PK, et al. Heterogeneity in treatment response of spine metastases to spine stereotactic radiosurgery within “radiosensitive” subtypes. Int J Radiat Oncol Biol Phys. 2017;99(5):1207–1215. doi:10.1016/j.ijrobp.2017.08.02829029886
  • Bernstein MB, Chang EL, Amini B, et al. Spine stereotactic radiosurgery for patients with metastatic thyroid cancer: secondary analysis of phase I/II trials. Thyroid. 2016;26(9):1269–1275. doi:10.1089/thy.2016.004627334245
  • Germano IM, Carai A, Pawha P, et al. Clinical outcome of vertebral compression fracture after single fraction spine radiosurgery for spinal metastases. Clin Exp Metastasis. 2016;33(2):143–149. doi:10.1007/s10585-015-9764-826578533
  • Lee E, Kim TG, Park HC, et al. Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma. Radiat Oncol J. 2015;33(3):217–225. doi:10.3857/roj.2015.33.3.21726484305
  • Amini A, Altoos B, Bourlon MT, et al. Local control rates of metastatic renal cell carcinoma (RCC) to the bone using stereotactic body radiation therapy: is RCC truly radioresistant? Pract Radiat Oncol. 2015;5(6):e589–e596. doi:10.1016/j.prro.2015.05.00426142027
  • Bishop AJ, Tao R, Rebueno NC, et al. Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence. Int J Radiat Oncol Biol Phys. 2015;92(5):1016–1026. doi:10.1016/j.ijrobp.2015.03.03726025777
  • Anand AK, Venkadamanickam G, Punnakal AU, et al. Hypofractionated stereotactic body radiotherapy in spinal metastasis - withor without epidural extension. Clin Oncol (R Coll Radiol). 2015;27(6):345–352. doi:10.1016/j.clon.2015.01.03525726363
  • Balagamwala EH, Angelov L, Koyfman SA, et al. Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma. J Neurosurg Spine. 2012;17(6):556–564. doi:10.3171/2012.8.SPINE1230323020208
  • Ahmed KA, Stauder MC, Miller RC, et al. Stereotactic body radiation therapy in spinal metastases. Int J Radiat Oncol Biol Phys. 2012;82(5):e803–e809. doi:10.1016/j.ijrobp.2011.11.03622330988
  • Wang XS, Rhines LD, Shiu AS, et al. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012;13(4):395–402. doi:10.1016/S1470-2045(11)70384-922285199
  • Martin AG, Cowley IR, Taylor BA, et al. (Stereotactic) radiosurgery XIX: spinal radiosurgery–two year experience in a UK centre. Br J Neurosurg. 2012;26(1):53–58. doi:10.3109/02688697.2011.60385722026444
  • Muacevic A, Kufeld M, Rist C, Wowra B, Stief C, Staehler M. Safety and feasibility of image-guided robotic radiosurgery for patients with limited bone metastases of prostate cancer. Urol Oncol. 2013;31(4):455–460. doi:10.1016/j.urolonc.2011.02.02321481619
  • Nguyen QN, Shiu AS, Rhines LD, et al. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010;76(4):1185–1192. doi:10.1016/j.ijrobp.2009.03.06219632064
  • Amdur RJ, Bennett J, Olivier K, et al. A prospective, phase II study demonstrating the potential value and limitation of radiosurgery for spine metastases. Am J Clin Oncol. 2009;32(5):515–520. doi:10.1097/COC.0b013e318194f70f19528790
  • Tsai JT, Lin JW, Chiu WT, Chu WC. Assessment of image-guided CyberKnife radiosurgery for metastatic spine tumors. J Neurooncol. 2009;94(1):119–127. doi:10.1007/s11060-009-9814-719255725
  • Chang EL, Shiu AS, Mendel E, et al. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007;7(2):151–160. doi:10.3171/SPI-07/08/15117688054
  • Gibbs IC, Kamnerdsupaphon P, Ryu MR, et al. Image-guided robotic radiosurgery for spinal metastases. Radiother Oncol. 2007;82(2):185–190. doi:10.1016/j.radonc.2006.11.02317257702
  • Sharma M, Bennett EE, Rahmathulla G, et al. Impact of cervicothoracic region stereotactic spine radiosurgery on adjacent organs at risk. Neurosurg Focus. 2017;42(1):E14. doi:10.3171/2016.10.FOCUS16364
  • Hashmi A, Guckenberger M, Kersh R, et al. Re-irradiation stereotactic body radiotherapy for spinal metastases: a multi-institutional outcome analysis. J Neurosurg Spine. 2016;25(5):646–653. doi:10.3171/2016.4.SPINE15152327341054
  • Moussazadeh N, Lis E, Katsoulakis E, et al. Five-year outcomes of high-dose single-fraction spinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2015;93(2):361–367. doi:10.1016/j.ijrobp.2015.05.03526232858